Biochimica et biophysica acta. Reviews on cancer最新文献

Rewiring amino acids in cancer 癌症中的氨基酸重新布线。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-26 DOI: 10.1016/j.bbcan.2025.189465

Yiqing Zhang , Jianxin Lyu , Hezhi Fang

引用次数: 0

The mechanical landscape of cancer: Exploring mechanical characteristics-based therapeutic approaches 癌症的机械景观：探索基于机械特征的治疗方法。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-26 DOI: 10.1016/j.bbcan.2025.189463

Hongdan Chen , Yinde Huang , Supeng Yin , Chong Li , Fan Zhang

{"title":"The mechanical landscape of cancer: Exploring mechanical characteristics-based therapeutic approaches","authors":"Hongdan Chen , Yinde Huang , Supeng Yin , Chong Li , Fan Zhang","doi":"10.1016/j.bbcan.2025.189463","DOIUrl":"10.1016/j.bbcan.2025.189463","url":null,"abstract":"<div><div>Tumor mechanical alterations have emerged as a critical but underexplored marker of cancer. Cells within the tumor microenvironment (TME) are constantly exposed to matrix remodeling, aberrant shear stress, cytoskeletal tension, and tumor thrombi, all of which modulate tumor progression, therapy resistance, and stromal remodeling. This review summarizes recent advances in understanding how mechanical cues regulate tumor behavior through mechanotransduction pathways, and evaluates therapeutic strategies targeting extracellular matrix (ECM) stiffness, cytoskeletal contractility, ion channels, and physical interventions. While these approaches demonstrate translational promise, most studies remain descriptive, and major challenges, including off-target effects, limited drug penetration, and biomarker validation, continue to impede clinical application. We highlight the emerging concept of “tumor mechanomics”, which integrates biomechanical fingerprints with molecular and clinical data, offering a framework for developing predictive biomarkers and guiding precision oncology.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189463"},"PeriodicalIF":9.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory neuro-tumor crosstalk: Therapeutic opportunities and emerging frontiers in cancer neuroscience 感觉神经肿瘤相声：癌症神经科学的治疗机会和新兴前沿。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-26 DOI: 10.1016/j.bbcan.2025.189464

Ying Wang , Zhixin Ye , Ye Yuan , Chuanhao Wang , Gang Chen , Yonghui Zhang

{"title":"Sensory neuro-tumor crosstalk: Therapeutic opportunities and emerging frontiers in cancer neuroscience","authors":"Ying Wang , Zhixin Ye , Ye Yuan , Chuanhao Wang , Gang Chen , Yonghui Zhang","doi":"10.1016/j.bbcan.2025.189464","DOIUrl":"10.1016/j.bbcan.2025.189464","url":null,"abstract":"<div><div>Emerging evidence in cancer neuroscience highlights the crucial role of sensory nerves in tumor progression, an aspect of cancer pathobiology previously overlooked. Mechanistically, tumor-associated sensory neurons establish a self-reinforcing oncogenic loop via secreted neurotrophic factors (e.g., NGF/BDNF), which directly promote cancer cell growth, spread, and treatment resistance through Trk activation. Concurrently, tumors rewire their local environment through dysregulated expression of axon guidance molecules, facilitating invasive growth. Importantly, nociceptive signaling activated during perineural invasion not only mediates cancer-related pain but also shapes an immunosuppressive microenvironment through neuropeptide-mediated changes in immune cell function. Current therapeutic strategies targeting tumor-associated nerves focus on: (1) Pharmacological blockade of nerve-tumor communication using small-molecule inhibitors (e.g., Trk inhibitor larotrectinib); (2) Bioelectronic modulation of neural activity via modalities such as transcutaneous electrical nerve stimulation. Notably, preclinical models reveal enhanced efficacy when combining neural modulation with immune checkpoint inhibitors. Technological breakthroughs, including single-cell analysis for precise nerve targeting and advanced drug delivery systems, are improving therapeutic precision. Consequently, understanding the complex interactions between nerves and tumors requires integrated approaches combining cancer biology, neuroimmunology, and systems neuroscience. This conceptual shift not only reshapes our understanding of cancer pathophysiology but also opens new avenues for precision therapies aligned with modern oncology.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189464"},"PeriodicalIF":9.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The bridging role of neutrophils in the progression of inflammation-induced colorectal cancer 中性粒细胞在炎症性结直肠癌进展中的桥接作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-24 DOI: 10.1016/j.bbcan.2025.189460

Jian Wang , Huihui Xiao , Siqian Cui , Chunrong Wu , Debing Xiang

引用次数: 0

Oncogenic mutation-driven metabolism-immunity regulatory axis: Potential prospects for thyroid cancer precision therapy 致癌突变驱动的代谢-免疫调节轴：甲状腺癌精准治疗的潜在前景

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-24 DOI: 10.1016/j.bbcan.2025.189459

Tingting Zhang , Hengtong Han , Tianying Zhang , Yating Zhang , Libin Ma , Ze Yang , Yong-xun Zhao

{"title":"Oncogenic mutation-driven metabolism-immunity regulatory axis: Potential prospects for thyroid cancer precision therapy","authors":"Tingting Zhang , Hengtong Han , Tianying Zhang , Yating Zhang , Libin Ma , Ze Yang , Yong-xun Zhao","doi":"10.1016/j.bbcan.2025.189459","DOIUrl":"10.1016/j.bbcan.2025.189459","url":null,"abstract":"<div><div>Oncogenes enhance cancer development, and their specific activating mutations exemplify the mechanisms that initiate and mediate thyroid cancer (TC) progression. Research has predominantly focused on how oncogenes promote the development of different TC subtypes by influencing the downstream signaling pathways. Targeted therapies show significant efficacy; however, they often induce drug resistance through feedback activation or compensatory signaling bypasses. Recent evidence indicates that thyroid oncogenes initiate and mediate TC progression, and contribute to drug resistance in distinct TC subtypes through induced metabolic reprogramming and immune microenvironment remodeling. Hence, we propose the concept “Oncogene-Metabolism-Immunity axis.” We discussed the molecular mechanisms by which oncogene-driven metabolic reprogramming and tumor immune microenvironment Remodeling (TIME), and their mutual interactions, induce TC progression, drug resistance, and immune evasion. Finally, we systematically evaluated and summarized potential strategies targeting key oncogenes, metabolic catalysts, immune checkpoints (ICs), and combination therapies to enhance the efficacy of targeted treatments for TC and overcome drug resistance.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189459"},"PeriodicalIF":9.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targetable axes of tumor-associated macrophages: An MSF framework for precision immunotherapy 肿瘤相关巨噬细胞的可靶向轴：精确免疫治疗的MSF框架。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-23 DOI: 10.1016/j.bbcan.2025.189458

Zhenting Lu , Midie Xu , Junzhe Tang , Xinyi Wang , Xinxiang Li , Qingguo Li

{"title":"Targetable axes of tumor-associated macrophages: An MSF framework for precision immunotherapy","authors":"Zhenting Lu , Midie Xu , Junzhe Tang , Xinyi Wang , Xinxiang Li , Qingguo Li","doi":"10.1016/j.bbcan.2025.189458","DOIUrl":"10.1016/j.bbcan.2025.189458","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) are a central component of the tumor microenvironment and exert dual, context-dependent effects on cancer progression. This review synthesizes the mechanisms that govern TAM polarization, their bidirectional crosstalk with tumor and stromal cells, and the consequences of metabolic reprogramming. Molecular and metabolic circuits that shape TAM phenotypes and sustain immune suppression are highlighted, and therapeutic strategies targeting TAM checkpoints, metabolism, and lineage pathways are summarized. To integrate immunometabolism with single-cell and spatial profiling, we introduce a Metabolic-Spatial-Functional Axis that links dominant metabolic programs, anatomic niches, and measurable effector functions. This framework organizes TAM heterogeneity and prioritizes biomarker-guided therapeutic combinations with clear translational readouts. Collectively, these advances support precision approaches that reprogram or constrain TAMs to enhance antitumor immunity and overcome therapeutic resistance.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189458"},"PeriodicalIF":9.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing bladder cancer research: Harnessing 3D organoid technology to decode tumor heterogeneity and propel personalized therapeutics 革命性的膀胱癌研究：利用3D类器官技术解码肿瘤异质性并推动个性化治疗。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-22 DOI: 10.1016/j.bbcan.2025.189454

Helin Kang , Xi Liu , Dan Ge , Yu Zeng

{"title":"Revolutionizing bladder cancer research: Harnessing 3D organoid technology to decode tumor heterogeneity and propel personalized therapeutics","authors":"Helin Kang , Xi Liu , Dan Ge , Yu Zeng","doi":"10.1016/j.bbcan.2025.189454","DOIUrl":"10.1016/j.bbcan.2025.189454","url":null,"abstract":"<div><div>Bladder cancer (BC), characterized by remarkable tumor heterogeneity, remains a challenging malignancy with limited therapeutic options. Emerging three-dimensional (3D) organoid models are transforming our understanding of BC biology by closely mimicking the complex tumor microenvironment (TME) and cellular interactions, far surpassing traditional two-dimensional (2D) cell culture systems. This review underscores the innovative advances in bladder cancer organoid technology, emphasizing their unique strengths in capturing intratumoral heterogeneity, enhancing drug sensitivity assessments, and facilitating personalized treatment approaches. We discuss diverse organoid systems, including spheroids, assembloids, and patient-derived organoid xenografts (PDOX), highlighting their exceptional ability to replicate individual patient tumor profiles. Furthermore, we explore integrated organoid-on-chip cultivation techniques incorporating 3D bioprinting and microfluidics, which notably improve precision, reproducibility, and scalability in organoid-based drug screening platforms. We advocate for optimized organoid cultivation protocols and synergistic integration with high-throughput analytical technologies, aiming ultimately to accelerate regimen breakthroughs in personalized medicine for bladder cancer patients.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189454"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in artificial intelligence for spatial transcriptomics in cancer: Special focus on Yin Yang 1 (YY1) and Raf kinase inhibitor protein (RKIP) 人工智能在癌症空间转录组学研究中的进展：重点关注阴阳1 （YY1）和Raf激酶抑制蛋白（RKIP）。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-22 DOI: 10.1016/j.bbcan.2025.189456

Lekhya Dommalapati , Rachael Guenter , Yuvasri Golivi , Swapna Priya Ganji , Tatekalva Sandhya , Ganji Purnachandra Nagaraju , Madhu Sudhana Saddala

{"title":"Advances in artificial intelligence for spatial transcriptomics in cancer: Special focus on Yin Yang 1 (YY1) and Raf kinase inhibitor protein (RKIP)","authors":"Lekhya Dommalapati , Rachael Guenter , Yuvasri Golivi , Swapna Priya Ganji , Tatekalva Sandhya , Ganji Purnachandra Nagaraju , Madhu Sudhana Saddala","doi":"10.1016/j.bbcan.2025.189456","DOIUrl":"10.1016/j.bbcan.2025.189456","url":null,"abstract":"<div><div>Spatial transcriptomics (ST) plays a pivotal role in cancer research, offering a unique perspective on gene expression within the cancer microenvironment, further revolutionizing our current understanding of the subject. From addressing the limitations of traditional bulk RNA sequencing by preserving spatial context, this review discusses the importance of integrating machine learning (ML), artificial intelligence (AI), and statistical methods for interpreting ST data within oncology. Herein, we use examples from studies involving Raf kinase inhibitor protein (RKIP) and Ying Yang 1 (YY1) to illustrate applications for some of the ST techniques discussed. We explore how applying supervised learning techniques, such as Support Vector Machines (SVMs) and Random Forests (RFs), can significantly help further cancer classification and prediction of clinical outcomes and advance personalized medicine. Additionally, exploring unsupervised learning approaches like clustering and dimensionality reduction methods (PCA, t-SNE, UMAP) allows us to see hidden structures in ST data that may be overlooked. This review discusses recent tools and techniques that have been introduced within the last few years, underlining the transformation brought into ST by ML, AI, and statistical methods that provide new insight into oncogenic drivers such as YY1 and RKIP, cancer heterogeneity, and avenues for personalized medicine approaches in cancer treatment.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189456"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of fatty acid oxidation in metabolic crosstalk between tumor cells and associated factors in the microenvironment 脂肪酸氧化在肿瘤细胞间代谢串扰及微环境中相关因子中的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-22 DOI: 10.1016/j.bbcan.2025.189447

Suman Pakhira , Subhadip Kundu , Sib Sankar Roy

{"title":"The role of fatty acid oxidation in metabolic crosstalk between tumor cells and associated factors in the microenvironment","authors":"Suman Pakhira , Subhadip Kundu , Sib Sankar Roy","doi":"10.1016/j.bbcan.2025.189447","DOIUrl":"10.1016/j.bbcan.2025.189447","url":null,"abstract":"<div><div>Metabolic reprogramming is a defining characteristic of cancer cells as they undergo multistage development. Cancer cells dynamically adjust their metabolism to aid their survival and to retain their malignant traits within the adverse tumour microenvironment (TME). Fatty acid oxidation (FAO) is a major source of cellular bioenergy, making it a key player in driving cancer cell growth. Over the past few years, an accumulating body of literature has shed light on the role of dysregulated FAO in cancer progression. Besides energy production, FAO also plays a protective role by mitigating lipotoxicity-induced cell death and preventing oxidative stress through NADPH production. Moreover, FAO is intricately linked with numerous critical signaling pathways, substantiating its importance as a pivotal metabolic adaptation in cancer cells. In the TME, various intrinsic and extrinsic factors continuously modulate the behaviour of cancer cells, including their metabolic attributes, such as the activation of FAO. Additionally, alterations in FAO within non-cancerous stromal cells also play a critical role in orchestrating the tumor progression. Despite the emerging recognition of FAO's significance in cancer biology, the precise molecular mechanisms underlying its dysregulation within the TME remain poorly understood. Given the pivotal role of FAO in bioenergetically priming the tumor progression, its aberrant regulation has become a focal point of cancer research, offering potential avenues for novel therapeutic strategies. This review provides an overview of recent advances in understanding how different microenvironmental factors modulate FAO to influence tumor progression.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189447"},"PeriodicalIF":9.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness 胆管癌癌症相关血栓形成：探讨肿瘤侵袭性的表型。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-09-21 DOI: 10.1016/j.bbcan.2025.189457

Luca Fabris , Yahima Frión-Herrera , Massimiliano Cadamuro , Elena Campello , Paolo Simioni

{"title":"Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness","authors":"Luca Fabris , Yahima Frión-Herrera , Massimiliano Cadamuro , Elena Campello , Paolo Simioni","doi":"10.1016/j.bbcan.2025.189457","DOIUrl":"10.1016/j.bbcan.2025.189457","url":null,"abstract":"<div><div>Cholangiocarcinoma (CCA) is the liver malignancy with the most rapid increase in incidence and lethality in recent years. Venous thromboembolism (VTE) is a common complication of the cancer-associated hypercoagulable state, which may incite tumor progression and dissemination, thereby increasing cancer-related morbidity and mortality. Compared to other cancer types, occurrence of VTE in CCA has been underestimated, though recent evidence indicates it may behave as prognostic factor of worst outcome. Given the need for novel predictive scores and treatment approaches when VTE occurs, identifying subgroups of patients with CCA who would benefit from thromboprophylaxis without increasing the risk of bleeding is a crucial but still neglected aspect of the management. The aim of this review is to summarize current observations on the clinical significance, prediction, risk assessment and the underlying mechanisms of cancer-induced thrombogenesis in CCA, as well as to identify research areas ripe for prioritization in the near future.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189457"},"PeriodicalIF":9.7,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0