Biochimica et biophysica acta. Reviews on cancer最新文献_第6页

Olfactomedin 4 in cancer development and progression Olfactomedin 4在癌症发生和发展中的作用

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-18 DOI: 10.1016/j.bbcan.2025.189423

Wenli Liu, Griffin P. Rodgers

引用次数: 0

Liquid-liquid phase separation: A dynamic driver of hepatocellular carcinoma 液-液相分离：肝细胞癌的动态驱动因素。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-14 DOI: 10.1016/j.bbcan.2025.189418

Tianle Zhou, Lei Li, Yuping Chen

{"title":"Liquid-liquid phase separation: A dynamic driver of hepatocellular carcinoma","authors":"Tianle Zhou, Lei Li, Yuping Chen","doi":"10.1016/j.bbcan.2025.189418","DOIUrl":"10.1016/j.bbcan.2025.189418","url":null,"abstract":"<div><div>Liquid-liquid phase separation (LLPS) is a physicochemical phenomenon prevalent in eukaryotic cells, mediating the compartmentalization of discrete subcellular regions through the formation of membrane-less organelles and biomolecular condensates and thereby enabling precise spatiotemporal regulation of cellular physiological processes. LLPS dysregulation constitutes a pathogenic mechanism underlying various diseases, with accumulating evidence demonstrating its critical involvement in hepatocellular carcinoma (HCC) progression. Here, we summarize the biophysical principles governing LLPS and the biological characteristics of intracellular phase separation, and primarily discuss the mechanistic contributions of aberrant LLPS to HCC pathogenesis, including disrupted gene expression, signal transduction, stress adaptation, etc. We further propose future research directions on LLPS in HCC and highlight its therapeutic potential through pharmacological modulation, aiming to provide novel perspectives for understanding the pathology of HCC and offer new therapeutic targets to facilitate effective strategies for HCC treatment.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189418"},"PeriodicalIF":9.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting cholesterol metabolism in tumor and its immune microenvironment: opportunities and challenges 靶向肿瘤中的胆固醇代谢及其免疫微环境：机遇与挑战。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-14 DOI: 10.1016/j.bbcan.2025.189422

Ziyi Wang , Xinyan Li , Xiangyu Sun

{"title":"Targeting cholesterol metabolism in tumor and its immune microenvironment: opportunities and challenges","authors":"Ziyi Wang , Xinyan Li , Xiangyu Sun","doi":"10.1016/j.bbcan.2025.189422","DOIUrl":"10.1016/j.bbcan.2025.189422","url":null,"abstract":"<div><div>Cholesterol metabolism provides cell and organelle membrane components, and its precursors and derivatives exert a variety of biological functions. Dysregulated cholesterol metabolism has emerged as a hallmark of tumors. In the tumor microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism to drive tumorigenesis and tumor development. Clinical studies and mechanistic investigations into cholesterol metabolism pathways have uncovered novel metabolic vulnerabilities that hold promise for cholesterol metabolism-targeted therapies for cancer. Moreover, recent studies highlight that manipulating cholesterol metabolism could reshape the immunological landscape and re-boost anti-tumor immunity. Thus, it is critical to deeply discuss the role of cholesterol metabolism in tumors and immune microenvironment to extend this knowledge into current immunotherapies. In this review, we summarize current insights into reprogrammed cholesterol metabolism in tumors and explore the complex interplay between cholesterol metabolism and anti-tumor immunity in diverse immune components within the tumor microenvironment. These findings may provide novel clinical strategies for targeting cholesterol metabolism in the context of cancers.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189422"},"PeriodicalIF":9.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STIM1-mediated calcium signalling in cancer: Its relation to tumour aggressiveness and therapeutic horizons 肿瘤中stim1介导的钙信号：与肿瘤侵袭性和治疗水平的关系。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-13 DOI: 10.1016/j.bbcan.2025.189420

Songling Fang , Yan Wang , Zixian Huang, Zhiquan Huang

{"title":"STIM1-mediated calcium signalling in cancer: Its relation to tumour aggressiveness and therapeutic horizons","authors":"Songling Fang , Yan Wang , Zixian Huang, Zhiquan Huang","doi":"10.1016/j.bbcan.2025.189420","DOIUrl":"10.1016/j.bbcan.2025.189420","url":null,"abstract":"<div><div>Calcium ions (Ca<sup>2+</sup>), pivotal regulators of tumour progression, drive cancer metastasis and therapy resistance via STIM1-mediated store-operated calcium entry (SOCE). This review focuses on the role of STIM1 and SOCE-mediated calcium signalling in various cancer types, with particular emphasis on oral cancer as a key area of our research, and future research directions in these areas are proposed. Specifically, this review reveals the mechanism by which the STIM1/Orai1 complex activates calmodulin (CaM)-dependent effectors to promote epithelial–mesenchymal transition (EMT) and remodelling of the cytoskeleton and immunosuppressive microenvironment. Clinically, STIM1 overexpression is correlated with advanced tumour stage, chemoresistance, and a poor prognosis, highlighting its dual role as a prognostic biomarker and therapeutic target. Although preclinical studies have demonstrated that calcium release-activated calcium (CRAC) channel inhibitors suppress tumour growth, challenges such as calcium signalling complexity and tissue-specific toxicity persist. Future research should integrate emerging technologies and systematic approaches to clarify the mechanisms underlying the dynamic regulation of calcium signalling networks, which will ultimately accelerate their clinical translation and therapeutic application.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189420"},"PeriodicalIF":9.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From infection to immune exhaustion: The Epstein-Barr virus and its contribution to Immunosenescence 从感染到免疫衰竭：爱泼斯坦-巴尔病毒及其对免疫衰老的贡献。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-13 DOI: 10.1016/j.bbcan.2025.189421

Longtai Hu , Tongxi Zhu , Jingyi Long , Qingshuang Luo , Xiaoming Lyu

{"title":"From infection to immune exhaustion: The Epstein-Barr virus and its contribution to Immunosenescence","authors":"Longtai Hu , Tongxi Zhu , Jingyi Long , Qingshuang Luo , Xiaoming Lyu","doi":"10.1016/j.bbcan.2025.189421","DOIUrl":"10.1016/j.bbcan.2025.189421","url":null,"abstract":"<div><div>Epstein-Barr virus (EBV), a common herpesvirus, is linked to chronic infections and malignancies like lymphomas and nasopharyngeal carcinoma. EBV's evasion of immune surveillance and induction of immune dysfunction are critical for disease progression. This review explores how EBV drives immune exhaustion and immunosenescence, focusing on its effects on T and NK cells. Chronic EBV infection causes persistent antigenic stimulation and upregulation of immune checkpoint molecules (PD-1, LAG-3, TIM-3, CTLA-4), leading to reduced T and NK cell proliferation, cytokine secretion, and cytotoxicity-hallmarks of immune exhaustion. EBV also modulates cytokines (IL-10, IL-18, IL-6, TNF-alpha), further disrupting immune surveillance and promoting tumor growth within the tumor microenvironment. Furthermore, EBV infection is associated with expanded populations of exhausted immune cells (CD28- CD8+ T cells and CD56<sup>dim</sup> NK cells), markers of immune dysfunction and aging. Immunotherapies, such as checkpoint inhibitors, offer promise for reversing EBV-induced immune exhaustion and restoring anti-tumor immunity. This review highlights EBV's role in immune regulation and the therapeutic potential of targeting EBV-driven immune dysfunction.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189421"},"PeriodicalIF":9.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical stress and mechanosensitive protein in skin tumors 皮肤肿瘤中的机械应力与机械敏感蛋白。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-13 DOI: 10.1016/j.bbcan.2025.189419

Baixin Li , Shuang Zhao , Lingling Zhang , Dongcheng Xie , Zixi Jiang

引用次数: 0

Targeting lipid metabolism to enhance cancer immunotherapy 靶向脂质代谢增强肿瘤免疫治疗

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-11 DOI: 10.1016/j.bbcan.2025.189416

Dan Zhao , Lei Wu , Yongsheng Li

{"title":"Targeting lipid metabolism to enhance cancer immunotherapy","authors":"Dan Zhao , Lei Wu , Yongsheng Li","doi":"10.1016/j.bbcan.2025.189416","DOIUrl":"10.1016/j.bbcan.2025.189416","url":null,"abstract":"<div><div>In recent years, the interaction between lipid metabolism and immune checkpoint inhibitors (ICIs) has become a key area of research in cancer treatment. Tumor cells utilize lipid metabolism reprogramming to promote rapid proliferation, evade immune surveillance, and develop resistance to treatment, highlighting the significant role of lipid metabolism in cancer progression and immune regulation. This review analyzes the mechanisms by which lipid metabolism reshapes the tumor microenvironment (TME) and collaborates with ICIs to enhance therapeutic effects. We discussed how lipid metabolism regulates tumor phenotypes and summarized the impact of dysregulated lipid metabolism on infiltrating immune cells in the TME. We propose that targeting lipid metabolism may be a promising strategy for improving immunotherapy. Furthermore, we suggest that lipid metabolism can serve as a predictive biomarker for the response to immunotherapy and guide the immunotherapy process. Finally, we outline future research directions, including the development of innovative drugs targeting lipid metabolism to enhance the effectiveness of immunotherapy.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189416"},"PeriodicalIF":9.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A primer on metabolic contributions in tumor angiogenic microenvironment 代谢在肿瘤血管生成微环境中的作用初探。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-11 DOI: 10.1016/j.bbcan.2025.189417

Ma Carmen Ocaña , Manuel Bernal , Ana R. Quesada , Miguel Ángel Medina

引用次数: 0

Role of YY1 in pancreatic ductal adenocarcinoma: Mechanisms and therapeutic perspectives YY1在胰腺导管腺癌中的作用：机制和治疗观点。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-09 DOI: 10.1016/j.bbcan.2025.189415

Pallavi Pellakuru , Rachael Guenter , Niharitha Hariharan , Ganji Purnachandra Nagaraju

引用次数: 0

Histological transformation in lung cancer: Mechanisms, clinical characteristics, and therapeutic approaches 肺癌的组织学转变：机制、临床特征和治疗方法。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-08 DOI: 10.1016/j.bbcan.2025.189413

Shiyi Liu , Tao Xu , Xiaojing Cao , Hecheng Li , Runsen Jin

{"title":"Histological transformation in lung cancer: Mechanisms, clinical characteristics, and therapeutic approaches","authors":"Shiyi Liu , Tao Xu , Xiaojing Cao , Hecheng Li , Runsen Jin","doi":"10.1016/j.bbcan.2025.189413","DOIUrl":"10.1016/j.bbcan.2025.189413","url":null,"abstract":"<div><div>Lung cancer, the leading cause of cancer-related mortality globally, exhibits remarkable histological plasticity, with non-small cell lung cancer (NSCLC) frequently transforming into small cell lung cancer (SCLC) as a resistance mechanism to targeted therapies and immunotherapies. The molecular mechanisms and treatments for SCLC transformation remain unclear. This review analyzes the mechanisms, molecular features, and treatment landscape of histological transformation, particularly in EGFR-mutant NSCLC. Key findings include: (1) RB1 and TP53 co-inactivation is a hallmark of transformed SCLC, enabling lineage plasticity via epigenetic and neuroendocrine changes; (2) the tumor immune microenvironment becomes immunosuppressive during transformation; and (3) new therapies targeting DLL3 and AURKA show promise in early trials. This study offers a comprehensive framework to understand histological transformation in lung cancer. It underscores the importance of routine re-biopsies for early detection and supports the development of biomarker-guided therapies. Future research should validate predictive biomarkers and optimizing combination therapies for transformed SCLC.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 5","pages":"Article 189413"},"PeriodicalIF":9.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0