Biochimica et biophysica acta. Reviews on cancer最新文献_第6页

Unstructured but critical: The role of YY1 and YY2 disorder in promoter recognition networks, transcriptional control, and oncogenesis 非结构化但关键：YY1和YY2紊乱在启动子识别网络、转录控制和肿瘤发生中的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-10-14 DOI: 10.1016/j.bbcan.2025.189475

Małgorzata Figiel , Katarzyna Pustelny , Marta Dziedzicka-Wasylewska , Rendy Hosea , Vivi Kasim , Andrzej Górecki

{"title":"Unstructured but critical: The role of YY1 and YY2 disorder in promoter recognition networks, transcriptional control, and oncogenesis","authors":"Małgorzata Figiel , Katarzyna Pustelny , Marta Dziedzicka-Wasylewska , Rendy Hosea , Vivi Kasim , Andrzej Górecki","doi":"10.1016/j.bbcan.2025.189475","DOIUrl":"10.1016/j.bbcan.2025.189475","url":null,"abstract":"<div><div>The transcription factors Yin Yang 1 and Yin Yang 2 are key regulators of gene expression and play complex roles in cancer development. Although closely related in sequence and structure, YY1 and YY2 differ in their degree of intrinsic disorder, interaction profiles, and regulatory potential. Both proteins are subject to cancer-associated alterations, including changes in expression levels and somatic mutations, many of which correlate with clinical outcomes.</div><div>This review synthesizes a comparative analysis of YY1 and YY2, with a focus on their disordered regions, interaction networks, and promoter targeting mechanisms. YY1 exhibits a higher degree of intrinsic disorder and a greater number of predicted Molecular Recognition Features (MoRFs), enabling a broader and more competitive range of interactions. YY2, in contrast, is more structurally ordered and engages a more limited set of partners. While both proteins recognize specific and highly similar DNA motifs, their binding is relatively weak, and functional specificity is conferred primarily through distinct protein–protein interactions and regulatory complex assembly.</div><div>We integrate these findings within the framework of Brodsky's model of promoter recognition, which emphasizes the role of dynamic, cooperative interactions in guiding transcription factor specificity. By mapping cancer-associated mutations and post-translational modifications onto functional regions, we highlight how such alterations may disrupt interaction networks and promoter selection. Finally, we explore the therapeutic potential of selectively targeting YY1/YY2 interactions, despite the challenges posed by their intrinsically disordered domains.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189475"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness 胆管癌癌症相关血栓形成：探讨肿瘤侵袭性的表型。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-09-21 DOI: 10.1016/j.bbcan.2025.189457

Luca Fabris , Yahima Frión-Herrera , Massimiliano Cadamuro , Elena Campello , Paolo Simioni

{"title":"Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness","authors":"Luca Fabris , Yahima Frión-Herrera , Massimiliano Cadamuro , Elena Campello , Paolo Simioni","doi":"10.1016/j.bbcan.2025.189457","DOIUrl":"10.1016/j.bbcan.2025.189457","url":null,"abstract":"<div><div>Cholangiocarcinoma (CCA) is the liver malignancy with the most rapid increase in incidence and lethality in recent years. Venous thromboembolism (VTE) is a common complication of the cancer-associated hypercoagulable state, which may incite tumor progression and dissemination, thereby increasing cancer-related morbidity and mortality. Compared to other cancer types, occurrence of VTE in CCA has been underestimated, though recent evidence indicates it may behave as prognostic factor of worst outcome. Given the need for novel predictive scores and treatment approaches when VTE occurs, identifying subgroups of patients with CCA who would benefit from thromboprophylaxis without increasing the risk of bleeding is a crucial but still neglected aspect of the management. The aim of this review is to summarize current observations on the clinical significance, prediction, risk assessment and the underlying mechanisms of cancer-induced thrombogenesis in CCA, as well as to identify research areas ripe for prioritization in the near future.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189457"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional dichotomy of autophagy signaling in tumor microenvironment driving hallmarks in oral cancer 口腔癌肿瘤微环境驱动标志中自噬信号的功能二分法。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-09-12 DOI: 10.1016/j.bbcan.2025.189451

Sushmita Patra , Bishnu Prasad Behera , Birija Sankar Patro , Sujit Kumar Bhutia

{"title":"Functional dichotomy of autophagy signaling in tumor microenvironment driving hallmarks in oral cancer","authors":"Sushmita Patra , Bishnu Prasad Behera , Birija Sankar Patro , Sujit Kumar Bhutia","doi":"10.1016/j.bbcan.2025.189451","DOIUrl":"10.1016/j.bbcan.2025.189451","url":null,"abstract":"<div><div>As a cytoprotective mechanism, autophagy recycles damaged proteins and organelles via the lysosomal degradation pathway in response to diverse stress conditions. However, its role in tumor microenvironment, including oral cancer, is still a point of contention. Although excessive autophagy is associated with cell death, many studies have revealed elevated autophagy levels in advanced stages of oral cancer, providing a suitable niche for growth and proliferation. On the contrary, disruption of basal level autophagy also contributes to oral cancer development at the early stage due to increased oxidative stress and accumulation of genetic mutations. This atypical dependence of oral cancer cells on autophagy is associated with cellular features, stage, and requirements. The present study highlights the involvement of key autophagy-related proteins in oral cancer progression and explores their interaction with oncogenic signaling pathways that drive proliferation, chemoresistance, metabolic reprogramming, and metastasis. Furthermore, increased autophagy in cancer-associated fibroblasts, immune cells, and macrophages within the tumor microenvironment contributes to fibroblast activation, cytokine secretion, and immune suppression, enhancing tumor plasticity. Notably, crosstalk between autophagy and the NLRP3 inflammasome has emerged as a significant factor in promoting oral cancer progression and metastasis. Finally, accumulating evidence supports the therapeutic potential of autophagy modulators, which enhance apoptosis and suppress tumor growth, suggesting that targeting autophagy could offer promising treatment strategies for resistant oral cancers.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189451"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rewiring amino acids in cancer 癌症中的氨基酸重新布线。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-09-26 DOI: 10.1016/j.bbcan.2025.189465

Yiqing Zhang , Jianxin Lyu , Hezhi Fang

引用次数: 0

Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression DRP1和相关线粒体裂变信号在癌变和癌症进展中的复杂作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-09-16 DOI: 10.1016/j.bbcan.2025.189453

Soumya Ranjan Mishra , Priyadarshini Mishra , Prakash Kumar Senapati , Kewal Kumar Mahapatra , Sujit Kumar Bhutia

{"title":"Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression","authors":"Soumya Ranjan Mishra , Priyadarshini Mishra , Prakash Kumar Senapati , Kewal Kumar Mahapatra , Sujit Kumar Bhutia","doi":"10.1016/j.bbcan.2025.189453","DOIUrl":"10.1016/j.bbcan.2025.189453","url":null,"abstract":"<div><div>The process of mitochondrial fission is a major determinant of mitochondrial homeostasis. DRP1 is the chief architect of the mitochondrial fission process, and the DRP1 recruitment to the mitochondrial outer membrane is necessary for the mitochondrial division. DRP1 contributes to cancer progression by promoting cell proliferation, enhancing resistance to therapy, inhibiting apoptosis, suppressing immune responses, and sustaining cancer stem cell heterogeneity and self-renewal. Moreover, DRP1 drives metabolic reprogramming to support enhanced energy production and biosynthesis required for tumor growth and survival. In addition, DRP1-mediated mitochondrial fission also favours NLRP3 inflammasome activation within the tumor microenvironment, which regulates cancer progression. Interestingly, elevated levels of DRP1 expression have been identified as a significant prognostic marker, correlating with poor survival outcomes across multiple cancer types. Many DRP1 inhibitors have been developed for cancer treatment, but more specific and selective agents are needed to improve efficacy and reduce off-target effects. A comprehensive understanding of DRP1's role in cancer cells is essential for developing DRP1 inhibitors, which hold promise as novel anticancer therapies and may enhance the effectiveness of conventional treatments.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189453"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperthermia-induced apoptosis: The role of magnetic nanoparticles in targeted delivery for breast cancer treatment 高温诱导的细胞凋亡：磁性纳米颗粒在乳腺癌治疗靶向递送中的作用

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-10-30 DOI: 10.1016/j.bbcan.2025.189490

Pankaj Garg , Madhu Krishna , David Horne , Ravi Salgia , Sharad S. Singhal

{"title":"Hyperthermia-induced apoptosis: The role of magnetic nanoparticles in targeted delivery for breast cancer treatment","authors":"Pankaj Garg , Madhu Krishna , David Horne , Ravi Salgia , Sharad S. Singhal","doi":"10.1016/j.bbcan.2025.189490","DOIUrl":"10.1016/j.bbcan.2025.189490","url":null,"abstract":"<div><div>Magnetochemistry is opening new frontiers in the targeted treatment of breast cancer (BC), offering a precise and innovative way to deliver therapies exactly where they're needed. Beyond drug delivery, magnetic nanoparticles (MNPs) can generate localized heat under alternating magnetic fields, initiating controlled hyperthermia that induces apoptotic cell death in tumor tissues. MNPs, particularly iron-oxide-based magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃), can be magnetically guided toward tumor sites and subsequently activated under alternating magnetic field (AMFs) (typically 100–500 kHz and 10–40 kA m<sup>−1</sup>) to generate therapeutic heat through Néel and Brownian relaxation losses. At the tumor, drugs can be released in a controlled manner in response to environmental cues such as pH changes, enzymes, or magnetic stimuli. By harnessing this dual role of MNPs, as targeted carriers and thermal effectors, researchers achieve spatially selective, minimally invasive treatment. Mechanistically, magnetically induced hyperthermia elevates local temperature to 42–46 °C, which triggers reactive oxygen species (ROS) generation, mitochondrial membrane depolarization, and caspase-3/9 activation—hallmarks of apoptosis in BC cells. This integrated approach not only concentrates drugs at the tumor but also sensitizes cancer cells to chemo- and radiotherapy, while minimizing systemic toxicity. Static or dynamic magnetic fields can be used to steer these particles, while their surfaces can be engineered through chemical bonding, physical encapsulation, or adsorption techniques. Moreover, combining magnetic targeting with antibody-based recognition improves specificity and therapeutic impact. While the promise of magnetochemistry in BC treatment is clear, ongoing research is essential to optimize these technologies and bring them fully into clinical practice.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189490"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

M6A methylation in tumor immune microenvironment: Multidimensional mechanism and targeted therapy strategies 肿瘤免疫微环境中的M6A甲基化：多维机制和靶向治疗策略

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-10-29 DOI: 10.1016/j.bbcan.2025.189489

Senxu Lu , Junxiu Liu , Shixin Chen , Binghao Li , Zhaoming Ye

引用次数: 0

Targetable axes of tumor-associated macrophages: An MSF framework for precision immunotherapy 肿瘤相关巨噬细胞的可靶向轴：精确免疫治疗的MSF框架。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-09-23 DOI: 10.1016/j.bbcan.2025.189458

Zhenting Lu , Midie Xu , Junzhe Tang , Xinyi Wang , Xinxiang Li , Qingguo Li

{"title":"Targetable axes of tumor-associated macrophages: An MSF framework for precision immunotherapy","authors":"Zhenting Lu , Midie Xu , Junzhe Tang , Xinyi Wang , Xinxiang Li , Qingguo Li","doi":"10.1016/j.bbcan.2025.189458","DOIUrl":"10.1016/j.bbcan.2025.189458","url":null,"abstract":"<div><div>Tumor-associated macrophages (TAMs) are a central component of the tumor microenvironment and exert dual, context-dependent effects on cancer progression. This review synthesizes the mechanisms that govern TAM polarization, their bidirectional crosstalk with tumor and stromal cells, and the consequences of metabolic reprogramming. Molecular and metabolic circuits that shape TAM phenotypes and sustain immune suppression are highlighted, and therapeutic strategies targeting TAM checkpoints, metabolism, and lineage pathways are summarized. To integrate immunometabolism with single-cell and spatial profiling, we introduce a Metabolic-Spatial-Functional Axis that links dominant metabolic programs, anatomic niches, and measurable effector functions. This framework organizes TAM heterogeneity and prioritizes biomarker-guided therapeutic combinations with clear translational readouts. Collectively, these advances support precision approaches that reprogram or constrain TAMs to enhance antitumor immunity and overcome therapeutic resistance.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189458"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in tumor micro-environment and immunotherapy of squamous cell carcinoma of the tongue 舌鳞癌肿瘤微环境及免疫治疗研究进展。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-10-24 DOI: 10.1016/j.bbcan.2025.189483

Shaopeng Chang , Longhui Li , Yumiao Liu , Gan Huang , Shu-Ting Pan

{"title":"Advances in tumor micro-environment and immunotherapy of squamous cell carcinoma of the tongue","authors":"Shaopeng Chang , Longhui Li , Yumiao Liu , Gan Huang , Shu-Ting Pan","doi":"10.1016/j.bbcan.2025.189483","DOIUrl":"10.1016/j.bbcan.2025.189483","url":null,"abstract":"<div><div>Tongue squamous cell carcinoma (TSCC), the most prevalent oral malignancy, demonstrates rising global incidence and mortality rates, while current therapies exhibit limited efficacy in advanced-stage disease. The tumor microenvironment (TME) constitutes an intricate ecosystem of immune cells, fibroblasts, and extracellular matrix (ECM), which collectively regulate TSCC progression, immune evasion, and therapeutic resistance. Tumor immunotherapies targeting TME have been increasingly validated in clinical trials, and despite the ability to capture relevant immune features in TME, challenges such as low individual response rates and immunotherapy resistance still exist in the clinic. In this review, we address the mechanisms of TSCC-associated immune cells as well as extracellular-related components in TME, summarize the effects of each component of TME on tumor immune response, and look forward to the application of tumor immunotherapy and immune-combination therapies to improve the efficacy of individualized precision medicine for TSCC.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189483"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding the role of zinc finger proteins in urological malignancies 破译锌指蛋白在泌尿系统恶性肿瘤中的作用。

IF 9.7 1区医学

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-11-01 Epub Date: 2025-10-09 DOI: 10.1016/j.bbcan.2025.189470

Lei Yang , Ying Gan , Yu Fan , Qian Zhang

{"title":"Decoding the role of zinc finger proteins in urological malignancies","authors":"Lei Yang , Ying Gan , Yu Fan , Qian Zhang","doi":"10.1016/j.bbcan.2025.189470","DOIUrl":"10.1016/j.bbcan.2025.189470","url":null,"abstract":"<div><div>Zinc finger proteins (ZNFs), among the most expansive families of transcription factors in eukaryotes, are distinguished by their distinctive zinc-coordinated motifs, which facilitate intricate interactions with DNA, RNA, and other proteins. These multifaceted interactions are central to their roles in regulating gene expression and modulating key signaling pathways, thus governing a spectrum of cellular processes such as differentiation, proliferation, and apoptosis. Recent studies have elucidated the crucial involvement of ZNFs in the pathogenesis of urological malignancies, including kidney, bladder, and prostate cancers. The inherent complexity and heterogeneity of these cancers necessitate an in-depth exploration of the molecular mechanisms underpinning tumor progression, with ZNFs emerging as central regulators in both oncogenic and tumor-suppressive capacities. This review provides a comprehensive examination of the diverse roles of ZNFs in urological cancers, highlighting their mechanistic actions, interactions with pivotal signaling networks, and contributions to the tumorigenic landscape. Furthermore, it delves into the translational potential of ZNFs, contemplating their utility as diagnostic biomarkers, prognostic tools, and promising therapeutic targets in clinical oncology.</div></div>","PeriodicalId":8782,"journal":{"name":"Biochimica et biophysica acta. Reviews on cancer","volume":"1880 6","pages":"Article 189470"},"PeriodicalIF":9.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0