Bangladesh Journal of Neuroscience最新文献_第4页

Association of Metabolic Syndrome with Migraine: A Case-Control Study 代谢综合征与偏头痛的关联:一项病例对照研究

Bangladesh Journal of Neuroscience Pub Date : 2018-01-31 DOI: 10.3329/bjn.v34i1.57531

Chowdhury Neamul Hassan Refayet, S. M. Alam, H. Z. Rahman, Md Rafiqul Islam, M. Bhuiyan, M. Hannan, A. N. Rizvi, Md Abdullah Yusuf, Md Jafrul Kawsar, Md. Habibur Rahaman, Md Rakib Hasan Mahmood, M. Hasan, Imran Sarker

{"title":"Association of Metabolic Syndrome with Migraine: A Case-Control Study","authors":"Chowdhury Neamul Hassan Refayet, S. M. Alam, H. Z. Rahman, Md Rafiqul Islam, M. Bhuiyan, M. Hannan, A. N. Rizvi, Md Abdullah Yusuf, Md Jafrul Kawsar, Md. Habibur Rahaman, Md Rakib Hasan Mahmood, M. Hasan, Imran Sarker","doi":"10.3329/bjn.v34i1.57531","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57531","url":null,"abstract":"Background: Migraine is a disabling primary headache disorder and metabolic syndrome is a major escalating public-health challenge worldwide. They share some common pathophysiology. But till date, their relationship is obscure.\u0000Methods: This study was conducted in headache clinic and inpatient-outpatient department of Neurology and Biochemistry laboratory of BSMMU, from June 2017 to February 2019. In these age-sex matched case control study, 30 migraine patient and equal number non migraine volunteer were taken according to inclusion exclusion criteria. Waist circumference (WC), blood pressure (BP), fasting plasma glucose (FPG), serum triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were measured among all.\u0000Results: In this case control study, 24 women and 6 men were taken in both case and control groups, with mean age (±SD) of 32 (±7.77) and 30 (±8.46) years respectively. Metabolic syndrome was significantly higher among migraineurs (36.7% in case and 13.3% in control group respectively, p=0.037). Patient with metabolic syndrome had 3.763 times more chance of having migraine then person without metabolic syndrome [p=0.037, OR=3.763, 95% C.I. (1.038-13.646)].\u0000Conclusion: There is an association between metabolic syndrome and migraine.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 17-24","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"113 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76901879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of Herpesviridae Genome in CSF of GBS Patients GBS患者脑脊液中疱疹病毒基因组的存在

Bangladesh Journal of Neuroscience Pub Date : 2018-01-31 DOI: 10.3329/bjn.v34i1.57534

H. Rahaman, H. Z. Rahman, M. Rana, Md. Rafiqul Islam, M. Hannan, Md Jafrul Kawsar, Chowdhury Neamul Hasan Refayet, M. Hasan, Imran Sarker, Maftahul Jannat, -. Md Wahiduzzaman

{"title":"Presence of Herpesviridae Genome in CSF of GBS Patients","authors":"H. Rahaman, H. Z. Rahman, M. Rana, Md. Rafiqul Islam, M. Hannan, Md Jafrul Kawsar, Chowdhury Neamul Hasan Refayet, M. Hasan, Imran Sarker, Maftahul Jannat, -. Md Wahiduzzaman","doi":"10.3329/bjn.v34i1.57534","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57534","url":null,"abstract":"Background: Guillain Barre Syndrome (GBS) is considered as an immune mediated inflammatory disease of peripheral nerves and nerve roots. Herpes viruses like CMV, EBV, HSV and VZV infections are associated with GBS. The aim of the study was to identify the presence and frequency of different Herpes virus genome by PCR assay in CSF of GBS patients\u0000Methods: An observational, cross sectional study was carried out in the Department of Neurology, BSMMU, and Dhaka. A total 50 (fifty) admitted GBS patients were included after fulfilling the inclusion and exclusion criteria. About 2 ml of CSF was taken for detection of viral nucleic of CMV, EBV, HSV1, HSV2, VZV and HHV6 by Multiplex PCR method.\u0000Results: Herpesviridae genome in CSF of study population was present in 9 (18%) patients. Maximum 3 (33.3%) cases were HSV1, EBV and HSV2 found in 2 (22.2%) patients, CMV and VZV in 1 (11.1%) patient respectively. AMAN (66.6%) was the most frequent electrophysiological pattern; followed by AIDP (33.3%), mean CSF protein was (159±81) mg/dl and mean cell count was (2±3)/cmm in these patients. Herpes virus genome positive group patients were more disabled and received definitive treatment more than the others.\u0000Conclusion: Herpesviridae genome was present in CSF of GBS especially in early collected CSF sample. Antiviral drugs might have a role in treating GBS patients having Herpes virus genome in CSF.\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 39-44","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89337951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Adulthood Joubert Syndrome 成人Joubert综合征1例

Bangladesh Journal of Neuroscience Pub Date : 2018-01-31 DOI: 10.3329/bjn.v34i1.57537

Muhammad Rezeul Huq, Imran Sarker, Md. Rafiqul Islam, Hannan Ma

引用次数: 0

Study of Etiological Pattern of Acute Meningo-Encephalitis Syndrome 急性脑膜脑炎综合征病因学模式的研究

Bangladesh Journal of Neuroscience Pub Date : 2018-01-31 DOI: 10.3329/bjn.v34i1.57535

M. N. Uddin, Md Mahtab Uddin Hassan

{"title":"Study of Etiological Pattern of Acute Meningo-Encephalitis Syndrome","authors":"M. N. Uddin, Md Mahtab Uddin Hassan","doi":"10.3329/bjn.v34i1.57535","DOIUrl":"https://doi.org/10.3329/bjn.v34i1.57535","url":null,"abstract":"Background: Acute meningo-encephalitis syndrome is a medical emergency which claim urgent management. So the objectives of the present study was to find out aetiological factors and differentiating parameter between different types acute meningoencephalitis syndrome with minimum investigation.\u0000Methods: This hospital based observational study was carried out in medicine units of Chittagong Medical College. Fifty cases were studied who present with acute onset fever with central nervous system dysfunction.\u0000Results: In this study it reveals that hospital rate of bacterial meningitis was 26%, viral encephalitis was 34% and severe malaria was 26% among the patient with acute meningo-encephalitis syndrome. It shows that mean age (years) in viral encephalitis was 33.71, bacterial meningitis was 34.15 & in severe malaria was 27.92. It reveals that all patients of this series presented with acute onset fever (n=50,100%), maximum patients present with sign of meningeal irritation (n=44, 88%) & altered mental state (n=41,82%). Few patients was present with new onset seizure (n=11,22%) & neurologic deficit (n=1,2%). In Bacterial meningitis most patient was with low CSF glucose (n=10, 76.9%). In viral meningitis there were normal CSF glucose level (n=17,100%). High protein content in bacterial (n=13,100%) & Viral (n=15,88.2%) was found. It shows differential count of CSF WBC in different type of meningitis where in Bacterial meningitis it is neutrophils & in other type of meningitis it is the lymphocyte.\u0000Conclusion: CSF findings are hallmark of diagnosing various type of meningitis. CSF glucose and protein content found in this study significantly correlate with different etiology (p value = 0.000).\u0000Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 45-51","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78312335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Serum Homocysteine Level with Migraine in Adults 血清同型半胱氨酸水平与成人偏头痛的关系

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57521

Md. Monirul Islam, M. Habib, Md. Rafiqul Islam, Hasan Rahman, A. N. Rizvi, R. K. Khan, M. Bhuiyan, Mohammad Saifullah Ahtesam, Mohammad Fakrul Islam, Mushfequl Salehin, -. Md Rakunuzzaman, M. Hannan

{"title":"Association of Serum Homocysteine Level with Migraine in Adults","authors":"Md. Monirul Islam, M. Habib, Md. Rafiqul Islam, Hasan Rahman, A. N. Rizvi, R. K. Khan, M. Bhuiyan, Mohammad Saifullah Ahtesam, Mohammad Fakrul Islam, Mushfequl Salehin, -. Md Rakunuzzaman, M. Hannan","doi":"10.3329/bjn.v33i2.57521","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57521","url":null,"abstract":"Background: Migraine is the second most common primary headache disorder that has close link to the neurovascular system. The exact pathogenesis of migraine is still not fully understood but several possible theories have been proposed. Hyperhomocysteinemia is one of the coincidental factors whose association with migraine is yet in obscure. \u0000Methods: This case control study was conducted in the department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka. A total of 65 patients, who were diagnosed as migraine (with aura or without aura) according to ICHD-3 criteria, were considered as case group and another 65 patients (age and sex matched) with headache other than migraine were considered as control group. Serum homocysteine levels were estimated for both groups and other relevant investigations were done in selective cases. Comparison of serum homocysteine levels between two groups were done to see association of serum homocysteine level with migraine in adults. \u0000Results: A total of 50 women and 15 men with mean age of 31 (±10.41) years and 50 women and 15 men with mean age of 33 (±10.91) years constituted case and control groups, respectively. The mean (±SD) serum homocysteine level in case group 10.71 (±4.16) ìmol/L was significantly higher than control group 7.62 (±2.26) ìmol/L, (P <0.001).The mean value of serum homocysteine level in migraine without aura (MWOA) patients 11.87 (±4.18) ìmol/L was found significantly higher than migraine with aura (MWA) patients 8.23 (±1.51) ìmol/L, (p<0.05). There was no significant correlation between severity of migraine headache and frequency of migraine attack with serum homocysteine level. \u0000Conclusion: Serum homocysteine level was found significantly higher in migraineurs than non-migraineurs. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 76-82","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75654782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Utility of Serum Copper Level Estimation in Patients Suffering from Alzheimer’s Disease 血清铜水平评估在阿尔茨海默病患者中的应用

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57524

Dewan Mushfiqur Rahman, Sk. Mahbub Alam, S. Quraishi, Imran Sarker, Md. Rafiqul Islam, Md Rezaul Karim Khan, Hannan Ma, H. Z. Rahman, M. Bhuiya, A. N. Rizvi

{"title":"Utility of Serum Copper Level Estimation in Patients Suffering from Alzheimer’s Disease","authors":"Dewan Mushfiqur Rahman, Sk. Mahbub Alam, S. Quraishi, Imran Sarker, Md. Rafiqul Islam, Md Rezaul Karim Khan, Hannan Ma, H. Z. Rahman, M. Bhuiya, A. N. Rizvi","doi":"10.3329/bjn.v33i2.57524","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57524","url":null,"abstract":"Background: Alzheimer’s disease is the most common cause of dementia. Metals such as zinc , copper, iron are likely involved in the neurodegeneration of Alzheimer’s disease . Copper can catalyze a flux of reactive oxygen species that can damage functional and structural macromolecules in brain. Most studies found association of high serum copper level with Alzheimer’s disease but also some studies did not. \u0000Methods: Total 48 patients of Alzheimer’s disease who were diagnosed according to NIA-AA ( National institute of Aging – Alzheimer’s Association) recommendation ( revised NINCDS-ADRDA) criteria were taken as study population purposively and 42 age and sex matched control were selected. Fasting serum copper level were done for both groups. Comparison of serum copper level of Alzheimer’s patients with that of the control group were done to see association. \u0000Results : A total of 28 male and 20 female with mean age of 66.20 ± 9.42 (mean±SD) years, 22 male and 20 female with mean age of 63.54 ± 9.74 (mean±SD) years constituted as case and control groups, respectively. The mean of serum copper in case and control groups were 0.95 ± 0.37 versus 0.92 ± 0.25 mg/L (P > 0.05). The present study found that serum copper levels are non-significantly higher in patients with AD than control group, however it did not show a significant relationship with severity of dementia. \u0000Conclusion: So our suggestion was to perform a study work including total serum copper level , serum ceruloplasmin level and free serum copper level comparing between a large Alzheimer’s Disease patients group and age , sex matched apparently healthy control group to understand the copper dyshomeostasis in Alzheimer’ Disease. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 96-102","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91535479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Modifiable Risk Factors and Stroke Recurrence in Patients with First Ever Ischemic Stroke 首次缺血性卒中患者可改变危险因素与卒中复发的关系

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57518

Shahadat Hassan, Md. Rafiqul Islam, H. Z. Rahman

{"title":"Association between Modifiable Risk Factors and Stroke Recurrence in Patients with First Ever Ischemic Stroke","authors":"Shahadat Hassan, Md. Rafiqul Islam, H. Z. Rahman","doi":"10.3329/bjn.v33i2.57518","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57518","url":null,"abstract":"Background: Stroke is the third leading cause of death in adult population throughout the world and is the most common cause of severe adult physical disability. It is increasing at an alarming rate in Asia including Bangladesh. The effect of recurrent stroke is devastating on patient as it is the main reason of mortality and morbidity among patients. \u0000Methods: A longitudinal, observational study was conducted from April 2018 to October 2018 in the department of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka. All the patients of first ever ischemic stroke confirmed by neuroimaging (CT scan of head / MRI of brain), meeting the inclusion and exclusion criteria were included in the study. Our study was performed with sixty stroke patients. We followed up patient up to 90 days and observed for stroke recurrence. \u0000Results: Present study showed among the 60 stroke patients, only 4 (6.67%) suffered from stroke recurrence within 3 months. In our study, uncontrolled systolic blood pressure (p=0.04), uncontrolled diastolic blood pressure (p=0.027), dyslipidaemia (p=0.001), smoking (p=0.0003) and antiplatelet discontinuation (p=0.0001) were significantly associated with stroke recurrence whereas uncontrolled diabetes mellitus (p=0.46) and presence of atrial fibrillation (p=0.057) had no significant association. \u0000Conclusion: Smoking, hypercholesterolemia, uncontrolled systolic &/or diastolic blood pressure and discontinuation of antiplatelet therapy were significantly associated with stroke recurrence in this population. Therefore, early identification and control of these risk factors are essential to prevent recurrent stroke, thereby decrease morbidity and mortality. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 55-62","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87058300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Chlamydia Pneumonia Seropositivity and Ischemic Stroke: A Case-Control Study 肺炎衣原体血清阳性与缺血性脑卒中的关系:一项病例对照研究

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57517

M. N. Uddin, S. Dey, A. Ahmed, Md. Rafiqul Islam, M. Jahan, Mohammad Abdur Rauf Dolan, Shahadat Hassan, -. Md Rakunuzzaman, M. B. Rashid

{"title":"Association between Chlamydia Pneumonia Seropositivity and Ischemic Stroke: A Case-Control Study","authors":"M. N. Uddin, S. Dey, A. Ahmed, Md. Rafiqul Islam, M. Jahan, Mohammad Abdur Rauf Dolan, Shahadat Hassan, -. Md Rakunuzzaman, M. B. Rashid","doi":"10.3329/bjn.v33i2.57517","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57517","url":null,"abstract":"Background: Apart from traditional risk factors, infectious agent might contribute to ischemic stroke. The aim of this study was to evaluate the association between Chlamydia pneumonia seropositivity and ischemic stroke. \u0000Methods: 42 ischemic stroke patients diagnosed by history, clinical examination and confirmed by CT scan or MRI of brain selected as case. The same number (42) of age and sex matched subjects having no history or clinical evidence of ischemic stroke were selected as control. Blood samples were collected within 2 to 14 days of ischemic stroke from indoor patients. Controls were collected from both indoor and outdoor patients with neurological disorders other than ischemic stroke. Anti-C. pneumoniae antibodies IgG and IgA were detected by ELISA (enzyme-linked immunosorbent assay) in the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU). \u0000Results: Among the study population, 66.7% of cases and 45.2 % of control patients were seropositive to C. Pneumoniae IgG (OR: 2.42, 95% CI: 1.00 - 5.85, p = 0.048). Whereas IgA were positive in 81% of case and 57.1% of control (OR: 3.19, 95% CI: 1.19 - 8.52, p = 0.018). Seropositivity to IgA showed more significant results than IgG. \u0000Conclusion: There was a significant association between Chlamydia pneumonia seropositivity both IgG and IgA with ischemic stroke. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 47-54","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"200 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75516007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Serum Magnesium Concentration with Alzheimer’s Disease 血清镁浓度与阿尔茨海默病的关系

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57520

M. Uddin, M. Habib, Md. Rafiqul Islam, M. R. K. Khan, H. Z. Rahman, A. N. Rizvi, M. Bhuiyan, K. K. Barman, Syeeda Showkat, Hannan Ma, Imran Sarker

{"title":"Association of Serum Magnesium Concentration with Alzheimer’s Disease","authors":"M. Uddin, M. Habib, Md. Rafiqul Islam, M. R. K. Khan, H. Z. Rahman, A. N. Rizvi, M. Bhuiyan, K. K. Barman, Syeeda Showkat, Hannan Ma, Imran Sarker","doi":"10.3329/bjn.v33i2.57520","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57520","url":null,"abstract":"Background: Alzheimer’s disease is a neurodegenerative disease. It is the most common cause of dementia in individuals older than 60 years of age. Age is the most important risk factor for Alzheimer’s disease. It is important to identify modifiable risk factors. One such important modifiable risk factor is Magnesium, a trace element. The objective of the study was to see the association of serum Magnesium concentration with Alzheimer’s disease patients. \u0000Method: It was a case control study carried out in neurology department of BSMMU, Dhaka. Total 68 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 34 were grouped as case and rest 34 were control. Serum Magnesium concentration was detected. \u0000Result: Serum Magnesium concentration was significantly lower in AD patients than that of control group [2.04±0.19 mg/dl vs 2.36±0.21 mg/dl. \u0000Conclusion: The results of our study revealed an expression that the trace element, Magnesium concentration has an association with Alzheimer’s disease. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 70-75","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78600206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient 癫痫患者胰岛素抵抗与丙戊酸钠治疗的关系

Bangladesh Journal of Neuroscience Pub Date : 2017-07-31 DOI: 10.3329/bjn.v33i2.57519

M. Haque, Md Rafiqul Islam, S. M. Alam, M. N. Haque, Md. Aynul Haque, N. Roy, Imran Sarker, Md. Habibur Rahman

{"title":"Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient","authors":"M. Haque, Md Rafiqul Islam, S. M. Alam, M. N. Haque, Md. Aynul Haque, N. Roy, Imran Sarker, Md. Habibur Rahman","doi":"10.3329/bjn.v33i2.57519","DOIUrl":"https://doi.org/10.3329/bjn.v33i2.57519","url":null,"abstract":"Background: Epilepsy is a common neurological disorder. Sodium valproate is one of the commonest broad spectrum antiepileptic drugs and it is used worldwide. Weight gain is the common side effect which is known to be associated with insulin resistance. The aim of this study was to see the association of sodium valproate therapy with insulin resistance among epileptic patients. \u0000Methods: It was a cross-sectional analytical study. Total 102 patients (51 epileptic patients with valproate monotherapy for at least one year and another 51 age and sex matched newly diagnosed epileptic patients without any anti-epileptic drugs) were selected in this study. The study was carried out from March 2016 to April 2017 for one year in the epilepsy clinic and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University, Dhaka. Participants underwent anthropometric evaluations and biochemical tests including fasting blood sugar and fasting insulin level. Insulin resistance (IR) index was calculated. \u0000Result: In this study mean duration of valproate treatment was 3.12±1.26 years and mean sodium valproate dose was 1133±440.5 mg/day (17.7±6.65 mg/kg/day). This study revealed serum fasting insulin level in valproate group and non-valproate group was 11.05±4.86 (ìU/ml) and 7.39±2.01 (ìU/ml) respectively. Fasting blood glucose was 4.71±0.79 (mmol/L) in valproate group and 4.41±0.62 (mmol/L) in non- valproate group. Calculated IR index in valproate group and non-valproate group was 2.17±0.55 and 1.46±0.39 respectively. IR index, fasting insulin and blood glucose all were significantly higher in valproate group than non- valproate group. This study also revealed mild positive correlation of IR index with dose and duration of valproate treatment. \u0000Conclusion: Sodium valproate treated patient had significantly higher IR index than control group. \u0000Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 63-69","PeriodicalId":8727,"journal":{"name":"Bangladesh Journal of Neuroscience","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73128595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0