Biochimica et biophysica acta. Reviews on cancer最新文献_第9页

Role of cell division cycle-associated proteins in regulating cell cycle and promoting tumor progression 细胞分裂周期相关蛋白在调节细胞周期和促进肿瘤进展中的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-30 DOI: 10.1016/j.bbcan.2024.189147

引用次数: 0

Pathophysiological role of histamine signaling and its implications in glioblastoma 组胺信号的病理生理学作用及其对胶质母细胞瘤的影响。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-30 DOI: 10.1016/j.bbcan.2024.189146

Poonam Yadav , Raghupathy Vengoji , Maneesh Jain , Surinder K. Batra , Nicole Shonka

{"title":"Pathophysiological role of histamine signaling and its implications in glioblastoma","authors":"Poonam Yadav , Raghupathy Vengoji , Maneesh Jain , Surinder K. Batra , Nicole Shonka","doi":"10.1016/j.bbcan.2024.189146","DOIUrl":"10.1016/j.bbcan.2024.189146","url":null,"abstract":"<div><p>Glioblastoma (GBM), an extremely aggressive and prevalent malignant brain tumor, remains a challenge to treat. Despite a multimodality treatment approach, GBM recurrence remains inevitable, particularly with the emergence of temozolomide (TMZ) resistance and limited treatment options. Surprisingly, previous studies show that a history of allergies, atopy, or asthma is inversely associated with GBM risk. Further, the electronic medical record at the University Hospital of Lausanne showed that the GBM patients taking antihistamine during treatment had better survival. Histamine is an essential neurotransmitter in the brain and plays a significant role in regulating sleep, hormonal balance, and cognitive functions. Elevated levels of histamine and increased histamine receptor expression have been found in different tumors and their microenvironments, including GBM. High histamine 1 receptor (HRH1) expression is inversely related to overall and progression-free survival in GBM patients, further emphasizing the role of histamine in disease progression. This review aims to provide insights into the challenges of GBM treatment, the role of histamine in GBM progression, and the rationale for considering antihistamines as targeted therapy. The review concludes by encouraging further investigation into antihistamine mechanisms and their impact on the tumor microenvironment.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189146"},"PeriodicalIF":9.7,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving treatment landscape in thymic epithelial tumors: From mechanism to therapy 胸腺上皮肿瘤治疗的演变：从机制到治疗。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-26 DOI: 10.1016/j.bbcan.2024.189145

Yehao Yang, Ying Yu, Yun Fan, Hui Li

{"title":"Evolving treatment landscape in thymic epithelial tumors: From mechanism to therapy","authors":"Yehao Yang, Ying Yu, Yun Fan, Hui Li","doi":"10.1016/j.bbcan.2024.189145","DOIUrl":"10.1016/j.bbcan.2024.189145","url":null,"abstract":"<div><p>Thymic epithelial tumors (TETs) are rare neoplasms of the anterior mediastinum that arise from thymic epithelial cells. Although surgery is the preferred treatment for resectable TETs, the options for unresectable or recurrent advanced-stage TETs are limited beyond platinum-based chemotherapy. The evolving landscape of TET treatments is marked by significant advancements in targeted therapies and immunotherapies, particularly with anti-angiogenic agents and immune checkpoint inhibitors (ICIs). While monotherapies demonstrated certain efficacy, the development of combination strategies is vital for improving patient outcomes. This review consolidates progress in anti-angiogenic therapies and ICIs, emphasizing the evolution of combination therapies of TETs. Furtherly, we particularly discuss new first-line strategies based on these advancements and emphasizes exploring novel treatments like antibody-drug conjugates, immunomodulatory drugs and cytokine-based agents for TETs. Mechanistically, the molecular features of TETs integrated with clinical diagnosis and targeted therapy, and immunophenotyping of TETs along with its impact on the efficacy and safety of immunotherapy are discussed. Thus, this review systemizes the development in the treatment landscape of TETs, integrating the corresponding molecular and immune mechanisms, aiming to provide new references for the treatment of TETs.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189145"},"PeriodicalIF":9.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000763/pdfft?md5=8d74ce616dcf2c44ed30be236d6130c8&pid=1-s2.0-S0304419X24000763-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting transposable elements in cancer: developments and opportunities 针对癌症中的转座元件：发展与机遇。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-25 DOI: 10.1016/j.bbcan.2024.189143

Zi-Yu Wang , Li-Ping Ge , Yang Ouyang , Xi Jin, Yi-Zhou Jiang

{"title":"Targeting transposable elements in cancer: developments and opportunities","authors":"Zi-Yu Wang , Li-Ping Ge , Yang Ouyang , Xi Jin, Yi-Zhou Jiang","doi":"10.1016/j.bbcan.2024.189143","DOIUrl":"10.1016/j.bbcan.2024.189143","url":null,"abstract":"<div><p>Transposable elements (TEs), comprising nearly 50% of the human genome, have transitioned from being perceived as “genomic junk” to key players in cancer progression. Contemporary research links TE regulatory disruptions with cancer development, underscoring their therapeutic potential. Advances in long-read sequencing, computational analytics, single-cell sequencing, proteomics, and CRISPR-Cas9 technologies have enriched our understanding of TEs' clinical implications, notably their impact on genome architecture, gene regulation, and evolutionary processes. In cancer, TEs, including long interspersed element-1 (LINE-1), Alus, and long terminal repeat (LTR) elements, demonstrate altered patterns, influencing both tumorigenic and tumor-suppressive mechanisms. TE-derived nucleic acids and tumor antigens play critical roles in tumor immunity, bridging innate and adaptive responses. Given their central role in oncology, TE-targeted therapies, particularly through reverse transcriptase inhibitors and epigenetic modulators, represent a novel avenue in cancer treatment. Combining these TE-focused strategies with existing chemotherapy or immunotherapy regimens could enhance efficacy and offer a new dimension in cancer treatment. This review delves into recent TE detection advancements, explores their multifaceted roles in tumorigenesis and immune regulation, discusses emerging diagnostic and therapeutic approaches centered on TEs, and anticipates future directions in cancer research.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189143"},"PeriodicalIF":9.7,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering extracellular vesicles protein cargo in pancreatic cancer 解密胰腺癌细胞外囊泡蛋白载体

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-22 DOI: 10.1016/j.bbcan.2024.189142

Yifan Hong , Jiaqi Yang , Xinyuan Liu , Sicong Huang , Tingbo Liang , Xueli Bai

引用次数: 0

Advances in immunotherapy for breast cancer and feline mammary carcinoma: From molecular basis to novel therapeutic targets 乳腺癌和猫乳腺癌免疫疗法的进展：从分子基础到新型治疗目标。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-22 DOI: 10.1016/j.bbcan.2024.189144

Tatiana Vilela , Sofia Valente , Jorge Correia , Fernando Ferreira

{"title":"Advances in immunotherapy for breast cancer and feline mammary carcinoma: From molecular basis to novel therapeutic targets","authors":"Tatiana Vilela , Sofia Valente , Jorge Correia , Fernando Ferreira","doi":"10.1016/j.bbcan.2024.189144","DOIUrl":"10.1016/j.bbcan.2024.189144","url":null,"abstract":"<div><p>The role of inflammation in cancer is a topic that has been investigated for many years. As established, inflammation emerges as a defining characteristic of cancer, presenting itself as a compelling target for therapeutic interventions in the realm of oncology. Controlling the tumor microenvironment (TME) has gained paramount significance, modifying not only the effectiveness of immunotherapy but also modulating the outcomes and prognoses of standard chemotherapy and other anticancer treatments. Immunotherapy has surfaced as a central focus within the domain of tumor treatments, using immune checkpoint inhibitors as cancer therapy. Immune checkpoints and their influence on the tumor microenvironment dynamic are presently under investigation, aiming to ascertain their viability as therapeutic interventions across several cancer types. Cancer presents a significant challenge in humans and cats, where female breast cancer ranks as the most prevalent malignancy and feline mammary carcinoma stands as the third most frequent. This review seeks to summarize the data about the immune checkpoints cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), lymphocyte activation gene-3 (LAG-3), programmed cell death protein-1 (PD-1), V-domain Ig suppressor of T cell activation (VISTA), and T-cell immunoglobulin and mucin domain 3 (TIM-3) respective ongoing investigations as prospective targets for therapy for human breast cancer, while also outlining findings from studies reported on feline mammary carcinoma (FMC), strengthening the rationale for employing FMC as a representative model in the exploration of human breast cancer.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189144"},"PeriodicalIF":9.7,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000751/pdfft?md5=a2e68749c8179036eb6844ccf765d905&pid=1-s2.0-S0304419X24000751-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase 关于 SCFFBXW7 E3 泛素连接酶抑制肿瘤作用的分子见解和临床意义。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-21 DOI: 10.1016/j.bbcan.2024.189140

Yihang Qi , Abdol-Hossein Rezaeian , Jingchao Wang , Daoyuan Huang , Hong Chen , Hiroyuki Inuzuka , Wenyi Wei

{"title":"Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase","authors":"Yihang Qi , Abdol-Hossein Rezaeian , Jingchao Wang , Daoyuan Huang , Hong Chen , Hiroyuki Inuzuka , Wenyi Wei","doi":"10.1016/j.bbcan.2024.189140","DOIUrl":"10.1016/j.bbcan.2024.189140","url":null,"abstract":"<div><p>FBXW7 is one of the most well-characterized F-box proteins, serving as substrate receptor subunit of SKP1-CUL1-F-box (SCF) E3 ligase complexes. SCF<sup>FBXW7</sup> is responsible for the degradation of various oncogenic proteins such as cyclin E, c-MYC, c-JUN, NOTCH, and MCL1. Therefore, FBXW7 functions largely as a major tumor suppressor. In keeping with this notion, <em>FBXW7</em> gene mutations or downregulations have been found and reported in many types of malignant tumors, such as endometrial, colorectal, lung, and breast cancers, which facilitate the proliferation, invasion, migration, and drug resistance of cancer cells. Therefore, it is critical to review newly identified FBXW7 regulation and tumor suppressor function under physiological and pathological conditions to develop effective strategies for the treatment of <em>FBXW7</em>-altered cancers. Since a growing body of evidence has revealed the tumor-suppressive activity and role of FBXW7, here, we updated FBXW7 upstream and downstream signaling including FBXW7 ubiquitin substrates, the multi-level FBXW7 regulatory mechanisms, and dysregulation of FBXW7 in cancer, and discussed promising cancer therapies targeting FBXW7 regulators and downstream effectors, to provide a comprehensive picture of FBXW7 and facilitate the study in this field.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189140"},"PeriodicalIF":9.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and molecular markers guide the genetics of pheochromocytoma and paraganglioma 临床和分子标记指导嗜铬细胞瘤和副神经节瘤的遗传学研究。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-21 DOI: 10.1016/j.bbcan.2024.189141

Alberto Cascón, Mercedes Robledo

引用次数: 0

Helicobacter pylori triggers inflammation and oncogenic transformation by perturbing the immune microenvironment 幽门螺杆菌通过扰乱免疫微环境引发炎症和致癌转化

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-17 DOI: 10.1016/j.bbcan.2024.189139

Xiuping Wang , Guang Zhao , Shihe Shao , Yongliang Yao

{"title":"Helicobacter pylori triggers inflammation and oncogenic transformation by perturbing the immune microenvironment","authors":"Xiuping Wang , Guang Zhao , Shihe Shao , Yongliang Yao","doi":"10.1016/j.bbcan.2024.189139","DOIUrl":"https://doi.org/10.1016/j.bbcan.2024.189139","url":null,"abstract":"<div><p>The immune microenvironment plays a critical regulatory role in the pathogenesis of <em>Helicobacter pylori</em> (<em>H. pylori</em>). Understanding the mechanisms that drive the transition from chronic inflammation to cancer may provide new insights for early detection of gastric cancer. Although chronic inflammation is frequent in precancerous gastric conditions, the monitoring function of the inflammatory microenvironment in the progression from <em>H. pylori</em>-induced chronic inflammation to gastric cancer remains unclear. This literature review summarizes significant findings on how <em>H. pylori</em> triggers inflammatory responses and facilitates cancer development through the immune microenvironment. Furthermore, the implications for future research and clinical applications are also addressed. The review is divided into four main sections: inflammatory response and immune evasion mechanisms induced by <em>H. pylori</em>, immune dysregulation associated with gastric cancer, therapeutic implications, and future perspectives on <em>H. pylori</em>-induced gastric carcinogenesis with a focus on the immune microenvironment.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189139"},"PeriodicalIF":11.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy for HPV negative head and neck squamous cell carcinoma 针对人乳头瘤病毒阴性头颈部鳞状细胞癌的免疫疗法

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-16 DOI: 10.1016/j.bbcan.2024.189138

Binyumeng Jiang , Ahmed Elkashif , Jonathan A. Coulter , Nicholas J. Dunne , Helen O. McCarthy

{"title":"Immunotherapy for HPV negative head and neck squamous cell carcinoma","authors":"Binyumeng Jiang , Ahmed Elkashif , Jonathan A. Coulter , Nicholas J. Dunne , Helen O. McCarthy","doi":"10.1016/j.bbcan.2024.189138","DOIUrl":"10.1016/j.bbcan.2024.189138","url":null,"abstract":"<div><p>Head and neck cancer (HNSCC) is the 8th most common cancer in the UK, with incidence increasing due to lifestyle factors such as tobacco and alcohol abuse. HNSCC is an immune-suppressive disease characterised by impaired cytokine secretion and dysregulation of immune infiltrate. As such, immunotherapy is a potential treatment option, with therapeutic cancer vaccination demonstrating the greatest potential. The success of cancer vaccination is dependent on informed antigen selection: an ideal antigen must be either tumour-specific or tumour-associated, as well as highly immunogenic. Stratification of the patient population for antigen expression and validated biomarkers are also vital. This review focuses on the latest developments in immunotherapy, specifically the development of therapeutic vaccines, and highlights successes, potential drawbacks and areas for future development. Immunotherapy approaches considered for HNSCC include monoclonal antibodies (mAb), Oncolytic viral (OV) therapies, Immune Checkpoint Inhibitors (ICIs) and cancer vaccines.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189138"},"PeriodicalIF":9.7,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000696/pdfft?md5=bdc7cbe790355737e7d62382e69fc496&pid=1-s2.0-S0304419X24000696-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141413692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0