Behavioral and neural biology最新文献_第6页

Interaction of GABAergic and β-noradrenergic drugs in the regulation of memory storage gaba能和β-去甲肾上腺素能药物在调节记忆储存中的相互作用

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80068-8

Ines B. Introini-Collison , Claudio Castellano , James L. McGaugh

{"title":"Interaction of GABAergic and β-noradrenergic drugs in the regulation of memory storage","authors":"Ines B. Introini-Collison , Claudio Castellano , James L. McGaugh","doi":"10.1016/S0163-1047(05)80068-8","DOIUrl":"10.1016/S0163-1047(05)80068-8","url":null,"abstract":"<div><p>These experiments examined the interaction of drugs affecting noradrenergic and GABAergic systems, administered post-training, in influencing retention of an inhibitory avoidance response. Male CD1 mice (23–28 g) were trained in an inhibitory avoidance task, given immediate post-training ip injections of saline or GABAergic and adrenergic drugs administered either alone or concurrently. Retention was tested 48 h later. In agreement with extensive previous evidence, the GABAergic antagonist bicuculline (0.3, 1.0, or 3.0 mg/kg) produced dosedependent (inverted-U) enhancement of retention and the GABAergic agonist muscimol (1.0 mg/kg) impaired retention. The retention-enhancing effects of bicuculline were blocked by concurrent administration of the <em>β</em>-noradrenoceptor antagonist propranolol (2.0 mg/kg). Also in agreement with previous evidence, the <em>β</em>-adrenoceptor agonist clenbuterol (0.030, 0.100, or 0.300 mg/kg, ip) produced dose-dependent (inverted-U) enhancement of retention. Clenbuterol also blocked the retention-impairing effects of muscimol (1.0 mg/kg). In addition, propranolol (2.0 mg/kg) potentiated the retention impairing effects of muscimol (1.0 or 3.0 mg/kg, ip). These findings support the view that GABAergic systems modulate memory through an interaction with <em>β</em>-noradrenergic mechanisms.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 150-155"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80068-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19193456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 78

Comparable dose-response functions for the effects of glucose and fructose on memory 葡萄糖和果糖对记忆影响的可比剂量-反应函数

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80070-6

Ward A. Rodriguez , C. Arlene Horne , Adela N. Mondragon , David D. Phelps

{"title":"Comparable dose-response functions for the effects of glucose and fructose on memory","authors":"Ward A. Rodriguez , C. Arlene Horne , Adela N. Mondragon , David D. Phelps","doi":"10.1016/S0163-1047(05)80070-6","DOIUrl":"10.1016/S0163-1047(05)80070-6","url":null,"abstract":"<div><p>A passive avoidance-to-active avoidance negative transfer paradigm was used to investigate in rats the effects of glucose and fructose on recently acquired memories. Immediate post-passive avoidance conditioning injections of glucose, fructose, or saline were followed 48 h later by active avoidance conditioning. Equimolar 10, 32, 100, and 2000 mg/kg sc doses of the two sugars significantly impaired acquisition of the reversal task, whereas 3.2 mg/kg doses of both sugars were without significant effect on subsequent performance and 320 mg/kg doses of both sugars significantly enhanced subsequent performance. The cubic trends for both dose-response functions were statistically significant and did not differ from each other. This is the first demonstration that glucose and fructose affect recently acquired memories in accord with comparable cubic dose-response functions, and that there are doses of both sugars that can enhance memory (as indicated by an increase in the number of trials required to reach criterion on the reversal task) and doses of both sugars that can impair memory (as indicated by a decrease in the number of trials required to reach criterion on the reversal task), compared to saline treatment. The similar cubic dose-response functions for glucose and fructose suggest that their mechanisms of action when they are injected peripherally are similar. In addition, because fructose does not readily pass the blood-brain barrier, the results suggest that these two monosaccharides may act through a common peripheral pathway.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 162-169"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80070-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19193457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

The effects of pregnenolone on acquisition and retention of a food search task 孕烯醇酮对食物搜寻任务的获得和保留的影响

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80071-8

Robert L. Isaacson, Patricia E. Yoder, Julie Varner

{"title":"The effects of pregnenolone on acquisition and retention of a food search task","authors":"Robert L. Isaacson, Patricia E. Yoder, Julie Varner","doi":"10.1016/S0163-1047(05)80071-8","DOIUrl":"10.1016/S0163-1047(05)80071-8","url":null,"abstract":"<div><p>Two experiments were undertaken in which the effects of semichronic administration of the precursor steroid, pregnenolone, were examined in a food search task. In both experiments male rats were required to find a food reward in a designated hole in an arena with 16 equally spaced holes. Hormone administration began 8 days before the onset of training. Training was given on an every-other-day schedule for five sessions. Animals were deprived of food for 18 h before training or testing. Retention testing occurred 10 days after acquisition and this was followed by 2 days of training using a different hole for the reward. The two experiments differed only in the method of hormone administration. In one experiment the rats received an implanted (sc) slow release pellet containing pregnenolone before training. In the second experiment the animals received ip injections of pregnenolone sulfate before and during initial training and then had the slow release pellet implanted between acquisition and retention. Significant enhancement of retention was found during the middle trials of the retention test when the treated and control groups from the two experiments were combined. No differences were found during acquisition training in either experiment. On the first day of training the animals to find the reward in a new location, the group injected with pregnenolone sulfate and later implanted with pregnenolone slow-release pellets exhibited performance superior to that of their matched control group.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 170-176"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80071-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19193458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Chronic corticosterone treatment impairs spontaneous alternation behavior in rats 慢性皮质酮治疗损害大鼠自发交替行为

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80074-3

Mark E. Bardgett , George T. Taylor , John G. Csernansky , John W. Newcomer , Bruce Nock

引用次数: 63

Honeybee olfactory sensilla behave as integrated processing units 蜜蜂的嗅感器是一个综合的处理单元

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80075-5

Wayne M. Getz, R. Patrick Akers

引用次数: 47

Memory for spatial location as a function of temporal lag in rats: Role of hippocampus and medial prefrontal cortex 大鼠空间定位记忆在时间滞后中的作用:海马和内侧前额叶皮层的作用

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80065-2

Andrea A. Chiba, Raymond P. Kesner, April M. Reynolds

{"title":"Memory for spatial location as a function of temporal lag in rats: Role of hippocampus and medial prefrontal cortex","authors":"Andrea A. Chiba, Raymond P. Kesner, April M. Reynolds","doi":"10.1016/S0163-1047(05)80065-2","DOIUrl":"10.1016/S0163-1047(05)80065-2","url":null,"abstract":"<div><p>Rats with medial prefrontal cortex, hippocampus, or cortical control lesions were tested on an eight-arm radial maze task, in order to examine memory for the temporal order of spatial locations as a function of temporal lag. During the study phase of each trial, rats were allowed to visit each of eitht arms once in an order that was randomly selected for that trial. The test phase required the rats to choose which of two arms occurred earlier in the sequence of arms visited during the study phase. The arms selected as test arms varied according to temporal lag (0–6) or the number of arms that occurred between the two test arms in the study phase. The control rats performed at chance at a temporal lag of zero, but their performance was above chance for the remaining lags, improving after the temporal lag exceeded zero. The hippocampal-lesioned rats showed a marked deficit, performing at chance for all lags, with some savings for those items occurring at the end of the list. The medial, prefrontal cortex-lesioned rats showed a less severe deficit. The results of these data support the notion that both the hippocampus and the medial prefrontal cortex play significant roles in memory for the temporal order of spatial locations.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 123-131"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80065-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 200

Neurobiology of Defense Conference 国防神经生物学会议

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80077-9

引用次数: 0

Effect of the infusion of the GABA-A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes GABA-A受体激动剂muscimol输注对内嗅皮质、杏仁核和海马在记忆过程中的作用的影响

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80066-4

Diana Jersalinsky , Jorge A. Quillfeldt , Roger Walz, Ricardo C. Da Silva , Marcia Bueno e Silva , Marino Bianchin , Paulo Schmitz , Marilene S. Zanatta , Anelise C. Ruschel , Natalia Paczko , Jorge H. Medina , Ivan Izquierdo

{"title":"Effect of the infusion of the GABA-A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes","authors":"Diana Jersalinsky , Jorge A. Quillfeldt , Roger Walz, Ricardo C. Da Silva , Marcia Bueno e Silva , Marino Bianchin , Paulo Schmitz , Marilene S. Zanatta , Anelise C. Ruschel , Natalia Paczko , Jorge H. Medina , Ivan Izquierdo","doi":"10.1016/S0163-1047(05)80066-4","DOIUrl":"10.1016/S0163-1047(05)80066-4","url":null,"abstract":"<div><p>Rats were bilaterally implanted with cannulae in the entorhinal cortex, amygdala, and hippocampus; after recovery, they were trained in a step-down inhibitory avoidance task and tested for retention 24 h later. Muscimol (0.03 μg) or <span>d</span>-amino-5-phosphonovalerate (5.0 μg) infused in the entorhinal cortex 20 min prior to training inhibited the amnestic effect of the same dose of muscimol infused into this area 100 min after training. Thus, memory-relevant information must be processed by the entorhinal cortex at the time of training in order that this cortex may play a late post-training role in memory processing. Pretraining intraenterhinal muscimol administration did not affect the amnestic effect of the post-training infusion of muscimol into the amygdala and hippocampus, or the inhibition of memory expression induced by a pretest infusion of CNQX into the amygdala and hippocampus or into the entorhinal cortex. Pretest intraentorhinal muscimol also did not influence the effect of pretest intraamygdala and intrahippocampal CNQX administration. These data indicate that the cells of the entorhinal cortex that are sensitive to pretraining muscimol are not part of the inputs that lead to post-training processing by the amygdala and hippocampus, or to the intervention of the amygdala, hippocampus, and entorhinal cortex in memory expression. The present findings are compatible with the possibility that, instead, the enterhinal cortex may be an output of the amygdala and hippocampus at the time of memory expression.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 132-138"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80066-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18908020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Training in a novel environment improves the appetitive learning performance of the snail, Lymnaea stagnalis 在一个新的环境中训练可以提高蜗牛的食欲学习表现

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80067-6

G. Kemenes, P.R. Benjamin

{"title":"Training in a novel environment improves the appetitive learning performance of the snail, Lymnaea stagnalis","authors":"G. Kemenes, P.R. Benjamin","doi":"10.1016/S0163-1047(05)80067-6","DOIUrl":"10.1016/S0163-1047(05)80067-6","url":null,"abstract":"<div><p>The effect of novelty, an environmental background variable affecting feeding and appetitive learning performance, was examined in a behavioral study of the pond snail <em>Lymnaea stagnalis</em>. Transfer of snails into a novel aquatic environment (clean water) evoked exploratory behavior which manifested itself in an increased number of spontaneous rasping movements of the mouth over the second to fifth minute after exposure to the novel environment. The intensity of this behavior was much weaker in a familiar environment (used water from the home tank). Similarly, sucrose-induced feeding rates were highest when the snails were given the sucrose stimulus in a novel environment. The effectiveness of appetitive conditioning using tactile stimulus paired with food (<span>Kemenes & Benjamin, 1989a</span>) improved when the snails were subjected to conditioning in a novel environment. Satiety, an internal variable, suppressed the stimulating effects of the novel environment on the spontaneous, unconditioned, and conditioned feeding alike. After training in the novel environment, the conditioned response was retained for up to 12 days and thus provided a robust behavioral paradigm for the extension of the analysis to the neurophysiological mechanisms of factors affecting appetitive learning in molluscs.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 139-149"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80067-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19193455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Baclofen produces dose-related working memory impairments after intraseptal injection 巴氯芬在脑内注射后产生剂量相关的工作记忆损伤

Behavioral and neural biology Pub Date : 1994-03-01 DOI: 10.1016/S0163-1047(05)80073-1

Robert W. Stackman, Thomas J. Walsh

{"title":"Baclofen produces dose-related working memory impairments after intraseptal injection","authors":"Robert W. Stackman, Thomas J. Walsh","doi":"10.1016/S0163-1047(05)80073-1","DOIUrl":"10.1016/S0163-1047(05)80073-1","url":null,"abstract":"<div><p>Altering the activity of the septohippocampal pathway can impair spatial memory in rats. Pharmacological manipulation of septal GABA-A receptors with the agonist, muscimol, or the benzodiazepine agonist, chlordiazepoxide, also impairs spatial memory and depresses hippocampal cholinergic activity. The present experiment examined the effects of intraseptal infusion of the GABA-B agonist baclofen on the performance of rats on a working memory radial arm maze (RAM) task. Post-training administration of baclofen (3 nmol, but not 1.5 or 0.75 nmol) produced a significant impairment of RAM performance. Baclofen significantly reduced the number of correct choices and increased the number of errors committed during testing without affecting latency per arm choice or the ability of the rats to navigate the maze and consume food pellets. The data suggest that baclofen impaired retention of the task without producing proactive performance deficits. Furthermore, the present data are consistent with the hypothesis that a GABAergic mechanism in the medial septum modulates the maintenance or retrieval of spatial working memory.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 181-185"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80073-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19193460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62