Biochimica et biophysica acta. Reviews on cancer最新文献_第10页

Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies 转移前生态位的时空动态：乳腺癌转移前肺微环境的重塑及靶向干预策略

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-06-02 DOI: 10.1016/j.bbcan.2025.189360

Xinjie Chang , Yan Yao , Minpu Zhang , Changgang Sun , Qiming Zhang

{"title":"Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies","authors":"Xinjie Chang , Yan Yao , Minpu Zhang , Changgang Sun , Qiming Zhang","doi":"10.1016/j.bbcan.2025.189360","DOIUrl":"10.1016/j.bbcan.2025.189360","url":null,"abstract":"<div><div>Breast cancer lung metastasis has attracted considerable research attention because of its complex molecular heterogeneity and refractory characteristics. Development of the pre-metastatic niche (PMN) is a key initiating event in the cancer metastatic cascade. The PMN can remodel the tissue microenvironment through the spatiotemporal induction of extracellular matrix remodeling, activation of inflammatory responses, formation of an immunosuppressive state, vascular anomalies, and metabolic reprogramming. In this review, we present a novel framework for the dynamic evolution of PMN in breast cancer, focusing on the mechanisms of cell-molecule network synergy during PMN formation in the lungs of patients with breast cancer. Additionally, we systematically review novel PMN monitoring modalities and therapeutic strategies targeting key regulatory nodes, and discuss the bottlenecks and potential solutions for their clinical translation. We aim to provide a scientific foundation for the development of preventive and therapeutic strategies for breast cancer lung metastasis based on the molecular characteristics of PMN and to provide a theoretical basis for breast cancer lung metastasis research and drug development.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189360"},"PeriodicalIF":9.7,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raf kinase inhibitor protein modulator of gut microbiota and immunotherapy responses in cancer 肠道微生物群和癌症免疫治疗反应的Raf激酶抑制剂蛋白调节剂。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-06-01 DOI: 10.1016/j.bbcan.2025.189364

Giuseppe Palma , Francesca Bruzzese , Concetta Meo , Filomena de Nigris

{"title":"Raf kinase inhibitor protein modulator of gut microbiota and immunotherapy responses in cancer","authors":"Giuseppe Palma , Francesca Bruzzese , Concetta Meo , Filomena de Nigris","doi":"10.1016/j.bbcan.2025.189364","DOIUrl":"10.1016/j.bbcan.2025.189364","url":null,"abstract":"<div><div>Cancer progression and the therapeutic efficacy of targeted treatments are increasingly recognized to be influenced by the gut microbiota (GM). This is particularly evident in the context of immunotherapies, as the composition of the GM can modulate the immune system through different mechanisms. Emerging evidence suggests that Raf kinase inhibitor protein (RKIP), a well-established tumor suppressor, may shape the GM by regulating immune and inflammatory pathways. Altered RKIP expression within tumors can reprogram the tumor microenvironment and microbiota composition, ultimately influencing the response to immunotherapy. In this review, we explore the complex interplay between RKIP, downstream pathway, the microbiota, and immunotherapy. Drawing from both preclinical and clinical studies, we examine how RKIP and kinase inhibitors change microbial composition and immune modulation, and how these interactions affect immunotherapeutic outcomes. A deeper understanding of these mechanisms could guide the development of more effective cancer treatment strategies and highlight the microbiome's potential role in shaping immunotherapy responses.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189364"},"PeriodicalIF":9.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer 阴阳1 （YY1）在肺癌微环境、信号通路和表观遗传学中的作用

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-30 DOI: 10.1016/j.bbcan.2025.189359

Seema Kumari , S.P.D. Ponamgi , Prashen Chelikani , Mundla Srilatha , Ganji Purnachandra Nagaraju , Sujatha Peela

{"title":"Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer","authors":"Seema Kumari , S.P.D. Ponamgi , Prashen Chelikani , Mundla Srilatha , Ganji Purnachandra Nagaraju , Sujatha Peela","doi":"10.1016/j.bbcan.2025.189359","DOIUrl":"10.1016/j.bbcan.2025.189359","url":null,"abstract":"<div><div>Lung cancer is a significant health concern worldwide. It is caused by smoking and exposure to carcinogens, although other factors like genetics, epigenetics, and transcription factors also play a role. Yin Yang 1 (YY1) is a transcription factor with a multifaceted role in regulating cellular functions in various cancers. It has a vital role in lung cancer progression, but also has tumor-suppressing activity. YY1 regulates epigenetic changes through DNA methylation, histone alteration, and non-coding RNAs. In lung cancer, YY1 is overexpressed and involved in metastatic mechanisms, including epithelial and mesenchymal transition (EMT), invasion, migration, and angiogenesis. These metastatic properties are influenced by various signaling pathways (PI3K-Akt-mTOR, RAF-MEK-ERK, JAK-STAT, and Wnt-β-catenin) through PD-L1 expression, autophagy, and drug insensitivity. The current review recapitulates the recent advances on YY1 research in lung cancer progression and its influence on oncogenic pathways, immune regulation, and clinical significance. Furthermore, this review also discusses using YY1 as a biomarker and targeted molecule in lung cancer.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189359"},"PeriodicalIF":9.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The roles and mechanisms of non-canonical RNA secondary structures in tumors 非规范RNA二级结构在肿瘤中的作用和机制

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-30 DOI: 10.1016/j.bbcan.2025.189363

Ziyi Pan , Zhaoyang Zeng , Wei Xiong , Chunmei Fan

{"title":"The roles and mechanisms of non-canonical RNA secondary structures in tumors","authors":"Ziyi Pan , Zhaoyang Zeng , Wei Xiong , Chunmei Fan","doi":"10.1016/j.bbcan.2025.189363","DOIUrl":"10.1016/j.bbcan.2025.189363","url":null,"abstract":"<div><div>In recent years, significant breakthroughs have been achieved in the study of RNA secondary structures. The roles of canonical structures, such as hairpins, internal loops, and stem-loops, in gene expression regulation, genome stability, and post-transcriptional control have been widely recognized. Meanwhile, non-canonical RNA secondary structures—such as R-loops, RNA G-quadruplexes (rG4s), <em>Z</em>-RNA, and pseudoknots—have garnered increasing attention due to their unique biological functions, becoming a frontier in research. The critical roles of these structures in gene regulation and tumorigenesis are gradually emerging, highlighting their importance. R-loops, composed of RNA-DNA hybrids, play central roles in genome stability, transcriptional regulation, and DNA repair; their abnormal accumulation is closely associated with tumorigenesis. rG4 regulates oncogene translation and stability, providing potential pathways for targeted cancer therapy. Although <em>Z</em>-RNA is still in its early stages of research, its unique role in interferon signaling and immune evasion opens new avenues for cancer immunotherapy. Pseudoknots, as highly complex RNA secondary structures, are indispensable in regulating the translational efficiency and functional stability of tumor-related genes. Recent progress in small-molecule drugs and RNA editing technologies targeting these RNA structures has demonstrated their potential applications in cancer diagnosis and treatment. This review provides a comprehensive perspective of the formation mechanisms, roles, and tumor-related research advancements of R-loops, rG4, <em>Z</em>-RNA, and pseudoknots. It delves into their mechanisms in cancer, outlines their potential applications in precision medicine, and discusses the challenges faced, offering innovative insights and directions for future research in the RNA structure field.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189363"},"PeriodicalIF":9.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fascin-1 in primary liver cancers, perspectives for targeted therapy 原发性肝癌中筋膜蛋白-1的靶向治疗前景

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-30 DOI: 10.1016/j.bbcan.2025.189361

Lydia Dif , Grégoire Manaud , Violaine Moreau

{"title":"Fascin-1 in primary liver cancers, perspectives for targeted therapy","authors":"Lydia Dif , Grégoire Manaud , Violaine Moreau","doi":"10.1016/j.bbcan.2025.189361","DOIUrl":"10.1016/j.bbcan.2025.189361","url":null,"abstract":"<div><div>Primary liver cancers are the third leading cause of cancer-related deaths worldwide. Despite the availability of chemotherapeutics, immunotherapies and anti-angiogenic drugs, survival rates have not improved. Worse, most patients do not respond to the most effective therapies. Patient stratification is necessary to increase the likelihood of effective treatment. More targeted therapies are definitely needed. Here, we provide an overview of the role of Fascin-1, an F-actin-bundling protein, in cell migration and invasion. We focus on its impact and clinical relevance in liver tumorigenesis. We propose Fascin-1 as a marker of poor prognosis for primary liver cancers including hepatocellular carcinoma, cholangiocarcinoma and hepatoblastoma. Fascin-1 is found to be overexpressed in all these cancers and is usually associated with undifferentiated tumors and worse outcomes. We then review current approaches to targeting Fascin-1 in primary liver cancers. Finally, we offer perspectives that may foster cancer research and open new avenues for Fascin-targeted therapies in liver cancers and beyond.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189361"},"PeriodicalIF":9.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of noncoding RNAs in rare gynecological cancers 非编码rna在罕见妇科癌症中的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-30 DOI: 10.1016/j.bbcan.2025.189362

Le Zhang, Xiujuan Chen, Yanbing Zhang, Saren Wang, Hailong Sun

{"title":"The role of noncoding RNAs in rare gynecological cancers","authors":"Le Zhang, Xiujuan Chen, Yanbing Zhang, Saren Wang, Hailong Sun","doi":"10.1016/j.bbcan.2025.189362","DOIUrl":"10.1016/j.bbcan.2025.189362","url":null,"abstract":"<div><div>Gynecological cancers are cancers that begin in the female reproductive organs. Gynecological cancer is the second most common cancer type among women and has become a global health burden for the female population. More than 50 % of all gynecological cancers can be defined as rare cancers. Three main types of noncoding RNAs (ncRNAs), namely, microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play crucial regulatory roles in physiological and pathological processes. Increasing evidence has revealed that ncRNAs closely participate in gynecological cancers. In this review, we focus on the role of ncRNAs in rare gynecological cancers. We first introduce the definitions, classifications, epidemiological characteristics, prognoses and treatments of rare gynecological cancers. Next, we summarize the differentially expressed ncRNAs and the molecular mechanisms underlying ncRNA connections to tumorigenesis, metastasis, chemoresistance, and recurrence. Finally, we highlight the potential applications of ncRNAs as diagnostic and prognostic biomarkers and therapeutic targets.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189362"},"PeriodicalIF":9.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic mechanisms in non-small cell lung cancer therapy and chemoresistance 非小细胞肺癌治疗和化疗耐药的表观遗传机制。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-28 DOI: 10.1016/j.bbcan.2025.189356

Ying Xu , Yang Meng , Yongfeng Xu , Junhong Han , Qing Zhu

{"title":"Epigenetic mechanisms in non-small cell lung cancer therapy and chemoresistance","authors":"Ying Xu , Yang Meng , Yongfeng Xu , Junhong Han , Qing Zhu","doi":"10.1016/j.bbcan.2025.189356","DOIUrl":"10.1016/j.bbcan.2025.189356","url":null,"abstract":"<div><div>Epigenetic mechanisms play a crucial role in cancer development and progression, encompassing DNA methylation, chromatin organization, histone modifications, and noncoding RNA regulation. Lung cancer is a major cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) accounting for approximately 85 % of all cases. Despite advances in detection and treatment, the prognosis for NSCLC patients remains poor, largely attributable to the development of chemoresistance. Chemoresistance is a key driver of cancer recurrence and metastasis. Targeting epigenetic modifications emerges as a promising strategy to reverse chemoresistance. Elucidating the mechanisms by which epigenetic modulation influences chemoresistance in NSCLC, coupled with the development of drugs to counteract this phenomenon, offers significant potential to improve the survival rates and quality of life for NSCLC patients. In this review, we comprehensively summarize the contributions of various epigenetic regulators to chemoresistance in NSCLC. We also explore the relationship between distinct epigenetic modifications and chemoresistance in NSCLC and discuss the translational potential of these findings into clinical therapies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189356"},"PeriodicalIF":9.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared mechanisms for metastasis and drug resistance in prostate cancer 前列腺癌转移和耐药的共同机制

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-28 DOI: 10.1016/j.bbcan.2025.189358

Yi-Min Chen , Lin Chen , Yu-Xin Xu , Hai-Bo Cheng , Jian-Liang Zhou

{"title":"Shared mechanisms for metastasis and drug resistance in prostate cancer","authors":"Yi-Min Chen , Lin Chen , Yu-Xin Xu , Hai-Bo Cheng , Jian-Liang Zhou","doi":"10.1016/j.bbcan.2025.189358","DOIUrl":"10.1016/j.bbcan.2025.189358","url":null,"abstract":"<div><div>Globally, prostate cancer (PCa) ranks as one of the most frequent malignant tumors in men, with metastasis and drug resistance significantly impacting clinical outcomes. Traditionally, cancer metastasis and drug resistance were regarded as separate research fields, but growing evidence now indicates a close interrelationship between them. Metastasis sets the stage for the development of drug resistance, and the emergence of resistance, in turn, enhances cancer metastasis through different mechanisms. Additionally, there are shared signaling pathways and regulatory mechanisms between metastasis and drug resistance, which interact and influence each other. This review provides a comprehensive overview of the advantages and limitations of various <em>in vivo</em> and <em>in vitro</em> models used to study metastasis and drug resistance in PCa. It also thoroughly investigates the common mechanisms underlying PCa metastasis and drug resistance, with particular emphasis on the roles of the androgen receptor signaling pathway, the tumor microenvironment, and cellular signaling pathways. Additionally, this review summarizes the therapeutic agents and investigational drugs under clinical trials for PCa, noting that existing research tends to focus on one aspect of the disease (either metastasis or drug resistance), rather than addressing both issues simultaneously. Through a systematic analysis of existing research, future drug development should prioritize the integrated regulation of these shared mechanisms, aiming to achieve dual inhibition of PCa metastasis and drug resistance.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189358"},"PeriodicalIF":9.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting the GIST of long non-coding RNA 获取长链非编码RNA的GIST

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-28 DOI: 10.1016/j.bbcan.2025.189357

Giulia Zerbo, Daniela Gasparotto

{"title":"Getting the GIST of long non-coding RNA","authors":"Giulia Zerbo, Daniela Gasparotto","doi":"10.1016/j.bbcan.2025.189357","DOIUrl":"10.1016/j.bbcan.2025.189357","url":null,"abstract":"<div><div>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancies of the digestive tract. About 85 % of them have gain-of-function mutations in KIT or PDGFRA, resulting in constitutive activation of these receptor tyrosine kinases, which are drivers of GIST development. While localized GIST can be cured by surgery alone, imatinib, a tyrosine kinase inhibitor, is the treatment of choice for advanced/metastatic disease. However, more than half of patients develop secondary resistance. Recent advances in the study of long non-coding RNA (lncRNA) have shed light on their role in the biology of GIST, revealing a complex level of gene expression regulation that contributes to pathogenesis, malignant progression, and therapeutic response to imatinib. This review aims to provide a comprehensive overview of the current knowledge regarding lncRNAs in GIST. An understanding of the roles of lncRNAs provides valuable insights into tumor behaviour and resistance mechanisms. The functions of the various lncRNAs are described as they can act as oncogenes or as tumor suppressor genes. The potential of lncRNAs in the clinical setting as prognostic and predictive indicators is also reviewed. The challenges in lncRNA research are discussed as well as the prospects of incorporating lncRNAs as target for GIST treatment, highlighting the importance of ongoing research to achieve its full potential to improve patient care.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189357"},"PeriodicalIF":9.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer 研究WNT信号在结直肠癌中的致瘤作用的实验工具。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-05-23 DOI: 10.1016/j.bbcan.2025.189354

Pujarini Dash , Vikas Yadav , Biswajit Das , Shakti Ranjan Satapathy

{"title":"Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer","authors":"Pujarini Dash , Vikas Yadav , Biswajit Das , Shakti Ranjan Satapathy","doi":"10.1016/j.bbcan.2025.189354","DOIUrl":"10.1016/j.bbcan.2025.189354","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-related death. Research over the years has postulated various experimental models that have facilitated an understanding of the complex mechanisms underlying WNT signaling in CRC. In the present review, we have comprehensively summarized the <em>in vitro</em>, <em>in vivo</em>, patient-derived, and computational models used to study the role of WNT signaling in CRC. We discuss the use of CRC cell lines and organoids in capturing the molecular intricacies of WNT signaling and implementing xenograft and genetically engineered mouse models to mimic the tumor microenvironment. Patient-derived models, including xenografts and organoids, provide valuable insights into personalized medicine approaches. Additionally, we elaborated on the role of computational models in simulating WNT signaling dynamics and predicting therapeutic outcomes. By evaluating the advantages and limitations of each model, this review highlights the critical contributions of these systems to our understanding of WNT signaling in CRC. We emphasize the need to integrate diverse model systems to enhance translational research and clinical applications, which is the primary goal of this review.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189354"},"PeriodicalIF":9.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0