Association of Plasma Brain Natriuretic Peptide with Severity of Acute Ischemic Stroke

Bangladesh Journal of Neuroscience Pub Date : 2018-07-31 DOI:10.3329/bjn.v34i2.57552

A. Agarwalla, Md Bahadur Ali Miah, Subash Kanti Dey, Md Rafiqul Islam, Md. Zahidul Islam, M. Hasan, Md. Shofikul Islam, Muhammad Rezeul Huq

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引用次数: 1

Abstract

Background: Stroke is responsible for the highest mortality and disability among adult population in Bangladesh. With a death rate of 125.6 per 100,000 populations, Bangladesh ranks 34th globally for stroke related death. This study was aimed to find out association of plasma BNP with acute ischemic stroke severity which may help in management of these patients. Methods: This cross-sectional study was conducted in the Department of Neurology, BSMMU, Dhaka from June 2018 to October 2019. Total 45 subjects with history within 7 days and confirmed by CT scan of head or MRI of brain were selected purposively from the Neurology departments of BSMMU, NINS&H and Internal Medicine department of DMCH, Dhaka, Bangladesh. Venous blood samples were collected from these patients and analyzed at the Department of Biochemistry and Molecular Biology, BSMMU, Dhaka for estimation of plasma BNP. Results: This study found increased plasma BNP of >100 pg/ml in 31.1 % of acute ischemic stroke patients. Mean plasma BNP level was (74.76±52.96 pg/ml) in acute ischemic stroke patient. Significant negative correlation was found between concentration of plasma BNP and time passed in days from first appearance of stroke symptoms (r = - 0.791; p < 0.001). Conclusion: Plasma BNP level was significantly associated with baseline severity of acute ischemic stroke. Bangladesh Journal of Neuroscience 2018; Vol. 34 (2): 85-91

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血浆脑钠肽与急性缺血性脑卒中严重程度的关系

背景:中风是导致孟加拉国成人死亡率和致残率最高的原因。孟加拉国中风死亡率为每10万人125.6人，在全球排名第34位。本研究旨在发现血浆BNP与急性缺血性脑卒中严重程度的关系，从而有助于这些患者的治疗。方法:本横断面研究于2018年6月至2019年10月在达卡BSMMU神经内科进行。在孟加拉国达卡的BSMMU、NINS&H的神经内科和DMCH的内科中，有目的地选取了45名有7天内病史并经头部CT扫描或脑部MRI证实的患者。从这些患者身上采集静脉血样本，并在达卡BSMMU生物化学和分子生物学系进行分析，以估计血浆BNP。结果:本研究发现31.1%的急性缺血性脑卒中患者血浆BNP升高>100 pg/ml。急性缺血性脑卒中患者血浆BNP水平平均值为(74.76±52.96 pg/ml)。血浆BNP浓度与首次出现卒中症状的时间呈显著负相关(r = - 0.791;P < 0.001)。结论:血浆BNP水平与急性缺血性脑卒中的基线严重程度显著相关。孟加拉国神经科学杂志2018;Vol. 34 (2): 85-91

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Bangladesh Journal of Neuroscience

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