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Burkholderia pseudomallei BipD initiates mitophagy to evade killing by hijacking host KLHL9-KLHL13-CUL3 E3 ligase to ubiquitinate IMMT Burkholderia pseudomallei BipD 通过劫持宿主 KLHL9-KLHL13-CUL3 Eigase 来泛素化 IMMT，从而启动有丝分裂以逃避杀戮
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-18 DOI: 10.1080/15548627.2024.2403125
Dongqi Nan, Xuhu Mao, Qian Li
{"title":"Burkholderia pseudomallei BipD initiates mitophagy to evade killing by hijacking host KLHL9-KLHL13-CUL3 E3 ligase to ubiquitinate IMMT","authors":"Dongqi Nan, Xuhu Mao, Qian Li","doi":"10.1080/15548627.2024.2403125","DOIUrl":"https://doi.org/10.1080/15548627.2024.2403125","url":null,"abstract":"Burkholderia pseudomallei (B. pseudomallei) is a facultative intracellular parasitic pathogen with multiple immune escape mechanisms. Mitophagy is critical for mitochondrial quality control and fun...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The interplay between probiotics and host autophagy: mechanisms of action and emerging insights. 益生菌与宿主自噬之间的相互作用：作用机制和新见解。
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-18 DOI: 10.1080/15548627.2024.2403277
Zahra Sadeghloo,Ali Nabavi-Rad,Mohammad Reza Zali,Daniel J Klionsky,Abbas Yadegar
{"title":"The interplay between probiotics and host autophagy: mechanisms of action and emerging insights.","authors":"Zahra Sadeghloo,Ali Nabavi-Rad,Mohammad Reza Zali,Daniel J Klionsky,Abbas Yadegar","doi":"10.1080/15548627.2024.2403277","DOIUrl":"https://doi.org/10.1080/15548627.2024.2403277","url":null,"abstract":"Autophagy, a lysosome-dependent protein degradation mechanism, is a highly conserved catabolic process seen in all eukaryotes. This cell protection system, which is present in all tissues and functions at a basic level, can be up- or downregulated in response to various stresses. A disruption in the natural route of the autophagy process is frequently followed by an interruption in the inherent operation of the body's cells and organs. Probiotics are live bacteria that protect the host through various mechanisms. One of the processes through which probiotics exert their beneficial effects on various cells and tissues is autophagy. Autophagy can assist in maintaining host homeostasis by stimulating the immune system and affecting numerous physiological and pathological responses. In this review, we particularly focus on autophagy impairments occurring in several human illnesses and investigate how probiotics affect the autophagy process under various circumstances.","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis. SQSTM1 的丝氨酸泛素化调节 NFE2L2 依赖性氧化还原稳态。
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-18 DOI: 10.1080/15548627.2024.2404375
Rukmini Mukherjee,Anshu Bhattacharya,João Mello-Vieira,Santosh Kumar Kuncha,Marina Hoffmann,Alexis Gonzalez,Rajeshwari Rathore,Attinder Chadha,Donghyuk Shin,Thomas Colby,Ivan Matic,Shaeri Mukherjee,Mohit Misra,Ivan Dikic
{"title":"Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis.","authors":"Rukmini Mukherjee,Anshu Bhattacharya,João Mello-Vieira,Santosh Kumar Kuncha,Marina Hoffmann,Alexis Gonzalez,Rajeshwari Rathore,Attinder Chadha,Donghyuk Shin,Thomas Colby,Ivan Matic,Shaeri Mukherjee,Mohit Misra,Ivan Dikic","doi":"10.1080/15548627.2024.2404375","DOIUrl":"https://doi.org/10.1080/15548627.2024.2404375","url":null,"abstract":"The KEAP1-NFE2L2 axis is essential for the cellular response against metabolic and oxidative stress. KEAP1 is an adaptor protein of CUL3 (cullin 3) ubiquitin ligase that controls the cellular levels of NFE2L2, a critical transcription factor of several cytoprotective genes. Oxidative stress, defective autophagy and pathogenic infections activate NFE2L2 signaling through phosphorylation of the autophagy receptor protein SQSTM1, which competes with NFE2L2 for binding to KEAP1. Here we show that phosphoribosyl-linked serine ubiquitination of SQSTM1 catalyzed by SidE effectors of Legionella pneumophila controls NFE2L2 signaling and cell metabolism upon Legionella infection. Serine ubiquitination of SQSTM1 sterically blocks its binding to KEAP1, resulting in NFE2L2 ubiquitination and degradation. This reduces NFE2L2-dependent antioxidant synthesis in the early phase of infection. Levels of serine ubiquitinated SQSTM1 diminish in the later stage of infection allowing the expression of NFE2L2-target genes; causing a differential regulation of the host metabolome and proteome in a NFE2L2-dependent manner.","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming 缺氧诱导的 BNIP3 通过驱动代谢重编程促进葡萄膜黑色素瘤的发展和转移
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-12 DOI: 10.1080/15548627.2024.2395142
Jie Sun, Jie Ding, Han Yue, Binbin Xu, Akrit Sodhi, Kang Xue, Hui Ren, Jiang Qian
{"title":"Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming","authors":"Jie Sun, Jie Ding, Han Yue, Binbin Xu, Akrit Sodhi, Kang Xue, Hui Ren, Jiang Qian","doi":"10.1080/15548627.2024.2395142","DOIUrl":"https://doi.org/10.1080/15548627.2024.2395142","url":null,"abstract":"Uveal melanoma (UM) is an aggressive intraocular malignancy derived from melanocytes in the uvea tract of the eye. Up to 50% of patients with UM develop distant metastases which is usually fatal wi...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergent effects of acute and chronic PPT1 inhibition in melanoma 急性和慢性 PPT1 抑制对黑色素瘤的不同影响
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-12 DOI: 10.1080/15548627.2024.2403152
Mary Ann S. Crissey, Amanda Versace, Monika Bhardwaj, Vaibhav Jain, Shujing Liu, Arpana Singh, Lynn A. Beer, Hsin-Yao Tang, Jessie Villanueva, Phyllis A. Gimotty, Xiaowei Xu, Ravi K. Amaravadi
{"title":"Divergent effects of acute and chronic PPT1 inhibition in melanoma","authors":"Mary Ann S. Crissey, Amanda Versace, Monika Bhardwaj, Vaibhav Jain, Shujing Liu, Arpana Singh, Lynn A. Beer, Hsin-Yao Tang, Jessie Villanueva, Phyllis A. Gimotty, Xiaowei Xu, Ravi K. Amaravadi","doi":"10.1080/15548627.2024.2403152","DOIUrl":"https://doi.org/10.1080/15548627.2024.2403152","url":null,"abstract":"Macroautophagy/autophagy-lysosome function promotes growth and survival of cancer cells, making them attractive targets for cancer therapy. One intriguing lysosomal target is PPT1 (palmitoyl-protei...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) suppresses anorexia 抑制自噬的组织激素 DBI/ACBP（地西泮结合抑制剂，酰基-CoA 结合蛋白）可抑制厌食症
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-09-12 DOI: 10.1080/15548627.2024.2402162
Hui Chen, Isabelle Martins, Guido Kroemer
{"title":"The autophagy-repressive tissue hormone DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) suppresses anorexia","authors":"Hui Chen, Isabelle Martins, Guido Kroemer","doi":"10.1080/15548627.2024.2402162","DOIUrl":"https://doi.org/10.1080/15548627.2024.2402162","url":null,"abstract":"DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) is produced by multiple cell types and detectable in blood plasma. DBI acts on GABRA (gamma-aminobutyric acid type A receptor) comple...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction 蛋白酶体功能失调时，PLK2 介导的 SQSTM1 S349 磷酸化会促进多泛素化蛋白质的聚集
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-06-19 DOI: 10.1080/15548627.2024.2361574
Yun-Da Chen, Xiu-Ping Lin, Zi-Lun Ruan, Mi Li, Xue-Mei Yi, Xu Zhang, Shu Li, Hong-Bing Shu
{"title":"PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction","authors":"Yun-Da Chen, Xiu-Ping Lin, Zi-Lun Ruan, Mi Li, Xue-Mei Yi, Xu Zhang, Shu Li, Hong-Bing Shu","doi":"10.1080/15548627.2024.2361574","DOIUrl":"https://doi.org/10.1080/15548627.2024.2361574","url":null,"abstract":"Dysregulation in protein homeostasis results in accumulation of protein aggregates, which are sequestered into dedicated insoluble compartments so-called inclusion bodies or aggresomes, where they ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141526875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes TIGAR 通过引发 LRRK2- 介导的脂肪细胞大自噬和伴侣介导的自噬缺陷，加剧肥胖症的发生
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-30 DOI: 10.1080/15548627.2024.2338576
Tian Zhang, Ke-Gang Linghu, Jia Tan, Mingming Wang, Diao Chen, Yan Shen, Junchao Wu, Mingjun Shi, Yuxia Zhou, Lei Tang, Lirong Liu, Zheng-Hong Qin, Bing Guo
{"title":"TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes","authors":"Tian Zhang, Ke-Gang Linghu, Jia Tan, Mingming Wang, Diao Chen, Yan Shen, Junchao Wu, Mingjun Shi, Yuxia Zhou, Lei Tang, Lirong Liu, Zheng-Hong Qin, Bing Guo","doi":"10.1080/15548627.2024.2338576","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338576","url":null,"abstract":"Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autoph...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140826787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice 沃尔夫拉姆样变体 WFS1E864K 会破坏 MAM 的稳定性，并损害人类和小鼠的自噬和有丝分裂能力
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-23 DOI: 10.1080/15548627.2024.2341588
Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Elodie M. Richard
{"title":"The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice","authors":"Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Elodie M. Richard","doi":"10.1080/15548627.2024.2341588","DOIUrl":"https://doi.org/10.1080/15548627.2024.2341588","url":null,"abstract":"Dominant variants in WFS1 (wolframin ER transmembrane glycoprotein), the gene coding for a mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) resident protein, have been associated w...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140826533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy cooperates with PDGFRA to support oncogenic growth signaling 自噬与 PDGFRA 合作支持致癌生长信号转导
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-18 DOI: 10.1080/15548627.2024.2338572
Joanne E. Simpson, Noor Gammoh
{"title":"Autophagy cooperates with PDGFRA to support oncogenic growth signaling","authors":"Joanne E. Simpson, Noor Gammoh","doi":"10.1080/15548627.2024.2338572","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338572","url":null,"abstract":"Macroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":null,"pages":null},"PeriodicalIF":13.3,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140611201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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