Behavior Genetics最新文献_第2页

Towards a Greater Understanding of the Role of the Environment: A Systematic Review of Qualitative MZ Twin Differences Studies.

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-02-23 DOI: 10.1007/s10519-025-10217-1

Filip Marzecki, Kennath Widanaralalage, Nandini Bhandoh, Tom A McAdams, Yasmin I Ahmadzadeh, Helena M S Zavos

{"title":"Towards a Greater Understanding of the Role of the Environment: A Systematic Review of Qualitative MZ Twin Differences Studies.","authors":"Filip Marzecki, Kennath Widanaralalage, Nandini Bhandoh, Tom A McAdams, Yasmin I Ahmadzadeh, Helena M S Zavos","doi":"10.1007/s10519-025-10217-1","DOIUrl":"https://doi.org/10.1007/s10519-025-10217-1","url":null,"abstract":"The environment is an important influence in the development of human behaviours and health outcomes. However, one of the most consistent findings from behavioural genetic studies is that most environmental influences are not shared between members of the same family. A compelling way of investigating these non-shared environmental influences is by using a monozygotic (MZ) twin differences design. Quantitative MZ differences studies have uncovered systematic non-shared environmental factors, i.e., those acting according to a general pattern in a population, for many traits, but may be omitting idiosyncratic or distinctive factors and mechanisms. Qualitative MZ differences design provides an alternative. In this study design, identical twins discordant on an outcome are interviewed in depth about the origins and context of their discordance, providing an insight into distinctive lived experiences. We conducted a systematic review examining the results and methodological features of studies using qualitative data collection and analyses to investigate differences in identical twins' experiences and outcomes. We applied a narrative synthesis. We identified seven studies, covering a range of phenotypes (e.g., anxiety or smoking) and participants (from children to older adults), which found a wide range of themes related to twins' discordance. A major theme arising from the narrative synthesis was the role of personality and individual traits, e.g., confidence or sexual orientation, in explaining MZ twins' discordant experiences and outcomes. Non-shared environmental factors are at least partly idiosyncratic and are therefore suitable for exploration with a qualitative research design, ideally in parallel with quantitative twin research in mixed-method research projects or programmes.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice? 杂交系能否打破小鼠行为进化的选择限制？

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1007/s10519-024-10209-7

Layla Hiramatsu, Vincent Careau, Theodore Garland

{"title":"Can a Hybrid Line Break a Selection Limit on Behavioral Evolution in Mice?","authors":"Layla Hiramatsu, Vincent Careau, Theodore Garland","doi":"10.1007/s10519-024-10209-7","DOIUrl":"10.1007/s10519-024-10209-7","url":null,"abstract":"Artificial selection yielded four replicate high runner (HR) lines of mice that reached apparent selection limits (~ threefold increase in wheel revolutions per day vs. four control lines), despite maintenance of additive genetic variance. After 68 generations, we used animal models to test for changes in additive-genetic variances and covariance of the two measured components (average speed and duration) of running distance. We also attempted to break the selection limit by crossing two HR lines, then continuing directional selection on this hybrid line and on the two parental lines for nine generations. The genetic correlation between speed and duration was positive in the base population, but evolved to be negative in the two parental HR lines. Although heritability for both speed and duration (but not distance) increased in the hybrid line, their genetic correlation remained negative. Hybrid F1 mice from generation 68 parents showed heterosis for running distance, which was lost in subsequent generations, and the hybrid line did not exceed the limit. Both male and female hybrids ran faster than parental lines for most generations, but running duration was intermediate or reduced, reflecting their negative genetic correlation. The evolved genetic trade-off between speed and duration may explain the inability for the hybrid line to break the selection limit for distance run, despite renewed additive genetic variance for at least one of its component traits.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"43-58"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Bifactor Twin Modeling to Assess the Genetic and Environmental Dimensionality of Adult ADHD Symptoms. 使用双因子双胞胎模型评估成人多动症症状的遗传和环境维度。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1007/s10519-024-10204-y

Jacob Knyspel, Geneviève Morneau-Vaillancourt, Thalia C Eley

{"title":"Using Bifactor Twin Modeling to Assess the Genetic and Environmental Dimensionality of Adult ADHD Symptoms.","authors":"Jacob Knyspel, Geneviève Morneau-Vaillancourt, Thalia C Eley","doi":"10.1007/s10519-024-10204-y","DOIUrl":"10.1007/s10519-024-10204-y","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is a common and heritable neurodevelopmental condition that has been the subject of a wealth of genetics research. Because ADHD has an early age of onset, most of this work has focused on children, meaning that less is known about the genetics of ADHD in adults. Additionally, while much research has assessed the heritability of ADHD as a general dimension, less has assessed the heritability of individual subtypes (inattention, hyperactivity) or symptoms of ADHD. It therefore remains unclear whether the genetic factors underlying ADHD symptoms conform to a unidimensional or multidimensional structure. The aim of this study was to assess the genetic and environmental dimensionality of adult ADHD symptoms. We analyzed data from 10,454 twins of the Twins Early Development Study, who provided self-reports of ADHD symptoms using the Conners scale at age 21 years. The data conformed well to a psychometric bifactor model, providing support for a general dimension of ADHD in addition to secondary dimensions for inattention and hyperactivity. However, a bifactor independent pathway twin model provided support for a general dimension only at the level of non-shared environmental effects and not additive genetic or shared environmental effects. This suggests that symptoms of ADHD cluster together under a general dimension of non-shared environmental effects, although the two subtypes of ADHD (inattention and hyperactivity) are meaningfully genetically distinct. We found the overall heritability of ADHD to be 40%, comparable with previous estimates for adult ADHD symptoms. Our results provide useful insights into the genetic and environmental architecture of specific ADHD symptoms.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"1-11"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Moderating Influence of School Achievement on Intelligence: A Cross-National Comparison. 学校成绩对智力的调节作用：跨国比较

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-01-01 Epub Date: 2024-11-02 DOI: 10.1007/s10519-024-10203-z

Emilie R Hegelund, Erik Lykke Mortensen, Trine Flensborg-Madsen, Jesper Dammeyer, Kaare Christensen, Matt McGue, Christoph H Klatzka, Frank M Spinath, Wendy Johnson

{"title":"The Moderating Influence of School Achievement on Intelligence: A Cross-National Comparison.","authors":"Emilie R Hegelund, Erik Lykke Mortensen, Trine Flensborg-Madsen, Jesper Dammeyer, Kaare Christensen, Matt McGue, Christoph H Klatzka, Frank M Spinath, Wendy Johnson","doi":"10.1007/s10519-024-10203-z","DOIUrl":"10.1007/s10519-024-10203-z","url":null,"abstract":"Education-related variables are positively associated with intelligence in both causal directions, but little is known about the associations' underlying genetically and environmentally intertwined processes and many 'third variables' are probably involved too. In this study, we investigated how school achievement, measured by grade point average (GPA), moderated intelligence test score variation in young adulthood in broadly representative samples from the U.S. state of Minnesota, Denmark, and Germany, attempting to improve both understanding of the importance of environmental contexts and the limitations of currently available modelling techniques to help remedy them. School achievement was positively associated with intelligence test scores in all three contexts, but it moderated variances differently, even within the two cohorts comprising the Minnesota sample. One Minnesota cohort and the German sample suggested that shared environmental variance was larger among individuals with extreme GPAs, while the Danish sample suggested that this was only true among individuals with low GPAs. In contrast to these observations, the other Minnesota cohort suggested that genetic and non-shared environmental variances were greater among individuals with high GPAs. These observations indicated that underlying individual developmental processes and population-level impacts differed. However, our statistical models did not capture these differences clearly. The ways in which they failed all suggested the model limitations involve an inability to address degrees to which environmental constraints restrain social movements that are confounded with individual variations in capacities to move within society.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"12-28"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Detection of Population Heterogeneity in Causation Between Two Variables: Finite Mixture Modeling of Data Collected from Twin Pairs. 关于检测两个变量之间因果关系的人群异质性：双胞胎数据的有限混合建模。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1007/s10519-024-10207-9

Philip B Vinh, Brad Verhulst, Hermine H M Maes, Conor V Dolan, Michael C Neale

{"title":"On the Detection of Population Heterogeneity in Causation Between Two Variables: Finite Mixture Modeling of Data Collected from Twin Pairs.","authors":"Philip B Vinh, Brad Verhulst, Hermine H M Maes, Conor V Dolan, Michael C Neale","doi":"10.1007/s10519-024-10207-9","DOIUrl":"10.1007/s10519-024-10207-9","url":null,"abstract":"Causal inference is inherently complex and relies on key assumptions that can be difficult to validate. One strong assumption is population homogeneity, which assumes that the causal direction remains consistent across individuals. However, there may be variation in causal directions across subpopulations, leading to potential heterogeneity. In psychiatry, for example, the co-occurrence of disorders such as depression and substance use disorder can arise from multiple sources, including shared genetic or environmental factors (common causes) or direct causal pathways between the disorders. A patient diagnosed with two disorders might have one recognized as primary and the other as secondary, suggesting the existence of different types of comorbidity. For example, in some individuals, depression might lead to substance use, while in others, substance use could lead to depression. We account for potential heterogeneity in causal direction by integrating the Direction of Causation (DoC) model for twin data with finite mixture modeling, which allows for the calculation of individual-level likelihoods for alternate causal directions. Through simulations, we demonstrate the effectiveness of using the Direction of Causation Twin Mixture (mixDoC) model to detect and model heterogeneity due to varying causal directions.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"59-70"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Evolution Induced by Maternal Post-copulatory Factors in Drosophila. 果蝇母体后代因素诱导的实验进化

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1007/s10519-024-10206-w

Ferveur Jean-François, Sanjenbam Pratibha, Fraichard Stéphane, Aruçi Enisa, Neiers Fabrice, Moussian Bernard, Agashe Deepa, Everaerts Claude

{"title":"Experimental Evolution Induced by Maternal Post-copulatory Factors in Drosophila.","authors":"Ferveur Jean-François, Sanjenbam Pratibha, Fraichard Stéphane, Aruçi Enisa, Neiers Fabrice, Moussian Bernard, Agashe Deepa, Everaerts Claude","doi":"10.1007/s10519-024-10206-w","DOIUrl":"10.1007/s10519-024-10206-w","url":null,"abstract":"Experimental evolution is a powerful approach to study the mechanisms underlying the adaptation of selected characters under the conditions chosen in the laboratory. Drosophila melanogaster is a species frequently used to investigate the experimental evolution of characters, especially those related to reproduction. Recent intra-generational studies showed that cis-vaccenyl acetate (cVa), a sex pheromone transferred with bacteria on eggs by females either 1 day (D1) or 5 days (D5) after copulation, differentially affected the behavior and pheromone release in adult males emerging from these eggs. Here, we extended this finding to determine whether this alternative egg exposure repeated over many generations could affect a larger set of reproduction-related characters in both sexes. To test the repetitive effects of maternal D1 or D5 post-copulatory factors, we carried out an experimental selection procedure consisting of exposing eggs during 40 successive generations to D1 or D5 maternal post-copulatory factors. We compared cVa and cuticular pheromones, courtship and mating behaviors, and fecundity at different generations in flies of D1 and D5 lines. Based on findings obtained at earlier generations, we also determined survival, bacterial composition and gene expression in adults. Some of these complex traits significantly diverged between D1 and D5 lines indicating that maternal post-copulatory factors transmitted to eggs can influence adult life history traits.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"29-42"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register. 消极生活事件和表观遗传衰老：荷兰双胞胎登记的研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-12-11 DOI: 10.1007/s10519-024-10211-z

Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Dorret I Boomsma, Jenny van Dongen

{"title":"Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register.","authors":"Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Dorret I Boomsma, Jenny van Dongen","doi":"10.1007/s10519-024-10211-z","DOIUrl":"10.1007/s10519-024-10211-z","url":null,"abstract":"We aimed to understand the long-term impact of negative life events on epigenetic aging in 1783 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of negative life events, including victimization and economic hardship. In population-level analyses, associations between a higher number of negative life events (particularly financial adversities, sexual crimes, and job loss) were seen for the GrimAge biomarker. The association between the number of negative life events and financial problems and epigenetic age acceleration measured by the GrimAge biomarker persisted after adjusting for BMI, smoking, and white blood cell counts. In monozygotic twin pairs discordant for negative life events (263 pairs) the associations were diminished, indicating that the population associations may be confounded by shared familial (genetic and environmental) factors. These findings underscore the intricate link between environmental stressors and biological aging, stressing the need for comprehensive studies considering both genetic and environmental influences.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewers for Volume 54 : The Behavior Genetics journal would like to thank the following reviewers. 第 54 卷审稿人：《行为遗传学》杂志感谢以下审稿人。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-11-04 DOI: 10.1007/s10519-024-10205-x

引用次数: 0

Two Decades of Accomplishment and Progress in Behavior Genetics. 行为遗传学二十年的成就与进步。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2024-11-01 DOI: 10.1007/s10519-024-10200-2

John K Hewitt

引用次数: 0

Correction: Alcohol Use Disorder Polygenic Risk Scores and Trajectories of Early Adolescent Externalizing Behaviors: Examining the Role of Parenting and Family Conflict in the Racially/Ethnically Diverse ABCD Sample. 更正：酒精使用障碍多基因风险评分与青少年早期外化行为轨迹：在种族/族裔多元化的 ABCD 样本中考察养育子女和家庭冲突的作用。

IF 2.6 4区医学