Journal of obesity and chronic diseases最新文献

Prescribing Patterns of SGLT2 Inhibitors and GLP-1 RAs in Patients with Type 2 Diabetes and Comorbid Conditions of Cardiovascular Disease, Chronic Kidney Disease, and Obesity SGLT2抑制剂和GLP-1 RAs在2型糖尿病和心血管疾病、慢性肾脏疾病和肥胖合并症患者中的处方模式

Journal of obesity and chronic diseases Pub Date : 2022-01-01 DOI: 10.17756/jocd.2022-050

引用次数: 0

Effects of Diaphragmatic Mobilization Techniques on Respiratory Functions, Respiratory Muscle Strength and Resting Metabolic Rate in Obese Individuals 膈肌动员技术对肥胖者呼吸功能、呼吸肌力和静息代谢率的影响

Journal of obesity and chronic diseases Pub Date : 2022-01-01 DOI: 10.17756/jocd.2022-049

引用次数: 0

fMRI Food Cue Reactivity as a Predictor for BMI Change Following Roux-en-Y Gastric Bypass (RYGB) or Diet Intervention 功能磁共振成像食物提示反应性作为Roux-en-Y胃旁路术（RYGB）或饮食干预后BMI变化的预测指标

Journal of obesity and chronic diseases Pub Date : 2021-06-28 DOI: 10.17756/jocd.2021-043

Shauntè M. Baboumian, Carol Cheney, Sumiyah Enayet, S. Pantazatos, A. Geliebter

{"title":"fMRI Food Cue Reactivity as a Predictor for BMI Change Following Roux-en-Y Gastric Bypass (RYGB) or Diet Intervention","authors":"Shauntè M. Baboumian, Carol Cheney, Sumiyah Enayet, S. Pantazatos, A. Geliebter","doi":"10.17756/jocd.2021-043","DOIUrl":"https://doi.org/10.17756/jocd.2021-043","url":null,"abstract":"Prevalence of severe obesity continues to increase, with only bariatric surgery showing long-term efficacy for sustained weight loss. Individuals with severe obesity (vs normal weight) show greater fMRI responsivity to high energy dense (ED) vs low ED food cues and reduced responsivity post-surgery. We examined responsivity to high vs low ED cues pre-intervention in association with postsurgical (RYGB) or dietary weight-loss (dWL) change in BMI at 4 and 18 mo. Region of interest (ROI) analysis employed separate ANCOVA models; group as single factor with three levels and baseline activation and interaction with group covarying for age and gender as nuisance covariates. Significant results were identified at p < 0.1 false discovery rate (FDR) corrected, following multiple comparisons across ROIs. In the precentral gyrus (motor and motor readiness area), higher baseline activation was associated with greater %BMI reduction in RYGB at 4 and 18 mo and less %BMI reduction in dWL at 4 mo (p = 0.006 uncorrected, P < 0.1 FDR corrected). The findings show opposite directionality in predicting change in BMI for RYGB vs. dWL from responsivity to high vs low ED food cues in the precentral gyrus. Greater baseline motor planning to ingest high ED foods may be associated with reduced weight loss in dWL, and with greater weight loss in RYGB due to neuromodulatory effects of surgery.","PeriodicalId":87308,"journal":{"name":"Journal of obesity and chronic diseases","volume":"5 1","pages":"23 - 29"},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48960905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of High-Fructose Diet vs. Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression 高果糖饮食与Teklad饮食对mnu诱导的大鼠乳腺癌模型的影响:改变肿瘤发生、代谢组学和肿瘤RNA表达

Journal of obesity and chronic diseases Pub Date : 2021-01-11 DOI: 10.17756/JOCD.2021-041

Amit Kumar, R. Lubet, Jennifer T Fox, W. Nelson, H. Seifried, C. Grubbs, M. S. Miller

{"title":"Effects of High-Fructose Diet vs. Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression","authors":"Amit Kumar, R. Lubet, Jennifer T Fox, W. Nelson, H. Seifried, C. Grubbs, M. S. Miller","doi":"10.17756/JOCD.2021-041","DOIUrl":"https://doi.org/10.17756/JOCD.2021-041","url":null,"abstract":"Epidemiology, clinical and experimental animal studies suggest high fructose diets are detrimental to metabolic status and may contribute to tumor development. This due to increased obesity and metabolic syndrome, known risk factors for many types of cancer. We compared tumor development in N-methyl-N-nitrosourea (MNU)-treated rats fed either a high (60%)-fructose diet (HFD) or a standard diet (SD). Female Sprague-Dawley rats at 43 days of age (DOA) were fed a SD or HFD followed by administration of MNU at 50 DOA. Rats were palpated weekly and sacrificed at 190 DOA. MNU-treated rats on HFD exhibited decreased tumor latency and roughly a two-fold increase in tumor multiplicity. RNA-Seq on frozen tumors (SD vs. HFD rats) showed altered expression of approximately 10% of genes (P < 0.05). When examined by Ingenuity Pathway Analysis, multiple highly significant pathways were identified including A) mechanisms of cancer, B) Wnt pathway, C) immune response (e.g., “Th1 and Th2 activation” and “antigen presentation”) and D) LXR/RXR nuclear receptor. These generalized pathways were indirectly confirmed by alterations of various interrelated disease pathways (epithelial cancers, T cell numbers and apoptosis). In a second study, serum was collected from rats on the HFD or SD pre-MNU and at the time of sacrifice. Metabolomics revealed that the HFD yielded: A) increased levels of fructose, B) increases of various monoglycerols, C) reduced levels of various diacylglycerols and oxygenated inflammatory lipids (9 and 13 HODE and 12,13 DHOME) and D) increased levels of secondary bile acids (hyodeoxycholate and 6-oxolithocholate), which may reflect microbiome changes. These metabolomic changes, which are distinct from those on a high-fat diet, may prove relevant when examining individuals who consume higher levels of fructose.","PeriodicalId":87308,"journal":{"name":"Journal of obesity and chronic diseases","volume":"5 1","pages":"67 - 78"},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42643058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of the Inbreeding Reproduction on the Obesity Phenotypes Over Generations 近交繁殖对代际肥胖表型的影响

Journal of obesity and chronic diseases Pub Date : 2021-01-01 DOI: 10.17756/jocd.2021-044

Alais Ferreira da Rocha de Oliveria, José Rebuglio Vellosa, Bruno Hartmann, Yasmin Fidler, C. A. Reis, J. R. Gomes

引用次数: 1

The Transition towards Sustainable Diets Should Encourage Pulse Consumption in Children’s Diets: Insights for Policies in Food Systems 向可持续饮食过渡应鼓励儿童饮食中的豆类消费:对粮食系统政策的见解

Journal of obesity and chronic diseases Pub Date : 2021-01-01 DOI: 10.17756/jocd.2021-047

E. D. Vieira, A. M. Gomes, A. M. Gil, M. Vasconcelos

引用次数: 0

Findings from a Pilot-Study: Nutrition Education Tele-Visits to Promote Healthy Dietary Habits among Adolescents 一项试点研究的结果:营养教育远程访问促进青少年健康饮食习惯

Journal of obesity and chronic diseases Pub Date : 2021-01-01 DOI: 10.17756/jocd.2021-045

Sabrina Spencer, C. Arthur

引用次数: 0

Effects of High-Fructose Diet vs. Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression. 高果糖饮食与Teklad饮食对mnu诱导的大鼠乳腺癌模型的影响:改变肿瘤发生、代谢组学和肿瘤RNA表达。

Journal of obesity and chronic diseases Pub Date : 2021-01-01 Epub Date: 2021-01-11

Amit Kumar, Ronald A Lubet, Jennifer T Fox, William G Nelson, Harold Seifried, Clinton J Grubbs, Mark Steven Miller

{"title":"Effects of High-Fructose Diet vs. Teklad Diet in the MNU-Induced Rat Mammary Cancer Model: Altered Tumorigenesis, Metabolomics and Tumor RNA Expression.","authors":"Amit Kumar, Ronald A Lubet, Jennifer T Fox, William G Nelson, Harold Seifried, Clinton J Grubbs, Mark Steven Miller","doi":"","DOIUrl":"","url":null,"abstract":"Epidemiology, clinical and experimental animal studies suggest high fructose diets are detrimental to metabolic status and may contribute to tumor development. This due to increased obesity and metabolic syndrome, known risk factors for many types of cancer. We compared tumor development in N-methyl-N-nitrosourea (MNU)-treated rats fed either a high (60%)-fructose diet (HFD) or a standard diet (SD). Female Sprague-Dawley rats at 43 days of age (DOA) were fed a SD or HFD followed by administration of MNU at 50 DOA. Rats were palpated weekly and sacrificed at 190 DOA. MNU-treated rats on HFD exhibited decreased tumor latency and roughly a two-fold increase in tumor multiplicity. RNA-Seq on frozen tumors (SD vs. HFD rats) showed altered expression of approximately 10% of genes (P < 0.05). When examined by Ingenuity Pathway Analysis, multiple highly significant pathways were identified including A) mechanisms of cancer, B) Wnt pathway, C) immune response (e.g., \"Th1 and Th2 activation\" and \"antigen presentation\") and D) LXR/RXR nuclear receptor. These generalized pathways were indirectly confirmed by alterations of various interrelated disease pathways (epithelial cancers, T cell numbers and apoptosis). In a second study, serum was collected from rats on the HFD or SD pre-MNU and at the time of sacrifice. Metabolomics revealed that the HFD yielded: A) increased levels of fructose, B) increases of various monoglycerols, C) reduced levels of various diacylglycerols and oxygenated inflammatory lipids (9 and 13 HODE and 12,13 DHOME) and D) increased levels of secondary bile acids (hyodeoxycholate and 6-oxolithocholate), which may reflect microbiome changes. These metabolomic changes, which are distinct from those on a high-fat diet, may prove relevant when examining individuals who consume higher levels of fructose.","PeriodicalId":87308,"journal":{"name":"Journal of obesity and chronic diseases","volume":"5 1","pages":"67-78"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25572973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgement of Manuscript Reviewers JOCD Volume – 5 (2021) JOCD第五卷(2021)

Journal of obesity and chronic diseases Pub Date : 2021-01-01 DOI: 10.17756/jocd.2021-048

引用次数: 0

Pulses’ Benefits in Children’s Diets: A Narrative Review 豆类在儿童饮食中的益处:一个叙述性的回顾

Journal of obesity and chronic diseases Pub Date : 2021-01-01 DOI: 10.17756/jocd.2021-042

E. D. Vieira, A. M. Gomes, A. M. Gil, Marta W. Vasconcelos

引用次数: 3