The Wolfram-like variant WFS1E864K destabilizes MAM and compromises autophagy and mitophagy in human and mice

IF 14.6 1区生物学 Q1 CELL BIOLOGY

Autophagy Pub Date : 2024-04-23 DOI:10.1080/15548627.2024.2341588

Simone Patergnani, Méghane S. Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, René Valéro, Lisbeth Tranebjærg, Tangui Maurice, Paolo Pinton, Benjamin Delprat, Elodie M. Richard

引用次数: 0

Abstract

Dominant variants in WFS1 (wolframin ER transmembrane glycoprotein), the gene coding for a mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) resident protein, have been associated w...

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沃尔夫拉姆样变体 WFS1E864K 会破坏 MAM 的稳定性，并损害人类和小鼠的自噬和有丝分裂能力

WFS1（wolframin ER跨膜糖蛋白）是一种线粒体相关内质网（ER）膜（MAM）驻留蛋白的编码基因，其显性变异与线粒体相关内质网（ER）膜（MAM）驻留蛋白有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.