Behavior Genetics最新文献

{"title":"Reviewers for Volume 56.","authors":"","doi":"10.1007/s10519-026-10291-z","DOIUrl":"https://doi.org/10.1007/s10519-026-10291-z","url":null,"abstract":"","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awards Presented at the 56th Annual Meeting of the Behavior Genetics Association.","authors":"","doi":"10.1007/s10519-026-10288-8","DOIUrl":"https://doi.org/10.1007/s10519-026-10288-8","url":null,"abstract":"","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heritability of Fruit and Vegetable Consumption and Depressive Symptoms in Community-Based Middle-Aged and Older Adults from Four International Twin Cohorts.","authors":"Annabel P Matison, Anbupalam Thalamuthu, Victoria M Flood, Vibeke S Catts, Kaare Christensen, Marianne Nygaard, Nancy L Pedersen, Perminder S Sachdev, Simone Reppermund, Karen A Mather","doi":"10.1007/s10519-026-10284-y","DOIUrl":"https://doi.org/10.1007/s10519-026-10284-y","url":null,"abstract":"<p><p>Fruit and vegetable intakes have been associated with reduced risk of depressive symptoms in observational studies, potentially due to anti-inflammatory properties, micronutrient content, and effects on the gut-brain axis. Understanding the genetic and environmental influences on these intakes may provide insight into factors influencing dietary behaviour. Participants were 5,789 individual twins (aged 45-90 years, 51.8% female; 2,208 monozygotic; 3,581 dizygotic) drawn from four international community-based cohorts. Consumption of fruit and vegetables was self-reported via food frequency questionnaires and depressive symptoms were measured with validated scales. Structural equation models were used to estimate the proportion of variation in intakes and depressive symptoms contributed by genetic and environmental influences, as well as assess genetic and environmental influences shared by fruit and vegetable intakes and depressive symptoms. Reported intakes and depressive symptoms were generally low (fruit 1.1 serves/day IQR 1.5, vegetables 1.7 serves/day IQR 1.3, depressive symptoms median 18 IQR 4 on a scale of 17-49). Heritability was 25% (95% CI 0.16, 0.34) for fruit intake, 17% for vegetable intake (95% CI 0.09, 0.25) and 29% for depressive symptoms (95% CI 0.19, 0.38). No shared environmental influences were detected. A weak-to-moderate positive genetic correlation was found between fruit and vegetable intakes and weak negative genetic correlations between each intake and depressive symptoms. These findings suggest low-to-moderate heritability of fruit and vegetable intakes and depressive symptoms. Shared genetic influences may exist, but do not imply causality. Longitudinal studies, including co-twin control designs, are needed to clarify the direction and nature of these associations.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Patterns of Assortative Mating for Educational, Substance Use, and Anthropometric Traits.","authors":"Gretchen R B Saunders","doi":"10.1007/s10519-026-10285-x","DOIUrl":"https://doi.org/10.1007/s10519-026-10285-x","url":null,"abstract":"<p><p>Assortative mating (AM) shapes population structure and genetic architecture, yet its temporal dynamics remain incompletely understood. Using UK Biobank (UKB) spouse pairs (N = 82,398), full siblings (N = 16,273), and large unrelated samples from the UKB (N = 333,491) and All of Us Research Program (N = 228,875), we examined phenotypic and genetic assortment for eight behavioral, anthropometric, and socioeconomic traits. Spousal phenotypic correlations were substantial, particularly for educational attainment (r_spouse = 0.45), drinks per week (r_spouse = 0.42), smoking cessation (r_spouse = 0.33), and BMI (r_spouse = 0.26), and revealed two broad cross-trait clusters reflecting lifestyle and health/socioeconomic profiles. Spousal polygenic score (PGS) correlations were smaller but robust, with the largest effects for educational attainment (r_spousePGS = 0.16), height (r_spousePGS = 0.08), and smoking initiation (r_spousePGS = 0.06). Sibling PGS correlations exceeded the expected 0.50 for all traits except age at smoking initiation and cigarettes per day, indicating genetic assortment in the parental generation. Even-odd chromosome PGS correlations (θ), measuring within-person cross-chromosome covariance induced by assortative mating, showed consistent genome-wide signatures of AM across cohorts, with θ = 0.07 for educational attainment, θ = 0.04 for height and smoking initiation, and smaller cross-trait θ values that mirrored phenotypic clustering. Birth-year analyses revealed cohort-specific changes: in the UKB, θ increased only for smoking cessation (γ = 0.01), whereas in All of Us we observed increasing θ across birth years for smoking cessation (γ = 0.014), smoking initiation (γ = 0.017), and educational attainment (γ = 0.02). Educational attainment θ remained stable (~ 0.07) across 1930-1970 UKB cohorts but rose from 0.04 in the 1930s to 0.09 by 2000 in All of Us. These findings indicate that genetic AM is pervasive, trait-specific, and, especially for education and some smoking behaviors, increasing across recent U.S. birth cohorts, with implications for how social and genetic variation becomes structured across generations.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.","authors":"Sophie Breunig, Lukas Schaffer, Jeremy Lawrence, Alexander Sheppard, Andrew Grotzinger","doi":"10.1007/s10519-026-10286-w","DOIUrl":"https://doi.org/10.1007/s10519-026-10286-w","url":null,"abstract":"","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of Educational Attainment and Childhood Problem Behavior: Direct Genetic Effects, Cognitive Pathways, and Sex Differences.","authors":"Lyydia Alajääskö, Marina Aguiar-Palma, Abdel Abdellaoui, Titus Galama","doi":"10.1007/s10519-026-10283-z","DOIUrl":"10.1007/s10519-026-10283-z","url":null,"abstract":"<p><p>We examined the genetic underpinnings of problem behavior in children and adolescents (4-17 years old) by leveraging a within-family trio design using data of European ancestry from the Lifelines cohort (N=3,160-4,611). We estimated direct genetic effects of educational attainment (EA) polygenic indices (PGIs), as a whole and decomposed into cognitive (Cog) and non-cognitive (NonCog) components via GWAS-by-subtraction, on a comprehensive set of internalizing and externalizing behaviors assessed via self- and parental report Achenbach System of Empirically Based Assessment (ASEBA) measures. We found that higher EA PGIs, particularly their Cog component, were robustly associated with lower levels of Attention Problems and Somatic Complaints, in parental and self-report samples respectively. These associations persisted after adjusting for parental PGIs, supporting a causal interpretation under counterfactual reasoning. In contrast, the NonCog EA PGI showed weaker and less consistent associations with problem behavior, though we cannot rule out that this reflects limited power to detect smaller effects. We observed pronounced sex differences, with associations largely driven by girls, for whom the Cog component was the primary predictor. In the self-report sample in particular, associations with Somatic Complaints were significantly stronger in girls, with no significant findings observed for boys. We also found that associations with Somatic Complaints were significantly larger in the self-report than the parental report sample, while for other scales, differences across informants were statistically negligible. Our findings contribute to a more holistic understanding of how EA-related genetics manifest in socioemotional processes beyond academic achievement.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral Genetics as a Public Science: Introduction to the Special Issue.","authors":"Evan J Giangrande, Lucas J Matthews","doi":"10.1007/s10519-026-10282-0","DOIUrl":"https://doi.org/10.1007/s10519-026-10282-0","url":null,"abstract":"","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and Environmental Associations Between Depressive Symptomatology and Loneliness in Adulthood.","authors":"Morgan E Lynch, Molly Gonenne, Colin D Freilich, Thalida Em Arpawong, Deborah Finkel, Eric Turkheimer, Christopher R Beam, Deborah W Davis","doi":"10.1007/s10519-026-10280-2","DOIUrl":"10.1007/s10519-026-10280-2","url":null,"abstract":"<p><p>The conceptual and symptom overlap between depression and loneliness is so strong that depressive symptom rating scales often include measures of loneliness, and their linear association ranges between .40 and .68. Despite these findings, few genetically informed studies have investigated the genetic and environmental association between them. We tested the degree to which depressive symptomatology and loneliness are correlated genetically and environmentally, and whether the environmental correlation in men is larger than in women. In this study, we used 428 individual twins (229 MZ twins and 187 DZ twins) from 266 families (139 MZ families and 127 DZ families) from the Louisville Twin Study (M_Age = 48.17; 56% female). Loneliness was measured using the UCLA Loneliness Scale (3 items), and depressive symptomatology was measured using the Center for iologic Studies Depression Scale. Statistical analysis included twin correlations and a correlated factors model. Results indicate that the genetic correlation between loneliness and depressive symptomatology is .47 [.95CI: .16-.78] and the nonshared environmental correlation is .28 [.95CI: .12-.43]. No sex differences were observed. In mid-adulthood, a little less than half of the genetic variance associated with depressive symptomatology is also associated with loneliness. Nonshared environmental factors underlying depressive symptomatology account for approximately 54.4% of the strong association with loneliness, too. These results are similar to bivariate estimates reported in a previous studies of young adulthood, suggesting that across adulthood, the contribution of genetic and non-shared environmental factors to the association between loneliness and depression is constant.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"225-235"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic and Environmental Influences on Caffeine Intake in Korean Twins.","authors":"Minsu Cho, Jiyoung Youn, Moonil Kang, Kyunga Kim, Joohon Sung, Jung Eun Lee","doi":"10.1007/s10519-026-10276-y","DOIUrl":"10.1007/s10519-026-10276-y","url":null,"abstract":"<p><p>Caffeine intake may be influenced by both genetic and environmental factors. This study aimed to examine the genetic contribution to variation in coffee and tea drinking, as well as total caffeine intake. A total of 1,106 Korean twins, comprising 456 monozygotic and 97 dizygotic twin pairs aged 30 years or older, from the Healthy Twin Study were included. Structural equation models were used to assess heritability estimates and their 95% confidence intervals (CIs). Heritability (95% CI) was estimated at 0.29 (0.21, 0.37) for coffee drinking, 0.11 (0.02, 0.20) for tea drinking, and 0.27 (0.16, 0.38) for total caffeine intake, with the remaining variance in each trait attributed to unique environmental factors. The unique environmental factors contributed more substantially to coffee drinking than genetic factors during early adulthood, while the genetic contribution to tea drinking remained consistently low across all ages. In conclusion, coffee drinking, tea drinking, and total caffeine intake were partly heritable, with unique environmental factors playing a predominant role.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"236-243"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Breeding for Voluntary Wheel-Running Behavior in Mice is not Associated with Reduced Lifetime Reproductive Success or Lifespan Under Long-Term Paired Breeding Conditions.","authors":"Natalie N Whitehead, Nicole E Schwartz, Chenkun Jiang, Haley M Read, Natalie C Holt, Theodore Garland","doi":"10.1007/s10519-026-10277-x","DOIUrl":"10.1007/s10519-026-10277-x","url":null,"abstract":"<p><p>We studied lifespan and lifetime reproductive success (LRS) in mice from a selection experiment that includes 4 replicate High Runner (HR) lines bred for voluntary wheel-running behavior and 4 non-selected Control (C) lines. HR mice typically run ~ threefold farther on a daily basis, leading to substantially increased energy expenditure and food consumption, and are also more active and eat more when housed without wheels. HR and C mice have been shown to differ for many other traits that could affect reproduction, including body mass and composition, aerobic capacity, hormonal profile (including corticosterone and leptin), and other behavioral traits (e.g., maternal care, thermoregulatory nesting, anxiety-like behavior in an elevated plus maze). At generation 97, male-female pairs were maintained until end of life in standard cages without wheels, with ad lib food and water. The number of pups weaned (LRS) ranged from 0-80, with a mean of 29.1 ± 8.1 (SE) for C lines and 25.8 ± 4.4 for HR (P = 0.73). Thus, artificial selection for high voluntary exercise did not significantly alter LRS. In addition, we found no statistical difference in average lifespan for dams or sires. However, replicate lines differed significantly for several traits, presumably due primarily to random genetic drift. At the level of individual variation, correlations among reproductive traits and lifespan provided little evidence for negative associations, and LRS was not negatively related to parental longevity. Overall, long-term selection on voluntary locomotor behavior did not produce detectable reductions in reproductive output or lifespan under standard laboratory conditions.</p>","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"259-274"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}