Biochimica et biophysica acta. Reviews on cancer最新文献

Some unanswered questions about the pyrimidine catabolic pathway: The human macrophage perspective

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-28 DOI: 10.1016/j.bbcan.2025.189306

Arnaud Millet

引用次数: 0

Decoding the genetic puzzle: Mutations in key driver genes of pancreatic neuroendocrine tumors

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-28 DOI: 10.1016/j.bbcan.2025.189305

Huanchang Jiang , Wuhu Zhang , Xiaowu Xu, Xianjun Yu, Shunrong Ji

{"title":"Decoding the genetic puzzle: Mutations in key driver genes of pancreatic neuroendocrine tumors","authors":"Huanchang Jiang , Wuhu Zhang , Xiaowu Xu, Xianjun Yu, Shunrong Ji","doi":"10.1016/j.bbcan.2025.189305","DOIUrl":"10.1016/j.bbcan.2025.189305","url":null,"abstract":"<div><div>Although pancreatic neuroendocrine tumors (PanNETs) are less common than other pancreatic tumors, they show significant differences in clinical behavior, genetics, and treatment responses. The understanding of the molecular pathways of PanNETs has gradually improved with advances in sequencing technology. Mutations in <em>MEN1</em> (the most frequently varied gene) may result in the deletion of the tumor suppressor menin, affecting gene regulation, DNA repair, and chromatin modification. Changes in ATRX and DAXX involve chromatin remodeling, telomere stability and are associated with the alternative lengthening of telomeres (ALT) pathway and aggressive tumors. <em>VHL</em> mutations emphasize the roles of hypoxia and angiogenesis. Mutations in <em>PTEN</em>, <em>TSC1/TSC2</em>, and <em>AKT1–3</em> often disrupt the mTOR pathway, complicating the genetic landscape of PanNETs. Understanding these genetic alterations and their impact on the PI3K/AKT/mTOR axis help to investigate new targeted therapies, which in turn can improve patient prognosis. This review aims to clarify PanNET pathogenesis through key mutations and their clinical relevance.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189305"},"PeriodicalIF":9.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role and application of Coronin family in human tumorigenesis and immunomodulation

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-26 DOI: 10.1016/j.bbcan.2025.189304

Huimeng Gao , Fuli Sun , Xuanyu Zhang , Xue Qiao , Yan Guo

{"title":"The role and application of Coronin family in human tumorigenesis and immunomodulation","authors":"Huimeng Gao , Fuli Sun , Xuanyu Zhang , Xue Qiao , Yan Guo","doi":"10.1016/j.bbcan.2025.189304","DOIUrl":"10.1016/j.bbcan.2025.189304","url":null,"abstract":"<div><div>The Coronin family, a class of actin-binding proteins involved in the formation and maintenance of cytoskeleton structural stability, is aberrantly expressed in various tumors, including lung, gastric and head and neck cancers. They can regulate tumor cell metabolism and proliferation through RAC-1 and Wnt/β-Catenin signaling pathways and regulate invasion by influencing the PI3K, PAK4, and MT1-MMP signaling pathways and impacting the actin-network dynamics. In recent years, an increasing number of studies have highlighted the crucial roles of the cytoskeleton and immune modulation in the occurrence and development of tumors. The article delves into the Coronin family's pivotal role in tumor immune evasion, highlighting its modulation of neutrophil, T cell, and vesicular transport functions, as well as its interactions with tumorigenesis related organelles such as the endoplasmic reticulum, Golgi apparatus, mitochondria, and lysosomes. It also summarizes the potential therapeutic applications of the Coronin family in oncology. This review provides valuable insights into the mechanisms through which the Coronin family is implicated in the onset and progression of tumors. It also provides more theoretical foundation for tumor immunotherapy and combination drug therapy.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189304"},"PeriodicalIF":9.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNAs and lysosomal membrane proteins: Critical interactions in tumor progression and therapy

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-23 DOI: 10.1016/j.bbcan.2025.189303

Jiahao Xu , Shiqiang Liu , Yujie Jin , Lizhuo Wang , Jialin Gao

引用次数: 0

Radiotherapy modulates autophagy to reshape the tumor immune microenvironment to enhance anti-tumor immunity in esophageal cancer

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-20 DOI: 10.1016/j.bbcan.2025.189302

Suna Zhou, Haihua Yang

{"title":"Radiotherapy modulates autophagy to reshape the tumor immune microenvironment to enhance anti-tumor immunity in esophageal cancer","authors":"Suna Zhou, Haihua Yang","doi":"10.1016/j.bbcan.2025.189302","DOIUrl":"10.1016/j.bbcan.2025.189302","url":null,"abstract":"<div><div>The combination of radiotherapy and immunotherapy exerts synergistic antitumor in a range of human cancers, and also in esophageal cancer. Radiotherapy-induced tumor immune microenvironment (TIME) reprogramming is an essential basis for the synergistic antitumor between radiotherapy and immunotherapy. Radiotherapy can induce autophagy in tumor cells and immune cells of TIME, and autophagy activation is involved in the modification of immunological characteristics of TIME. The TIME landscape of esophageal cancer, especially ESCC, can be affected by radiotherapy or autophagy regulation. In this review, we depicted that local radiotherapy-induced autophagy could promote the maturation, migration, infiltration, and function of immune cells by complicated mechanisms to make TIME from immune “cold” to “hot”, resulting in the synergistic antitumor of RT and IO. We argue that unraveling the relevance of radiotherapy-initiated autophagy to driving radiotherapy reprogramming TIME will open new ideas to explore new targets or more efficiently multimodal therapeutic interventions in ESCC.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189302"},"PeriodicalIF":9.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes: Traversing the blood-brain barrier and their therapeutic potential in brain cancer

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-15 DOI: 10.1016/j.bbcan.2025.189300

Xiaopei Zhang , Nichole Artz , Dennis A. Steindler , Shawn Hingtgen , Andrew Benson Satterlee

{"title":"Exosomes: Traversing the blood-brain barrier and their therapeutic potential in brain cancer","authors":"Xiaopei Zhang , Nichole Artz , Dennis A. Steindler , Shawn Hingtgen , Andrew Benson Satterlee","doi":"10.1016/j.bbcan.2025.189300","DOIUrl":"10.1016/j.bbcan.2025.189300","url":null,"abstract":"<div><div>The blood-brain barrier (BBB) presents a major challenge for the effective delivery of therapeutic agents to the brain tumor cells from the peripheral blood circulation, making the treatment of central nervous system (CNS)-related cancers more difficult and resistant to both standard treatments and emerging therapies. Exosomes, which serve as messengers for intercellular communication throughout the body, can naturally or be modified to penetrate the BBB. Recently, exosomes have been increasingly explored as an invasive or non-invasive approach for delivering therapeutic agents to the CNS. With their low immunogenicity, ease of modification, excellent cargo protection, and inherent ability to cross the BBB, exosomes hold great promise for revolutionizing targeted therapy for CNS-related diseases, including brain cancer. In this review, we highlight recent discoveries and insights into the mechanisms exosomes use to penetrate the BBB, the methods they employ to payload diverse therapeutics, and their roles in transporting therapeutic compounds for brain cancer and other neurological disorders.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189300"},"PeriodicalIF":9.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging importance of m6A modification in liver cancer and its potential therapeutic role

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-13 DOI: 10.1016/j.bbcan.2025.189299

Tao Chen , Wufei Ye , Songsen Gao , Yueran Li , Jiajie Luan , Xiongwen Lv , Sheng Wang

{"title":"Emerging importance of m6A modification in liver cancer and its potential therapeutic role","authors":"Tao Chen , Wufei Ye , Songsen Gao , Yueran Li , Jiajie Luan , Xiongwen Lv , Sheng Wang","doi":"10.1016/j.bbcan.2025.189299","DOIUrl":"10.1016/j.bbcan.2025.189299","url":null,"abstract":"<div><div>Liver cancer refers to malignant tumors that form in the liver and is usually divided into several types, the most common of which is hepatocellular carcinoma (HCC), which originates in liver cells. Other rare types of liver cancer include intrahepatic cholangiocarcinoma (iCCA). m6A modification is a chemical modification of RNA that usually manifests as the addition of a methyl group to adenine in the RNA molecule to form N6-methyladenosine. This modification exerts a critical role in various biological processes by regulating the metabolism of RNA, affecting gene expression. Recent studies have shown that m6A modification is closely related to the occurrence and development of liver cancer, and m6A regulators can further participate in the pathogenesis of liver cancer by regulating the expression of key genes and the function of specific cells. In this review, we provided an overview of the latest advances in m6A modification in liver cancer research and explored in detail the specific functions of different m6A regulators. Meanwhile, we deeply analyzed the mechanisms and roles of m6A modification in liver cancer, aiming to provide novel insights and references for the search for potential therapeutic targets. Finally, we discussed the prospects and challenges of targeting m6A regulators in liver cancer therapy.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189299"},"PeriodicalIF":9.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into cancer immune checkpoints landscape from single-cell RNA sequencing 从单细胞 RNA 测序中了解癌症免疫检查点的新情况。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-13 DOI: 10.1016/j.bbcan.2025.189298

Qian Wang , Jiahui He , Tianyu Lei , Xiaohui Li , Shengqin Yue , Chao Liu , Qinyong Hu

{"title":"New insights into cancer immune checkpoints landscape from single-cell RNA sequencing","authors":"Qian Wang , Jiahui He , Tianyu Lei , Xiaohui Li , Shengqin Yue , Chao Liu , Qinyong Hu","doi":"10.1016/j.bbcan.2025.189298","DOIUrl":"10.1016/j.bbcan.2025.189298","url":null,"abstract":"<div><div>Immune checkpoint blockade (ICB) therapy represents a pivotal advancement in tumor immunotherapy by restoring the cytotoxic lymphocytes' anti-tumor activity through the modulation of immune checkpoint functions. Nevertheless, many patients experience suboptimal therapeutic outcomes, likely due to the immunosuppressive tumor microenvironment, drug resistance, and other factors. Single-cell RNA sequencing has assisted to precisely investigate the immune infiltration patterns before and after ICB treatment, enabling a high-resolution depiction of previously unrecognized functional interaction among immune checkpoints. This review addresses the heterogeneity between tumor microenvironments that respond to or resist ICB therapy, highlighting critical factors underlying the variation in immunotherapy efficacy and elucidating treatment failure. Furthermore, a comprehensive examination is provided of how specific ICBs modulate immune and tumor cells to achieve anti-tumor effects and generate treatment resistance, alongside a summary of emerging immune checkpoints identified as promising targets for cancer immunotherapy through single-cell RNA sequencing applications.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 3","pages":"Article 189298"},"PeriodicalIF":9.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SOXs: Master architects of development and versatile emulators of oncogenesis

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-07 DOI: 10.1016/j.bbcan.2025.189295

Saloni , Manisha Sachan , Rahul , Rama Shanker Verma , Girijesh Kumar Patel

{"title":"SOXs: Master architects of development and versatile emulators of oncogenesis","authors":"Saloni , Manisha Sachan , Rahul , Rama Shanker Verma , Girijesh Kumar Patel","doi":"10.1016/j.bbcan.2025.189295","DOIUrl":"10.1016/j.bbcan.2025.189295","url":null,"abstract":"<div><div>Transcription factors regulate a variety of events and maintain cellular homeostasis. Several transcription factors involved in embryonic development, has been shown to be closely associated with carcinogenesis when deregulated. Sry-like high mobility group box (SOX) proteins are potential transcription factors which are evolutionarily conserved. They regulate downstream genes to determine cell fate, via various signaling pathways and cellular processes essential for tissue and organ development. Dysregulation of SOXs has been reported to promote or suppress tumorigenesis by modulating cellular reprogramming, growth, proliferation, angiogenesis, metastasis, apoptosis, immune modulation, lineage plasticity, maintenance of the stem cell pool, therapy resistance and cancer relapse. This review provides a crucial understanding of the molecular mechanism by which SOXs play multifaceted roles in embryonic development and carcinogenesis. It also highlights their potential in advancing therapeutic strategies aimed at targeting SOXs and their downstream effectors in various malignancies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189295"},"PeriodicalIF":9.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-07 DOI: 10.1016/j.bbcan.2025.189296

Yunxiao Ge , Victor Janson , Zigang Dong , Hui Liu

{"title":"Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression","authors":"Yunxiao Ge , Victor Janson , Zigang Dong , Hui Liu","doi":"10.1016/j.bbcan.2025.189296","DOIUrl":"10.1016/j.bbcan.2025.189296","url":null,"abstract":"<div><div>Gastric cancer, a globally prevalent malignant tumor, is characterized by low early diagnosis rate, high metastasis rate, and poor prognosis, particularly in East Asia, Eastern Europe, and South America. <em>Helicobacter pylori</em> (<em>H. pylori</em>) is recognized as the primary risk factor for gastric cancer. However, the fact that fewer than 3 % of infected individuals develop cancer suggests that other bacteria may also influence gastric carcinogenesis. A diverse community of microorganisms may interact with <em>H. pylori</em>, thereby driving disease progression. Here, the role of the cytokine IL-33, a member of the IL-1 family, is scrutinized. Its production can be induced by <em>H. pylori</em> through the activation of specific signaling pathways, and it contributes to the inflammatory environment by promoting the release of pro-inflammatory cytokines. This article reviews the conflicting evidence regarding IL-33's role in the progression from gastritis to gastric cancer and discusses the potential therapeutic implications of targeting the IL-33/ST2 axis, with various antibodies and inhibitors in development or undergoing clinical trials for inflammatory diseases. However, the role of IL-33 in gastric cancer treatment remains to be fully elucidated, with its effects potentially dependent on the cellular context and stage of cancer progression. In summary, this review provides a comprehensive overview of the intricate relationship between gastric microbiota, IL-33, and gastritis - gastric cancer transition, offering insights into potential therapeutic targets and the development of novel treatment strategies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189296"},"PeriodicalIF":9.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0