Behavioral and neural biology最新文献_第9页

NMDA receptor blockers facilitate and impair learning via different mechanisms NMDA受体阻滞剂通过不同的机制促进和损害学习

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90371-N

Cesare Mondadori , Lawrence Weiskrantz

引用次数: 65

Effect of the calcium channel blocker amlodipine on memory in mice 钙通道阻滞剂氨氯地平对小鼠记忆的影响

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90390-4

David Quartermain, Allison Hawxhurst, Brandon Ermita, Jorge Puente

{"title":"Effect of the calcium channel blocker amlodipine on memory in mice","authors":"David Quartermain, Allison Hawxhurst, Brandon Ermita, Jorge Puente","doi":"10.1016/0163-1047(93)90390-4","DOIUrl":"10.1016/0163-1047(93)90390-4","url":null,"abstract":"<div><p>Five experiments were performed to investigate the effects of amlodipine, a calcium channel antagonist of the 1,4-dihydropyridine class, on consolidation and retrieval of memory in mice. In a single-trial passive avoidance task, amlodipine was administered pretraining, post-training, or pretesting. Results of temporal and dose—response studies showed that memory enhancement (significant increase in step-through latency) occurred when amlodipine (5, 7, 9, 15, and 30 mg/kg) was given either immediately post-training or (15 mg/kg) 15 min pretesting. Using a conditioned emotional response task, tone was paired with shock using Pavlovian conditioning procedures. Strength of conditioning was assessed by measuring suppression of drinking in the presence of a tone. Amlodipine (7 mg/kg) given immediately following both high- and low-intensity shock significantly enhanced conditioned suppression. In the third experiment thirsty mice were trained on a spatial discrimination task in a linear maze. Correct choices were reinforced with liquid reinforcement. Amlodipine (10 mg/kg) injected immediately after the training session produced a significant enhancement of discrimination performance on a 24-h retention test. In the fourth experiment mice were given 25 training trials in a two-way active avoidance task and were treated with either amlodipine (10 mg/kg) or saline after training. Amlodipine-treated mice made significantly more avoidances on the test session than control animals. The final experiment demonstrated that the deficit in approach-avoidance behavior seen in 18-month-old mice could be reversed by amlodipine treatment after the training session. These studies suggest that amlodipine can facilitate memory consolidation and retrieval.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 211-219"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90390-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19284186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Early experience effects on the development of fear in the squirrel monkey 早期经验对松鼠猴恐惧发展的影响

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90428-K

Seymour Levine, Kerry Atha, Sandra G. Wiener

{"title":"Early experience effects on the development of fear in the squirrel monkey","authors":"Seymour Levine, Kerry Atha, Sandra G. Wiener","doi":"10.1016/0163-1047(93)90428-K","DOIUrl":"10.1016/0163-1047(93)90428-K","url":null,"abstract":"<div><p>This study was conducted to determine whether juvenile squirrel monkeys exposed to a snake for a 60-min episode during the preweaning period display behavioral and physiological responses to a snake similar to those displayed by feral-born adult monkeys. Juvenile male monkeys born to feral mothers in the lab were either exposed to a live snake during infancy or were snake-naive. Simultaneously tested were adult feral-born and adult lab-born (snake-naive) males. Juveniles exposed as infants to a snake displayed behavioral responses and plasma cortisol elevations following exposure to the snake that were similar to those of feral-born adults. In contrast, the snake-naive monkeys, regardless of age, rarely vocalized at the snake and displayed lower plasma cortisol elevations. These behavioral and physiological responses did not appear to be elicited by a moving animate stimulus per se, insofar as exposure to a moving fish elicited minimal behavioral changes and no cortisol elevations. In contrast to previous findings, these studies indicate that lab-born snake-naive squirrel monkeys are responsive to snakes, but that experience with snakes in infancy produces behavioral and physiological responses more similar to those observed in feral-born monkeys.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 225-233"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90428-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19284187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Visual cortex ablations do not prevent extinction of fear-potentiated startle using a visual conditioned stimulus 视觉皮质消融不能阻止使用视觉条件刺激消除恐惧增强的惊吓

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90504-B

William A. Falls, Michael Davis

引用次数: 41

Sensory control of the male rat's copulatory thrusting patterns 对雄性大鼠交配插入方式的感觉控制

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90447-P

José Luís Contreras , Anders Agmo

{"title":"Sensory control of the male rat's copulatory thrusting patterns","authors":"José Luís Contreras , Anders Agmo","doi":"10.1016/0163-1047(93)90447-P","DOIUrl":"10.1016/0163-1047(93)90447-P","url":null,"abstract":"<div><p>The effects of reduced somatosensory feedback from the penis and/or the preputial region upon the male rat's copulatory thrusting patterns and sexual behavior were analyzed. Copulatory thrusting was recorded with an accelerometric technique allowing for the determination of duration and frequency of the thrusting trains. Section of the dorsal penile nerves (denervation) or lidocaine applied to the distal part of the penis reduced the number of intromissions and the intromission ratio. These treatments had no effect on copulatory thrusting patterns. Lidocaine injected into the preputial region also reduced the number of intromissions and the intromission ratio. Moreover, the number of disorganized mounts, as revealed by the accelerometric record, was much increased by this treatment. In addition, the duration of the thrusting trains associated with mount and intromission was increased. No effect was found on thrusting frequency. These data suggest that somatosensory feedback from the penis is critical for the achievement of intromission, whereas feedback from the preputial region is important for the execution of copulatory thrusting. Furthermore, it is possible that the strong sensory stimulation of the prepuce associated with penile insertion participates in the termination of thrusting and penile withdrawal.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 234-240"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90447-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19284188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Acknowledgment 鸣谢

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90599-D

引用次数: 0

Glucose enhancement of memory is not state-dependent 葡萄糖对记忆的增强不依赖于状态

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90333-D

Silvia R. Kopf, Javier W. Opezzo, Carlos M. Baratti

{"title":"Glucose enhancement of memory is not state-dependent","authors":"Silvia R. Kopf, Javier W. Opezzo, Carlos M. Baratti","doi":"10.1016/0163-1047(93)90333-D","DOIUrl":"10.1016/0163-1047(93)90333-D","url":null,"abstract":"<div><p>Immediate post-training intraperitoneal administration of <em>α</em>-<span>d</span>[+]-glucose (10–300 mg/kg) significantly enhanced retention of male Swiss mice tested 24 h after training in an inhibitory avoidance task. The dose—response curve was an inverted U in this range of dose. However, of the doses tested, only 30 mg/kg was effective. Glucose did not affect response latencies in mice not given the footshock on the training trial, suggesting that the actions of glucose on retention performance were not due to nonspecific effects on response latencies. The influence of glucose (30 mg/kg) was time-dependent, which suggests that glucose facilitated memory consolidation processes. Administration of glucose (30 mg/kg) 2 or 10 min prior to the retention test did not affect the retention performance of mice given post-training injections of either saline or glucose (30 mg/kg). These findings indicate that the memory-enhancing effects of post-training administration of glucose are not state-dependent and are consistent with the view that the behavioral effects of glucose are mediated through an interaction with the neural or neurohumoral processes underlying the storage of acquired information.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 192-195"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90333-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19284183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Behavioral analysis of asymmetries induced by unilateral 6-OHDA injections into the substantia nigra 单侧黑质注射6-羟色胺致不对称的行为学分析

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90466-U

S. Morgan, G. Nomikos , J.P. Huston

{"title":"Behavioral analysis of asymmetries induced by unilateral 6-OHDA injections into the substantia nigra","authors":"S. Morgan, G. Nomikos , J.P. Huston","doi":"10.1016/0163-1047(93)90466-U","DOIUrl":"10.1016/0163-1047(93)90466-U","url":null,"abstract":"<div><p>The intent of this study was to perform a detailed analysis of behavioral asymmetries (turning behavior) exhibited by animals which had sustained a unilateral lesion of the substantia nigra (SN). Rats were tested for behavior asymmetries over 16 days, once before, and 7 times after 6-OHDA had been injected into one SN. On the basis of the number of narrow diameter ipsiversive half turns produced during testing, they were then assigned to one of three groups: (a) those which showed an initial asymmetry from which they recovered, (b) those which were asymmetrical throughout testing, and (c) those in which the asymmetry only emerged during the testing period. We examined several different aspects of turning behavior. Recovery from asymmetry was associated with an increase in the number of contraversive, as well as a decrease in the number of ipsiversive narrowangle turns. The average diameter of these ipsiversive turns also increased. Animals which recovered showed a contraversive asymmetry for wide-diameter turns which increased during testing. Narrow-diameter contraversive turns decreased during testing in the two nonrecovery groups. Both nonrecovery groups showed a contraversive asymmetry for wide-diameter turns. Asymmetry was attributable to a tendency to circle and move ipsiversively in the two nonrecovery groups, whereas it was due to circling behavior in animals which showed recovery. Additionally, more cells, labeled by HRP injected into the ipsilateral caudate putamen, were found in the damaged SN of animals which recovered.</p></div>","PeriodicalId":8732,"journal":{"name":"Behavioral and neural biology","volume":"60 3","pages":"Pages 241-250"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0163-1047(93)90466-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19284189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The effect of US preexposure on conditioned taste aversion: Lack of postconditioning recovery of the aversion 美国前暴露对条件性味觉厌恶的影响:厌恶缺乏后条件恢复

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90523-K

K. Casey Cole, Lee Bakner, Angela Vernon, David C. Riccio

引用次数: 7

Lead exposure and latent learning ability of adult female rats 成年雌性大鼠铅暴露与潜在学习能力的关系

Behavioral and neural biology Pub Date : 1993-11-01 DOI: 10.1016/0163-1047(93)90542-P

Ana Lúcia Severo Rodrigues , Maribel Antonello Rubin , Diogo Onofre Souza , Carlos Fernando De Mello

引用次数: 12