Basic & Clinical Pharmacology & Toxicology最新文献

{"title":"Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients","authors":"Morten Baltzer Houlind, Alberte Linnet Nielsen, Anne Byriel Walls, Louise Westberg Strejby Christensen, Rikke Lundsgaard Nielsen, Aino Andersen, Baker Nawfal Jawad, Ove Andersen, Morten Damgaard, Esben Iversen, Juliette Tavenier, Helle Gybel Juul-Larsen","doi":"10.1111/bcpt.70002","DOIUrl":"10.1111/bcpt.70002","url":null,"abstract":"<p>Accurate glomerular filtration rate (GFR) estimation is crucial for diagnosing kidney disease and prescribing renal risk medications [<span>1-3</span>]. In clinical practice, estimated GFR (eGFR) is typically determined by plasma creatinine levels adjusted for age and sex (eGFR<sub>cre</sub>) [<span>4</span>]. However, creatinine is an imperfect metric of GFR, particularly in older (age ≥ 65 years) hospitalized patients, due to age-related changes in non-GFR factors such as muscle mass and nutritional status that affect creatinine level [<span>5</span>]. The addition of cystatin C to creatinine (eGFR<sub>comb</sub>) improves the accuracy of GFR estimates for older hospitalized patients, but there remains a large and unpredictable margin of error compared with measured GFR (mGFR) [<span>5</span>].</p><p>mGFR is not feasible for large-scale use due to its complexity, underscoring the need for alternative biomarkers to improve GFR estimation. We previously reported that the addition of β-trace protein (BTP) and β2-microglobulin (B2M) (eGFR<sub>panel</sub>) did not substantially improve accuracy beyond eGFR<sub>comb</sub>, so we considered other novel biomarkers that may reflect kidney function. We are currently evaluating the utility of neutrophil gelatinase–associated lipocalin (NGAL), soluble urokinase plasminogen activator receptor (suPAR), kidney injury molecule-1 (KIM-1) and growth differentiation factor-15 (GDF-15) as early diagnostic and prognostic tools for acutely hospitalized patients. Elevated levels of these biomarkers have been associated with accelerated GFR decline [<span>6-9</span>]; therefore, we hypothesized that they may improve the accuracy of GFR estimates for older hospitalized patients.</p><p>The study was carried out in compliance with the guidelines set by the Basic & Clinical Pharmacology & Toxicology policy for experimental and clinical research [<span>10</span>]. This is a post-hoc analysis of data from a previously described study of GFR performance [<span>5, 11</span>] based on data from the umbrella ‘OptiNAM’ clinical trial [<span>12</span>]. The study included older Caucasian patients admitted to the Emergency Department at Hvidovre Hospital in Denmark. All patients provided informed written consent, and the clinical trial was approved by the Regional Ethical Review Board (H-18023853) and the Danish Data Protection Agency (H-18023853) and registered at ClinicalTrials.gov (NCT03741283). Additional details, including eligibility criteria, are described elsewhere [<span>5</span>]. Importantly, patients in this study were excluded because of dialysis, clinical signs of ascites or edema, prior amputation, use of immunosuppressants or acute kidney injury [<span>5</span>].</p><p>In total, data was analysed for 106 older hospitalized patients (median age 78 years, 43% male). The median body mass index was 26.0 kg/m<sup>2</sup>, the median mGFR was 62.9 mL/min/1.73 m<sup>2</sup>, 49% of patients had hypertension and","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gossypin Ameliorates Collagen-Induced Arthritic Rats by Inhibiting Angiogenesis, Inflammation and Oxidative Stress","authors":"Caiyou He,&nbsp;Ankit Kumar","doi":"10.1111/bcpt.14128","DOIUrl":"10.1111/bcpt.14128","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rheumatoid arthritis (RA) is a long-term inflammatory autoimmune disease that damages cartilage and synovial membranes while also affecting bones and joints. The aim of the current study was to investigate the antiarthritic effect of gossypin against collagen-induced arthritis (CIA) in rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Intraperitoneal administration of Type II collagen (2 mg/mL) was used to induce arthritis in the rats, followed by oral administration of gossypin (5, 10 and 15 mg/kg) for 28 days. Various parameters were assessed, including body weight, paw swelling, arthritis score, organ weights, RF, haematological parameters, inflammatory markers, MMP levels, antioxidants, cytokines and nonhepatic and hepatic liver parameters. Additionally, the expression of various mRNAs was analysed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gossypin significantly (<i>p</i> &lt; 0.001) altered the body weight, paw swelling, arthritis score and organ weights along with RF level. Gossypin treatment significantly (<i>p</i> &lt; 0.001) altered the level of antioxidant and hepatic parameters; inflammatory cytokines; and inflammatory parameters such as PGE2, COX-2, NF-κB and VEGF, respectively. Gossypin also enhanced the level of HO-1 and Nrf2 and suppressed the level of MMP parameters such as MMP-2, MMP-3 and MMP-9. Gossypin also modified the mRNA expression of MMP-3, MMP-9, TRAP, RANK, Ctsk and RANKL, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gossypin demonstrated antiarthritic effects against CIA in rats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Cannabidiol's Protective Effects on Cadmium-Induced Toxicity in Mice","authors":"Serkan Sahin,&nbsp;Tulay Mortas,&nbsp;Ahmet Muderrisoglu,&nbsp;Vugar Ali Turksoy","doi":"10.1111/bcpt.14131","DOIUrl":"10.1111/bcpt.14131","url":null,"abstract":"<p>Current chelation treatments used for cadmium poisoning may cause some serious side effects. Thus, safer novel treatments could be promising for clinical use. This study evaluated the effects of cannabidiol on Cd toxicity. Four groups of 10 mice were formed: Groups I and III were cadmium-free, while groups II and IV received 50 mg/L cadmium in drinking water. Groups III and IV received daily cannabidiol (25 mg/kg) via intragastric gavage. After 30 days, the animals were killed, and blood and tissue samples were collected. Oxidative stress and inflammation markers, including glutathione, catalase, myeloperoxidase, TNF-α, IL-1β and IL-6, were analysed using ELISA. Additionally, histological evaluations of the liver, kidney and testis were performed. Cadmium exposure reduced glutathione and catalase levels in the blood, liver, kidney and testis, while increasing myeloperoxidase. Cannabidiol mitigated these effects on oxidative stress markers. Cannabidiol also reduced the increase in proinflammatory cytokines. Histopathological analysis revealed reduced liver and kidney damage in cannabidiol-treated groups compared to cadmium-only groups. In addition, histopathological evaluation showed CBD had no protective effect on the testicular tissue against Cd toxicity. Our results indicate that cannabidiol protects against some toxic effects of cadmium. If confirmed by future studies, cannabidiol may be proposed as a novel treatment for cadmium toxicity.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Overdose in Patients With Dental Pain. A Cross-Sectional Study in Two Dental Emergency Clinics","authors":"Sofie Krahl Larsen,&nbsp;Merete Markvart,&nbsp;Rasmus Søndenbroe,&nbsp;Kim Dalhoff,&nbsp;Simon Storgård Jensen","doi":"10.1111/bcpt.14124","DOIUrl":"10.1111/bcpt.14124","url":null,"abstract":"<p>Dental pain is common, and many patients use analgesics to alleviate the pain. Analgesics are readily accessible, and overdosing may lead to severe complications. This study explores the extent of analgesic overdosing in patients with dental pain. Data were collected from two dental emergency clinics in Copenhagen, Denmark, via questionnaires and interviews with 180 patients. Results showed that 82.8% (<i>n</i> = 149) had taken at least one type of analgesic, and 9% (<i>n</i> = 15) had exceeded the recommended maximum dosage. Of all patients with dental pain, 75.6% (<i>n</i> = 136) used paracetamol, 54.4% (<i>n</i> = 98) ibuprofen, 10% (<i>n</i> = 18) opioids, and 11.1% (<i>n</i> = 20) other types of analgesics. Most frequently, the pain was of pulpal origin (<i>n</i> = 119; 66.1%). Of all analgesics used, most were obtained places where guidance should be available, for example, pharmacies, dental clinics or hospitals (<i>n</i> = 152; 54%). The patients were aware of the recommended maximum daily dosage for paracetamol and ibuprofen in 39% (<i>n</i> = 70) and 41% (<i>n</i> = 73) of the cases, respectively. In conclusion, most patients with dental pain use analgesics to alleviate their pain. A substantial proportion of these patients overdose themselves, potentially putting them at risk of severe systemic complications. This study highlights the need for better patient education and safer pain management strategies.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Nerolidol on Paclitaxel-Induced Reproductive Toxicity in Rats: Oxidative Stress and Inflammation","authors":"İdris Ayhan,&nbsp;Nese Basak Turkmen,&nbsp;Asli Taslidere,&nbsp;Muhterem Aydin,&nbsp;Osman Ciftci","doi":"10.1111/bcpt.14126","DOIUrl":"10.1111/bcpt.14126","url":null,"abstract":"<div>\u0000 \u0000 <p>Paclitaxel (PAC), derived from <i>Taxus brevifolia</i>, is used to treat solid tumours but causes reproductive toxicity due to oxidative stress, affecting sperm quality and testicular tissue. Nerolidol (NRL), an antioxidant sesquiterpene alcohol, has not been studied for its potential to reduce PAC-induced reproductive damage. This study investigates NRL's ability to mitigate PAC-induced reproductive toxicity in rats. Forty healthy adult male Spraque Dawley rats were randomly divided into four equal groups (Control, PAC, NRL, PAC + NRL). PAC was given intraperitoneally at a dose of 2 mg/kg once a week for 4 weeks. NRL was given orally at a dose of 100 mg/kg/day for 4 weeks. Control group received PAC and NRL vehicles. After 4 weeks, testis tissue samples were collected, and parameters, including oxidants, antioxidants, sperm motility, density, abnormal spermatozoon ratios and cytokines, were measured. PAC administration increased oxidant levels and decreased antioxidant enzyme activities. Nerolidol mitigated these alterations significantly. Similarly, PAC elevated IL-1, IL-6, TNF-α levels and lowered IL-10 levels, these effects attenuated by nerolidol in the PAC + NRL group. In conclusion, it was determined that PAC induces reproductive toxicity through oxidative stress, and NRL demonstrates potential in ameliorating these effects through its antioxidant activity.</p>\u0000 </div>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘Effect of Bariatric Surgery on the Pharmacokinetics of Drugs Used for Attention-Deficit Hyperactivity Disorder—A Case Series’","authors":"","doi":"10.1111/bcpt.14129","DOIUrl":"10.1111/bcpt.14129","url":null,"abstract":"<p>\u0000 <span>Krabseth, H-M</span>, <span>Strømmen, M</span>, <span>Helland, A</span>, <span>Spigset, O</span>. <span>Effect of Bariatric Surgery on the Pharmacokinetics of Drugs Used for Attention-Deficit Hyperactivity Disorder—A Case Series</span>. <i>Basic Clin Pharmacol Toxicol.</i> <span>2025</span>: <span>136</span>(<span>1</span>):e14099. https://doi.org/10.1111/bcpt.14099\u0000 </p><p>In the article cited above, two errors have been found in reference to two figures.</p><p>For Figure 1, the type of operation for Patient 6 was incorrect. SG should be replaced with RYGB as shown in the corrected figure below.</p><p>In the caption for Figure 3, sleeve gastrectomy is replaced by Roux-en-Y gastric bypass for Patient 6 as shown below.</p><p>We apologize for these errors.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.14129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of New Psychoactive Substances in Relation to Traditional Drugs of Abuse in Clinical Oral Fluid Samples","authors":"Magnus A. B. Axelsson,&nbsp;Hanna Lövgren,&nbsp;Robert Kronstrand,&nbsp;Henrik Green,&nbsp;Moa Andresen Bergström","doi":"10.1111/bcpt.14117","DOIUrl":"10.1111/bcpt.14117","url":null,"abstract":"<p>New psychoactive substances (NPS) are health-hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter.</p><p>Up to 138 NPS were retrospectively identified using liquid chromatography-high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish health care region 2019–2020 representing 9468 psychiatric and addiction care patients. In total, 618 findings representing 58 NPS were detected in 481 samples from 201 patients. Male gender and age ≥25 years correlated positively with NPS use. Ketamine correlated positively with all NPS classes except cannabinoids; additionally, fentanyl, methadone, tapentadol and clonazepam correlated with multiple NPS classes. More numerous traditional drugs of abuse (DoA) correlated positively with sedative/hypnotic NPS, indicating that these are used in broader patient groups than other NPS. Mitragynine correlated negatively with other NPS in general and with several traditional DoA, but positively with the potential opioid abstinence remedies buprenorphine, loperamide and tapentadol aside from ketamine. In conclusion, NPS use is infrequent but occur also at higher ages, certain traditional DoA and particularly ketamine could have clinical value as NPS use signals, and mitragynine exhibited an atypical NPS consumption pattern indicating significant use as an opioid abstinence remedy.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to ‘Decreased Blood Pressure With Acute Administration of Quercetin in L-NAME-Induced Hypertensive Rats’","authors":"","doi":"10.1111/bcpt.14130","DOIUrl":"10.1111/bcpt.14130","url":null,"abstract":"<p>\u0000 <span>Mkhize, SA</span>, <span>Nthlane, RA</span>, <span>Xhakaza, SP</span>, et al. <span>Decreased Blood Pressure With Acute Administration of Quercetin in L-NAME-Induced Hypertensive Rats</span>. <i>Basic Clin Pharmacol Toxicol</i>. <span>2025</span>; <span>136</span>(<span>1</span>):e14113. https://doi.org/10.1111/bcpt.14113\u0000 </p><p>In the article cited above, Figure 7 was published with an incorrect label on the x-axis. The corrected figure and legend are published below.</p><p>We apologize for this error.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.14130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Importance of the Small Artery Media–Lumen Ratio: Past and Present","authors":"Christian Aalkjaer","doi":"10.1111/bcpt.14127","DOIUrl":"10.1111/bcpt.14127","url":null,"abstract":"<p>The media–lumen diameter ratio of small arteries is increased in hypertension, diabetes and obesity. It is likely that both shear stress on the endothelial cells, transmural pressure and smooth muscle cell tone are important for the altered vascular structure. However, the precise interaction and importance of these factors are incompletely understood. At the molecular level transglutaminases, metalloproteinases, integrins, NO and several other factors have been suggested to be important, but our understanding of how the many factors together control vascular structure is surprisingly limited. The media–lumen diameter ratio of the small arteries has prognostic value, which is independent of the classical risk factors for cardiovascular disease. Importantly this is also the case in patients treated pharmacologically for high blood pressure. It is therefore relevant to consider small artery structure as a potential target in relation to prevention of cardiovascular disease.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.14127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Related Factors Associated With the Initiation of Potentially Inappropriate Medication in Home Care: An Observational Study Based on Resident Assessment Instrument Data","authors":"Jasmin Paulamäki,&nbsp;Johanna Jyrkkä,&nbsp;Virva Hyttinen-Huotari,&nbsp;Heini Huhtala,&nbsp;Esa Jämsen","doi":"10.1111/bcpt.14125","DOIUrl":"10.1111/bcpt.14125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The harmful outcomes of potentially inappropriate medications (PIMs) are highlighted among multimorbid older home care clients using several medicines. The aim of this study was to identify patient-related factors associated with the initiation of PIMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This register-based study used Resident Assessment Instrument-Home Care (RAI-HC) assessments (<i>n</i> = 6176) from year 2014 to 2015. PIMs were identified according to the Beers criteria. Generalised estimating equations were used to identify factors associated with the initiation of PIMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>A total of 228 (11.3%) clients initiated PIMs during the follow-up (mean 13 months). Factors associated with higher odds to initiate PIMs were higher education (OR = 1.36, 95% CI 1.02–1.82), cognitive impairment (OR = 1.70, 1.02–2.82), reduced social interaction (OR = 1.50, 1.06–2.13), independent activity outdoors (OR = 1.72, 1.18–2.51), diabetes (OR = 1.47, 1.12–1.94), Parkinson's disease (OR = 3.42, 1.86–6.27) and longer interval between RAI assessments (OR = 1.09 per month, 1.02–1.18).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Incidence of PIMs among home care clients was common. The results help healthcare professionals to focus more attention on clients more susceptible to PIM prescribing. Preventing PIM use is essential, especially among older adults with cognitive impairment, to prevent further decline of health status and admission to long-term care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}