AutophagyPub Date : 2024-04-14DOI: 10.1080/15548627.2024.2340415
Jimmy Beckers, Philip Van Damme
{"title":"Toxic gain-of-function mechanisms in C9orf72 ALS-FTD neurons drive autophagy and lysosome dysfunction","authors":"Jimmy Beckers, Philip Van Damme","doi":"10.1080/15548627.2024.2340415","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340415","url":null,"abstract":"Hexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative dise...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"50 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response","authors":"Yajuan Jiao, Pengwei Zhao, Ling-Dong Xu, Jia-Qi Yu, Hou-Li Cai, Chong Zhang, Chao Tong, Yong-Le Yang, Pinglong Xu, Qiming Sun, Ning Chen, Bin Wang, Yao-Wei Huang","doi":"10.1080/15548627.2024.2340420","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340420","url":null,"abstract":"Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PED...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"76 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-10DOI: 10.1080/15548627.2024.2340413
Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo
{"title":"Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies","authors":"Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo","doi":"10.1080/15548627.2024.2340413","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340413","url":null,"abstract":"SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets en...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-10DOI: 10.1080/15548627.2024.2340399
Mohamed A. Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N. Bayne, Jean-François Trempe, Edward A. Fon
{"title":"MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX","authors":"Mohamed A. Eldeeb, Armaan Fallahi, Andrea Soumbasis, Andrew N. Bayne, Jean-François Trempe, Edward A. Fon","doi":"10.1080/15548627.2024.2340399","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340399","url":null,"abstract":"Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"3 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-10DOI: 10.1080/15548627.2024.2340417
Yuki Hayashi, Hidenori Ichijo
{"title":"Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP","authors":"Yuki Hayashi, Hidenori Ichijo","doi":"10.1080/15548627.2024.2340417","DOIUrl":"https://doi.org/10.1080/15548627.2024.2340417","url":null,"abstract":"Proteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lyso...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-09DOI: 10.1080/15548627.2024.2329476
Amanda J. Macke, Taylor E. Divita, Artem N. Pachikov, Sundararajan Mahalingam, Ramesh Bellamkonda, Karuna Rasineni, Carol A. Casey, Armen Petrosyan
{"title":"Alcohol-induced Golgiphagy is triggered by the downregulation of Golgi GTPase RAB3D","authors":"Amanda J. Macke, Taylor E. Divita, Artem N. Pachikov, Sundararajan Mahalingam, Ramesh Bellamkonda, Karuna Rasineni, Carol A. Casey, Armen Petrosyan","doi":"10.1080/15548627.2024.2329476","DOIUrl":"https://doi.org/10.1080/15548627.2024.2329476","url":null,"abstract":"The development of alcohol-associated liver disease (ALD) is associated with disorganized Golgi apparatus and accelerated phagophore formation. While Golgi membranes may contribute to phagophores, ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-02DOI: 10.1080/15548627.2024.2338575
Yueming Yuan, An Fang, Zhihui Wang, Huanchun Chen, Zhen F. Fu, Ming Zhou, Ling Zhao
{"title":"The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif","authors":"Yueming Yuan, An Fang, Zhihui Wang, Huanchun Chen, Zhen F. Fu, Ming Zhou, Ling Zhao","doi":"10.1080/15548627.2024.2338575","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338575","url":null,"abstract":"Lyssaviruses are well-known worldwide and often cause fatal encephalitis. Previous studies have shown that autophagy is beneficial for the replication of rabies virus (RABV), the representative lys...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-02DOI: 10.1080/15548627.2024.2338577
Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Gabriella D’Orazi, Mara Cirone
{"title":"ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression","authors":"Rossella Benedetti, Maria Anele Romeo, Andrea Arena, Maria Saveria Gilardini Montani, Gabriella D’Orazi, Mara Cirone","doi":"10.1080/15548627.2024.2338577","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338577","url":null,"abstract":"The inhibition of the unfolded protein response (UPR), which usually protects cancer cells from stress, may be exploited to potentiate the cytotoxic effect of drugs inducing ER stress. However, in ...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"123 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AutophagyPub Date : 2024-04-02DOI: 10.1080/15548627.2024.2338573
Baptiste Pradel, Guilhem Cantaloube, Marie Villares, Maïka S. Deffieu, Véronique Robert-Hebmann, Vincent Lucansky, Mathias Faure, Nathalie Chazal, Raphaël Gaudin, Lucile Espert
{"title":"LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes","authors":"Baptiste Pradel, Guilhem Cantaloube, Marie Villares, Maïka S. Deffieu, Véronique Robert-Hebmann, Vincent Lucansky, Mathias Faure, Nathalie Chazal, Raphaël Gaudin, Lucile Espert","doi":"10.1080/15548627.2024.2338573","DOIUrl":"https://doi.org/10.1080/15548627.2024.2338573","url":null,"abstract":"HIV-1 entry into CD4+ T lymphocytes relies on the viral and cellular membranes’ fusion, leading to viral capsid delivery in the target cell cytoplasm. Atg8/LC3B conjugation to lipids, process named...","PeriodicalId":8722,"journal":{"name":"Autophagy","volume":"22 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}