TIGAR 通过引发 LRRK2- 介导的脂肪细胞大自噬和伴侣介导的自噬缺陷，加剧肥胖症的发生

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2024-04-30 DOI:10.1080/15548627.2024.2338576

Tian Zhang, Ke-Gang Linghu, Jia Tan, Mingming Wang, Diao Chen, Yan Shen, Junchao Wu, Mingjun Shi, Yuxia Zhou, Lei Tang, Lirong Liu, Zheng-Hong Qin, Bing Guo

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引用次数: 0

摘要

肥胖症是全球最常见的代谢性疾病之一，其特征是甘油三酯在脂肪细胞内异常堆积。最近的研究发现，自噬...

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TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes

Obesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autoph...

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.