Association of Serum Ceruloplasmin Level with Parkinson’s’s Disease

Bangladesh Journal of Neuroscience Pub Date : 2018-07-31 DOI:10.3329/bjn.v34i2.57547

Md. Zahidul Islam, K. K. Barman, M. Habib, Md Rafiqul Islam, M. Hasan, Md. Shofikul Islam, Muhammad Rezeul Huq, Imran Sarker, A. Agarwalla

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Abstract

Background: Parkinson’s disease, though a common neurodegenerative disease, is still elusive regarding its pathobiology. Neuronal degeneration in the midbrain substantia nigra by excess oxidative stress may play a role. As ceruloplasmin (Cp), a plasma protein is important to maintain intracellular iron homeostasis and reduce cellular oxidative stress, decreased serum Cp level may be an important factor in the pathogenesis of Parkinson’s disease. Methods: This case-control study was conducted in the department of Neurology, BSMMU. Forty-five Parkinson’s disease patients and equal number of controls were selected. Serum ceruloplasmin level was measured in the department of Biochemistry and Molecular Biology, BSMMU. Results: Mean serum Cp level was significantly lower (p-value <0.001) in case (27.64 mg/dl) than in control group (33.10 mg/dl). Conclusion: The association of low serum Cp level with Parkinson’s disease may indicate a possible iron homeostasis abnormality as a pathogenic factor in Parkinson’s disease. Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 63-65

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血清铜蓝蛋白水平与帕金森病的关系

背景:帕金森病虽然是一种常见的神经退行性疾病，但其病理生物学尚不明确。过度氧化应激可能导致中脑黑质神经元变性。血浆蛋白铜蓝蛋白(ceruloplasmin, Cp)对维持细胞内铁稳态和减少细胞氧化应激具有重要作用，血清Cp水平降低可能是帕金森病发病的重要因素。方法:本病例-对照研究在BSMMU神经内科进行。选取了45名帕金森病患者和同等数量的对照组。血清铜蓝蛋白水平在北京医科大学生物化学与分子生物学系检测。结果:实验组血清Cp均值(27.64 mg/dl)显著低于对照组(33.10 mg/dl) (p值<0.001)。结论:低血清Cp水平与帕金森病的相关性提示铁稳态异常可能是帕金森病的致病因素之一。孟加拉国神经科学杂志2018;Vol. 34 (2): 63-65

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Bangladesh Journal of Neuroscience

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