microrna和溶酶体膜蛋白：肿瘤进展和治疗中的关键相互作用。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-03-23 DOI:10.1016/j.bbcan.2025.189303

Jiahao Xu , Shiqiang Liu , Yujie Jin , Lizhuo Wang , Jialin Gao

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引用次数: 0

摘要

癌症的发展受到遗传和表观遗传变异的影响，microRNAs （miRNAs）和溶酶体膜蛋白（LMPs）之间的相互作用代表了具有潜在治疗靶点的关键调控机制。本文综述了mirna和LMPs在肿瘤进展中的复杂调控机制，重点介绍了它们在肿瘤抑制、肿瘤促进、肿瘤治疗和耐药中的作用，以及它们在治疗策略中的未来应用。总之，LMPs与mirna的相互作用在肿瘤调控中具有关键作用，对这些相互作用的研究将进一步强调它们在癌症发展中的分子作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

MicroRNAs and lysosomal membrane proteins: Critical interactions in tumor progression and therapy

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MicroRNAs and lysosomal membrane proteins: Critical interactions in tumor progression and therapy

Cancer development is influenced by genetic and epigenetic variations, with the interactions between microRNAs (miRNAs) and lysosomal membrane proteins (LMPs) representing key regulatory mechanisms with potential as therapeutic targets. This review focuses on the complex regulatory mechanisms of miRNAs and LMPs in tumor progression, specifically highlighting their roles in tumor suppression, tumor promotion, tumor therapy, and drug resistance and their future application in treatment strategies. Overall, the interactions of LMPs with miRNAs have critical roles in tumor regulation, and studies of these interactions will further highlight their molecular contributions to cancer development.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.