Biochimica et biophysica acta. Reviews on cancer最新文献_第2页

Decoding secret role of mesenchymal stem cells in regulating cancer stem cells and drug resistance 解密间充质干细胞在调节癌症干细胞和耐药性方面的秘密作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189205

Sameer Kumar Panda , Nirmal Robinson , Vincenzo Desiderio

引用次数: 0

Mechanisms of cancer cachexia and targeted therapeutic strategies 癌症恶病质的机理和靶向治疗策略。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189208

Long Li , Zhi-Qiang Ling

{"title":"Mechanisms of cancer cachexia and targeted therapeutic strategies","authors":"Long Li , Zhi-Qiang Ling","doi":"10.1016/j.bbcan.2024.189208","DOIUrl":"10.1016/j.bbcan.2024.189208","url":null,"abstract":"<div><div>Tumor cachexia is a multifactorial syndrome characterized by systemic dysfunction, including anorexia and severe weight loss that is resistant to standard nutritional interventions. It is estimated that approximately 20 % of cancer patients succumb to cachexia in the later stages of their disease. Thus, understanding its pathogenesis is vital for improving therapeutic outcomes. Recent research has focused on the imbalance between energy intake and expenditure in cachexia. Clinically, cachexia presents with anorexia, adipose tissue atrophy, and skeletal muscle wasting, each driven by distinct mechanisms. Anorexia arises primarily from tumor-secreted factors and cancer-induced hormonal disruptions that impair hypothalamic regulation of appetite. Adipose tissue atrophy is largely attributed to enhanced lipolysis, driven by increased activity of enzymes such as adipose triglyceride lipase and hormone-sensitive lipase, coupled with decreased lipoprotein lipase activity. The browning of white adipose tissue, facilitated by uncoupling protein 1, further accelerates fat breakdown by increasing energy expenditure. Skeletal muscle atrophy, a hallmark of cachexia, results from dysregulated protein turnover via the ubiquitin-proteasome and autophagy-lysosomal pathways, as well as mitochondrial dysfunction. Additionally, chemotherapy can exacerbate cachexia. This review examines the molecular mechanisms underlying cancer cachexia and discusses current therapeutic strategies, aiming to inform future research and improve treatment approaches.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189208"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of TRP channels as new prognostic and therapeutic targets against prostate cancer progression TRP 通道作为抗击前列腺癌进展的新预后和治疗靶点的潜力。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189226

Giorgia Chinigò, Federico Alessandro Ruffinatti, Luca Munaron

{"title":"The potential of TRP channels as new prognostic and therapeutic targets against prostate cancer progression","authors":"Giorgia Chinigò, Federico Alessandro Ruffinatti, Luca Munaron","doi":"10.1016/j.bbcan.2024.189226","DOIUrl":"10.1016/j.bbcan.2024.189226","url":null,"abstract":"<div><div>Prostate cancer (PCa) is the second deadliest cancer among men worldwide. Particularly critical is its development towards metastatic androgen-independent forms for which the current therapies are ineffective. Indeed, the 5-year relative survival for PCa drops dramatically to 34 % in the presence of metastases. The superfamily of Transient Receptor Potential (TRP) channels could answer the urgent request to identify new prognostic and therapeutic tools against metastatic PCa. Indeed, this class of ion channels revealed an appealing de-regulation during PCa development and its progression towards aggressive forms. Altered expression and/or functionality of several TRPs have been associated with the PCa metastatic cascade by significantly impacting tumor growth, invasiveness, and angiogenesis. In this review, we will dissect the contribution of TRP channels in such hallmarks of PCa and then discuss their applicability as new prognostic and therapeutic agents in the fight against metastatic PCa. In particular, the great potential of TRPM8, TRPV6, and TRPA1 in opening the way to new treatment perspectives will be highlighted.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189226"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142718029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers in high grade serous ovarian cancer 高级别浆液性卵巢癌的生物标志物

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189224

Mark Bates PhD , Bashir M. Mohamed PhD , Faye Lewis MSc , Sharon O’Toole PhD , John J. O’Leary MD, DSc, PhD

{"title":"Biomarkers in high grade serous ovarian cancer","authors":"Mark Bates PhD , Bashir M. Mohamed PhD , Faye Lewis MSc , Sharon O’Toole PhD , John J. O’Leary MD, DSc, PhD","doi":"10.1016/j.bbcan.2024.189224","DOIUrl":"10.1016/j.bbcan.2024.189224","url":null,"abstract":"<div><div>High-grade serous ovarian cancer (HGSC) is the most common subtype of ovarian cancer. HGSC patients typically present with advanced disease, which is often resistant to chemotherapy and recurs despite initial responses to therapy, resulting in the poor prognosis associated with this disease. There is a need to utilise biomarkers to manage the various aspects of HGSC patient care. In this review we discuss the current state of biomarkers in HGSC, focusing on the various available immunohistochemical (IHC) and blood-based biomarkers, which have been examined for their diagnostic, prognostic and theranostic potential in HGSC. These include various routine clinical IHC biomarkers such as p53, WT1, keratins, PAX8, Ki67 and p16 and clinical blood-borne markers and algorithms such as CA125, HE4, ROMA, RMI, ROCA, and others. We also discuss various components of the liquid biopsy as well as a number of novel IHC biomarkers and non-routine blood-borne biomarkers, which have been examined in various ovarian cancer studies. We also discuss the future of ovarian cancer biomarker research and highlight some of the challenges currently facing the field.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189224"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An updated outlook on autophagy mechanism and how it supports acute myeloid leukemia maintenance 自噬机制及其如何支持急性髓性白血病维持的最新展望。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189214

Brunno Gilberto Santos de Macedo , Manuela Albuquerque de Melo , Diego Antonio Pereira-Martins , João Agostinho Machado-Neto , Fabiola Traina

{"title":"An updated outlook on autophagy mechanism and how it supports acute myeloid leukemia maintenance","authors":"Brunno Gilberto Santos de Macedo , Manuela Albuquerque de Melo , Diego Antonio Pereira-Martins , João Agostinho Machado-Neto , Fabiola Traina","doi":"10.1016/j.bbcan.2024.189214","DOIUrl":"10.1016/j.bbcan.2024.189214","url":null,"abstract":"<div><div>The gradual acquisition of genetic and epigenetic disturbances bestows malignant traits upon hematopoietic stem cells, subverting them into a founder and reservoir cell for <em>de novo</em> acute myeloid leukemia (AML) known as leukemic stem cells (LSC). Beyond its molecular heterogeneity, AML is also characterized by rewiring biological processes to support its onset and maintenance.</div><div>LSC were observed to inherently and actively trigger mitochondrial turnover through selective autophagic removal such that impairing the process led to cell differentiation at the expense of its stemness.</div><div>This review provides a current take on autophagy regulation mechanisms according to the current molecular characterization of the process; describes autophagy as a drug resistance mechanism, and a pivotal mechanism whereby LSC harmonize their strong reliance on mitochondrial respiration to obtain energy, and their necessity for lower internal oxidative stress to avoid exhaustion. Therefore, targeting autophagy presents a promising strategy to promote long-term remissions in AML.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189214"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting extracellular matrix interaction in gastrointestinal cancer: Immune modulation, metabolic reprogramming, and therapeutic strategies 针对胃肠道癌症中细胞外基质的相互作用：免疫调节、代谢重编程和治疗策略。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189225

Jiyifan Li , Wenxin Zhang , Lu Chen , Xinhai Wang , Jiafeng Liu , Yuxin Huang , Huijie Qi , Li Chen , Tianxiao Wang , Qunyi Li

{"title":"Targeting extracellular matrix interaction in gastrointestinal cancer: Immune modulation, metabolic reprogramming, and therapeutic strategies","authors":"Jiyifan Li , Wenxin Zhang , Lu Chen , Xinhai Wang , Jiafeng Liu , Yuxin Huang , Huijie Qi , Li Chen , Tianxiao Wang , Qunyi Li","doi":"10.1016/j.bbcan.2024.189225","DOIUrl":"10.1016/j.bbcan.2024.189225","url":null,"abstract":"<div><div>The extracellular matrix (ECM) is a major constituent of the tumor microenvironment, acting as a mediator that supports the progression of gastrointestinal (GI) cancers, particularly in mesenchymal subtypes. Beyond providing structural support, the ECM actively shapes the tumor microenvironment (TME) through complex biochemical and biomechanical remodeling. Dysregulation of ECM composition and signaling is closely linked to increased cancer aggressiveness, poor prognosis, and resistance to therapy. ECM components, such as collagen, fibronectin, laminin, and periostin, influence tumor growth, metastasis, immune modulation, and metabolic reprogramming by interacting with tumor cells, immune cells, and cancer-associated fibroblasts. In this review, we highlight the heterogeneous nature of the ECM and the dualistic roles of its components across GI cancers, with a focus on their contributions to immune evasion and metabolic remodeling via intercellular interactions. Additionally, we explore therapeutic strategies targeting ECM remodeling and ECM-centered interactions, emphasizing their potential in enhancing existing anti-tumor therapies.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189225"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances of SS18-SSX fusion gene in synovial sarcoma: Emerging novel functions and therapeutic potentials 滑膜肉瘤中 SS18-SSX 融合基因的研究进展：新功能和治疗潜力。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189215

Chongmin Ren , Jia Liu , Francis J. Hornicek , Bin Yue , Zhenfeng Duan

{"title":"Advances of SS18-SSX fusion gene in synovial sarcoma: Emerging novel functions and therapeutic potentials","authors":"Chongmin Ren , Jia Liu , Francis J. Hornicek , Bin Yue , Zhenfeng Duan","doi":"10.1016/j.bbcan.2024.189215","DOIUrl":"10.1016/j.bbcan.2024.189215","url":null,"abstract":"<div><div>Synovial sarcoma is a rare type of soft tissue sarcoma that primarily affects adolescents and young adults, featured by aggressive behavior and a high potential for metastasis. Genetically, synovial sarcoma is defined by the fusion oncogene SS18-SSX arising from the translocation of t(X;18)(p11;q11). SS18-SSX fusion gene is the major driver of the oncogenic event in synovial sarcoma. SS18-SSX fusion protein, while not containing any DNA-binding motifs, binds to the SWI/SNF (BAF) complex, a major epigenetic regulator, leading to the disruption of gene expression which results in tumor initiation and progression. Emerging studies on the molecular mechanisms of SS18-SSX associated signaling pathway hold promise for developments in diagnosis and treatments. Advanced diagnostic methods facilitate early and precise detection of the tumor, enabling disease monitoring and prognostic improvements. Treatment of synovial sarcoma typically comprises local surgery, radiotherapy and chemotherapy, while novel managements such as immunotherapy, targeted therapies and epigenetic modifiers are explored. This review focuses on the recent studies of SS18-SSX fusion gene, epigenetic landscape, signaling pathways, diagnostic techniques, and relevant therapeutic advances, aiming to inhibit the oncogenic processes and improve outcomes for patients with synovial sarcoma.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189215"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing pioneering pharmacological strategies with CRISPR/Cas9 library screening to overcome cancer drug resistance 利用 CRISPR/Cas9 文库筛选技术开发开创性药理学策略，克服癌症抗药性。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189212

Yu He , Huan Li , Xueming Ju , Bo Gong

引用次数: 0

Epigenetic regulation of TGF-β and vice versa in cancers – A review on recent developments 癌症中 TGF-β 和 TGF-β 的表观遗传调控--最新进展综述。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189219

Ankit Naik, Noopur Thakur

{"title":"Epigenetic regulation of TGF-β and vice versa in cancers – A review on recent developments","authors":"Ankit Naik, Noopur Thakur","doi":"10.1016/j.bbcan.2024.189219","DOIUrl":"10.1016/j.bbcan.2024.189219","url":null,"abstract":"<div><div>This review explores the complex relationship between epigenetic mechanisms and Transforming Growth Factor-beta (TGF-β) signalling pathways in the field of cancer research. The study provides an overview of the latest advancements in understanding the crucial functions of epigenetic alterations, such as DNA methylation, histone modifications, and chromatin remodeling, in significantly impacting the TGF-β signalling pathway. The dynamic epigenetic modifications are essential in determining the behaviour of cancer cells, impacting the interactions with the tumor microenvironment, and affecting the overall process of carcinogenesis. Significant attention is given to Breast cancer, Lung cancer, Liver cancer, Prostate cancer, and Pancreatic cancer. Research has revealed intricate regulatory networks in these cancers, involving long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and histone post-translational modifications. These networks are closely connected to TGF-β signalling. Both findings highlight the significant interaction between epigenetic regulation and TGF-β signalling in cancer. They provide valuable insights that can guide the development of new treatment approaches to target both pathways and prevent cancer growth and metastasis.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189219"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer 微生物组和宿主因素在头颈癌发病和治疗中的相互作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-11-01 DOI: 10.1016/j.bbcan.2024.189216

Martina Raudenská , Maria Bugajová , David Kalfeřt , Jan Plzák , Adam Šubrt , Petra Tesařová , Michal Masařík

{"title":"The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer","authors":"Martina Raudenská , Maria Bugajová , David Kalfeřt , Jan Plzák , Adam Šubrt , Petra Tesařová , Michal Masařík","doi":"10.1016/j.bbcan.2024.189216","DOIUrl":"10.1016/j.bbcan.2024.189216","url":null,"abstract":"<div><div>Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 6","pages":"Article 189216"},"PeriodicalIF":9.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0