Bangladesh Journal of Neuroscience最新文献

{"title":"Migraine Headache: A Bangladesh Perspective","authors":"Kazi Giasuddin Ahmed, Reaz Mahmud, Md. Rafiqul Islam, A. Chowdhury, Iftekher Alam, Mohammad Aftab Rassel, F. B. Monayem","doi":"10.3329/bjn.v35i1.57618","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57618","url":null,"abstract":"Background: Migraine headache is one of the commonest cause of primary headache. This study aims to reveal the clinical profile of migraine headache in Bangladeshi people presented in Headache clinic, Dhaka Medical College Hospital. It will give an overview on presentation of migraine and its functional consequences among the people of Bangladesh. \u0000Methods: The study was a hospital based cross sectional observational study. It was conducted in the Headache clinic Dhaka Medical college Hospital from January 2018 to December 2018. About 854 patients with headache was attended in the headache clinic during the study period. Of that 234 patients were diagnosed as migraine according to ICHD-3 classification and 75 patents were enrolled in this study by systematic sampling. Details were collected using a preformed questioner. \u0000Results: In this study migraine burden among the headache patients found to be about 25%.The mean age of the onset of the migraine headache in this study was found to be 25.2±11.86 years, in most of the cases (4 68%) in 15-34 years age group. In this study 36% of the patient with migraine had positive family history which is significantly higher in patients with migraine with aura (52% vs. 30% p value <0.5). In this study about 81% of the patient has single or multiple trigger factors. Along with other known factor sun exposure and journey was found to be the important trigger factors for Bangladeshi population. In this study 22% of the female migraineurs and 33% of male migraineurs had aura. About 53% of the patient with aura had combinations of aura and 47% patient had exclusive visual aura. In the present study 100% of the patient had visual aura, 42% had brainstem aura and 10% had sensory aura. The study revealed that 25% patient had chronic daily headache due to migraine, 26% patient had >5 attack/ month and 15% patient had < 4 attack per month. In this study 44% had moderate headache and 56% had severe headache according to VAS score. Chronic migraine with anxiety, chronic migraine with medication overuse Migralepsy, Status migrainosus were found as a complications of migraine in this study. According to MIDAS score Patient largely had Mild (32%) to Moderate (34.67%) disability. \u0000Conclusions: Clinical profile of migraine in Bangladesh differs in some trigger points and migraine subtypes than the western world. Sun exposure and journey found to be most important triggers. Migraine with brainstem aura occurs in a significant number of the patient. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 1-9","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86342197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic Pattern of Alzheimer’s Disease in Bangladesh","authors":"N. Roy, Md Rezaul Karim Khan, Md Bahadur Ali Miah, Md. Rafiqul Islam, Bipasha Majumder, Saumitra Das, M. Uddin, M. Haque, Imran Sarker","doi":"10.3329/bjn.v35i1.57619","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57619","url":null,"abstract":"Background: AD is the most common cause of dementia in elderly which causes economic burden for the affected individual, caregivers and society. The objective of this study was to see demographic characteristics among AD patients and it will provide magnitude of the problem and planning of health programme for prevention of disease. \u0000Methods: This observational analytical study was carried out in the Neurology ward, OPD and Dementia clinic of BSMMU, Dhaka from May’ 15 to February’ 17. A total of 45 patients were recruited as study population after satisfying all the criteria for enrollment. \u0000Results: A total of 27 male and 18 female with mean age of 69.20 ± 11.16 years, constituted as cases. \u0000Conclusion: The occurrence of AD found more after the age of 65 years. The present study found that lower educational level is associated with more chance of getting AD. Higher rate of Alzheimer’s disease was found in older man than women. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 10-13","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76449224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Imaging Based Subtyping of Ischemic Stroke in BSMMU","authors":"-. Md Shahidullah, Subash Kanti Dey, A. Ahmed, Panchanan Das, N. Sultana","doi":"10.3329/bjn.v35i1.57622","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57622","url":null,"abstract":"Background: Most strokes and stroke related death & disability happened in low and middle income countries. The clinician should be familiar with the sub typing of ischemic stroke patients and the risk factors analysis. Vascular imaging is necessary for classifying the patient. The main objective of this study was to evaluate the subtype of ischemic stroke patients and risk factor analysis of different etiology. \u0000Method: This is a hospital based prospective study in Bangladesh. Within the time frame of 2014 March to 2017 November; we analyzed 1978 patients of ischemic stroke within 10 days of symptom onset. Among them 877 patients have been selected for this study to whom brain imaging (CT/ MRI), vascular imaging (MRA, DSA), ECG and echocardiography have been done. We did subtyping according to TOAST criteria. \u0000Results: The mean age of patients was 60.5±11 years with 70.47% subjects male and 29.53% female. Within the classification of TOAST, we have found 43.87% of patients were in large artery atherosclerosis group, 23.83.% in small vessel occlusion group, 8.46% in cardiac embolism group, 19.30% in undetermined etiology group and 4.54% in other determined etiology. Among risk factors hypertension in 58.15%, DM was found in 38.42%, hypercholesterolemia in 38.88% of patients. Hypertension was significantly high in large artery atherosclerosis group. \u0000Conclusion: In ischemic stroke patients, large artery atherosclerosis was the most common subtype and hypertension was significant in this group. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 27-32","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88510610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Limb Weakness in A Young Man: A Case Report of POEMS Syndrome","authors":"A. Chowdhury, Sujan Saha, Md Abdullah Al Muzahid, Uttam Roy, Md Suman Kabir, A. Agarwalla, Samim Reza, Imran Sarker, Md Rafiqul Islam","doi":"10.3329/bjn.v35i1.57626","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57626","url":null,"abstract":"Polyneuropathy is an initial presentation and essential feature of POEMS ( polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome. Neuropathy is typically distal, symmetric and slowly progressive with demyelinating changes. After a gradual proximal spread, it usually results in severe muscle weakness and functional disabilities. In the present report, we describe a 40-year-old diabetic male presented with gradually progressive weakness of both lower limbs for 1 year followed by the involvement of both upper limbs for the last 3 months. On examination hyperpigmentation, lymphadenopathy, gynecomastia, anasarca, hepatomegaly, bilateral optic disc swelling, sensory-motor polyneuropathy was found. Laboratory findings showed IgG lambda monoclonal gammopathy, raised VEGF, sensory-motor demyelinating and axonal polyneuropathy. All findings were consistent with POEMS syndrome. The patient was treated with lenalidomide and dexamethasone cyclical therapy with some clinical improvement. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 51-56","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73271289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Ischemic Stroke Patients with Common Risk Factors","authors":"Subash Kanti Dey, L. Bakshi, A. Ahmed, -. Md Shahidullah, A. Habib, A. Chowdhury, Md. Rafiqul Islam","doi":"10.3329/bjn.v35i1.57623","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57623","url":null,"abstract":"Background: Mortality and morbidity due to recurrent ischemic stroke is gradually increasing in Bangladesh due to gradual increase of life expectancy. Previously many studies were done to identify the risk factors of ischemic stroke. But there was scanty data about risk factors of recurrent ischemic stroke. So,it is time demanding to find out those risk factors for ischemic stroke recurrence to reduce the mortality and morbidity from recurrent ischemic stroke. The objective of the study was to determine the frequency of recurrence ischemic stroke events within one year of follow up after discharge from hospital admitted due to first ever stroke. \u0000Methods: This is a prospective cohort study. This study was conducted on 150 patients admitted in Neurology ward of BSMMU, presenting with first ever ischemic stroke. Patients mRS were evaluated three monthly interval for one year. Sudden onset mRS deterioration than previous one during this one year period was categorized as recurrence. \u0000Results: Stroke recurrence was found in 30 patients including 8 patients who died due to stroke recurrence. the most frequent age group was > 75 years representing 44.4% who developed recurrence of stroke The cumulative risk of recurrence rate was 14.7% at three months, 15.3% at six months, 17.3% at ninth months,20% at one year. Old age, Male sex, Hypertension, DM and dyslipidemia were the most common risk factors among recurrent stroke patients. \u0000Conclusion: It was concluded that in hospital admitted patients of first ever stroke, recurrence events was more in patients of older male patients with multiple risk factors.First three months was the worst period for recurrence after index stroke. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 33-38","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90915266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Analysis in Various Subtypes of Ischemic Stroke According to TOAST Criteria in a Tertiary Care Hospital","authors":"Rakib Hasan Mohammad, Md. Rafiqul Islam, -. Md Shahidullah, H. Z. Rahman, Chowdhury Neamul Hossain Refayet, M. B. Rashid","doi":"10.3329/bjn.v35i1.57620","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57620","url":null,"abstract":"Background: Stroke is the third leading cause of death in adult population throughout the world and is the most common cause of severe adult physical disability. The aim of the study is to identify the major risk factors in various subtypes of ischemic stroke according to TOAST criteria. Methods: A Cross-sectional observational study was conducted from January, 2018 to December 2018 in the department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka. All the patients of first ever ischemic stroke within 14 days diagnosed by history, clinical examination and neuroimaging (CT scan of head / MRI of brain), meeting the inclusion and exclusion criteria were included in the study. Results: Present study showed that among the 52 ischemic stroke patients mean age of the respondents was 57 ± 12.37 years with a slightly higher male predominance. Male to female ratio was 1.2:1. Dyslipidemia 44 (84.6 %) and hypertension 37 (71.2 %) were the most common risk factors, followed by obesity and overweight 33(63.5%), smoking 32 (61.5%), diabetes mellitus 29 (55.8%), family history of vascular event 27(51.9 %) and past history of vascular event 14 (26.9%). TOAST Subtype distribution of study population was large-artery atherosclerosis 18 (34.6%) followed by cardioembolism 11(21.2%), small-vessel occlusion 10(19.2%), stroke of other determined etiology 3(5.8%), and stroke of undetermined etiology 10(19.2 %) of patients. In cardioembolic subtype significant association was found with ischemic heart disease (P=0.001) and chronic rheumatic heart disease (P= <0.001). Conclusion: In this study large-artery atherosclerosis was the most common subtype, followed by cardioembolism, small vessel occlusion, stroke of undetermined etiology and stroke of other determined etiology subtypes. Dyslipidemia was found to be the most common risk factor, others were HTN, diabetes and smoking. Ischemic heart disease and rheumatic heart disease were very important cause and comorbidities of cardioembolic types of ischemic stroke. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 14-21","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"163 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87485932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socio Demographic and Headache Characteristics of Migraine Patients in a Tertiary Care Hospital in Bangladesh","authors":"M. Bhattacharjee, Md. Rezaul Karim, A. Hossain, G. Mondol, R. Biswas","doi":"10.3329/bjn.v35i1.57621","DOIUrl":"https://doi.org/10.3329/bjn.v35i1.57621","url":null,"abstract":"Migraine is a common type of headache. After tension type headache, it is the second common cause of primary headache disorder with a female preponderance.This cross sectional study was done toassess the sociodemographic characteristics of migraine patients in Bangladeshi population and to see the characteristics of headache and associated comorbidities of migraine patients.The study was conducted in a tertiary care hospital (Mymensingh medical college) of Bangladesh.The study subjects consisted of 60 patients with migraine headache seen in neurology OPD.Mean age was 32.03± 11.74 yrs. Male female ratio was 1: 2.7.Most of them are housewives (61.6%). 22% had family history of headache. Most of the patients had severe (53.4%) and frequent (e”3 per month) headache attacks. Aura was present in 25% patients. Depressive illness was the associated comorbid condition which was found in 15% patients. \u0000Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 22-26","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76294934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Ceruloplasmin Level with Parkinson’s’s Disease","authors":"Md. Zahidul Islam, K. K. Barman, M. Habib, Md Rafiqul Islam, M. Hasan, Md. Shofikul Islam, Muhammad Rezeul Huq, Imran Sarker, A. Agarwalla","doi":"10.3329/bjn.v34i2.57547","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57547","url":null,"abstract":"Background: Parkinson’s disease, though a common neurodegenerative disease, is still elusive regarding its pathobiology. Neuronal degeneration in the midbrain substantia nigra by excess oxidative stress may play a role. As ceruloplasmin (Cp), a plasma protein is important to maintain intracellular iron homeostasis and reduce cellular oxidative stress, decreased serum Cp level may be an important factor in the pathogenesis of Parkinson’s disease.\u0000Methods: This case-control study was conducted in the department of Neurology, BSMMU. Forty-five Parkinson’s disease patients and equal number of controls were selected. Serum ceruloplasmin level was measured in the department of Biochemistry and Molecular Biology, BSMMU.\u0000Results: Mean serum Cp level was significantly lower (p-value <0.001) in case (27.64 mg/dl) than in control group (33.10 mg/dl).\u0000Conclusion: The association of low serum Cp level with Parkinson’s disease may indicate a possible iron homeostasis abnormality as a pathogenic factor in Parkinson’s disease.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 63-65","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74084561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum Lipid Levels with Parkinson’s Disease: A Case-Control Study","authors":"Muhammad Rezeul Huq, M. Hannan, M. Habib, Md Rafiqul Islam, Md Bahadur Ali Miah, A. Ahmed, Imran Sarker, Md. Zahidul Islam, A. Agarwalla, M. Hasan, Md. Shofikul Islam","doi":"10.3329/bjn.v34i2.57548","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57548","url":null,"abstract":"Background: Parkinson’s disease (PD) is a common neurodegenerative disorder. Many hypotheses have been put forward for PD pathogenesis including role of lipid metabolism. Methods: This case control study was carried out in the department of neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from April 2018 to September 2019. A total of 90 persons were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 42 PD patients were grouped as cases and 48 healthy persons were controls. Results: We have compared the mean (±SD) value (mg/dl) of serum lipid variables among the cases and the controls. Serum total cholesterol in PD patients was found lower than that of control group (176.88 ± 41.12 vs 209.27 ± 43.69 mg/dl) which was statistically significant (p = 0.001) and mean (±SD) value (mg/dl) of serum LDL-C in PD patients was also found significantly lower than that of control group (107 .44 ± 39.04 vs 127.40 ± 37.83 mg/dl, p = 0.017). Serum TG levels were also significantly lower among PD patients than that of controls (152.40 ±77.86 vs 206.71 ±94.76 mg/dl, p = 0.04). Serum high-density lipoprotein cholesterol (HDL-C) levels were statistically similar among cases and controls (39.81 ± 9.79 vs 39.33 ±12.21 mg/dl, p = 0.840). Conclusion: There is an association between low serum TC, LDL-C and TG levels with PD. Further prospective studies are necessary to confirm the association. Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 66-71","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85270976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Subcortical Band Heterotopia Presented with Epilepsy and Speech Regression","authors":"Reaz Mahmud, Kazi Giasuddin Ahmed, M. Rassel","doi":"10.3329/bjn.v34i2.57555","DOIUrl":"https://doi.org/10.3329/bjn.v34i2.57555","url":null,"abstract":"Subcortical Heterotopia is a rare developmental disorder of human brain due to mutation in the DCX or LIS1gene.It is predominantly a disease of female. It usually present with refractory seizure and varying degree of mental retardation. Here a case of 22 years lady who presented with refractory seizure is reported. Her MRI revealed Double cortex and her EEG revealed Frontal intermittent rhythmic delta activity (FIRDA).\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 106-109","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86976947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}