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The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice 沃尔夫拉姆样变体 WFS1E864K 会破坏 MAM 的稳定性，并损害人类和小鼠的自噬和有丝分裂能力
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-23 DOI: 10.1080/15548627.2024.2341588
Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Elodie M. Richard
{"title":"The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice","authors":"Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Elodie M. Richard","doi":"10.1080/15548627.2024.2341588","DOIUrl":"https://doi.org/10.1080/15548627.2024.2341588","url":null,"abstract":"Dominant variants in WFS1 (wolframin ER transmembrane glycoprotein), the gene coding for a mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) resident protein, have been associated w...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"58 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140826533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy cooperates with PDGFRA to support oncogenic growth signaling 自噬与 PDGFRA 合作支持致癌生长信号转导
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-18 DOI: 10.1080/15548627.2024.2338572
Joanne E. Simpson, Noor Gammoh
{"title":"Autophagy cooperates with PDGFRA to support oncogenic growth signaling","authors":"Joanne E. Simpson, Noor Gammoh","doi":"10.1080/15548627.2024.2338572","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338572","url":null,"abstract":"Macroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"44 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140611201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms 患有核心自噬基因相关多态性的羊角风病患者成熟树突状细胞的自噬通量重编程功能受损
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-14 DOI: 10.1080/15548627.2024.2338574
Gaëlle Quiniou, Leslie Andromaque, Rémi Duclaux-Loras, Océane Dinet, Ornella Cervantes, Mallorie Verdet, Camille Meunier, Gilles Boschetti, Christophe Viret, Stéphane Nancey, Mathias Faure, Aurore Rozières
{"title":"Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms","authors":"Gaëlle Quiniou, Leslie Andromaque, Rémi Duclaux-Loras, Océane Dinet, Ornella Cervantes, Mallorie Verdet, Camille Meunier, Gilles Boschetti, Christophe Viret, Stéphane Nancey, Mathias Faure, Aurore Rozières","doi":"10.1080/15548627.2024.2338574","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338574","url":null,"abstract":"Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associate...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"60 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxic gain-of-function mechanisms in C9orf72 ALS-FTD neurons drive autophagy and lysosome dysfunction C9orf72 ALS-FTD 神经元的毒性功能增益机制驱动自噬和溶酶体功能障碍
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-14 DOI: 10.1080/15548627.2024.2340415
Jimmy Beckers, Philip Van Damme
{"title":"Toxic gain-of-function mechanisms in C9orf72 ALS-FTD neurons drive autophagy and lysosome dysfunction","authors":"Jimmy Beckers, Philip Van Damme","doi":"10.1080/15548627.2024.2340415","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340415","url":null,"abstract":"Hexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative dise...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"50 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response 肠道冠状病毒 nsp2 是一种毒力决定因子，它能招募 NBR1 以 TBK1 为目标进行自噬，从而削弱先天性免疫反应
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-10 DOI: 10.1080/15548627.2024.2340420
Yajuan Jiao, Pengwei Zhao, Ling-Dong Xu, Jia-Qi Yu, Hou-Li Cai, Chong Zhang, Chao Tong, Yong-Le Yang, Pinglong Xu, Qiming Sun, Ning Chen, Bin Wang, Yao-Wei Huang
{"title":"Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response","authors":"Yajuan Jiao, Pengwei Zhao, Ling-Dong Xu, Jia-Qi Yu, Hou-Li Cai, Chong Zhang, Chao Tong, Yong-Le Yang, Pinglong Xu, Qiming Sun, Ning Chen, Bin Wang, Yao-Wei Huang","doi":"10.1080/15548627.2024.2340420","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340420","url":null,"abstract":"Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PED...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"76 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies 自噬 SQSTM1 小液滴向依赖 SQSTM1 的 P 小体转化
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-10 DOI: 10.1080/15548627.2024.2340413
Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo
{"title":"Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies","authors":"Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo","doi":"10.1080/15548627.2024.2340413","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340413","url":null,"abstract":"SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets en...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX 间充质输入压力和 PINK1 介导的间充质：PINK1-TOMM-TIMM23 超级复合物的作用
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-10 DOI: 10.1080/15548627.2024.2340399
Mohamed A. Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N. Bayne, Jean-François Trempe, Edward A. Fon
{"title":"MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX","authors":"Mohamed A. Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N. Bayne, Jean-François Trempe, Edward A. Fon","doi":"10.1080/15548627.2024.2340399","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340399","url":null,"abstract":"Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"3 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP 网状吞噬受体大规模处理 ER 蛋白质和 TOLLIP 选择性处理 ER 蛋白质
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-10 DOI: 10.1080/15548627.2024.2340417
Yuki Hayashi, Hidenori Ichijo
{"title":"Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP","authors":"Yuki Hayashi, Hidenori Ichijo","doi":"10.1080/15548627.2024.2340417","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340417","url":null,"abstract":"Proteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lyso...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-induced Golgiphagy is triggered by the downregulation of Golgi GTPase RAB3D 酒精诱导的高尔基体吞噬作用是由下调高尔基体 GTPase RAB3D 触发的
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-09 DOI: 10.1080/15548627.2024.2329476
Amanda J. Macke, Taylor E. Divita, Artem N. Pachikov, Sundararajan Mahalingam, Ramesh Bellamkonda, Karuna Rasineni, Carol A. Casey, Armen Petrosyan
{"title":"Alcohol-induced Golgiphagy is triggered by the downregulation of Golgi GTPase RAB3D","authors":"Amanda J. Macke, Taylor E. Divita, Artem N. Pachikov, Sundararajan Mahalingam, Ramesh Bellamkonda, Karuna Rasineni, Carol A. Casey, Armen Petrosyan","doi":"10.1080/15548627.2024.2329476","DOIUrl":"https://doi.org/10.1080/15548627.2024.2329476","url":null,"abstract":"The development of alcohol-associated liver disease (ALD) is associated with disorganized Golgi apparatus and accelerated phagophore formation. While Golgi membranes may contribute to phagophores, ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif 黏液病毒的基质蛋白通过其 PPxY 基序招募 NEDD4，从而劫持自噬体，实现有效排出
IF 13.3 1区 生物学
Autophagy Pub Date : 2024-04-02 DOI: 10.1080/15548627.2024.2338575
Yueming Yuan, An Fang, Zhihui Wang, Huanchun Chen, Zhen F. Fu, Ming Zhou, Ling Zhao
{"title":"The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif","authors":"Yueming Yuan, An Fang, Zhihui Wang, Huanchun Chen, Zhen F. Fu, Ming Zhou, Ling Zhao","doi":"10.1080/15548627.2024.2338575","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338575","url":null,"abstract":"Lyssaviruses are well-known worldwide and often cause fatal encephalitis. Previous studies have shown that autophagy is beneficial for the replication of rabies virus (RABV), the representative lys...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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