格陵兰岛的药物中毒事件

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Kim Dalhoff, Johanne Mølby Hansen, Søren Bøgevig, Tonny S. Petersen
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引用次数: 0

摘要

丹麦毒物信息中心(DPIC)在2007-2022年期间收到了来自格陵兰的1827份查询。格陵兰岛的中毒风险和治疗可能与丹麦不同。与丹麦相比,格陵兰在药品的使用和可得性、族裔和医疗保健的邻近性方面都有所不同。本研究使用DPIC数据检查了丹麦和格陵兰之间的毒理学特征是否不同。格陵兰岛最常见的药物中毒是扑热息痛,其次是布洛芬和喹硫平(分别为6.6、4.5和1.6查询/1000居民)。与丹麦相比,格陵兰岛明显更严重的中毒(36%对12%的中度或危及生命的中毒;p = 0.0004)。从格陵兰岛打给太平洋医疗保险中心的电话主要来自卫生保健专业人员。此外,与丹麦相比,格陵兰岛中毒患者的年龄组也不同。在丹麦,38%的调查是关于0-4岁的儿童,而在格陵兰,这一比例为17%。在20-29岁年龄组中,14%来自丹麦,23%来自格陵兰。总之,我们发现格陵兰的HCPs向DPIC拨打的电话过多,中毒更严重,主要是扑热息痛,而儿童的电话较少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pharmaceutical-Related Poisonings in Greenland

Pharmaceutical-Related Poisonings in Greenland

The Danish Poison Information Centre (DPIC) received 1827 enquiries from Greenland in the period 2007–2022. The risk and the treatment of poisonings in Greenland are potentially different from those in Denmark. The use and availability of medicines, the ethnicity and the vicinity of health care are different in Greenland compared with Denmark. This study examined whether the toxicological profile was different between Denmark and Greenland using DPIC data. The most frequent drug poisoning in Greenland was paracetamol, followed by ibuprofen and quetiapine (6.6, 4.5 and 1.6 enquiries/1000 inhabitants, respectively). There were significantly more serious poisonings in Greenland compared with Denmark (36% vs. 12% moderate or life-threatening poisonings; p = 0.0004). Most of the calls from Greenland to the DPIC came primarily from health care professionals (HCPs). Also, the age groups of the poisoned patients were different in Greenland compared with Denmark. In Denmark, 38% of the enquiries were regarding children aged 0–4, compared with 17% in Greenland. In the age group 20–29 years, 14% came from Denmark and 23% from Greenland. In conclusion, we found an excessive number of calls to the DPIC from HCPs in Greenland with more serious poisonings, primarily with paracetamol, and fewer calls regarding children.

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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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