H. Imam, S. K. Roy, Pinaki Das, A. R. Bhuiyan, Md. Zakir Hossain, Md. Rafiquzzaman Khan
{"title":"Association of Hypertension with Body Mass Index","authors":"H. Imam, S. K. Roy, Pinaki Das, A. R. Bhuiyan, Md. Zakir Hossain, Md. Rafiquzzaman Khan","doi":"10.3329/bjn.v34i2.57553","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57553","url":null,"abstract":"Background: Body mass index (BMI) is positively associated with blood pressure (BP). Weight loss significantly reduces blood pressure (BP).The principal aim was to find out the association of Body Mass Index (BMI) with hypertension.\u0000Methods: This crosssectional study was conducted at outpatient department of Bangabandhu Sheikh Mujib Medical University (BSMMU). A total of 1128 hypertensive patients were included in this study by purposive sampling method. Staging of hypertension was done according to The JNC 7 Hypertension Guidelines. BMI was calculated by measuring weight in kilograms divided by height in meters squared.\u0000Results: This study demonstrated that majority (58.1%) were within 40 to 60 years. 63.7% patients were male and 36.3% were female. Maximum observed systolic blood pressure was 170 mm of Hg and minimum 110 mm of Hg. Maximum diastolic blood pressure was 120 mm of Hg and minimum 60 mm of Hg. Out of 1128 hypertensive patients’ 21% patients had normal BMI, 66.7% overweight, 8.8% obese and 3.5% patients were under weight. So hypertension was found more in overweight study subjects which was found statistically significant.\u0000Conclusion: The prevalence of hypertension is more in increased BMI.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 92-95","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"224 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77448555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kinghshuk Dhar, M. Habib, Swapan Kumar Ghose, Kazi Giasuddin Ahmed, A. Chowdhury, Konol Shaha, H. Sina
{"title":"Short-Term Outcome in Patients with Acute Ischemic Stroke on the Basis of Admission Plasma D-Dimer Level","authors":"Kinghshuk Dhar, M. Habib, Swapan Kumar Ghose, Kazi Giasuddin Ahmed, A. Chowdhury, Konol Shaha, H. Sina","doi":"10.3329/bjn.v34i2.57550","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57550","url":null,"abstract":"Background: Elevated levels of plasma D-dimer increase the risk of ischemic stroke, stroke severity, and the progression of stroke status, but the association between plasma D-dimer level and functional outcome is unclear.\u0000Methods: This observational cohort type of study was done in the Department of Neurology Dhaka Medical College Hospital, Dhaka during August, 2017 to July, 2019. Total 100 patients having acute ischemic stroke were included in this study. Age > 18 year of both male & female patients with first-ever acute ischemic stroke confirmed by CT scan/ MRI who gave informed written consent including consent to give blood sample for plasma D-dimer level measurement were enrolled in this study.\u0000Results: Mean D-dimer level was 0.49±0.00 found in MRS 0, 0.57±0.19 in MRS 1, 0.49±0.00 in MRS 2, 0.70±0.33 in MRS 3, 1.46±0.77 in MRS 4, 1.60±0.59 in MRS 5 and 3.17±0.93 in MRS 6. The above findings indicate that MRS score increased with mean D-dimer significantly (p<0.05). Receiver-operator characteristic (ROC) was constructed by using D-dimer level, which gave a cut off value 1.7, with 90.9% sensitivity and 89.4% specificity for prediction of prognosis.\u0000Conclusion: Elevated plasma D-dimer level on admission was significantly associated with short-term poor outcome in patients with acute ischemic stroke.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 72-78","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83327313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Abdullah Al Muzahid, A. Chowdhury, Sujan Saha, Uttam Roy, Md Suman Kabir, Imran Sarker, Md. Rafiqul Islam
{"title":"Cerebellar Ataxia with Progressive Optic Atrophy and Deafness (CAPOS Syndrome): A Rare Case Report","authors":"Md Abdullah Al Muzahid, A. Chowdhury, Sujan Saha, Uttam Roy, Md Suman Kabir, Imran Sarker, Md. Rafiqul Islam","doi":"10.3329/bjn.v34i2.57556","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57556","url":null,"abstract":"CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, sensorineural hearing loss) is a rare autosomal dominant disorder caused by ATP1A3 mutation. Fever triggered cerebellar dysfunction along with progressive optic atrophy and sensorineural deafness are typical features. Herein, we report a 20-year-old female with multiple fever induced cerebellar dysfunction with partial improvement. Pendular nystagmus and optic atrophy were prominent which were also present in patient’s younger sister. As there was progressive sensorineural hearing loss and areflexia, CAPOS syndrome was diagnosed. Though specific therapy is yet to be developed, acetazolamide, cochlear implantation, visual aid and family screening may improve quality of life.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 110-114","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77396084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Agarwalla, Md Bahadur Ali Miah, Subash Kanti Dey, Md Rafiqul Islam, Md. Zahidul Islam, M. Hasan, Md. Shofikul Islam, Muhammad Rezeul Huq
{"title":"Association of Plasma Brain Natriuretic Peptide with Severity of Acute Ischemic Stroke","authors":"A. Agarwalla, Md Bahadur Ali Miah, Subash Kanti Dey, Md Rafiqul Islam, Md. Zahidul Islam, M. Hasan, Md. Shofikul Islam, Muhammad Rezeul Huq","doi":"10.3329/bjn.v34i2.57552","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57552","url":null,"abstract":"Background: Stroke is responsible for the highest mortality and disability among adult population in Bangladesh. With a death rate of 125.6 per 100,000 populations, Bangladesh ranks 34th globally for stroke related death. This study was aimed to find out association of plasma BNP with acute ischemic stroke severity which may help in management of these patients.\u0000Methods: This cross-sectional study was conducted in the Department of Neurology, BSMMU, Dhaka from June 2018 to October 2019. Total 45 subjects with history within 7 days and confirmed by CT scan of head or MRI of brain were selected purposively from the Neurology departments of BSMMU, NINS&H and Internal Medicine department of DMCH, Dhaka, Bangladesh. Venous blood samples were collected from these patients and analyzed at the Department of Biochemistry and Molecular Biology, BSMMU, Dhaka for estimation of plasma BNP.\u0000Results: This study found increased plasma BNP of >100 pg/ml in 31.1 % of acute ischemic stroke patients. Mean plasma BNP level was (74.76±52.96 pg/ml) in acute ischemic stroke patient. Significant negative correlation was found between concentration of plasma BNP and time passed in days from first appearance of stroke symptoms (r = - 0.791; p < 0.001).\u0000Conclusion: Plasma BNP level was significantly associated with baseline severity of acute ischemic stroke.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 85-91","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"459 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77030948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. Kamal, M. Habib, Md. Rafiqul Islam, Swapan Kumar Ghose, Kazi Gias Uddin, A. Chowdhury, Konol Shaha, R. Amin, H. Sina, Kinghshuk Dhar
{"title":"Cerebrospinal Fluid Protein Level and Nerve Conduction Study as Short-Term Prognostic Marker of Guillain Barré Syndrome","authors":"M. M. Kamal, M. Habib, Md. Rafiqul Islam, Swapan Kumar Ghose, Kazi Gias Uddin, A. Chowdhury, Konol Shaha, R. Amin, H. Sina, Kinghshuk Dhar","doi":"10.3329/bjn.v34i2.57551","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57551","url":null,"abstract":"Background: Guillain Barré Syndrome (GBS) diagnosis is based on a combination of clinical features, Nerve conduction studies (NCS) and analysis of the cerebrospinal fluid (CSF) which eventually assist in monitoring disease progression as well as the efficacy of immunotherapy. The main objective of this study was to determine the relation of CSF protein level and nerve conduction study with short-term prognosis of GBS patients.\u0000Methods: This observational study was carried out in the Department of Neurology and Medicine, Dhaka Medical College Hospital, Dhaka during the period August, 2017 to July, 2018. Total 50 patients suffering from GBS were enrolled in this study. Lumber puncture (LP) and NCS were done at day 10 of symptom onset.\u0000Results: In this study majority (87.5%) of the patients had GBS Disability score <3 in demyelinating and 16(47.1%) in axonal on day 90. Three fourth (75.0%) patients EGRIS score was ³3 in demyelinating and 34(100.0%) in axonal and mEGOS it was revealed that more than two third (68.8%) patients mEGOS score was ³6 in Demyelinating and 33(97.1%) in axonal. More than three fourth (76.0%) patients ³6 mEGOS score in CSF protein <100 (mg/dl) and 25(100.0%) in CSF protein ³100 (mg/dl). Multiple logistic regression analysis showing a subject with axonal GBS had 1.579 (95.0% C.I 1.717 to 3.475), CSF Protein had 1.013 (95.0% C.I. 1.001 to 1.026) (PÂ0.05%).\u0000Conclusion: CSF analysis for protein and NCS examination appeared as the essential short term predictors in evaluating diagnostic accuracy and prognostic determinant of GBS early.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 79-84","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89551934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aminur Rahman, Farhan Salam, Rubina Begum, A. Akhter, Shahryar Nabi, Md. Khalilur Rahman, Md. Tariqul Islam, Z. Ali, U. K. Saha, Firoz Ahmed Quraishi
{"title":"Functional Neuroimaging: Single Photon Emission Computed Tomography (SPECT) In Neurological Disorders","authors":"Aminur Rahman, Farhan Salam, Rubina Begum, A. Akhter, Shahryar Nabi, Md. Khalilur Rahman, Md. Tariqul Islam, Z. Ali, U. K. Saha, Firoz Ahmed Quraishi","doi":"10.3329/bjn.v34i2.57554","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57554","url":null,"abstract":"A single photon emission computed tomography (SPECT) scan is a functional nuclear imaging technique performed to evaluate regional cerebral perfusion. Because cerebral blood flow is closely linked to neuronal activity, the activity distribution is presumed to reflect neuronal activity levels in several areas of the brain. Although structural magnetic resonance imaging (MRI) and computed tomography (CT) provide exquisite anatomical detail, SPECT provide complementary functional information. Frequently, brain pathology will manifest as functional changes before anatomical changes are detectable. SPECT has clinical value in the diagnosis, therapeutic management, and follow-up of patients. A general consideration of the clinical value of this technique is followed by relevant information on cerebral physiology and pathology for proper understanding of brain SPECT images. The diversity of central nervous system diseases and therefore the still incomplete knowledge of the mechanisms that underlie them have contributed to the success of brain perfusion SPECT as a research tool in neurosciences. Finally, stepby- step recommendations for interpreting and reporting brain perfusion SPECT images are provided to get the utmost clinical beneût from this technique.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 96-105 ","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89568753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Ashrafuzzaman Khan, -. Md Hassanuzzaman, Prodip Kumar Kayasthagir, Md. Rafiqul Islam, -. Md Mashihuzzaman, MR Alam, Md. Ruhul Amin, Md Monzurul Kader Chowdhury, Md.Kamal Uddin, Z. Ahmed
{"title":"Accuracy of Gene-Xpert In Diagnosis of Suspected Tuberculous Meningitis","authors":"Md. Ashrafuzzaman Khan, -. Md Hassanuzzaman, Prodip Kumar Kayasthagir, Md. Rafiqul Islam, -. Md Mashihuzzaman, MR Alam, Md. Ruhul Amin, Md Monzurul Kader Chowdhury, Md.Kamal Uddin, Z. Ahmed","doi":"10.3329/bjn.v34i1.57529","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57529","url":null,"abstract":"Background: The diagnosis of Extra Pulmonary Tuberculosis, especially tubercular meningitis (TBM) is challenging due to frequent atypical clinical presentation, inadequate clinical sample, and paucibacillary nature of the biological samples, which frequently results in a delay or deprivation of treatment. A semi quantitative, nested, real time PCR Gene-Xpert test is showing promising result in diagnosing pulmonary TB diagnosis, but its role in TBM is yet to be validated.\u0000Methods: It was a cross sectional observational study carried out on 40 clinically suspected TBM patients admitted in neuromedicine, medicine and pediatric medicine at CMCH. Clinical, radiological evaluation and conventional tests were done before PCR (Gene-Xpert) using cerebrospinal fluid.\u0000Results: The mean age of the study population was 28.59 (±16.87) years. Seventeen (42.5%) were male and 23 (57.5%) were female with a male to female ratio of 1:1.35. Out of 40 study cases AFB was presesnt in direct microscopy in only 1(2.5%) case, positive growth on culture in 5 (12.5%) cases and positive Gene-Xpert test in 9 (22.5%) cases. Sensitivity, specificity, PPV, NPV and diagnostic accuracy of Gene-Xpert (PCR) was 44.44%, 96.77%, 80%, 85.71%, and 85.0% respectively considering culture as gold standard. Sensitivity of Gene-Xpert in CSF was 22.5% as compared to culture which was only 12.5 % among the study cases.\u0000Conclusion: PCR (Gene-Xpert) is highly sensitive and speed in diagnosis of TBM compared to conventional methods.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 1-8","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84651721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Jafrul Kawsar, M. Bhuiyan, K. K. Barman, Md. Rafiqul Islam, H. Z. Rahman, M. Hannan, A. N. Rizvi, Chowdhury Neamul Hassan Refayet, H. Rahaman, Rakib Hasan Mohammod
{"title":"Effect of Carbamazepine on Serum Cholesterol and Atherogenic Ratios in Young Adults with Epilepsy","authors":"Md Jafrul Kawsar, M. Bhuiyan, K. K. Barman, Md. Rafiqul Islam, H. Z. Rahman, M. Hannan, A. N. Rizvi, Chowdhury Neamul Hassan Refayet, H. Rahaman, Rakib Hasan Mohammod","doi":"10.3329/bjn.v34i1.57533","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57533","url":null,"abstract":"Background: Epilepsy is a common chronic neurological disorder worldwide. Carbamazepine is one of the most commonly used antiepileptic drugs. It is a hepatic cytochrome P 450 enzyme inducer which is thought to cause alteration of serum lipids.\u0000Objective: To evaluate the effect of carbamazepine on serum cholesterol and atherogenic ratios in young adult epileptic patients.\u0000Materials and methods: This prospective study was conducted in the epilepsy clinic and Neurology OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from December, 2017 to March, 2019. A total fifty seven newly diagnosed epileptic patients fulfilling the study criteria were studied. Serum TC, HDL-C, TG was measured by using Beckman Coulter- AU680 analyzer machine and LDL-C was calculated according to the Friedewald formula in the laboratory of Department of Biochemistry, BSMMU.\u0000Results: The mean (±SD) serum TC, LDL, TG, TC/HDL-C and LDL-C/HDL-C were significantly increased (p-value < 0.001) at 3 months of carbamazepine therapy in comparison to the baseline levels. The mean (±SD) serum HDL was decreased at 3 months of therapy which was not statistically significant (p-value: 0.135).\u0000Conclusion: Carbamazepine caused significant rise in serum TC, LDL-C, TG and atherogenic ratios (TC/HDL-C, LDL-C/HDL-C), and insignificant reduction in the serum HDL-C level after three months of therapy.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 32-38","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89315623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Rafiqul Islam, Mohammad Saifullah Ahtesam, -. Md Wahiduzzaman, Md. Habibur Rahman, Md. Monirul Islam, D. Nath
{"title":"A Patient with Sub Acute Viral Hepatitis (HEV) and Nonalcoholic Wernicke’s Encephalopathy: A Case Report","authors":"Md. Rafiqul Islam, Mohammad Saifullah Ahtesam, -. Md Wahiduzzaman, Md. Habibur Rahman, Md. Monirul Islam, D. Nath","doi":"10.3329/bjn.v34i1.57536","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57536","url":null,"abstract":"Wernicke’s encephalopathy (WE) is an acute neurological disorder resulting from thiamine deficiency. It is mainly related to alcohol abuse but it can be associated with other conditions such as gastrointestinal disorders like hyperemesis. A 38-year-old man with acute viral hepatitis presented with severe weakness, yellow discoloration of the body, hyperemesis in addition with disorientation, horizontal and vertical gaze-evoked nystagmus. MRI of brain showed typical findings of WE. Adequate treatment with parenteral thiamine was given. Neurological symptoms (Disorientation, Nystagmus and Ataxia) ameliorated during hospital stay and radiological abnormalities markedly improved in a follow up MRI after 2 months. This case suggests that WE may be associated with hyperemesis in non-alcoholic patients. Early thiamine treatment in symptomatic patients may improve prognosis. This extraordinary presentation of WE with hyperemesis, encouraged us to presentthis case history.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 52-57","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87951288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. B. Rashid, Subash Kanti Dey, Hannan Ma, Md Rafiqul Islam, Md. Fakrul Islam, Imran Sarker, M. N. Uddin, Shahadat Hassan
{"title":"Association between Serum Thyroid Hormone Levels and Functional Outcome in Acute Ischemic Stroke Patients","authors":"M. B. Rashid, Subash Kanti Dey, Hannan Ma, Md Rafiqul Islam, Md. Fakrul Islam, Imran Sarker, M. N. Uddin, Shahadat Hassan","doi":"10.3329/bjn.v34i1.57530","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57530","url":null,"abstract":"Background and Objectives: Neuroendocrine profile is significantly altered in acute ischemic stroke. Objective of the study was to determine association between serum thyroid hormone levels and functional outcome in acute ischemic stroke patients.\u0000Method: It was a cross sectional analytical study which was conducted in the Department of Neurology, BSMMU, Dhaka. Total 60 acute ischemic stroke patients within 14 days of onset of symptoms confirmed by neuroimaging were selected purposively from department of Neurology, BSMMU. Blood sample was collected from the patient on admission, and was analyzed at the Department of Biochemistry, BSMMU for estimation of serum Thyroid hormones (FT3, FT4, TSH) level. Modified Rankin Scale (mRS) score was done after 1 month of stroke. Poor outcome was defined as mRS>2 and good outcome was defined as 0-2.\u0000Result: Among Sixty patients 39(65%) had normal FT3 level and rest 21(35%) had low FT3 level.The mean (± SD) serum FT3 Level was 2.77 (±0.99) pmol/L in poor outcome group and 3.67 (±0.65) pmol/L in good outcome group which was statistically significant (p=0.001).A negative correlation co-efficient (r = - 0.380) was found between mRS score and serum FT3 concentration,which was also statistically significant (p=0.001).On logistic regression analysis, low serum FT3 concentration remained independent predictor of poor outcome of acute ischemic stroke patients (p=0.001, Odds Ratio = 3.567).\u0000Conclusion: In patients with acute ischemic stroke lower serum FT3 level was significantly associated with poor functional outcome.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 9-16","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77622004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}