益生菌与宿主自噬之间的相互作用:作用机制和新见解。

IF 14.6 1区 生物学 Q1 CELL BIOLOGY
Zahra Sadeghloo,Ali Nabavi-Rad,Mohammad Reza Zali,Daniel J Klionsky,Abbas Yadegar
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引用次数: 0

摘要

自噬是一种依赖溶酶体的蛋白质降解机制,是一种高度保守的分解代谢过程,见于所有真核生物。这种细胞保护系统存在于所有组织中,在基本层面上发挥着作用,但在应对各种压力时会被上调或下调。自噬过程的自然途径一旦中断,人体细胞和器官的固有运作也会随之中断。益生菌是通过各种机制保护宿主的活细菌。自噬是益生菌对各种细胞和组织产生有益影响的过程之一。自噬可以刺激免疫系统,影响多种生理和病理反应,从而帮助维持宿主的平衡。在这篇综述中,我们特别关注在几种人类疾病中出现的自噬损伤,并研究益生菌如何在不同情况下影响自噬过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The interplay between probiotics and host autophagy: mechanisms of action and emerging insights.
Autophagy, a lysosome-dependent protein degradation mechanism, is a highly conserved catabolic process seen in all eukaryotes. This cell protection system, which is present in all tissues and functions at a basic level, can be up- or downregulated in response to various stresses. A disruption in the natural route of the autophagy process is frequently followed by an interruption in the inherent operation of the body's cells and organs. Probiotics are live bacteria that protect the host through various mechanisms. One of the processes through which probiotics exert their beneficial effects on various cells and tissues is autophagy. Autophagy can assist in maintaining host homeostasis by stimulating the immune system and affecting numerous physiological and pathological responses. In this review, we particularly focus on autophagy impairments occurring in several human illnesses and investigate how probiotics affect the autophagy process under various circumstances.
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来源期刊
Autophagy
Autophagy 生物-细胞生物学
CiteScore
21.30
自引率
2.30%
发文量
277
审稿时长
1 months
期刊介绍: Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.
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