Behavioral and neural biology最新文献_第5页

Intra-amygdala infusion of the N-methyl-d-aspartate receptor antagonist AP5 impairs acquisition but not performance of discriminated approach to an appetitive CS 杏仁核内输注n -甲基-d-天冬氨酸受体拮抗剂AP5会损害对食欲性CS的鉴别途径的获得，但不会损害其表现

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80007-X

Lindsay H. Burns , Barry J. Everitt , Trevor W. Robbins

{"title":"Intra-amygdala infusion of the N-methyl-d-aspartate receptor antagonist AP5 impairs acquisition but not performance of discriminated approach to an appetitive CS","authors":"Lindsay H. Burns , Barry J. Everitt , Trevor W. Robbins","doi":"10.1016/S0163-1047(05)80007-X","DOIUrl":"10.1016/S0163-1047(05)80007-X","url":null,"abstract":"<div>The present experiments investigated the effects ofblocking glutamate transmission in the amygdala on the learning and subsequent performance of a discriminated approach response to food, as well as on locomotor activity and a test of neophobia to food. In the appetitive conditioning experiment, three separate groups of rats received intra-amgydala infusions of PBS (phosphate-buffered saline) or 1.0 or 3.0 nmol of AP5, an antagonist at the NMDA glutamate receptor subtype, immediately before each conditioning session. The effects of AP5 on the performance of the discriminated approach response were tested in a fourth group of animals. AP5 dose-dependently impaired the discriminated approach response during the acquisition of the stimulus-reward association but had no effect on the performance of this response after this association was learned. These results suggest that glutamate transmission in the amgydala at the NMDA glutamate receptor subtype is important in the learning process. In separate experiments, intra-amygdala AP5 increased locomotor activity and attenuated the neophobia to food in a novel environment by increasing approaches to the food. Together, these findings parallel the effects of lesions to the basolateral amgydala. In addition, the specific effects on learning are consistent with the hypothesis that NMDA-receptor-mediated LTP underlies specific forms of learning within the amygdala.</div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 3","pages":"Pages 242-250"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80007-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18911173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Chronic aluminum fluoride administration 慢性氟化铝给药

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80006-8

Julie A. Varner , William J. Horvath , Carmen W. Huie , H.R. Naslund , Robert L. Isaacson

{"title":"Chronic aluminum fluoride administration","authors":"Julie A. Varner , William J. Horvath , Carmen W. Huie , H.R. Naslund , Robert L. Isaacson","doi":"10.1016/S0163-1047(05)80006-8","DOIUrl":"10.1016/S0163-1047(05)80006-8","url":null,"abstract":"<div>This study examined the behavioral effects of chronicingestion of various monofluoroaluminum complexes (AlF3) in drinking water. Forty young adult male Long-Evans rats were divided into four groups of 10 rats each. The groups received different concentrations of AlF3 in the drinking water from three sample solutions having a total Al concentration of 0.5, 5.0, and 50 ppm, respectively, or double-distilled deionized water on an ad lib. basis for 45 weeks. General decline of bodily appearance was observed in the lowest concentration AlF3 group, and animals in this group succumbed in greater numbers during the course of the study than those in any other group. Examinations of performance in an open field, an analysis of walking patterns, and a balance beam test did not find any difficulties indicative of motor disorder. Indeed, on the initial trial on the balance beam, the AlF3-treated animals exhibited superior performance. No group differences were found in behavior assessed by spontaneous alternation or by a modified Morris water maze test. When retested in the Morris maze after a low dose of scopolamine (0.4 mg/kg), the control animals took longer to reach the platform while the AlF3-treated rats were not affected. In an olfactory preference test, the AlF3-treated animals failed to show preferences exhibited by the controls, indicating a possible olfactory impairment. The level of Al in the brains of the AlF3-exposed rats, as determined by direct current plasma analysis, was almost double that of the control animals. There was a similar trend for the Al content found in the kidneys.</div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 3","pages":"Pages 233-241"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80006-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19061976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Contents of volume 61 第61卷内容

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80013-5

引用次数: 0

Unilateral inferior olive NMDA lesion leads to unilateral deficit in acquisition and retention of eyelid classical conditioning 单侧下橄榄NMDA损伤导致单侧眼睑经典条件反射的获得和保留缺陷

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80004-4

M. Mintz, D.G. Lavond, A.A. Zhang, Y. Yun, R.F. Thompson

引用次数: 36

Selective activity enhancement and persistence in weanling rats after hippocampal X-irradiation in infancy: Possible relevance for ADHD 婴儿期海马x光照射后断奶大鼠的选择性活动增强和持久性:可能与ADHD相关

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80008-1

Jaime L. Diaz-Granados , Paul L. Greene , Abram Amsel

引用次数: 34

Ontogeny of serotonin-immunoreactive neurons in juvenile Aplysia californica: Implications for the development of learning 幼年加利福尼亚巨噬细胞中血清素免疫反应神经元的个体发育:对学习发育的影响

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80011-1

Thomas G. Nolen , Thomas J. Carew

{"title":"Ontogeny of serotonin-immunoreactive neurons in juvenile Aplysia californica: Implications for the development of learning","authors":"Thomas G. Nolen , Thomas J. Carew","doi":"10.1016/S0163-1047(05)80011-1","DOIUrl":"10.1016/S0163-1047(05)80011-1","url":null,"abstract":"<div>Serotonin has been implicated in both nonassociative learning (sensitization and dishabituation) as well as associative learning (classical conditioning) in Aplysia californica. Dishabituation and sensitization, and their underlying physiological analogs, emerge according to different developmental timetables—sensitization develops 4 to 6 weeks after dishabituation (Rankin & Carew, 1988; Nolen & Carew, 1988; Wright, McCance, Lu, & Carew, 1991). Since the late emergence of sensitization could result from the delayed expression of facilitatory neurotransmitters, we have examined the ontogeny of serotonin immunoreactivity in juvenile A. californica by means of indirect immunohistofluorescence. The purpose of these experiments was to describe the developmental timetable for the expression of serotonin immunoreactivity and to correlate the emergence of immunoreactive neurons with the ontogenetic expression of different forms of learning. While the addition of serotonin-immunoreactive cells tracked the growth of the central nervous system, juveniles contained a relatively higher proportion of immunoreactive cells than adults. Immunoreactive cell bodies were present in the abdominal, cerebral, and pedal ganglia as early as juvenile Stage 9, prior to the emergence of dishabituation in Stage 10. The posterior cerebral cluster (PCC) contained four pairs of immunoreactive cells by Stage 9, including the facilitator CB1, which, as shown in adults, heterosynaptically facilitates siphon sensory neurons. The PCC reached the adult complement of five pairs of cells, by Stage 10, long before the development of sensitization, but at the time corresponding to the emergence of dishabituation. These results suggest that the late emergence of sensitization is not simply a consequence of the late expression of serotonergic facilitatory interneurons.</div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 3","pages":"Pages 282-295"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80011-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19061945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

2-Deoxygalactose interferes with an intermediate processing stage of memory 2-脱氧半乳糖干扰记忆的中间处理阶段

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80002-0

Simon F. Crowe, Wei-Qin Zhao, G.L. Sedman, Kim T. Ng

引用次数: 23

Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick 磷脂酶A2的抑制剂使雏鸡在被动回避任务中失忆

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80005-6

Christian Hölscher , Steven P.R. Rose

{"title":"Inhibitors of phospholipase A2 produce amnesia for a passive avoidance task in the chick","authors":"Christian Hölscher , Steven P.R. Rose","doi":"10.1016/S0163-1047(05)80005-6","DOIUrl":"10.1016/S0163-1047(05)80005-6","url":null,"abstract":"<div>The effects of blocking phospholipase A2 (PLA2), a key enzyme in arachidonic acid (ArA) release, on memory retention have been studied in a one-trial passive avoidance task in the day-old chick. Bilateral intracerebral injections of the PLA2 and lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) (15 μl of 4 mM NDGA/hemisphere, calculated to give an equivalent intracerebral concentration of 120 μM) or the PLA2 inhibitor aristolochic acid (AST) (5 μl of a 4 mM AST/hemisphere, calculated to give an equivalent intracerebral concentration of ∼40 μM) were made into the intermediate medial hyperstriatum ventrale (IMHV), an area that is of crucial importance for memory formation in the chick in this task. Pretraining injections of either inhibitor resulted in the chicks showing lasting amnesia for the avoidance response. The onset of amnesia with both inhibitors NDGA and AST was at 1.25 h post-training. Injection of drugs post-training had no effect on retention. Time and dose dependencies of both drugs were evaluated. Additional tests showed that the amnestic effect is not due to state-dependent learning nor to interference of the drugs with general motor ability or motivation. The results support the theory that arachidonic acid release is a necessary step in the early, although not immediate, events mediating the synaptic plasticity associated with memory formation. This is compatible with the hypothesis that ArA may serve as a late retrograde messenger between post- and presynaptic sites of plasticity, although it is not proof of such a role.</div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 3","pages":"Pages 225-232"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80005-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19061975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Author index for volume 61 第61卷作者索引

Behavioral and neural biology Pub Date : 1994-05-01 Epub Date: 2006-09-20 DOI: 10.1016/S0163-1047(05)80012-3

引用次数: 0

Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats 训练后海马内输注蛋白激酶C抑制剂导致大鼠失忆

Behavioral and neural biology Pub Date : 1994-03-01 Epub Date: 2006-08-22 DOI: 10.1016/S0163-1047(05)80063-9

Diana Jerusalinsky, Jorge A. Quillfeldt, Roger Walz, Ricardo C. Da Silva, Jorge H. Medina, Ivan Izquierdo

{"title":"Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats","authors":"Diana Jerusalinsky, Jorge A. Quillfeldt, Roger Walz, Ricardo C. Da Silva, Jorge H. Medina, Ivan Izquierdo","doi":"10.1016/S0163-1047(05)80063-9","DOIUrl":"10.1016/S0163-1047(05)80063-9","url":null,"abstract":"<div>This experiment investigated the effect on memory, in rats, of the bilateral intrahippocampal post-training infusion of two different inhibitors of protein kinase C activity, staurosporin and CGP41231. Male Wistar rats were implanted bilaterally with cannulae aimed at the CA1 region of the dorsal hippocampus. After recovery from surgery, they were trained in step-down inhibitory avoidance using a 0.5-mA footshock and tested for retention 24 h later. Immediately or 30, 120, or 180 min after training they received, through the cannulae, infusions of vehicle, staurosporin (1.0 μg), or CGP41231 (2.5 μg). The two drugs caused full retrograde amnesia when given immediately or 30 min post-training, partial amnesia when given 120 min after training, and had no effect when given 180 min after training. The results support the suggestion that memory involves long-term potentiation initiated at the time of training in the hippocampus. Inhibitors of protein kinase C block the development of long-term potentiation when administered in the first 2 h after induction.</div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"61 2","pages":"Pages 107-109"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0163-1047(05)80063-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 74