代谢在肿瘤血管生成微环境中的作用初探。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-08-11 DOI:10.1016/j.bbcan.2025.189417

Ma Carmen Ocaña , Manuel Bernal , Ana R. Quesada , Miguel Ángel Medina

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引用次数: 0

摘要

血管生成和代谢重塑是癌症的两个标志。本文旨在综合目前将这两个过程联系起来的科学文献，概述促进肿瘤血管生成微环境的主要代谢机制。此外，它还强调了代谢重塑作为治疗血管生成依赖性病理（包括不同类型的癌症）的有希望的治疗靶点。最后，基于新的工作假设，提出了该领域未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A primer on metabolic contributions in tumor angiogenic microenvironment

Angiogenesis and metabolic remodeling are two hallmarks of cancer. This review aims to synthesize the current scientific literature linking these two processes, providing an overview of the principal metabolic mechanisms that contribute to the tumor angiogenic microenvironment. Additionally, it highlights metabolic remodeling as a promising therapeutic target for the treatment of angiogenesis-dependent pathologies, including different kinds of cancer. Finally, future directions for research on the field are suggested based on new working hypotheses.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.