Prediction of Arterial Oxygen Saturation With Partial Pressure of Oxygen Using a Turnover Model in Volunteers

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Basic & Clinical Pharmacology & Toxicology Pub Date : 2025-03-18 DOI:10.1111/bcpt.70019

Jung-Min Yi, Ji-Yeon Bang, Kyung Mi Kim, Eun-Kyung Lee, Byung-Moon Choi

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Abstract

Background

The relational equation for predicting arterial oxygen saturation (SaO₂) with a partial pressure of oxygen (PaO₂) has been described and used in clinical settings. However, the equation has limitations as it was derived empirically. This study aimed to assess the relationship between PaO₂ and SaO₂ using a turnover model.

Material and Methods

In a controlled desaturation study to assess the accuracy of a pulse oximeter, volunteers (n = 12) breathed hypoxic gas mixtures via a mouthpiece. Various target SaO₂ values were achieved within the range of 70%–100%. PaO₂ and SaO₂ were measured using a CO-oximeter. A turnover model was fitted to PaO₂–SaO₂ pair data. The performance of the two SaO₂ prediction methods (conventional formula and turnover model) was evaluated using additional volunteer data not used in the model-building process.

Results

The pharmacodynamic parameters were as follows: k_out (1/min) = 4.45 for Asians, 0.93 for Africans, I_max = 0.837 and IC₅₀ (mmHg) = 79.2%, γ = 5.24. PaCO₂ and pH were not significant covariates. The median prediction and median absolute prediction error were 5.6% and 5.7%, respectively, for the conventional formula, and 0.1% and 1.2%, respectively, for the turnover model.

Conclusion

The relationship between PaO₂ and SaO₂ was better explained by the turnover model than by the conventional formula within the 70%–100% SaO₂ range.

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来源期刊

Basic & Clinical Pharmacology & Toxicology 医学-毒理学

CiteScore

5.60

自引率

6.50%

发文量

126

审稿时长

1 months

期刊介绍： Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.