Biochimica et biophysica acta. Reviews on cancer最新文献

SOXs: Master architects of development and versatile emulators of oncogenesis

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-07 DOI: 10.1016/j.bbcan.2025.189295

Saloni , Manisha Sachan , Rahul , Rama Shanker Verma , Girijesh Kumar Patel

{"title":"SOXs: Master architects of development and versatile emulators of oncogenesis","authors":"Saloni , Manisha Sachan , Rahul , Rama Shanker Verma , Girijesh Kumar Patel","doi":"10.1016/j.bbcan.2025.189295","DOIUrl":"10.1016/j.bbcan.2025.189295","url":null,"abstract":"<div><div>Transcription factors regulate a variety of events and maintain cellular homeostasis. Several transcription factors involved in embryonic development, has been shown to be closely associated with carcinogenesis when deregulated. Sry-like high mobility group box (SOX) proteins are potential transcription factors which are evolutionarily conserved. They regulate downstream genes to determine cell fate, via various signaling pathways and cellular processes essential for tissue and organ development. Dysregulation of SOXs has been reported to promote or suppress tumorigenesis by modulating cellular reprogramming, growth, proliferation, angiogenesis, metastasis, apoptosis, immune modulation, lineage plasticity, maintenance of the stem cell pool, therapy resistance and cancer relapse. This review provides a crucial understanding of the molecular mechanism by which SOXs play multifaceted roles in embryonic development and carcinogenesis. It also highlights their potential in advancing therapeutic strategies aimed at targeting SOXs and their downstream effectors in various malignancies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189295"},"PeriodicalIF":9.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-07 DOI: 10.1016/j.bbcan.2025.189296

Yunxiao Ge , Victor Janson , Zigang Dong , Hui Liu

{"title":"Role and mechanism of IL-33 in bacteria infection related gastric cancer continuum: From inflammation to tumor progression","authors":"Yunxiao Ge , Victor Janson , Zigang Dong , Hui Liu","doi":"10.1016/j.bbcan.2025.189296","DOIUrl":"10.1016/j.bbcan.2025.189296","url":null,"abstract":"<div><div>Gastric cancer, a globally prevalent malignant tumor, is characterized by low early diagnosis rate, high metastasis rate, and poor prognosis, particularly in East Asia, Eastern Europe, and South America. <em>Helicobacter pylori</em> (<em>H. pylori</em>) is recognized as the primary risk factor for gastric cancer. However, the fact that fewer than 3 % of infected individuals develop cancer suggests that other bacteria may also influence gastric carcinogenesis. A diverse community of microorganisms may interact with <em>H. pylori</em>, thereby driving disease progression. Here, the role of the cytokine IL-33, a member of the IL-1 family, is scrutinized. Its production can be induced by <em>H. pylori</em> through the activation of specific signaling pathways, and it contributes to the inflammatory environment by promoting the release of pro-inflammatory cytokines. This article reviews the conflicting evidence regarding IL-33's role in the progression from gastritis to gastric cancer and discusses the potential therapeutic implications of targeting the IL-33/ST2 axis, with various antibodies and inhibitors in development or undergoing clinical trials for inflammatory diseases. However, the role of IL-33 in gastric cancer treatment remains to be fully elucidated, with its effects potentially dependent on the cellular context and stage of cancer progression. In summary, this review provides a comprehensive overview of the intricate relationship between gastric microbiota, IL-33, and gastritis - gastric cancer transition, offering insights into potential therapeutic targets and the development of novel treatment strategies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189296"},"PeriodicalIF":9.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-07 DOI: 10.1016/j.bbcan.2025.189297

Sun-Kyu Jin, Kwang-Hyun Baek

{"title":"Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers","authors":"Sun-Kyu Jin, Kwang-Hyun Baek","doi":"10.1016/j.bbcan.2025.189297","DOIUrl":"10.1016/j.bbcan.2025.189297","url":null,"abstract":"<div><div>The use of platinum-based drugs in cancer treatment is one of the most common methods in chemotherapy. Especially, cisplatin induces cell death by interrupting DNA synthesis by binding to the DNA bases, thereby leading to the apoptosis via multiple pathways. However, the major hurdle in chemotherapy is drug resistance. To overcome drug resistance, the ubiquitin-proteasome system (UPS) has emerged as a potential therapeutic target. The UPS is a pivotal signaling pathway that regulates the majority of cellular proteins by attaching ubiquitin to substrates, leading to proteasomal degradation. Conversely, deubiquitinating enzymes (DUBs) remove tagged ubiquitin from the substrate and inhibit degradation, thereby maintaining proteostasis. Recently, studies have been conducted to identify the substrates of DUBs and investigated the cellular mechanisms, and now the development of therapeutics using DUB inhibitors is in clinical trials. However, the mechanism of the DUB response to cisplatin remains still unclear. In this review, we summarize the research reported on the function of DUBs responding to cisplatin.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189297"},"PeriodicalIF":9.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD47 as a potent target in cancer immunotherapy: A review

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-06 DOI: 10.1016/j.bbcan.2025.189294

Hiva Ahvati , Raheleh Roudi , Navid Sobhani , Fatemeh Safari

引用次数: 0

In vitro models: Can they unravel the complexities of cancer cell metastasis?

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-05 DOI: 10.1016/j.bbcan.2025.189293

Stefanos Pafitanis , Lefteris C. Zacharia , Andreas Stylianou , Vasiliki Gkretsi

{"title":"In vitro models: Can they unravel the complexities of cancer cell metastasis?","authors":"Stefanos Pafitanis , Lefteris C. Zacharia , Andreas Stylianou , Vasiliki Gkretsi","doi":"10.1016/j.bbcan.2025.189293","DOIUrl":"10.1016/j.bbcan.2025.189293","url":null,"abstract":"<div><div>Metastasis still accounts for the majority of cancer-related deaths despite intense research efforts made worldwide to better understand the determinants involved and discover novel ways to halt it. However, studying the pathogenesis of metastasis in actual patients is indeed challenging which renders the need for the development of relevant experimental models urgent. Traditionally, several <em>in vitro</em> and <em>in vivo</em> models have been developed to study metastasis each of which having its own advantages and limitations. In the present review, we analyzed the current approaches used in cancer biology research to study cancer cell metastasis giving emphasis on the newly developed <em>in vitro</em> systems that take into account factors like the three-dimensional (3D) nature of the tumor, the interaction between cancer cells and the extracellular matrix or other cells present in the tumor microenvironment, and thus, better recapitulate the metastatic process. These approaches, namely 3D bioprinting, 3D tissue models, microfluidics systems, and spheroid generation are currently used separately or in combination depending on the research question and the cancer type in order to better represent the actual <em>in vivo</em> setting.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189293"},"PeriodicalIF":9.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-02 DOI: 10.1016/j.bbcan.2025.189292

Mrudula Gore , Shama Prasada Kabekkodu , Sanjiban Chakrabarty

{"title":"Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets","authors":"Mrudula Gore , Shama Prasada Kabekkodu , Sanjiban Chakrabarty","doi":"10.1016/j.bbcan.2025.189292","DOIUrl":"10.1016/j.bbcan.2025.189292","url":null,"abstract":"<div><div>The role of human Papillomavirus (HPV) in metabolic reprogramming is implicated in the development and progression of cervical cancer. During carcinogenesis, cancer cells modify various metabolic pathways to generate energy and sustain their growth and development. Cervical cancer, one of the most prevalent malignancies affecting women globally, involves metabolic alterations such as increased glycolysis, elevated lactate production, and lipid accumulation. The oncoproteins, primarily E6 and E7, which are encoded by high-risk HPVs, facilitate the accumulation of several cancer markers, promoting not only the growth and development of cancer but also metastasis, immune evasion, and therapy resistance. HPV oncoproteins interact with cellular MYC (c-MYC), retinoblastoma protein (pRB), p53, and hypoxia-inducible factor 1α (HIF-1α), leading to the induction of metabolic reprogramming and favour the Warburg effect. Metabolic reprogramming enables HPV to persist for an extended period and accelerates the progression of cervical cancer. This review summarizes the role of HPV oncoproteins in metabolic reprogramming and their contributions to the development and progression of cervical cancer. Additionally, this review provides insights into how metabolic reprogramming opens avenues for novel therapeutic strategies, including the discovery of new and repurposed drugs that could be applied to treat cervical cancer.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189292"},"PeriodicalIF":9.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated fibroblasts in breast cancer in the single-cell era: Opportunities and challenges

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-28 DOI: 10.1016/j.bbcan.2025.189291

Jingtong Yang, Benkai Xin, Xiaoyu Wang, Youzhong Wan

引用次数: 0

Evaluation of ImmunoPET in the efficacy and prognosis of immunotherapy for lung cancer

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-23 DOI: 10.1016/j.bbcan.2025.189289

Yiran Liang , Mei Xie , Xuefeng Zang , Xin Zhang , Xinying Xue

{"title":"Evaluation of ImmunoPET in the efficacy and prognosis of immunotherapy for lung cancer","authors":"Yiran Liang , Mei Xie , Xuefeng Zang , Xin Zhang , Xinying Xue","doi":"10.1016/j.bbcan.2025.189289","DOIUrl":"10.1016/j.bbcan.2025.189289","url":null,"abstract":"<div><div>Advances in immune oncology have established immunotherapy as the first-line standard treatment for lung cancer; however, its efficacy remains limited to a subset of patients. Developing predictive biomarkers within the tumor microenvironment (TME) to assess the efficacy and prognosis of immunotherapy can enhance drug development and treatment strategies. Immuno-positron emission tomography (ImmunoPET) non-invasively visualizes the biological distribution of key targets in the TME using highly specific, radiolabeled tracers. PET imaging of the TME can serve as a reliable biomarker for predicting and monitoring responses to immune therapy, complementing existing immunohistochemical techniques. This review will focus on the development of ImmunoPET biomarkers, as well as the application of corresponding tracers and radionuclides in lung cancer. We will focus on available clinical tracers and those under development, outlining each TME target and its clinical validation for tumor immunotherapy efficacy and prognosis, while discussing the latest advances that may enhance ImmunoPET in future.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189289"},"PeriodicalIF":9.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha-1 antitrypsin deficiency and primary liver cancers

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-23 DOI: 10.1016/j.bbcan.2025.189290

Carolin Victoria Schneider , Marie Decraecker , Aurélie Beaufrère , Audrey Payancé , Audrey Coilly , Kai Markus Schneider , Paulette Bioulac , Jean-Frédéric Blanc , Brigitte Le Bail , Samuel Amintas , Marion Bouchecareilh

{"title":"Alpha-1 antitrypsin deficiency and primary liver cancers","authors":"Carolin Victoria Schneider , Marie Decraecker , Aurélie Beaufrère , Audrey Payancé , Audrey Coilly , Kai Markus Schneider , Paulette Bioulac , Jean-Frédéric Blanc , Brigitte Le Bail , Samuel Amintas , Marion Bouchecareilh","doi":"10.1016/j.bbcan.2025.189290","DOIUrl":"10.1016/j.bbcan.2025.189290","url":null,"abstract":"<div><div>Primary liver cancers (PLCs) remain a major challenge to global health and an escalating threat to human life, with a growing incidence worldwide. PLCs are composed of hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and mixed HCC-CCA, accounting for 85 %, 10 %, and 5 % of cases, respectively. Among the numerous identified risk factors associated with liver cancers, Alpha 1-AntiTrypsin Deficiency (AATD) genetic disease emerges as an intriguing one. AATD-related liver disease may lead to chronic hepatitis, cirrhosis, and PLCs in adulthood. Although our knowledge about the natural history of AATD-liver disease has improved recently, liver cancers associated with AATD remain poorly understood and explored, while this specific population is at a 20 to 50 times higher risk of developing PLC. Thus, we review here current knowledge about AATD-associated PLCs, describing the impact of AATD genotypes on their occurrence. We also discuss emerging hypotheses regarding the AATD PiZZ genotype-related hepatic carcinogenesis process. Finally, we perform an updated analysis of the United Kingdom Biobank database that highlights and confirms AATD PiZZ genotype as an important HCC risk factor.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 2","pages":"Article 189290"},"PeriodicalIF":9.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of splicing variation in ovarian cancer

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-02-22 DOI: 10.1016/j.bbcan.2025.189288

Min Zhou, Mengdie Tian, Zhuoer Li, Chunli Wang, Zhiqiang Guo

引用次数: 0