Behavior Genetics最新文献

No Evidence of Genetic Basis to Variation in Human Offspring Sex Ratio. 没有证据表明人类后代性别比例的变异有遗传基础。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-05-05 DOI: 10.1007/s10519-026-10266-0

Kaitlyn T Harper, Ralf Kuja-Halkola, Karin J H Verweij, Patrik K E Magnusson, Brendan P Zietsch

{"title":"No Evidence of Genetic Basis to Variation in Human Offspring Sex Ratio.","authors":"Kaitlyn T Harper, Ralf Kuja-Halkola, Karin J H Verweij, Patrik K E Magnusson, Brendan P Zietsch","doi":"10.1007/s10519-026-10266-0","DOIUrl":"https://doi.org/10.1007/s10519-026-10266-0","url":null,"abstract":"Fisher's principle proposes that the population sex ratio remains approximately equal (around 1:1) through a process of negative frequency-dependent selection. However, large-scale studies show that human offspring sex ratio (OSR) is not heritable in humans, raising doubts about whether Fisher's principle is a valid explanatory framework for human OSR evolution. Song and Zhang recently proposed a mechanism where OSR propensity is genetically influenced but produces an OSR phenotype with negligible observable heritability due to probabilistic sex determination and small family sizes. Here, we conducted an evaluation of this proposal by simulating the proposed mechanism under a broader range of assumptions, revealing that it only produces undetectable OSR heritability under a specific set of parameters. We further explored whether Fisher's principle could operate under such low OSR heritability and found, by reanalysing simulation outcomes, that there is only a very narrow parameter space where Fisher's principle operated and OSR heritability was realistically low. We also make multiple corrections to Song and Zhang's original analyses which weaken their claim. In sum, our assessment is that evidence for a genetic mechanism that yields undetectable OSR heritability, but allows the operation of Fisher's Principle, is weak. The proposed mechanism lacks sufficient evidence to overturn the simpler conclusion that OSR is not heritable in humans, and consequently that Fisher's principle is not a valid explanatory framework for human OSR.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honoring Matt McGue with a Novel Idiographic Behavior Genetics Design. 表彰马特·麦克格的独特行为遗传学设计。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-05-04 DOI: 10.1007/s10519-026-10268-y

S Alexandra Burt

引用次数: 0

Insights into the Cross-Population Transferability of Polygenic Scores for Substance Use. 物质使用多基因评分的跨种群可转移性研究。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-04-29 DOI: 10.1007/s10519-026-10265-1

Gretchen R B Saunders, Scott Vrieze, Dajiang J Liu

{"title":"Insights into the Cross-Population Transferability of Polygenic Scores for Substance Use.","authors":"Gretchen R B Saunders, Scott Vrieze, Dajiang J Liu","doi":"10.1007/s10519-026-10265-1","DOIUrl":"https://doi.org/10.1007/s10519-026-10265-1","url":null,"abstract":"Polygenic scores have potential for predicting health outcomes based on genomic data. However, their portability across diverse populations is hindered by the overrepresentation of European ancestries in discovery genome-wide association (GWAS) studies. The current study evaluated the transferability of substance use polygenic scores across European, African, American, and East Asian populations. European-based scores demonstrated reduced predictive accuracy in non-European populations with mean relative accuracies of 36% in American, 22.5% in East Asian, and 3.8% in African ancestries. Beyond discrete genetic ancestry groups, we found that European-based score prediction declined as a function of genetic distance from the European-stratified GWAS. That is, predictive accuracy declines as genetic distance, derived from continuous measures of ancestry, from the discovery GWAS increases. We evaluated the extent to which differences across populations in linkage disequilibrium (LD), allele frequency, and heritability explained the reduction in accuracy. Across phenotypes we found that approximately 56.0% of accuracy decline in American ancestries was explained by LD and allele frequency differences, with differences in LD appearing to be the primary factor. For East Asian ancestries this was 67.1% and was 84.0% in African ancestries. Differences across populations in heritability accounted for only small portions of reduced polygenic score transferability. This suggests that LD and frequency differences explain significant portions of accuracy loss, but substantial reductions persist, suggesting contributions from other factors like causal effect size differences. The current study provides important information on the causes and extent of the polygenic score transferability problem and has important implications for refinement of polygenic scores. Expanding the diversity of GWAS and target samples remains essential for improving accuracy and equity in prediction.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No Argument with Biology? The Effects of Genetic Explanations for Socioeconomic Outcomes on American and Swedish Citizens' Attitudes Towards Government Intervention. 对生物学没有异议？社会经济结果的遗传解释对美国和瑞典公民对政府干预态度的影响。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-03-10 DOI: 10.1007/s10519-026-10258-0

Oskar Pettersson

{"title":"No Argument with Biology? The Effects of Genetic Explanations for Socioeconomic Outcomes on American and Swedish Citizens' Attitudes Towards Government Intervention.","authors":"Oskar Pettersson","doi":"10.1007/s10519-026-10258-0","DOIUrl":"https://doi.org/10.1007/s10519-026-10258-0","url":null,"abstract":"For half a century, scholars have debated the societal implications of research that suggests genetic explanations for socioeconomic disparities. However, studies of whether and how such genetic explanations affect the attitudes of citizens are surprisingly limited. Using two identical, pre-registered survey experiments fielded in the United States (N=2003) and Sweden (N=2005), this study tests whether a short, twin study-based genetic explanation for income and education differences leads to citizens adopting a lower perceived possibility, as well as a lower perceived fairness, of the government reducing socioeconomic differences. The results do not provide systematic evidence to this effect. Rather, there are indications that citizens increase their belief in the effectiveness, as well as in the fairness of government intervention. Most clearly, the treatment increased citizens' support for a set of redistributive policy proposals, particularly in Sweden. Overall, however, the treatment effects appear to have been limited. This is likely attributable to the experimental manipulation being inadequate in magnitude. This study suggests that genetic explanations for socioeconomic differences do not necessarily have to cause a naturalization of inequality among citizens, but further research on this important topic is needed.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociability is a Multidimensional Trait in Drosophila melanogaster. 社交能力是黑腹果蝇的一种多维特征。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-04-03 DOI: 10.1007/s10519-026-10261-5

Tiphaine P M Bailly, Sanne J C Lamers, Adithya Sarma, Anne C M Jansen, Koen Freerks, Michael van Dijk, Rampal S Etienne, Bregje Wertheim, Jean-Christophe Billeter

{"title":"Sociability is a Multidimensional Trait in Drosophila melanogaster.","authors":"Tiphaine P M Bailly, Sanne J C Lamers, Adithya Sarma, Anne C M Jansen, Koen Freerks, Michael van Dijk, Rampal S Etienne, Bregje Wertheim, Jean-Christophe Billeter","doi":"10.1007/s10519-026-10261-5","DOIUrl":"10.1007/s10519-026-10261-5","url":null,"abstract":"Sociability-the propensity of an individual to engage in group activities-is a trait present in all social species. In humans and many animals, sociability varies between individuals yet remains consistent across contexts, qualifying it as a personality trait. Sociability influences health and physiology, but the mechanisms underlying sociability and its inter-individual variation remain poorly understood. The genetically tractable fruit fly, Drosophila melanogaster, is increasingly used to study social behavior and exhibits a wide range of sociability phenotypes. However, previous studies have relied on distinct behavioral paradigms, limiting cross-context comparisons and motivating a more extensive characterization of sociability in this species. Here, we quantified sociability in D. melanogaster using a multidimensional approach encompassing three paradigms that capture engagement in group activities across contexts: (1) preference for communal versus solitary egg-laying, (2) egg-laying latency in a group, and (3) frequency and duration of spontaneous social interactions and interindividual distance. We assessed these behaviors in 105 lines of the Drosophila Genetic Reference Panel and observed substantial variation in responses to conspecific presence across paradigms. Sociability-related behaviors differed between genetically distinct lines, indicating a genetic component. However, the three sociability traits were uncorrelated, demonstrating that sociability in D. melanogaster is multidimensional. These findings suggest that sociability is not governed by a single central mechanism, but instead arises from multiple context-dependent pathways.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"49-65"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder. 多重多基因评分在预测重度抑郁障碍及其与酒精使用障碍共病的倾向中的作用

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-04-10 DOI: 10.1007/s10519-026-10263-3

Jonathan L Wells, Jill A Rabinowitz, Brion S Maher, Amanda E Gentry, James B Burch, Elizabeth C Prom-Wormley

{"title":"The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.","authors":"Jonathan L Wells, Jill A Rabinowitz, Brion S Maher, Amanda E Gentry, James B Burch, Elizabeth C Prom-Wormley","doi":"10.1007/s10519-026-10263-3","DOIUrl":"10.1007/s10519-026-10263-3","url":null,"abstract":"The inclusion of polygenic scores (PGS) from genetically correlated traits such as Major Depressive Disorder (MDD) and alcohol use disorder (AUD) may improve the prediction of these outcomes and their comorbidity. Despite the importance of this work, few studies have evaluated the efficacy of this possibility. The current study evaluates the use of MDD and AUD PGS individually and together to improve the prediction of MDD, AUD, and comorbid MDD-AUD using a sample of European, African, or Admixed American Ancestry participants from the National Longitudinal Study of Adolescent to Adult Health (N = 7,965). Cross-ancestry MDD and AUD PGS were created using PRS-CSx. The best fitting model of comorbid MDD-AUD in the whole sample included PGS for MDD and AUD (PGSMDD OR: 1.26, 95% CI 1.16-1.35, p = 2.69 × 10- 6; PGSAUD OR: 1.77, 95% CI 1.66-1.87, p = 3.49 × 10- 28), explaining an additional 4.88% of variance compared to a model only including sociodemographic covariates. For MDD, the best fitting model included the MDD PGS (OR: 1.25, 95% CI 1.17-1.33, p = 2.05 × 10- 8), explaining an additional 0.65% of variance. For AUD, the best fitting model included the AUD PGS (OR: 1.37, 95% CI 1.32-1.43, p = 1.25 × 10-28), which explained an additional 1.52% of variance. Inclusion of both PGS did not significantly improve the prediction of individual MDD or AUD. Inclusion of PGS for MDD and AUD significantly improved prediction for comorbid MDD-AUD, but not in MDD or AUD. These results help clarify the role of utilizing genetically correlated PGS in improving prediction of MDD, AUD, and comorbid MDD-AUD.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"80-98"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability and Change in Wellbeing Throughout Adolescence and Its Relationship with Life Events: A Longitudinal Twin Study. 青春期幸福感的稳定性和变化及其与生活事件的关系：一项纵向双胞胎研究。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-04-11 DOI: 10.1007/s10519-026-10262-4

Eirunn Skaug, Trine Waaktaar, Svenn Torgersen

{"title":"Stability and Change in Wellbeing Throughout Adolescence and Its Relationship with Life Events: A Longitudinal Twin Study.","authors":"Eirunn Skaug, Trine Waaktaar, Svenn Torgersen","doi":"10.1007/s10519-026-10262-4","DOIUrl":"10.1007/s10519-026-10262-4","url":null,"abstract":"Wellbeing-the balance of positive and negative affect and life satisfaction-is closely tied to mental health. However, the sources of stability and change and how life events shape wellbeing are not well understood. Data from the Oslo University Adolescent and Young Adult Project (2,879 individuals from 1,483 families) provided wellbeing and life‑event data across three waves ~ 2 years apart (ages 12-18 at Wave 1). We used a trivariate Cholesky decomposition to estimate genetic and environmental contributions to wellbeing, and genetically informative random intercept cross‑lagged panel models (RI‑CLPMs) to test prospective effects of life events on wellbeing. Wellbeing showed moderate stability, predominantly driven by genetic influences (81%). Cross-sectional heritability was about 50% at Waves 1-2 and declined to 26% at Wave 3. Negative life events were correlated with lower wellbeing (concurrent r = - 0.34 to - 0.28; 2-year r = - 0.26 to - 0.19; 4-year r = - 0.22 to - 0.12). However, RI‑CLPMs indicated minimal longitudinal effects of life events on wellbeing after accounting for genetics and trait stability: negative dependent life events explained 1% of change from Wave 1 to Wave 2 and ≈ 0% (non-significant) from Wave 2 to Wave 3. Genetic factors primarily account for stability in wellbeing, while measured life events showed limited prospective influence on wellbeing levels. Future research should combine richer genetically informed longitudinal designs (e.g., measured genotypes and GxE models) and examine biological pathways and person-level processes (e.g., neural and epigenetic mechanisms) to clarify pathways influencing wellbeing and inform interventions.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"99-109"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and Environmental Influences on Singing Self-Evaluation and its Relationship with Singing Ability: An Australian Twin Study. 遗传和环境对歌唱自我评价的影响及其与歌唱能力的关系：一项澳大利亚双胞胎研究。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-03-01 Epub Date: 2026-02-09 DOI: 10.1007/s10519-026-10254-4

Daniel Yeom, Kendall S Stead, Yi Ting Tan, Gary E McPherson, Miriam A Mosing, Sarah J Wilson

{"title":"Genetic and Environmental Influences on Singing Self-Evaluation and its Relationship with Singing Ability: An Australian Twin Study.","authors":"Daniel Yeom, Kendall S Stead, Yi Ting Tan, Gary E McPherson, Miriam A Mosing, Sarah J Wilson","doi":"10.1007/s10519-026-10254-4","DOIUrl":"10.1007/s10519-026-10254-4","url":null,"abstract":"People evaluate their singing ability to varying degrees of accuracy, but why these individual differences occur is largely unknown. Objectively evaluated, everyday singing ability is influenced by both genetic and environmental factors. Since singing self-evaluation (SSE) strongly correlates with everyday singing ability, it is possible that the same factors might influence both. Using a classical twin design, we estimated genetic and environmental influences on SSE and its phenotypic relationship with everyday singing ability in Australian twins (N = 996). Two validated measures of SSE were used: a single self-report item assessing overall singing ability (SSE-Single) and a four-item composite measure (SSE-Factor). Both measures showed significant genetic (SSE-Single A = 42%; SSE-Factor A = 53%) and unshared environmental influences (both E = 29%). Phenotypic correlations between the SSE measures and everyday singing ability ranged from rp = 0.67 - 0.68 and were significantly influenced by genetic, shared and unshared environmental factors (SSE-Single A = 41%, C = 51%, E = 8%; SSE-Factor A = 37%, C = 52%, E = 11%). Strong genetic correlations (rg = 0.63 - 0.64) were observed between SSE measures and everyday singing ability, as well as between both SSE measures (rg = 0.82), suggesting shared underlying genes. Taken together, our findings indicate that both genes and environments affect how individuals evaluate their own singing ability and how accurate these evaluations are compared to their actual ability.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"66-79"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming. 遗传和环境对游戏开始年龄影响的性别差异。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-28 DOI: 10.1007/s10519-026-10253-5

Yubin Kim, Yoon-Mi Hur

{"title":"Sex Differences in Genetic and Environmental Influences on Age at Initiation of Gaming.","authors":"Yubin Kim, Yoon-Mi Hur","doi":"10.1007/s10519-026-10253-5","DOIUrl":"https://doi.org/10.1007/s10519-026-10253-5","url":null,"abstract":"The link between age at initiation of gaming (AAIG) and gaming addiction (GA) is well established, but the genetic and environmental etiology of AAIG remains poorly understood due to the scarcity of genetically informative studies. This study investigated genetic and environmental influences on AAIG using data from 1,394 South Korean adult twins (mean age = 23.0 ± 2.6 years; range = 19 to 30 years). Tetrachoric correlations for AAIG were 0.96 (95% CI = 0.92, 0.98) for monozygotic (MZ) male, 0.84 (95%CI = 0.69, 0.92) for dizygotic (DZ) male, 0.80 (95%CI = 0.73, 0.85) for MZ female, 0.56 (95% CI = 0.38, 0.70) for DZ female, and 0.54 (95% CI = 0.36, 0.68) for opposite-sex DZ twins. Model-fitting analysis incorporating sex differences revealed that shared environmental factors dominated (71%; 95% CI = 39%, 89%), with a smaller but significant genetic component (24%; 95% CI = 6%, 57%) in males, whereas genetic factors played a larger role (59%; 95% CI = 37%, 77%), while shared environmental (21%; 95% CI = 5%, 41%) and non-shared environmental influences (20%; 95% CI = 15%, 27%) were also significant in females. Our findings highlight sex differences in genetic and shared environmental influences in the etiology of AAIG. Effective prevention and intervention strategies for GA should consider genetic vulnerability to AAIG and family exposures, incorporating sex-specific approaches.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public Perception of Genetic Research on Sexual Orientation and Gender Identity. 公众对性取向和性别认同基因研究的认知。

IF 2.2 4区医学

Behavior Genetics Pub Date : 2026-02-28 DOI: 10.1007/s10519-026-10257-1

Briana L Kunstman, Allison M Woosley, Jaime Derringer

{"title":"Public Perception of Genetic Research on Sexual Orientation and Gender Identity.","authors":"Briana L Kunstman, Allison M Woosley, Jaime Derringer","doi":"10.1007/s10519-026-10257-1","DOIUrl":"https://doi.org/10.1007/s10519-026-10257-1","url":null,"abstract":"Genetic research on sexual orientation and gender identity (SOGI) receives disproportionate public attention compared to the limited depth of existing research. However, newer genetically informative datasets include more detailed measures of SOGI than were previously available, establishing the potential for rapid expansion of research in this area. Prior research on the relationship between genetic knowledge and social attitudes related to genetics research suggests the potential to both reduce stigma and reify genetic determinism, highlighting the need to explore stakeholder opinions regarding the impacts of genetics research. We explored public attitudes toward and anticipated risks and benefits of SOGI genetic research. Survey responses from 338 participants were collected via social media. In regression analyses, higher scores on genetic knowledge were related to more negative attitudes toward SOGI genetics research (β = -0.16) and participants who held sexual and/or gender minority (SGM) identities had more negative attitudes toward SOGI genetic research than non-SGM participants (β = -0.17). In qualitative analysis of responses to open-ended questions, participants expressing a diverse range of formal scientific training and political attitudes consistently questioned the usefulness of SOGI genetic research. Ethical concerns were described as unresolvable, both in broad terms and concerning specific applications that are currently plausible, especially related to data privacy and politicizing research results, regardless of the content. We discuss public attitudes toward SOGI genetic research in the context of the broader literature on the social, legal, and ethical implications of behavior genetics research and provide recommendations for planning and communicating SOGI genetics research.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0