Biochimica et biophysica acta. Reviews on cancer最新文献_第10页

Dissecting SOX2 expression and function reveals an association with multiple signaling pathways during embryonic development and in cancer progression 对 SOX2 表达和功能的剖析揭示了其在胚胎发育和癌症进展过程中与多种信号通路的关联。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-15 DOI: 10.1016/j.bbcan.2024.189136

Niharika, Lina Ureka, Ankan Roy, Samir Kumar Patra

{"title":"Dissecting SOX2 expression and function reveals an association with multiple signaling pathways during embryonic development and in cancer progression","authors":"Niharika, Lina Ureka, Ankan Roy, Samir Kumar Patra","doi":"10.1016/j.bbcan.2024.189136","DOIUrl":"10.1016/j.bbcan.2024.189136","url":null,"abstract":"<div><p>SRY (Sex Determining Region) box 2 (SOX2) is an essential transcription factor that plays crucial roles in activating genes involved in pre- and post-embryonic development, adult tissue homeostasis, and lineage specifications. SOX2 maintains the self-renewal property of stem cells and is involved in the generation of induced pluripotency stem cells. SOX2 protein contains a particular high-mobility group domain that enables SOX2 to achieve the capacity to participate in a broad variety of functions. The information about the involvement of SOX2 with gene regulatory elements, signaling networks, and microRNA is gradually emerging, and the higher expression of SOX2 is functionally relevant to various cancer types. SOX2 facilitates the oncogenic phenotype via cellular proliferation and enhancement of invasive tumor properties. Evidence are accumulating in favor of three dimensional (higher order) folding of chromatin and epigenetic control of the SOX2 gene by chromatin modifications, which implies that the expression level of SOX2 can be modulated by epigenetic regulatory mechanisms, specifically, via DNA methylation and histone H3 modification. In view of this, and to focus further insights into the roles SOX2 plays in physiological functions, involvement of SOX2 during development, precisely, the advances of our knowledge in pre- and post-embryonic development, and interactions of SOX2 in this scenario with various signaling pathways in tumor development and cancer progression, its potential as a therapeutic target against many cancers are summarized and discussed in this article.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189136"},"PeriodicalIF":11.2,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cellular-centered view of hypoxia tumor microenvironment: Molecular mechanisms and therapeutic interventions 以细胞为中心的缺氧肿瘤微环境观：分子机制和治疗干预。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-14 DOI: 10.1016/j.bbcan.2024.189137

Tian-Qi Zhang , Qian-Yu Lv , Wei-Lin Jin

{"title":"The cellular-centered view of hypoxia tumor microenvironment: Molecular mechanisms and therapeutic interventions","authors":"Tian-Qi Zhang , Qian-Yu Lv , Wei-Lin Jin","doi":"10.1016/j.bbcan.2024.189137","DOIUrl":"10.1016/j.bbcan.2024.189137","url":null,"abstract":"<div><p>Cancer is a profoundly dynamic, heterogeneous and aggressive systemic ailment, with a coordinated evolution of various types of tumor niches. Hypoxia plays an indispensable role in the tumor micro-ecosystem, drastically enhancing the plasticity of cancer cells, fibroblasts and immune cells and orchestrating intercellular communication. Hypoxia-induced signals, particularly hypoxia-inducible factor-1α (HIF-1α), drive the reprogramming of genetic, transcriptional, and proteomic profiles. This leads to a spectrum of interconnected processes, including augmented survival of cancer cells, evasion of immune surveillance, metabolic reprogramming, remodeling of the extracellular matrix, and the development of resistance to conventional therapeutic modalities like radiotherapy and chemotherapy. Here, we summarize the latest research on the multifaceted effects of hypoxia, where a multitude of cellular and non-cellular elements crosstalk with each other and co-evolve in a synergistic manner. Additionally, we investigate therapeutic approaches targeting hypoxic niche, encompassing hypoxia-activated prodrugs, HIF inhibitors, nanomedicines, and combination therapies. Finally, we discuss some of the issues to be addressed and highlight the potential of emerging technologies in the treatment of cancer.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189137"},"PeriodicalIF":11.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophages and tertiary lymphoid structures as indicators of prognosis and therapeutic response in cancer patients 作为癌症患者预后和治疗反应指标的巨噬细胞和三级淋巴结构。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-06 DOI: 10.1016/j.bbcan.2024.189125

Li Niu , Ting Chen , Aodan Yang , Xiwen Yan , Feng Jin , Ang Zheng , Xinyue Song

引用次数: 0

The neoantigens derived from transposable elements – A hidden treasure for cancer immunotherapy 源自转座元件的新抗原--癌症免疫疗法的隐藏宝藏。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-06-06 DOI: 10.1016/j.bbcan.2024.189126

Zhixiang Hu , Xinyi Guo , Ziteng Li , Zhiqiang Meng , Shenglin Huang

{"title":"The neoantigens derived from transposable elements – A hidden treasure for cancer immunotherapy","authors":"Zhixiang Hu , Xinyi Guo , Ziteng Li , Zhiqiang Meng , Shenglin Huang","doi":"10.1016/j.bbcan.2024.189126","DOIUrl":"10.1016/j.bbcan.2024.189126","url":null,"abstract":"<div><p>Neoantigen-based therapy is a promising approach that selectively activates the immune system of the host to recognize and eradicate cancer cells. Preliminary clinical trials have validated the feasibility, safety, and immunogenicity of personalized neoantigen-directed vaccines, enhancing their effectiveness and broad applicability in immunotherapy. While many ongoing oncological trials concentrate on neoantigens derived from mutations, these targets do not consistently provoke an immune response in all patients harboring the mutations. Additionally, tumors like ovarian cancer, which have a low tumor mutational burden (TMB), may be less amenable to mutation-based neoantigen therapies. Recent advancements in next-generation sequencing and bioinformatics have uncovered a rich source of neoantigens from non-canonical RNAs associated with transposable elements (TEs). Considering the substantial presence of TEs in the human genome and the proven immunogenicity of TE-derived neoantigens in various tumor types, this review investigates the latest findings on TE-derived neoantigens, examining their clinical implications, challenges, and unique advantages in enhancing tumor immunotherapy.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189126"},"PeriodicalIF":11.2,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141289035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer 与膀胱癌卡介苗（BCG）治疗相关的表观遗传学变化。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-26 DOI: 10.1016/j.bbcan.2024.189123

Lucy C. Picard, Fenella J. Rich, Diane N. Kenwright, Aaron J. Stevens

引用次数: 0

Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment? 铁凋亡和铜凋亡：传统化疗激活的金属依赖性细胞死亡途径--对癌症治疗的意义？

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-25 DOI: 10.1016/j.bbcan.2024.189124

M. Kciuk , A. Gielecińska , Ż. Kałuzińska-Kołat , E.B. Yahya , R. Kontek

{"title":"Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?","authors":"M. Kciuk , A. Gielecińska , Ż. Kałuzińska-Kołat , E.B. Yahya , R. Kontek","doi":"10.1016/j.bbcan.2024.189124","DOIUrl":"10.1016/j.bbcan.2024.189124","url":null,"abstract":"<div><p>Apoptosis has traditionally been regarded as the desired cell death pathway activated by chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent discoveries of alternative cell death pathways have paved the way for immune-stimulatory treatment approaches in cancer. Ferroptosis (dependent on iron) and cuproptosis (dependent on copper) hold promise for selective cancer cell targeting and overcoming drug resistance. Copper ionophores and iron-bearing nano-drugs show potential for clinical therapy as single agents and as adjuvant treatments. Here we review up-to-date evidence for the involvement of metal ion-dependent cell death pathways in the cytotoxicity of classical chemotherapeutic agents (alkylating agents, topoisomerase inhibitors, antimetabolites, and mitotic spindle inhibitors) and their combinations with cuproptosis and ferroptosis inducers, indicating the prospects, advantages, and obstacles of their use.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 4","pages":"Article 189124"},"PeriodicalIF":11.2,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000556/pdfft?md5=e522af3f11fb9f2662348ecfe1234e20&pid=1-s2.0-S0304419X24000556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbonic anhydrase IX: An atypical target for innovative therapies in cancer 碳酸酐酶 IX：癌症创新疗法的非典型靶点

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-25 DOI: 10.1016/j.bbcan.2024.189120

Roberto Ronca , Claudiu T. Supuran

{"title":"Carbonic anhydrase IX: An atypical target for innovative therapies in cancer","authors":"Roberto Ronca , Claudiu T. Supuran","doi":"10.1016/j.bbcan.2024.189120","DOIUrl":"10.1016/j.bbcan.2024.189120","url":null,"abstract":"<div><p>Carbonic anhydrases (CAs), are metallo-enzymes implicated in several pathophysiological processes where tissue pH regulation is required. CA IX is a tumor-associated CA isoform induced by hypoxia and involved in the adaptation of tumor cells to acidosis. Indeed, several tumor-driving pathways can induce CA IX expression, and this in turn has been associated to cancer cells invasion and metastatic features as well as to induction of stem-like features, drug resistance and recurrence. After its functional and structural characterization CA IX targeting approaches have been developed to inhibit its activity in neoplastic tissues, and to date this field has seen an incredible acceleration in terms of therapeutic options and biological readouts. Small molecules inhibitors, hybrid/dual targeting drugs, targeting antibodies and adoptive (CAR-T based) cell therapy have been developed at preclinical level, whereas a sulfonamide CA IX inhibitor and an antibody entered Phase Ib/II clinical trials for the treatment and imaging of different solid tumors. Here recent advances on CA IX biology and pharmacology in cancer, and its therapeutic targeting will be discussed.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 4","pages":"Article 189120"},"PeriodicalIF":11.2,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000519/pdfft?md5=6d3ac5790309de74d9844f45f2d450f2&pid=1-s2.0-S0304419X24000519-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications 肿瘤微环境中的神经-肿瘤串扰：从肿瘤的发生、发展到临床意义

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-23 DOI: 10.1016/j.bbcan.2024.189121

Zheng Zhang , Zhen Gang Lv , Miao Lu , Haifeng Li , Jiahua Zhou

{"title":"Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications","authors":"Zheng Zhang , Zhen Gang Lv , Miao Lu , Haifeng Li , Jiahua Zhou","doi":"10.1016/j.bbcan.2024.189121","DOIUrl":"10.1016/j.bbcan.2024.189121","url":null,"abstract":"<div><p>The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition, the dynamic interaction between nerve and tumor cells in the tumor microenvironment also regulate tumor progression. On the one hand, nerves are passively invaded by tumor cells, that is, perineural invasion (PNI). On the other hand, compared with normal tissues, tumor tissues are subject to more abundant innervation, and nerves can influence tumor progression through regulating tumor proliferation, metastasis and drug resistance. A large number of studies have shown that nerve-tumor crosstalk, including PNI and innervation, is closely related to the prognosis of patients, and contributes to the formation of cancer pain, which significantly deteriorates the quality of life for patients. These findings suggest that nerve-tumor crosstalk represents a potential target for anti-tumor therapies and the management of cancer pain in the future. In this review, we systematically describe the mechanism by which nerve-tumor crosstalk regulates tumorigenesis and progression.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 4","pages":"Article 189121"},"PeriodicalIF":11.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of methioninase for cancer treatment 蛋氨酸酶治疗癌症的潜力

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-23 DOI: 10.1016/j.bbcan.2024.189122

Louay Abo Qoura , Konstantin V. Balakin , Robert M. Hoffman , Vadim S. Pokrovsky

引用次数: 0

Bacteria-based cancer therapy: Looking forward 基于细菌的癌症疗法：展望未来。

IF 11.2 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-05-16 DOI: 10.1016/j.bbcan.2024.189112

My-Van Tieu , Duc-Trung Pham , Sungbo Cho

引用次数: 0