Behavior Genetics最新文献_第2页

Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias. 用扩展谱系模型检测mtDNA效应：统计能力和估计偏差分析。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2025-07-01 Epub Date: 2025-07-16 DOI: 10.1007/s10519-025-10225-1

Xuanyu Lyu, Michael D Hunter, S Alexandra Burt, Rachel Good, Sarah L Carroll, S Mason Garrison

{"title":"Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.","authors":"Xuanyu Lyu, Michael D Hunter, S Alexandra Burt, Rachel Good, Sarah L Carroll, S Mason Garrison","doi":"10.1007/s10519-025-10225-1","DOIUrl":"10.1007/s10519-025-10225-1","url":null,"abstract":"Mitochondrial DNA (mtDNA) plays a crucial role in numerous cellular processes, yet its impact on human complex behavior remains underexplored. The current paper proposes a novel covariance structure model with seven parameters to specifically isolate and quantify mtDNA effects on human complex traits. This approach uses extended pedigrees to obtain estimates of mtDNA variance while controlling for other genetic and environmental influences. Our Monte-Carlo simulations indicate that a sample size of approximately 5,000 individuals is sufficient to detect medium mtDNA effects ([Formula: see text]), while a more substantial cohort of around 30,000 is required for small effects ([Formula: see text]). We show that deeper pedigrees increase power to detect the mtDNA effect while wider pedigrees decrease power, given the equal total sample size. We evaluated how missing kinship records and mtDNA mutations impact bias. Both lead to underestimation of mtDNA variance, and an overestimation of the interaction between nuclear DNA and mtDNA. In addition, the false positive rate of mtDNA effect estimation is low when fitting the model with data generated without mtDNA effects. Collectively, we demonstrate that using extended pedigrees to quantify the influence of mtDNA on human behavior is robust and powerful.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"320-337"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents. 测量未吸毒青少年物质使用障碍的脑形态测量和多基因风险评分之间的关系。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2025-07-01 Epub Date: 2025-07-25 DOI: 10.1007/s10519-025-10227-z

Sydney Kramer, Mei-Hsin Su, Mallory Stephenson, Jill Rabinowitz, Brion Maher, Roxann Roberson-Nay, Luis F S Castro-de-Araujo, Yi Zhou, Michael C Neale, Nathan A Gillespie

{"title":"Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.","authors":"Sydney Kramer, Mei-Hsin Su, Mallory Stephenson, Jill Rabinowitz, Brion Maher, Roxann Roberson-Nay, Luis F S Castro-de-Araujo, Yi Zhou, Michael C Neale, Nathan A Gillespie","doi":"10.1007/s10519-025-10227-z","DOIUrl":"10.1007/s10519-025-10227-z","url":null,"abstract":"Substance use has been associated with differences in adult brain morphology; however, it is unclear whether these differences precede or are a result of substance use substance use. We investigated the impact of polygenic risk scores (PRSs) for cannabis use disorder (CUD) and general substance use and substance use disorder liability (SU/SUD) on brain morphology in drug-naïve adolescents. Baseline data were used from 1874 European-descent participants (ages 9-11) comprising 222, 328 and 387 pairs of MZ twins, DZ twins, and Non-Twin Siblings, respectively, in the Adolescent Brain Cognitive Development Study. We fitted multivariate twin models to estimate the putative effects of CUD, SU/SUD, and brain region-specific PRSs. These models assessed their influence on six subcortical and two cortical phenotypes. PRS for CUD and SU/SUD were created based on GWAS conducted by Johnson et al. (Lancet Psychiatry 7:1032, 2020) and Hatoum et al. (Nat Ment Health 1:210-223, 2023), respectively. When decomposing variance in each brain region of interest (ROI), we used the corresponding ROI-specific PRS. Brain morphometry in drug-naive subjects was unrelated to CUD PRS. The variance explained in each ROI by its corresponding PRS ranged from 0.8 to 4.4%. The SU/SUD PRS showed marginally significant effects (0.2-0.4%) on cortical surface area and nucleus accumbens volume, but overall effect sizes were small. This study failed to reject the null hypothesis of no association between genetic risk for substance use and brain morphometry among baseline drug-naive adolescents. Genetic risk for CUD was not associated with brain morphometry among drug-naive adolescents, but a weak association with general addiction and substance use risk (SU/SUD) particularly in nucleus accumbens volume and total cortical surface area, was observed.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"302-319"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Frequency of Social Media Use, Wellbeing, and Depressive Symptoms: Disentangling Genetic and Environmental Factors. 社交媒体使用频率、幸福感和抑郁症状之间的关系：分离遗传和环境因素。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2025-07-01 Epub Date: 2025-06-21 DOI: 10.1007/s10519-025-10224-2

Selim Sametoğlu, Dirk H M Pelt, Meike Bartels

{"title":"The Association Between Frequency of Social Media Use, Wellbeing, and Depressive Symptoms: Disentangling Genetic and Environmental Factors.","authors":"Selim Sametoğlu, Dirk H M Pelt, Meike Bartels","doi":"10.1007/s10519-025-10224-2","DOIUrl":"10.1007/s10519-025-10224-2","url":null,"abstract":"Meta-analyses report small to moderate effect sizes or inconsistent associations (usually around r = -0.10) between wellbeing (WB) and social media use (SMU) and between anxious-depressive symptoms (ADS) and SMU (also around r = 0.10). This study employs the classical twin design, utilizing data from 6492 individuals from the Netherlands Twin Register, including 3369 MZ twins (893 complete twin pairs, 1583 incomplete twin pairs) and 3123 DZ twins (445 complete, 2233 incomplete) to provide insights into the sources of overlap between WB/ADS and SMU. Both hedonic and eudaimonic WB scales were used. SMU was measured by (1) the time spent on different social media platforms (SMUt), (2) the frequency of posting on social media (SMUf), and (3) the number of social media accounts individuals have (SMUn). Our results confirmed the low phenotypic correlations between WB and SMU (between r = -0.09 and 0.04) as well as between ADS and SMU (between r = 0.07 and 0.10). For SMU, heritability estimates between 32 and 72% were obtained. The small but significant phenotypic correlations between WB/ADS and the SMU phenotypes were mainly determined by genetic factors (in the range of 80-90%). For WB and SMU, genetic correlations were between -0.10 and -0.0, and for ADS and SMU genetic correlations were between 0.10 and 0.23. Genetic correlations implied limited but statistically significant sets of genes that affect WB/ADS and SMU levels. Overall, the results indicate that there is evidence that the small associations between WB/ADS and SMU are partly driven by overlapping genetic influences. We encourage researchers and experts to consider more personalized approaches when considering the association between WB and SMU, as well as understanding the reasons for individuals' observed SMU levels.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"255-269"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raising the Floor? Genetic Influences on Educational Attainment Through the Lens of the Evolving Swedish Welfare State. 提高最低标准？从不断发展的瑞典福利国家看遗传对教育成就的影响》。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-05-01 Epub Date: 2025-03-15 DOI: 10.1007/s10519-025-10219-z

Oskar Pettersson

{"title":"Raising the Floor? Genetic Influences on Educational Attainment Through the Lens of the Evolving Swedish Welfare State.","authors":"Oskar Pettersson","doi":"10.1007/s10519-025-10219-z","DOIUrl":"10.1007/s10519-025-10219-z","url":null,"abstract":"Interest in the role of genetics in influencing key life outcomes such as educational attainment has grown quickly. However, the question of whether genetic influences on educational attainment, on average as well as in conjunction with socioeconomic circumstances, are moderated by macro-level factors has not yet received sufficient attention. This study combines polygenic indices for educational attainment (EA PGI) with high-quality register data in a large sample of Swedish twins of European ancestry born 1920-1999. Employing both conventional between-family and within-family models, the analyses suggest that the influences of education-related genetic propensities on educational attainment have increased in Sweden during the twentieth century, a period featuring major expansions of the Swedish educational system, and decreasing economic inequality. The analyses also suggest that the degree to which socioeconomic background enhances genetic influences on education has decreased across cohorts. Genetic influences on education do not appear to have translated into increased genetic influences on income. Additionally, there is some evidence of floor and ceiling effects in the analyses of dichotomous educational outcomes.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"199-214"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register. 更正：负面生活事件和表观遗传衰老：荷兰双胞胎登记册的研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-05-01 DOI: 10.1007/s10519-025-10221-5

Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Dorret I Boomsma, Jenny van Dongen

引用次数: 0

The Assessment and Heritability of a Brief Measure of Agency. 代理简要测度的评估与遗传力。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-05-01 Epub Date: 2025-03-15 DOI: 10.1007/s10519-025-10220-6

Eleanor J Junkins, D A Briley, Jaime Derringer

{"title":"The Assessment and Heritability of a Brief Measure of Agency.","authors":"Eleanor J Junkins, D A Briley, Jaime Derringer","doi":"10.1007/s10519-025-10220-6","DOIUrl":"10.1007/s10519-025-10220-6","url":null,"abstract":"The interpersonal circumplex describes two major axes of personality that guide much of social behavior. Agency, one half of the interpersonal circumplex, refers to relatively stable behavioral patterns that center on self-focused dominance and assertiveness assessed in terms of goals, values, or personality traits. However, the psychometric overlap between agency and the most closely linked big five dimension, extraversion, is not well-established, and little behavior genetic work has documented evidence concerning the role of genetic and environmental influences on trait agency. We used the Midlife Development in the United States study to examine agency, big five, and generativity with replication and robustness checks (Nnon-twins = 5,194; Ntwins = 1,914; NMilwaukee = 592). Results indicated that agency was higher in men (d = - 0.24), moderately heritable (44.4%), strongly correlated with extraversion (r =.51), moderately correlated with generativity (r =.36), and approximately 41% of the variance in agency was shared with the big five. The current brief measure of agency across two samples reflected smaller gender differences than historical expectations but supported its distinction from the big five traits at the current levels of analysis.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"185-198"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a Greater Understanding of the Role of the Environment: A Systematic Review of Qualitative MZ Twin Differences Studies. 迈向对环境作用的更深入了解：对定性MZ双生子差异研究的系统回顾。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2025-05-01 Epub Date: 2025-02-23 DOI: 10.1007/s10519-025-10217-1

Filip Marzecki, Kennath Widanaralalage, Nandini Bhandoh, Tom A McAdams, Yasmin I Ahmadzadeh, Helena M S Zavos

{"title":"Towards a Greater Understanding of the Role of the Environment: A Systematic Review of Qualitative MZ Twin Differences Studies.","authors":"Filip Marzecki, Kennath Widanaralalage, Nandini Bhandoh, Tom A McAdams, Yasmin I Ahmadzadeh, Helena M S Zavos","doi":"10.1007/s10519-025-10217-1","DOIUrl":"10.1007/s10519-025-10217-1","url":null,"abstract":"The environment is an important influence in the development of human behaviours and health outcomes. However, one of the most consistent findings from behavioural genetic studies is that most environmental influences are not shared between members of the same family. A compelling way of investigating these non-shared environmental influences is by using a monozygotic (MZ) twin differences design. Quantitative MZ differences studies have uncovered systematic non-shared environmental factors, i.e., those acting according to a general pattern in a population, for many traits, but may be omitting idiosyncratic or distinctive factors and mechanisms. Qualitative MZ differences design provides an alternative. In this study design, identical twins discordant on an outcome are interviewed in depth about the origins and context of their discordance, providing an insight into distinctive lived experiences. We conducted a systematic review examining the results and methodological features of studies using qualitative data collection and analyses to investigate differences in identical twins' experiences and outcomes. We applied a narrative synthesis. We identified seven studies, covering a range of phenotypes (e.g., anxiety or smoking) and participants (from children to older adults), which found a wide range of themes related to twins' discordance. A major theme arising from the narrative synthesis was the role of personality and individual traits, e.g., confidence or sexual orientation, in explaining MZ twins' discordant experiences and outcomes. Non-shared environmental factors are at least partly idiosyncratic and are therefore suitable for exploration with a qualitative research design, ideally in parallel with quantitative twin research in mixed-method research projects or programmes.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"153-168"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are Depressive and Anxiety Symptoms Differentially Associated with Alcohol Use Behaviors: Multivariate Behavioral Genetic Analyses. 抑郁和焦虑症状与酒精使用行为有差异吗：多变量行为遗传分析

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1007/s10519-025-10218-0

Tong Chen, Amanda M Ramos, Hermine H M Maes, Jennifer L Maggs, Jenae M Neiderhiser

{"title":"Are Depressive and Anxiety Symptoms Differentially Associated with Alcohol Use Behaviors: Multivariate Behavioral Genetic Analyses.","authors":"Tong Chen, Amanda M Ramos, Hermine H M Maes, Jennifer L Maggs, Jenae M Neiderhiser","doi":"10.1007/s10519-025-10218-0","DOIUrl":"10.1007/s10519-025-10218-0","url":null,"abstract":"This study examined whether adolescent depressive and anxiety symptoms were differentially associated with alcohol use behaviors, and how these associations were explained by genetic, shared, and nonshared environmental influences. Participants were from the Nonshared Environment and Adolescent Development project of same-sex twin/sibling pairs from 720 families. Twin/sibling depressive and anxiety symptoms were measured by self-report at Time 1 (Mage = 13.71 years, range = 9-18 years). Alcohol initiation and alcohol use severity were measured by self-report three years after Time 1 (age range = 12-21 years). Phenotypic Cholesky models were used to estimate the variance of depressive symptoms and the unique variance of anxiety symptoms (independent of depressive symptoms), and how these variances were associated with alcohol initiation and alcohol use severity. Biometric Cholesky models then estimated contributions of genetic, shared and nonshared environmental influences to these variances and covariances. Antisocial behaviors were included in all analyses to account for their associations with depressive symptoms, anxiety symptoms and alcohol use behaviors. Analyses were conducted using the full, the younger half, and the older half of the sample to explore age differences in all associations. Depressive or anxiety symptoms were not associated with alcohol use behaviors after controlling for variance shared with antisocial behaviors, although age-specific analyses suggested some potential effects to explore in future studies for late adolescence. To conclude, longitudinal associations between depressive or anxiety symptoms and alcohol use behaviors during adolescence were mainly driven by the general psychopathology factor shared between internalizing and externalizing problems.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"169-184"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register. 消极生活事件和表观遗传衰老：荷兰双胞胎登记的研究。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.1007/s10519-024-10211-z

Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Dorret I Boomsma, Jenny van Dongen

{"title":"Negative Life Events and Epigenetic Ageing: A Study in the Netherlands Twin Register.","authors":"Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Dorret I Boomsma, Jenny van Dongen","doi":"10.1007/s10519-024-10211-z","DOIUrl":"10.1007/s10519-024-10211-z","url":null,"abstract":"We aimed to understand the long-term impact of negative life events on epigenetic aging in 1783 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of negative life events, including victimization and economic hardship. In population-level analyses, associations between a higher number of negative life events (particularly financial adversities, sexual crimes, and job loss) were seen for the GrimAge biomarker. The association between the number of negative life events and financial problems and epigenetic age acceleration measured by the GrimAge biomarker persisted after adjusting for BMI, smoking, and white blood cell counts. In monozygotic twin pairs discordant for negative life events (263 pairs) the associations were diminished, indicating that the population associations may be confounded by shared familial (genetic and environmental) factors. These findings underscore the intricate link between environmental stressors and biological aging, stressing the need for comprehensive studies considering both genetic and environmental influences.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"215-230"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability. 控制一般认知能力后认知测试的遗传特异性。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.1007/s10519-025-10213-5

Francesca Procopio, Engin Keser, Jacob Knyspel, Margherita Malanchini, Kaili Rimfeld, Robert Plomin

{"title":"The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability.","authors":"Francesca Procopio, Engin Keser, Jacob Knyspel, Margherita Malanchini, Kaili Rimfeld, Robert Plomin","doi":"10.1007/s10519-025-10213-5","DOIUrl":"10.1007/s10519-025-10213-5","url":null,"abstract":"Diverse tests of cognitive abilities correlate about 0.30 phenotypically and about 0.60 genetically. Their phenotypic overlap defines general cognitive ability (g), driven largely by genetic overlap. Consequently, much of our understanding of the genetic landscape of specific cognitive tests likely reflects g rather than the tests themselves. Removing this g-associated genetic variance will sharpen research on cognitive tests. Here, we use Genomic Structural Equation Modelling (Genomic SEM) to remove shared genetic variance among 12 diverse cognitive tests that capture verbal and nonverbal cognitive domains. We applied Genomic SEM to summary statistics from the largest genome-wide association studies of verbal tests (GenLang Consortium, five tests) and largely nonverbal tests (UK Biobank, seven tests) to chart the genetic landscape of the 12 tests independent of g as compared to uncorrected cognitive tests. We found that SNP heritabilities were nearly as high for the tests corrected for g as uncorrected: the average SNP heritability was 0.16 (SE = 0.02) for the uncorrected tests and 0.13 (SE = 0.02) for the tests corrected for g. Despite this, the genetic landscape of the cognitive tests transformed after controlling for genomic g. The matrix of positive genetic correlations for the cognitive tests (average 0.45) disappeared after g-correction, and some strong negative correlations emerged; for instance, Memory and Word (-0.72), Fluid and Symbol (-0.72), and Tower and Spelling (-0.79). The summary statistics for these g-corrected cognitive tests can be used by researchers to create polygenic scores that focus on the specificity of the tests.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"103-113"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0