Behavior Genetics最新文献_第10页

Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth. ABCD青年社会逆境对外化行为的基因与环境交互效应。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-05-01 Epub Date: 2023-02-16 DOI: 10.1007/s10519-023-10136-z

Genevieve F Dash, Sarah L Karalunas, Emily A Kenyon, Emily K Carter, Michael A Mooney, Joel T Nigg, Sarah W Feldstein Ewing

{"title":"Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth.","authors":"Genevieve F Dash, Sarah L Karalunas, Emily A Kenyon, Emily K Carter, Michael A Mooney, Joel T Nigg, Sarah W Feldstein Ewing","doi":"10.1007/s10519-023-10136-z","DOIUrl":"10.1007/s10519-023-10136-z","url":null,"abstract":"This study tested whether multiple domains of social adversity, including neighborhood opportunity/deprivation and life stress, moderate genetic (A), common environmental (C), and unique environmental (E) influences on externalizing behaviors in 760 same-sex twin pairs (332 monozygotic; 428 dizygotic) ages 10-11 from the ABCD Study. Proportion of C influences on externalizing behavior increased at higher neighborhood adversity (lower overall opportunity). A decreased and C and E increased at lower levels of educational opportunity. A increased at lower health-environment and social-economic opportunity levels. For life stress, A decreased and E increased with number of experienced events. Results for educational opportunity and stressful life experiences suggest a bioecological gene-environment interaction pattern such that environmental influences predominate at higher levels of adversity, whereas limited access to healthcare, housing, and employment stability may potentiate genetic liability for externalizing behavior via a diathesis-stress mechanism. More detailed operationalization of social adversity in gene-environment interaction studies is needed.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 3","pages":"219-231"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heritability Estimation of Cognitive Phenotypes in the ABCD Study^® Using Mixed Models. 使用混合模型的ABCD研究®中认知表型的遗传力估计。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-05-01 Epub Date: 2023-04-07 DOI: 10.1007/s10519-023-10141-2

Diana M Smith, Robert Loughnan, Naomi P Friedman, Pravesh Parekh, Oleksandr Frei, Wesley K Thompson, Ole A Andreassen, Michael Neale, Terry L Jernigan, Anders M Dale

{"title":"Heritability Estimation of Cognitive Phenotypes in the ABCD Study® Using Mixed Models.","authors":"Diana M Smith, Robert Loughnan, Naomi P Friedman, Pravesh Parekh, Oleksandr Frei, Wesley K Thompson, Ole A Andreassen, Michael Neale, Terry L Jernigan, Anders M Dale","doi":"10.1007/s10519-023-10141-2","DOIUrl":"10.1007/s10519-023-10141-2","url":null,"abstract":"Twin and family studies have historically aimed to partition phenotypic variance into components corresponding to additive genetic effects (A), common environment (C), and unique environment (E). Here we present the ACE Model and several extensions in the Adolescent Brain Cognitive Development℠ Study (ABCD Study®), employed using the new Fast Efficient Mixed Effects Analysis (FEMA) package. In the twin sub-sample (n = 924; 462 twin pairs), heritability estimates were similar to those reported by prior studies for height (twin heritability = 0.86) and cognition (twin heritability between 0.00 and 0.61), respectively. Incorporating SNP-derived genetic relatedness and using the full ABCD Study® sample (n = 9,742) led to narrower confidence intervals for all parameter estimates. By leveraging the sparse clustering method used by FEMA to handle genetic relatedness only for participants within families, we were able to take advantage of the diverse distribution of genetic relatedness within the ABCD Study® sample.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 3","pages":"169-188"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9819683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study. 欧洲血统儿童中晚期阿尔茨海默病遗传风险的全表型关联研究 (PheWAS)：ABCD 研究的结果

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-05-01 Epub Date: 2023-04-18 DOI: 10.1007/s10519-023-10140-3

Aaron J Gorelik, Sarah E Paul, Nicole R Karcher, Emma C Johnson, Isha Nagella, Lauren Blaydon, Hailey Modi, Isabella S Hansen, Sarah M C Colbert, David A A Baranger, Sara A Norton, Isaiah Spears, Brian Gordon, Wei Zhang, Patrick L Hill, Thomas F Oltmanns, Janine D Bijsterbosch, Arpana Agrawal, Alexander S Hatoum, Ryan Bogdan

{"title":"A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study.","authors":"Aaron J Gorelik, Sarah E Paul, Nicole R Karcher, Emma C Johnson, Isha Nagella, Lauren Blaydon, Hailey Modi, Isabella S Hansen, Sarah M C Colbert, David A A Baranger, Sara A Norton, Isaiah Spears, Brian Gordon, Wei Zhang, Patrick L Hill, Thomas F Oltmanns, Janine D Bijsterbosch, Arpana Agrawal, Alexander S Hatoum, Ryan Bogdan","doi":"10.1007/s10519-023-10140-3","DOIUrl":"10.1007/s10519-023-10140-3","url":null,"abstract":"Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear. Using data from 5556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®), our phenome-wide association study estimating associations between four indices of genetic risk for late-onset AD (i.e., AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (ADPRS-APOE), and an interaction between ADPRS-APOE and APOE genotype) and 1687 psychosocial, behavioral, and neural phenotypes revealed no significant associations after correction for multiple testing (all ps > 0.0002; all pfdr > 0.07). These data suggest that AD genetic risk may not phenotypically manifest during middle-childhood or that effects are smaller than this sample is powered to detect.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 3","pages":"249-264"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10309061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9728272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Adolescent Pain and Psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study. 青少年脑认知发展 (ABCD) 研究中青少年疼痛与心理病理学之间的关联。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-05-01 Epub Date: 2023-04-10 DOI: 10.1007/s10519-023-10138-x

Lydia Rader, Samantha M Freis, Naomi P Friedman

{"title":"Associations Between Adolescent Pain and Psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.","authors":"Lydia Rader, Samantha M Freis, Naomi P Friedman","doi":"10.1007/s10519-023-10138-x","DOIUrl":"10.1007/s10519-023-10138-x","url":null,"abstract":"Pain and psychopathology co-occur in adolescence, but the directionality and etiology of these associations are unclear. Using the pain questionnaire and the Child Behavior Checklist from the Adolescent Brain Cognitive Development study (n = 10,414 children [770 twin pairs] aged 12-13), we estimated longitudinal, co-twin control, and twin models to evaluate the nature of these associations. In two-wave cross-lag panel models, there were small cross-lag effects that suggested bidirectional associations. However, the co-twin control models suggested that most associations were familial. Pain at age 12 and 13 was mostly environmental (A = 0-12%, C = 15-30%, E = 70-73%) and the twin models suggested that associations with psychopathology were primarily due to shared environmental correlations. The exception was externalizing, which had a phenotypic prospective effect on pain, a significant within-family component, and a non-shared environmental correlation at age 12. Environmental risk factors may play a role in pain-psychopathology co-occurrence. Future studies can examine risk factors such as stressful life events.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 3","pages":"232-248"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10246734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress Disorder and Hippocampal Subregion Volumes in Middle Childhood. 精神分裂症、重度抑郁症和创伤后应激障碍的多基因风险与儿童中期的海马亚区体积。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-05-01 Epub Date: 2023-01-31 DOI: 10.1007/s10519-023-10134-1

Jacob G Pine, Sarah E Paul, Emma Johnson, Ryan Bogdan, Sridhar Kandala, Deanna M Barch

{"title":"Polygenic Risk for Schizophrenia, Major Depression, and Post-traumatic Stress Disorder and Hippocampal Subregion Volumes in Middle Childhood.","authors":"Jacob G Pine, Sarah E Paul, Emma Johnson, Ryan Bogdan, Sridhar Kandala, Deanna M Barch","doi":"10.1007/s10519-023-10134-1","DOIUrl":"10.1007/s10519-023-10134-1","url":null,"abstract":"Studies demonstrate that individuals with diagnoses for Major Depressive Disorder (MDD), Post-traumatic Stress Disorder (PTSD), and Schizophrenia (SCZ) may exhibit smaller hippocampal gray matter relative to otherwise healthy controls, although the effect sizes vary in each disorder. Existing work suggests that hippocampal abnormalities in each disorder may be attributable to genetic liability and/or environmental variables. The following study uses baseline data from the Adolescent Brain and Cognitive Development[Formula: see text] Study (ABCD Study[Formula: see text]) to address three open questions regarding the relationship between genetic risk for each disorder and hippocampal volume reductions: (a) whether polygenic risk scores (PGRS) for MDD, PTSD, and SCZ are related to hippocampal volume; (b) whether PGRS for MDD, PTSD, and SCZ are differentially related to specific hippocampal subregions along the longitudinal axis; and (c) whether the association between PGRS for MDD, PTSD, and SCZ and hippocampal volume is moderated by sex and/or environmental adversity. In short, we did not find associations between PGRS for MDD, PTSD, and SCZ to be significantly related to any hippocampal subregion volumes. Furthermore, neither sex nor enviornmental adversity significantly moderated these associations. Our study provides an important null finding on the relationship genetic risk for MDD, PTSD, and SCZ to measures of hippocampal volume.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 3","pages":"279-291"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9818634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional Causal Associations Between Same-Sex Attraction and Psychological Distress: Testing Moderation and Mediation Effects. 同性吸引力与心理困扰之间的双向因果关系：测试调节和中介效应

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-03-01 Epub Date: 2022-12-15 DOI: 10.1007/s10519-022-10130-x

Olakunle A Oginni, Kai X Lim, Qazi Rahman, Patrick Jern, Thalia C Eley, Frühling V Rijsdijk

{"title":"Bidirectional Causal Associations Between Same-Sex Attraction and Psychological Distress: Testing Moderation and Mediation Effects.","authors":"Olakunle A Oginni, Kai X Lim, Qazi Rahman, Patrick Jern, Thalia C Eley, Frühling V Rijsdijk","doi":"10.1007/s10519-022-10130-x","DOIUrl":"10.1007/s10519-022-10130-x","url":null,"abstract":"Only one study has examined bidirectional causality between sexual minority status (having same-sex attraction) and psychological distress. We combined twin and genomic data from 8700 to 9700 participants in the UK Twins Early Development Study cohort at ≈21 years to replicate and extend these bidirectional causal effects using separate unidirectional Mendelian Randomization-Direction of Causation models. We further modified these models to separately investigate sex differences, moderation by childhood factors (retrospectively-assessed early-life adversity and prospectively-assessed childhood gender nonconformity), and mediation by victimization. All analyses were carried out in OpenMx in R. Same-sex attraction causally influenced psychological distress with significant reverse causation (beta = 0.19 and 0.17; 95% CIs = 0.09, 0.29 and 0.08, 0.25 respectively) and no significant sex differences. The same-sex attraction → psychological distress causal path was partly mediated by victimization (12.5%) while the reverse causal path was attenuated by higher childhood gender nonconformity (moderation coefficient = -0.09, 95% CI: -0.13, -0.04).","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 2","pages":"118-131"},"PeriodicalIF":2.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10732355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating a Century of Research in Behavioral Genetics. 庆祝行为遗传学研究一个世纪。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-03-01 Epub Date: 2023-01-20 DOI: 10.1007/s10519-023-10132-3

Robert Plomin

引用次数: 0

Using the Flanker Task to Examine Genetic and Environmental Contributions in Inhibitory Control Across the Preschool Period. 使用侧卫任务检查遗传和环境在抑制控制在整个学前时期的贡献。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-03-01 DOI: 10.1007/s10519-022-10129-4

I-Tzu Hung, Jody M Ganiban, Kimberly J Saudino

引用次数: 1

Integrative Multi-omics Analysis of Childhood Aggressive Behavior. 儿童攻击行为的综合多组学分析。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-03-01 DOI: 10.1007/s10519-022-10126-7

Fiona A Hagenbeek, Jenny van Dongen, René Pool, Peter J Roetman, Amy C Harms, Jouke Jan Hottenga, Cornelis Kluft, Olivier F Colins, Catharina E M van Beijsterveldt, Vassilios Fanos, Erik A Ehli, Thomas Hankemeier, Robert R J M Vermeiren, Meike Bartels, Sébastien Déjean, Dorret I Boomsma

{"title":"Integrative Multi-omics Analysis of Childhood Aggressive Behavior.","authors":"Fiona A Hagenbeek, Jenny van Dongen, René Pool, Peter J Roetman, Amy C Harms, Jouke Jan Hottenga, Cornelis Kluft, Olivier F Colins, Catharina E M van Beijsterveldt, Vassilios Fanos, Erik A Ehli, Thomas Hankemeier, Robert R J M Vermeiren, Meike Bartels, Sébastien Déjean, Dorret I Boomsma","doi":"10.1007/s10519-022-10126-7","DOIUrl":"https://doi.org/10.1007/s10519-022-10126-7","url":null,"abstract":"This study introduces and illustrates the potential of an integrated multi-omics approach in investigating the underlying biology of complex traits such as childhood aggressive behavior. In 645 twins (cases = 42%), we trained single- and integrative multi-omics models to identify biomarkers for subclinical aggression and investigated the connections among these biomarkers. Our data comprised transmitted and two non-transmitted polygenic scores (PGSs) for 15 traits, 78,772 CpGs, and 90 metabolites. The single-omics models selected 31 PGSs, 1614 CpGs, and 90 metabolites, and the multi-omics model comprised 44 PGSs, 746 CpGs, and 90 metabolites. The predictive accuracy for these models in the test (N = 277, cases = 42%) and independent clinical data (N = 142, cases = 45%) ranged from 43 to 57%. We observed strong connections between DNA methylation, amino acids, and parental non-transmitted PGSs for ADHD, Autism Spectrum Disorder, intelligence, smoking initiation, and self-reported health. Aggression-related omics traits link to known and novel risk factors, including inflammation, carcinogens, and smoking.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"53 2","pages":"101-117"},"PeriodicalIF":2.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10790893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A General Cognitive Ability Factor for the UK Biobank. 英国生物银行的一般认知能力因子。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2023-03-01 Epub Date: 2022-11-15 DOI: 10.1007/s10519-022-10127-6

Camille Michèle Williams, Ghislaine Labouret, Tobias Wolfram, Hugo Peyre, Franck Ramus

引用次数: 0