Behavioral and neural biology最新文献_第10页

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90618-R

引用次数: 0

Sexual experience and preferences for odors of estrous females in staggerer mutant male mice 错落突变雄鼠发情雌鼠的性经验和气味偏好

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90561-U

Christophe Féron, Claude Baudoin

引用次数: 13

Effects of catecholaminergic depletion of the amygdala and insular cortex on the potentiation of odor by taste aversions 杏仁核和岛叶皮质的儿茶酚胺能耗竭对味觉厌恶增强气味的影响

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90314-8

Juan Fernandez-Ruiz , Maria Isabel Miranda , Federico Bermúdez-Rattoni , René Drucker-Colín

{"title":"Effects of catecholaminergic depletion of the amygdala and insular cortex on the potentiation of odor by taste aversions","authors":"Juan Fernandez-Ruiz , Maria Isabel Miranda , Federico Bermúdez-Rattoni , René Drucker-Colín","doi":"10.1016/0163-1047(93)90314-8","DOIUrl":"10.1016/0163-1047(93)90314-8","url":null,"abstract":"<div><p>This experiment examined the effects of catecholamine depletion of the amygdala or insular cortex on the acquisition of olfactory and gustatory learning tasks. Bilateral lesions with 6-hydroxydopamine (4 <em>μ</em>g/0.5 <em>μ</em>l) were done in either amygdala or insular cortex of Wistar male rats, with two groups receiving sham lesions. All four groups of animals were trained and tested in the potentiation of odor by taste aversion paradigm. The results showed that the amygdala-lesioned group acquired the taste, but not the odor aversion, while the insular cortexlesioned group acquired odor, but not taste aversion. Both sham groups showed strong taste and odor aversions. Catecholamine levels in both lesioned groups were significantly lower than those in the sham groups. These results suggest that catecholamines are necessary in the insular cortex for the acquisition of taste and in the amygdala for the acquisition of odor aversion in the potentiation of odor by taste aversion paradigm.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 189-191"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90314-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19285671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Cumulative subject index for volumes 59–60 第59-60卷的累积主题索引

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90637-W

引用次数: 0

Serotonergic influence on olfactory learning in the neonate rat 血清素对新生大鼠嗅觉学习的影响

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90257-I

John H. McLean , Andrea Darby-King , Regina M. Sullivan , Shelley R. King

{"title":"Serotonergic influence on olfactory learning in the neonate rat","authors":"John H. McLean , Andrea Darby-King , Regina M. Sullivan , Shelley R. King","doi":"10.1016/0163-1047(93)90257-I","DOIUrl":"10.1016/0163-1047(93)90257-I","url":null,"abstract":"<div><p>The role of the serotonergic innervation of the olfactory bulb was examined in neonate rat pups (Sprague—Dawley) by utilizing an olfactory learning paradigm (<span>Sullivan, McGaugh, & Leon, 1991</span>;<span>Sullivan, Wilson, & Leon, 1989</span>). One hundred fifty nanoliters of the neurotoxin 5,7-dihydroxytryptamine (5,7-dHT, 10 <em>μ</em>g/<em>μ</em>l) was injected into each anterior olfactory nucleus of Postnatal Day 2 (PND 2) pups in order to selectively deplete the serotonergic (5-HT) innervation of the olfactory bulb. On PND 8, control, sham-operated, or 5-HT-depleted pups were presented with stroke (unconditioned stimulus) paired with peppermint odor (conditioned stimulus) or were presented with peppermint alone. Other pups remained naive, i.e., they were not presented with either stroke or odor. The following day, the pups were placed on a mesh screen above two boxes containing either fresh bedding or bedding with peppermint odor for five 1-min trials. Control and sham-operated pups that were previously trained by the odor/stroke paradigm spent significantly more time over the peppermint odor than similarly trained 5-HT-depleted pups, pups trained using the odor only paradigm, or naive pups. Immunocytochemistry verified that the 5,7-dHT injections specifically depleted the 5-HT innervation of the olfactory bulb and left the 5-HT innervation of more caudal levels of the neuraxis (e.g., piriform cortex) intact. The locomotor behavior of the pups was not affected by the 5-HT depletions. This study is the initial investigation to suggest that 5-HT innervation to the olfactory bulb is important in the acquisition or expression of olfactorybased learned behavior in the neonate rat.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 2","pages":"Pages 152-162"},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90257-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18906158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 101

Acknowledgment 鸣谢

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90313-7

引用次数: 0

Interaction of β-endorphin and GABAergic drugs in the regulation of memory storage β-内啡肽与gaba能药物在记忆储存调节中的相互作用

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90215-4

Claudio Castellano, Ines B. Introini-Collison , James L. McGaugh

{"title":"Interaction of β-endorphin and GABAergic drugs in the regulation of memory storage","authors":"Claudio Castellano, Ines B. Introini-Collison , James L. McGaugh","doi":"10.1016/0163-1047(93)90215-4","DOIUrl":"10.1016/0163-1047(93)90215-4","url":null,"abstract":"<div><p>These experiments examined the interaction of <em>β</em>-endorphin and GABAergic drugs, administered post-training, in influencing retention of an inhibitory avoidance response. Male CD1 mice were trained in an inhibitory avoidance task, given immediate post-training ip injections and tested 24 h later for retention. <em>β</em>-Endorphin (0.5, 1.0, or 2.0 <em>μ</em>g/kg) and muscimol (0.5, 1.0, or 2.0 mg/kg) produced dose-dependent impairment of retention; picrotoxin (0.25, 0.5, or 1.0 mg/kg) and bicuculline (0.1, 0.25, or 0.5 mg/kg) produced dose-dependent enhancement of retention. A low subeffective dose of muscimol (0.5 mg/kg) potentiated the retention-impairing effect of <em>β</em>-endorphin (1.0 <em>μ</em>g/kg). In addition, concurrent administration of low, subeffective doses of bicuculline (0.1 mg/kg) or picrotoxin (0.25 mg/kg) attenuated the retention-impairing effects of <em>β</em>-endorphin (1.0 <em>μ</em>g/kg). The findings are consistent with previous evidence indicating that <em>β</em>-endorphin influences memory through an interaction with GABAergic mechanisms.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 2","pages":"Pages 123-128"},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90215-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19109711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Time gradient for post-test vulnerability to scopolamine-induced amnesia following the initial acquisition session of a spatial reference memory task in mice 空间参考记忆任务初始习得阶段后东莨菪碱诱发失忆症的时间梯度

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90243-B

Abdoulaye Toumane , Thomas P. Durkin

{"title":"Time gradient for post-test vulnerability to scopolamine-induced amnesia following the initial acquisition session of a spatial reference memory task in mice","authors":"Abdoulaye Toumane , Thomas P. Durkin","doi":"10.1016/0163-1047(93)90243-B","DOIUrl":"10.1016/0163-1047(93)90243-B","url":null,"abstract":"<div><p>The time course for vulnerability to the amnestic effects of the cholinergic antagonist, scopolamine, during the postacquisition period has been investigated. We have examined the effects of post-test injections of scopolamine (1 mg/kg ip) given at different times from 30 s for up to 6 h following the end of the first acquisition session of a concurrent spatial discrimination (reference memory) protocol in an 8-arm radial maze on subsequent long-term (24 h) retention performance in C57BL/6 mice. Results show that the immediate (30 s) post-test injection of scopolamine—HCl on Day 1 produces marked perturbation (amnesia) of long-term retention as attested to by significant deficits in various indices of spatial discrimination performance gain on Day 2 as compared to control subjects injected either with scopolamine—MBr or saline. The severity of this scopolamine-induced amnesia declines only slightly as a function of the treatment period 30 s—3 h post-test. However, no evidence for amnesia is observed if scopolamine—HCl injections are delayed for 6 h postsession. This important latter observation attests to the absence of any significant proactive effects of scopolamine on the ability of mice to perform the retention test via possible long-term effects on attention, motivation, or locomotor performance. These results thus constitute evidence for the existence of a limited (30 s–3 h) time gradient for vulnerability of the early memory trace to disruption by scopolamine. The present results are dis cussed in relation to our previous direct neurochemical observations describing the differential time courses of intervention of the ascending septohippocampal and nBM—cortical cholinergic pathways in the postlearning period. In particular, the presently observed time window concerning post-test vulnerability to scopolamine-induced amnesia corresponds more closely to the time course of the acute activation of the nBM—cortical cholinergic pathway, induced by testing with the same spatial memory protocol as used in the present study in mice.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 2","pages":"Pages 139-151"},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90243-B","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19109609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus) 7-Chlorokynurenate是NMDA受体上甘氨酸结合位点的拮抗剂，可抑制日龄雏鸡的记忆形成(Gallus domesticus)。

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90145-8

Robert J. Steele, Michael G. Stewart

{"title":"7-Chlorokynurenate, an antagonist of the glycine binding site on the NMDA receptor, inhibits memory formation in day-old chicks (Gallus domesticus)","authors":"Robert J. Steele, Michael G. Stewart","doi":"10.1016/0163-1047(93)90145-8","DOIUrl":"10.1016/0163-1047(93)90145-8","url":null,"abstract":"<div><p>Unilateral intracranial injection into the left intermediate and medial hyperstriatum ventrale of 100 <em>μ</em>mol · liter<sup>−1</sup> 7-chlorokynurenate, a highly selective antagonist of the glycine site on the <em>N</em>-methyl-<span>d</span>-aspartate receptor, prevents acquisition of memory for one-trial passive avoidance training in day-old chicks, in which the aversive stimulus is an unpleasant tasting substance, methyl anthranilate. Injections were given 30 min pretraining and the chicks were tested 30 min or 1 or 3 h post-training. Unilateral injections into the left intermediate and medial hyperstriatum ventrale were found to significantly block memory acquisition when birds were tested at all three time points, but unilateral injections in the right intermediate and medial hyperstriatum ventrale had no significant effect. Bilateral injections did not significantly increase the memory block. Injections of 7-chlorokynurenate given 5 min post-training failed to produce amnesia for the avoidance task when chicks were tested either 30 min or 1 h after training.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 2","pages":"Pages 89-92"},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90145-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19109612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Conditioned defeat in the Syrian golden hamster (Mesocricetus auratus) 叙利亚金仓鼠(Mesocricetus auratus)的条件失败

Behavioral and neural biology Pub Date : 1993-09-01 DOI: 10.1016/0163-1047(93)90159-F

M. Potegal, K. Huhman , T. Moore, J. Meyerhoff

{"title":"Conditioned defeat in the Syrian golden hamster (Mesocricetus auratus)","authors":"M. Potegal, K. Huhman , T. Moore, J. Meyerhoff","doi":"10.1016/0163-1047(93)90159-F","DOIUrl":"10.1016/0163-1047(93)90159-F","url":null,"abstract":"<div><p>When singly housed under laboratory conditions, male Syrian golden hamsters routinely attack novel conspecific intruders introduced into their home cages. As we report here, after being repeatedly defeated by a larger, more aggressive intruder, such normal territorial aggression on the part of the resident hamsters is replaced by defensive behavior and flight. We have found that such conditioned defeat (CD) can be reliably induced by a series of 5-min trials with an aggressive intruder whether these trials are spread over 4 days or are all given on the same day. A useful behavioral criterion for the appearance of CD during acquisition is the first occurrence of anticipatory flight (AF), i.e., the first time the resident flees from the next aggressive intruder <em>before</em> being attacked. CD shows generalization: Animals trained to the AF criterion (AF Group) subsequently show defensive behavior toward, and even flee from, intruders which show absolutely no sign of aggressiveness. Animals in the AF Group persisted in such defense behavior for two test sessions; animals given three additional defeat trials beyond the appearance of AF (AF + 3 Group) showed a greater magnitude and persistence of defense and flight. A comparison of CD-trained animals which met a nonaggressive intruder (NAI) every day for 5 days to similarly trained animals which met the intruder only on the fifth day after acquisition suggests that CD diminishes passively as a function of time and not as the consequence of repeated encounters with a nonaggressive stimulus animal. We also found that near ideal NAIs could be prepared by treating nonaggressive hamsters with high doses of diazepam: animals so treated locomote more or less continuously around the cage virtually ignoring the subject. An unexpected observation was that subjects in the AF Group tended to closely follow these diazepam-treated, rapidly locomoting NAIs around the cage. Following may be an example of the “risk assessment” activities directed toward a potential threat. The development of a rapid and reliable technique for inducing CD in hamsters sets the stage for further physiological and pharmacological work on this interesting phenomenon.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 2","pages":"Pages 93-102"},"PeriodicalIF":0.0,"publicationDate":"1993-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90159-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19109613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 128