Biochimica et biophysica acta. Reviews on cancer最新文献_第8页

Raf-kinase inhibitor protein (RKIP): A therapeutic target in colon cancer raf激酶抑制蛋白（RKIP）：结肠癌的治疗靶点

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-16 DOI: 10.1016/j.bbcan.2025.189387

Seema Kumari , Sujatha Peela , Pallaval Veera Bramhachari , Kokkanti Mallikarjuna , Ganji Purnachandra Nagaraju , Mundla Srilatha

{"title":"Raf-kinase inhibitor protein (RKIP): A therapeutic target in colon cancer","authors":"Seema Kumari , Sujatha Peela , Pallaval Veera Bramhachari , Kokkanti Mallikarjuna , Ganji Purnachandra Nagaraju , Mundla Srilatha","doi":"10.1016/j.bbcan.2025.189387","DOIUrl":"10.1016/j.bbcan.2025.189387","url":null,"abstract":"<div><div>Raf-kinase inhibitor protein (RKIP) plays a significant role in maintaining cell homeostasis, and its downregulation is a hallmark of various cancers, including colorectal cancer (CRC). It modulates several signals, including MAPK (Raf/MEK/ERK), NF-κB, STAT3, cell cycle, and GPCR signaling by modulating phosphorylation state. It's binding to Raf-1 inhibits phosphorylation and makes the signaling molecules inactive. In the case of NF-κB, which plays a central role in drug resistance, RKIP interacts with IκBα and inhibits IKKα, IKKβ, and NIK by preventing their phosphorylation, thereby maintaining NF-κB in an inactive state. A reduction in the expression level of RKIP increases the metastasis and promotes the signaling associated with cancer progression. This review examines the role of RKIP in the aggressiveness and metastasis of CRC. Several signal pathways influenced by changes in the expression level of RKIP are discussed in detail. Strategies like the use of inhibitors, understanding the role of miRNA, immunotherapy, and combined therapies have been discussed in detail, along with the clinical implications of RKIP in CRC.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189387"},"PeriodicalIF":9.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating circulating tumour cells and tumour microemboli: Where we stand in bridging their molecular dynamics with clinical translation 导航循环肿瘤细胞和肿瘤微栓子：我们在桥接分子动力学与临床翻译的立场。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-11 DOI: 10.1016/j.bbcan.2025.189384

Deepa Bisht , Vivek Kumar , Sudha Gupta , Manisha Sachan

{"title":"Navigating circulating tumour cells and tumour microemboli: Where we stand in bridging their molecular dynamics with clinical translation","authors":"Deepa Bisht , Vivek Kumar , Sudha Gupta , Manisha Sachan","doi":"10.1016/j.bbcan.2025.189384","DOIUrl":"10.1016/j.bbcan.2025.189384","url":null,"abstract":"<div><div>Circulating tumour cells (CTCs) and circulating tumour microemboli (CTM) are key liquid biopsy biomarkers that reflect tumour invasiveness and metastatic potential. CTM, compared to single CTCs, exhibit greater heterogeneity, epithelial–mesenchymal plasticity, immune evasion, stemness and metastatic potential. Technological developments in microfluidics, nanomaterials, and biosensing have enabled high-sensitivity, label-free isolation and molecular classification of CTCs/CTM, simplifying real-time diagnosis, prognosis, and treatment monitoring. While promising, challenges such as heterogeneity, low abundance, and lack of standardization limit their clinical translation. Integrating robust, scalable enrichment and detection platforms with molecular profiling may unlock their full potential in oncology. Our present review provides a comprehensive and comparative investigation of CTC/CTM biology, highlights recent advancements in their isolation and detection technologies, underlines their growing role along with associated challenges in oncology and clinical management.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189384"},"PeriodicalIF":9.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential γ-分泌酶复合物关键亚基与乳腺癌进展：生物学功能、调控模式及治疗潜力

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-11 DOI: 10.1016/j.bbcan.2025.189386

Ran Xu , Xin Yang , Kuo Yao , Ke-Fan Yang , Li-Zhi Hu , Xiang-Yi Zhan , Ming-Sheng Zhou , Hui Jia

{"title":"Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential","authors":"Ran Xu , Xin Yang , Kuo Yao , Ke-Fan Yang , Li-Zhi Hu , Xiang-Yi Zhan , Ming-Sheng Zhou , Hui Jia","doi":"10.1016/j.bbcan.2025.189386","DOIUrl":"10.1016/j.bbcan.2025.189386","url":null,"abstract":"<div><div>Breast cancer (BC) is the most prevalent malignant tumor among females. The primary therapeutic options currently available include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the emergence of drug resistance has resulted in a gradual decline in the efficacy of these treatments. The activation of the Notch signaling pathway is closely associated with the development and progression of breast cancer. γ-secretase, a crucial hydrolase in the Notch pathway, consists of four subunits: presenilin 1 and 2 (PSEN1 and 2), presenilin enhancer 2 (PEN-2), Nicastrin (NCSTN), and anterior pharynx defective 1 (APH-1). These subunits interact to maintain the overall biological function and stability of the complex. This review utilizes the key subunits of γ-secretase as a focal point to elucidate the structure-function relationships, interactions, and their relevance to the progression of breast cancer for each complex subunit, and the preclinical studies and clinical trials were discussed, emphasizing the relationship between the key subunits of γ-secretase complex and the pathogenesis of BC. Furthermore, the challenges and prospects of γ-secretase inhibitors as potential therapies for chemoresistance in breast cancer were discussed.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189386"},"PeriodicalIF":9.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the triad: phenotypic plasticity, tumor microenvironment and bone microenvironment in prostate cancer bone-metastatic events 靶向三合一：前列腺癌骨转移事件中的表型可塑性、肿瘤微环境和骨微环境。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-11 DOI: 10.1016/j.bbcan.2025.189388

Ma Chi-Cheng , Ou-Yang Ao-Rong , Chen Zi-Xian , Zhao Shan-Chao , Chen Ming-Kun

{"title":"Targeting the triad: phenotypic plasticity, tumor microenvironment and bone microenvironment in prostate cancer bone-metastatic events","authors":"Ma Chi-Cheng , Ou-Yang Ao-Rong , Chen Zi-Xian , Zhao Shan-Chao , Chen Ming-Kun","doi":"10.1016/j.bbcan.2025.189388","DOIUrl":"10.1016/j.bbcan.2025.189388","url":null,"abstract":"<div><div>The incidence and mortality rates of prostate cancer are increasing annually, indicating that it poses a serious threat to men's health. Previous studies have demonstrated that bone-metastatic tumor cells undergo four hallmark bone-metastatic events, including colonization, dormancy, reactivation and bone reconstruction. However, most advanced patients experience four stages of progression and undergo advanced bone reconstruction—the “vicious circle”—which is irreversible. These patients have a poor prognosis and can even die. Therefore, determining how various components in the tumor and bone microenvironments affect the progression and events of bone metastasis is crucial. Here, <em>we integrate the latest mechanisms of phenotypic plasticity and microenvironment interactions, proposing potential therapeutic targets to disrupt the ‘vicious cycle’ in advanced bone metastasis.</em> We look forward to providing direction and guidance for the future treatment of prostate cancer bone metastasis.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189388"},"PeriodicalIF":9.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the role of mucins and gut microbiota in gastrointestinal cancers chemoresistance 揭示粘蛋白和肠道微生物群在胃肠道癌症化疗耐药中的作用

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-08 DOI: 10.1016/j.bbcan.2025.189385

A.M. Vrinda , Muthusamy Thangaraju , S. Asha Nair , Gordon S. Howarth , Ramesh Pothuraju

{"title":"Unraveling the role of mucins and gut microbiota in gastrointestinal cancers chemoresistance","authors":"A.M. Vrinda , Muthusamy Thangaraju , S. Asha Nair , Gordon S. Howarth , Ramesh Pothuraju","doi":"10.1016/j.bbcan.2025.189385","DOIUrl":"10.1016/j.bbcan.2025.189385","url":null,"abstract":"<div><div>The interaction between heavily glycosylated mucin proteins in the mucus layer, gut microbes, and gastrointestinal (GI) tract cancers has been extensively studied to improve treatment outcomes and survival rates in cancer patients. Colorectal and pancreatic cancers, among the most common GI cancers, are leading causes of cancer-related deaths due to their high recurrence rates and resistance to therapy. Tumor resistance is influenced by multiple factors, notably the tumor microenvironment, which is largely shaped by the gut microbiota. A bidirectional relationship between gut microbes and mucins helps maintain intestinal homeostasis. Mucins, along with gut microbes and their metabolites, play significant roles in oncogenic signaling pathways and have been identified as key biomarkers for cancer. Additionally, mucins and microbes contribute to the response to treatments like chemotherapy and immunotherapy. This review highlights the critical role of mucins and gut microbiota interactions in therapy response, exploring recent advancements in therapies targeting these factors. By focusing on mucin- and microbiota-targeted treatments and combination therapies, these strategies offer potential for improving therapeutic outcomes and increasing survival rates in patients with these challenging cancers.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189385"},"PeriodicalIF":9.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Unveiling the TGF-β/Smad signaling in renal carcinoma progression: Prognostic and therapeutic insights” [Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1880, Issue 4, (2025) / 189372] “揭示肾癌进展中的TGF-β/Smad信号：预后和治疗见解”[生物化学与生物物理学报(BBA) -癌症评论，卷1880，第4期，(2025)/ 189372]的勘误表。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-05 DOI: 10.1016/j.bbcan.2025.189378

Vânia Dias , Ângela Alves , Rui Medeiros , Ana Luísa Teixeira , Francisca Dias

引用次数: 0

Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma 肠道微生物群作为癌症发展和管理的中介：从结肠炎到结肠炎相关的不典型增生和癌症。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-04 DOI: 10.1016/j.bbcan.2025.189381

Wanyue Dan , Cenxi Xiong , Guanzhou Zhou , Junzhe Chen , Fei Pan

{"title":"Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma","authors":"Wanyue Dan , Cenxi Xiong , Guanzhou Zhou , Junzhe Chen , Fei Pan","doi":"10.1016/j.bbcan.2025.189381","DOIUrl":"10.1016/j.bbcan.2025.189381","url":null,"abstract":"<div><div>Colitis-associated colorectal cancer (CAC) develops as a result of prolonged colitis in patients with inflammatory bowel disease. In recent years, the role of the gut microbiota in colitis-associated colorectal carcinogenesis has begun to be recognized. Specific microbes, such as enterotoxigenic <em>Bacteroides fragilis</em>, <em>Fusobacterium nucleatum</em>, and pks<sup>+</sup> <em>Escherichia coli</em>, promote carcinogenesis by regulating oncogenic signaling, epithelial-mesenchymal transition, autophagy induction, and the immune microenvironment. Conversely, commensal fungi and probiotics exert tumor-suppressive effects by inhibiting inflammatory pathways and immune cell recruitment. Emerging microbiota-targeted strategies, including precision probiotics and fecal microbiota transplantation, can restore ecological homeostasis, attenuate inflammation, and enhance the efficacy of conventional therapies. This review summarizes the current understanding of the mechanisms underlying microbiota-driven CAC pathogenesis and assesses the potential applications of gut microbiota in the development of diagnostic tools and therapeutic interventions.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189381"},"PeriodicalIF":9.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting cu metabolism as a potential therapeutic strategy for pulmonary fibrosis 靶向铜代谢作为肺纤维化的潜在治疗策略

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-04 DOI: 10.1016/j.bbcan.2025.189379

Bo Li , Min Zhang , Jing Cai , Na-mei Li , Xiao-hong Li , Hai-peng Cheng

{"title":"Targeting cu metabolism as a potential therapeutic strategy for pulmonary fibrosis","authors":"Bo Li , Min Zhang , Jing Cai , Na-mei Li , Xiao-hong Li , Hai-peng Cheng","doi":"10.1016/j.bbcan.2025.189379","DOIUrl":"10.1016/j.bbcan.2025.189379","url":null,"abstract":"<div><div>Cuproptosis, a recently identified form of programmed cell death driven by copper (Cu) ions, has gained attention owing to its involvement in metabolic disorders and degenerative conditions. Pulmonary fibrosis, characterized by abnormal extracellular matrix accumulation and gradual deterioration of lung function, persists as a lethal disorder with few effective treatments. Dysfunctions in Cu metabolism or regulatory pathways lead to an imbalance in pulmonary Cu homeostasis, thereby influencing the onset and progression of lung diseases. These findings have renewed the interest in the role of cuproptosis in pulmonary fibrosis. However, given that research on cuproptosis in the field of pulmonary fibrosis is in its early stages, our current understanding of its role in this condition is limited. Thus, this review summarizes the biochemical pathways underlying cuproptosis, discusses its possible contribution to the development of pulmonary fibrosis, and presents therapeutic strategies focused on modulating Cu homeostasis. Although conclusive data directly associating cuproptosis with pulmonary fibrosis remain limited, growing evidence highlighting Cu imbalance, mitochondrial impairment, and dysregulated cell death mechanisms strengthens the need for deeper exploration in this field. Future research may pave the way for developing novel therapeutic approaches targeting Cu metabolism to address the unmet clinical needs of patients with pulmonary fibrosis.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189379"},"PeriodicalIF":9.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial heterogeneity in glioblastoma: Decoding the role of perfusion 胶质母细胞瘤的空间异质性：解读灌注的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-03 DOI: 10.1016/j.bbcan.2025.189383

Shubhraneel Saha , Anjali Bhat , Samiksha Kukal , Manoj Phalak , Saran Kumar

{"title":"Spatial heterogeneity in glioblastoma: Decoding the role of perfusion","authors":"Shubhraneel Saha , Anjali Bhat , Samiksha Kukal , Manoj Phalak , Saran Kumar","doi":"10.1016/j.bbcan.2025.189383","DOIUrl":"10.1016/j.bbcan.2025.189383","url":null,"abstract":"<div><div>Glioblastoma multiforme (GBM) is a highly aggressive brain cancer marked by aggressive growth and therapeutic resistance. A growing body of research highlights substantial spatial heterogeneity within GBM tumors as a critical factor contributing to treatment failure. Advanced molecular techniques, including third-generation genomics, high-resolution metabolomics, and single-cell and spatial transcriptomics, have illuminated the detailed genetic and epigenetic landscape, revealing a complex interplay of molecular modifications. A key determinant of spatial heterogeneity is differential perfusion, which leads to the formation of distinct microenvironmental niches characterized by varying oxygen, nutrient, and growth factor availability. This ITH impacts not only GBM cancer cells but also the entire tumor microenvironment, including immune and other stromal cells. Interactions between cancer cells and the surrounding stroma significantly modulate immune surveillance, frequently promoting tumor malignancy. Perfusion further dictates the plasticity in GBM, enabling their transformation into the aggressive mesenchymal subtype. This review examines how such perfusion-driven differences affect GBM intra-tumoral heterogeneity, focussing on the aspects of immune regulation, and treatment resistance. We discuss emerging therapeutic strategies that target perfusion-induced heterogeneity, including anti-angiogenic and immunotherapeutic approaches. Further, the review emphasizes the importance of the tumor microenvironment and highlights the complex interplay of factors driving GBM progression, paving the way for more effective and personalized treatment strategies aimed at enhancing patient survival.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 4","pages":"Article 189383"},"PeriodicalIF":9.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting KRAS in colorectal cancer immunotherapy: rationale, challenges and future directions 靶向KRAS在结直肠癌免疫治疗中的应用：原理、挑战和未来方向

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-07-03 DOI: 10.1016/j.bbcan.2025.189382

Gongmin Zhu , Lijiao Pei , Di Ye , Qiulin Tang , Huanji Xu , Feng Bi

引用次数: 0