Biochimica et biophysica acta. Reviews on cancer最新文献_第7页

Decoding PTEN regulation in clear cell renal cell carcinoma: Pathway for biomarker discovery and therapeutic insights 解码透明细胞肾细胞癌中 PTEN 的调控：发现生物标志物和深入了解治疗的途径。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-06 DOI: 10.1016/j.bbcan.2024.189165

Ângela Alves , Rui Medeiros , Ana Luísa Teixeira , Francisca Dias

{"title":"Decoding PTEN regulation in clear cell renal cell carcinoma: Pathway for biomarker discovery and therapeutic insights","authors":"Ângela Alves , Rui Medeiros , Ana Luísa Teixeira , Francisca Dias","doi":"10.1016/j.bbcan.2024.189165","DOIUrl":"10.1016/j.bbcan.2024.189165","url":null,"abstract":"<div><p>Renal cell carcinoma is the most common adult renal solid tumor and the deadliest urological cancer, with clear cell renal cell carcinoma (ccRCC) being the predominant subtype. The <em>PI3K/AKT</em> signaling pathway assumes a central role in ccRCC tumorigenesis, wherein its abnormal activation confers a highly aggressive phenotype, leading to swift resistance against current therapies and distant metastasis. Thus, treatment resistance and disease progression remain a persistent clinical challenge in managing ccRCC effectively. <em>PTEN</em>, an antagonist of the <em>PI3K/AKT</em> signaling axis, emerges as a crucial factor in tumor progression, often experiencing loss or inactivation in ccRCC, thereby contributing to elevated mortality rates in patients. Therefore, understanding the molecular mechanisms underlying <em>PTEN</em> suppression in ccRCC tumors holds promise for the discovery of biomarkers and therapeutic targets, ultimately enhancing patient monitoring and treatment outcomes. The present review aims to summarize these mechanisms, emphasizing their potential prognostic, predictive, and therapeutic value in managing ccRCC.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189165"},"PeriodicalIF":9.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000969/pdfft?md5=d9597b8b01b08ed530470f53a334850d&pid=1-s2.0-S0304419X24000969-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymic epithelial tumor medical treatment: A narrative review 胸腺上皮肿瘤的医学治疗：叙述性综述。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-06 DOI: 10.1016/j.bbcan.2024.189167

Qian Huang , Lingling Zhu , Yanyang Liu , Yan Zhang

{"title":"Thymic epithelial tumor medical treatment: A narrative review","authors":"Qian Huang , Lingling Zhu , Yanyang Liu , Yan Zhang","doi":"10.1016/j.bbcan.2024.189167","DOIUrl":"10.1016/j.bbcan.2024.189167","url":null,"abstract":"<div><p>Thymic epithelial tumors, a malignancy originating in the thymus, are the commonest primary neoplasm of the anterior mediastinum; however, among thoracic tumors, they have a relatively low incidence rare. Thymic epithelial tumors can be broadly classified into thymic carcinoma and thymoma. As the cornerstone of thymic tumor treatment, surgery is the preferred treatment for early-stage patients, whereas, for advanced unresectable thymic tumors, the treatment is chemoradiotherapy. Targeted therapy is less effective for thymic tumors. Moreover, the use of immune checkpoint inhibitors as another effective treatment option for advanced unresectable thymic tumors, particularly thymomas, is limited owing to immune-related adverse effects. Here, we have summarized all pertinent information regarding chemotherapy, especially preoperative neoadjuvant chemotherapy, and chemotherapy in combination with other treatments, and reviewed the effectiveness of these procedures and recent advances in targeted therapy. In addition, we analyzed the efficacy and safety of immune checkpoint inhibitors in thymic epithelial tumors, to provide a holistic treatment view.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189167"},"PeriodicalIF":9.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0304419X24000982/pdfft?md5=6c59e45b25294aad40d8fae7504c6e78&pid=1-s2.0-S0304419X24000982-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms 癌症中的 Cullin-RING 连接酶 4：结构、功能和机制

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-06 DOI: 10.1016/j.bbcan.2024.189169

Jingyi Cheng , Xin Bin , Zhangui Tang

引用次数: 0

Unlocking the potential: Targeting metabolic pathways in the tumor microenvironment for Cancer therapy 释放潜能：针对肿瘤微环境中的代谢途径进行癌症治疗。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-05 DOI: 10.1016/j.bbcan.2024.189166

Siyuan Jia , Ann M. Bode , Xue Chen , Xiangjian Luo

引用次数: 0

Targeting the MHC-I endosomal-lysosomal trafficking pathway in cancer: From mechanism to immunotherapy 针对癌症中的 MHC-I 内体-溶酶体转运途径：从机制到免疫疗法

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-02 DOI: 10.1016/j.bbcan.2024.189161

Di Ye , Shuang Zhou , Xinyu Dai , Huanji Xu, Qiulin Tang, Huixi Huang, Feng Bi

{"title":"Targeting the MHC-I endosomal-lysosomal trafficking pathway in cancer: From mechanism to immunotherapy","authors":"Di Ye , Shuang Zhou , Xinyu Dai , Huanji Xu, Qiulin Tang, Huixi Huang, Feng Bi","doi":"10.1016/j.bbcan.2024.189161","DOIUrl":"10.1016/j.bbcan.2024.189161","url":null,"abstract":"<div><p>Immune checkpoint blockade (ICB) therapy has achieved broad applicability and durable clinical responses across cancer types. However, the overall response rate remains suboptimal because some patients do not respond or develop drug resistance. The low infiltration of CD8<sup>+</sup> cytotoxic T cells (CTLs) in the tumor microenvironment due to insufficient antigen presentation is closely related to the innate resistance to ICB. The duration and spatial distribution of major histocompatibility complex class I (MHC-I) expression on the cell surface is critical for the efficient presentation of endogenous tumor antigens and subsequent recognition and clearance by CTLs. Tumor cells reduce the surface expression of MHC-I via multiple mechanisms to impair antigen presentation pathways and evade immunity and/or develop resistance to ICB therapy. As an increasing number of studies have focused on membrane MHC-I trafficking and degradation in tumor cells, which may impact the effectiveness of tumor immunotherapy. It is necessary to summarize the mechanism regulating membrane MHC-I translocation into the cytoplasm and degradation via the lysosome. We reviewed recent advances in the understanding of endosomal-lysosomal MHC-I transport and highlighted the means exploited by tumor cells to evade detection and clearance by CTLs. We also summarized new therapeutic strategies targeting these pathways to enhance classical ICB treatment and provide new avenues for optimizing cancer immunotherapy.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189161"},"PeriodicalIF":9.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactic acid: The culprit behind the immunosuppressive microenvironment in hepatocellular carcinoma 乳酸：肝细胞癌免疫抑制微环境的罪魁祸首。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-02 DOI: 10.1016/j.bbcan.2024.189164

Xiaopei Peng , Zhenhu He , Dandan Yuan , Zhenguo Liu , Pengfei Rong

引用次数: 0

T cell exhaustion in human cancers 人类癌症中的 T 细胞衰竭

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-30 DOI: 10.1016/j.bbcan.2024.189162

Kuan Kang , Xin Lin , Pan Chen , Huai Liu , Feng Liu , Wei Xiong , Guiyuan Li , Mei Yi , Xiayu Li , Hui Wang , Bo Xiang

{"title":"T cell exhaustion in human cancers","authors":"Kuan Kang , Xin Lin , Pan Chen , Huai Liu , Feng Liu , Wei Xiong , Guiyuan Li , Mei Yi , Xiayu Li , Hui Wang , Bo Xiang","doi":"10.1016/j.bbcan.2024.189162","DOIUrl":"10.1016/j.bbcan.2024.189162","url":null,"abstract":"<div><p>T cell exhaustion refers to a progressive state in which T cells become functionally impaired due to sustained antigenic stimulation, which is characterized by increased expression of immune inhibitory receptors, but weakened effector functions, reduced self-renewal capacity, altered epigenetics, transcriptional programme and metabolism. T cell exhaustion is one of the major causes leading to immune escape of cancer, creating an environment that supports tumor development and metastatic spread. In addition, T cell exhaustion plays a pivotal role to the efficacy of current immunotherapies for cancer. This review aims to provide a comprehensive view of roles of T cell exhaustion in cancer development and progression. We summerized the regulatory mechanisms that involved in T cell exhaustion, including transcription factors, epigenetic and metabolic reprogramming events, and various microenvironmental factors such as cytokines, microorganisms, and tumor autocrine substances. The paper also discussed the challenges posed by T cell exhaustion to cancer immunotherapies, including immune checkpoint blockade (ICB) therapies and chimeric antigen receptor T cell (CAR-T) therapy, highlightsing the obstacles encountered in ICB therapies and CAR-T therapies due to T cell exhaustion. Finally, the article provides an overview of current therapeutic options aimed to reversing or alleviating T cell exhaustion in ICB and CAR-T therapies. These therapeutic approaches seek to overcome T cell exhaustion and enhance the effectiveness of immunotherapies in treating tumors.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189162"},"PeriodicalIF":9.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging preclinical models of metastatic breast cancer 利用转移性乳腺癌的临床前模型。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-29 DOI: 10.1016/j.bbcan.2024.189163

Diego A. Pedroza , Yang Gao , Xiang H.-F. Zhang , Jeffrey M. Rosen

引用次数: 0

Schwann cells and enteric glial cells: Emerging stars in colorectal cancer 许旺细胞和肠胶质细胞：大肠癌中的新星。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-24 DOI: 10.1016/j.bbcan.2024.189160

Kexin He , Hao Wang , Ruixue Huo , Shu-Heng Jiang , Junli Xue

{"title":"Schwann cells and enteric glial cells: Emerging stars in colorectal cancer","authors":"Kexin He , Hao Wang , Ruixue Huo , Shu-Heng Jiang , Junli Xue","doi":"10.1016/j.bbcan.2024.189160","DOIUrl":"10.1016/j.bbcan.2024.189160","url":null,"abstract":"<div><p>Cancer neuroscience, a promising field dedicated to exploring interactions between cancer and the nervous system, has attracted growing attention. The gastrointestinal tracts exhibit extensive innervation, notably characterized by intrinsic innervation. The gut harbors a substantial population of glial cells, including Schwann cells wrapping axons of neurons in the peripheral nervous system and enteric glial cells intricately associated with intrinsic innervation. Glial cells play a crucial role in maintaining the physiological functions of the intestine, encompassing nutrient absorption, barrier integrity, and immune modulation. Nevertheless, it has only been in recent times that the significance of glial cells within colorectal cancer (CRC) has begun to receive considerable attention. Emerging data suggests that glial cells in the gut contribute to the progression and metastasis of CRC, by interacting with cancer cells, influencing inflammation, and modulating the tumor microenvironment. Here, we summarize the significant roles of glial cells in the development and progression of CRC and discuss the latest technologies that can be integrated into this field for in-depth exploration, as well as potential specific targeted strategies for future exploration to benefit patients.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189160"},"PeriodicalIF":9.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights into the role of mixed lineage kinase 3 in cancer hallmarks 混合系激酶 3 在癌症特征中作用的分子见解。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-07-18 DOI: 10.1016/j.bbcan.2024.189157

Rong Ke , Sandeep Kumar , Sunil Kumar Singh , Ajay Rana , Basabi Rana

{"title":"Molecular insights into the role of mixed lineage kinase 3 in cancer hallmarks","authors":"Rong Ke , Sandeep Kumar , Sunil Kumar Singh , Ajay Rana , Basabi Rana","doi":"10.1016/j.bbcan.2024.189157","DOIUrl":"10.1016/j.bbcan.2024.189157","url":null,"abstract":"<div><p>Mixed-lineage kinase 3 (MLK3) is a serine/threonine kinase of the MAPK Kinase kinase (MAP3K) family that plays critical roles in various biological processes, including cancer. Upon activation, MLK3 differentially activates downstream MAPKs, such as JNK, p38, and ERK. In addition, it regulates various non-canonical signaling pathways, such as β-catenin, AMPK, Pin1, and PAK1, to regulate cell proliferation, apoptosis, invasion, and metastasis. Recent studies have also uncovered other potentially diverse roles of MLK3 in malignancy, which include metabolic reprogramming, cancer-associated inflammation, and evasion of cancer-related immune surveillance. The role of MLK3 in cancer is complex and cancer-specific, and an understanding of its function at the molecular level aligned specifically with the cancer hallmarks will have profound therapeutic implications for diagnosing and treating MLK3-dependent cancers. This review summarizes the current knowledge about the effect of MLK3 on the hallmarks of cancer, providing insights into its potential as a promising anticancer drug target.</p></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1879 5","pages":"Article 189157"},"PeriodicalIF":9.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0