Behavior Genetics最新文献_第10页

Correction to: Investigating the Causal risk Factors for self-harm by Integrating Mendelian Randomisation Within twin Modelling. 修正:通过在双胞胎模型中整合孟德尔随机化来调查自我伤害的因果风险因素。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-11-01 DOI: 10.1007/s10519-022-10117-8

Kai Xiang Lim, Olakunle Ayokunmi Oginni, Kaili Rimfeld, Jean-Baptiste Pingault, Frühling Rijsdijk

引用次数: 0

Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample. 探索当代跨祖先美国样本中自合子、教育程度和认知能力之间的关系。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-11-01 Epub Date: 2022-09-28 DOI: 10.1007/s10519-022-10113-y

Sarah Mc Colbert, Matthew C Keller, Arpana Agrawal, Emma C Johnson

{"title":"Exploring the Relationships Between Autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-Ancestral American Sample.","authors":"Sarah Mc Colbert, Matthew C Keller, Arpana Agrawal, Emma C Johnson","doi":"10.1007/s10519-022-10113-y","DOIUrl":"10.1007/s10519-022-10113-y","url":null,"abstract":"Previous studies have found significant associations between estimated autozygosity - the proportion of an individual's genome contained in homozygous segments due to distant inbreeding - and multiple traits, including educational attainment (EA) and cognitive ability. In one study, estimated autozygosity showed a stronger association with parental EA than the subject's own EA. This was likely driven by parental EA's association with mobility: more educated parents tended to migrate further from their hometown, and because of the strong correlation between ancestry and geography in the Netherlands, these individuals chose partners farther from their ancestry and therefore more different from them genetically. We examined the associations between estimated autozygosity, cognitive ability, and parental EA in a contemporary sub-sample of adolescents from the Adolescent Brain Cognitive Development Study℠ (ABCD Study®) (analytic N = 6,504). We found a negative association between autozygosity and child cognitive ability consistent with previous studies, while the associations between autozygosity and parental EA were in the expected direction of effect (with greater levels of autozygosity being associated with lower EA) but the effect sizes were significantly weaker than those estimated in previous work. We also found a lower mean level of autozygosity in the ABCD sample compared to previous autozygosity studies, which may reflect overall decreasing levels of autozygosity over generations. Variation in spousal similarities in ancestral background in the ABCD study compared to other studies may explain the pattern of associations between estimated autozygosity, EA, and cognitive ability in the current study.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"315-323"},"PeriodicalIF":2.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40380019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling. 通过在双胞胎模型中整合孟德尔随机化来调查自我伤害的因果风险因素。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-11-01 Epub Date: 2022-09-14 DOI: 10.1007/s10519-022-10114-x

Kai Xiang Lim, Olakunle Ayokunmi Oginni, Kaili Rimfeld, Jean-Baptiste Pingault, Frühling Rijsdijk

{"title":"Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling.","authors":"Kai Xiang Lim, Olakunle Ayokunmi Oginni, Kaili Rimfeld, Jean-Baptiste Pingault, Frühling Rijsdijk","doi":"10.1007/s10519-022-10114-x","DOIUrl":"https://doi.org/10.1007/s10519-022-10114-x","url":null,"abstract":"Previous genetically informed studies have uncovered likely causal relationships between mental health problems and self-harm but resulting causal estimates may be biased due to unmediated pleiotropy. By fitting Mendelian Randomization - Direction of Causation (MR-DoC) models that explicitly model pleiotropy, we investigated the effect of four quantitatively measured mental health problems - major depressive disorder (MDD), schizophrenia, attention-deficit hyperactivity disorder (ADHD), and insomnia, on non-suicidal self-harm (NSSH) and suicidal self-harm (SSH), separately. We used data of 12,723 twins (56.6% females) in the Twins Early Development Study. Besides substantial pleiotropy, we found effects from child-rated depressive symptoms to both NSSH (β = 0.194, 95% CIs: 0.131, 0.257) and SSH (β = 0.210, 95% CIs: 0.125, 0.295). Similarly, effects flowed from parent-rated depressive symptoms to NSSH (β = 0.092, 95% CIs: 0.004, 0.181) and SSH (β = 0.165, 95% CIs: 0.051, 0.281). We did not find evidence of aetiological difference between NSSH and SSH.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":" ","pages":"324-337"},"PeriodicalIF":2.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40354928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Minutes of the Annual Business Meeting of the Members of the BEHAVIOR GENETICS ASSOCIATION 行为遗传学协会会员年度业务会议纪要

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-10-26 DOI: 10.1007/s10519-022-10121-y

引用次数: 0

Awards Presented at the 52nd Annual Meeting of the Behavior Genetics Association June 25 2022 2022年6月25日在行为遗传学协会第52届年会上颁发的奖项

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-10-26 DOI: 10.1007/s10519-022-10120-z

引用次数: 0

Behavior Genetics Association 52st Annual Meeting Abstracts. 行为遗传学协会第 52 届年会摘要。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-10-21 DOI: 10.1007/s10519-022-10119-6

引用次数: 0

Announcement of the Fulker Award for a Paper Published in Behavior Genetics, Volume 51, 2021 公告富尔克奖发表在行为遗传学，第51卷，2021年的一篇论文

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-10-01 DOI: 10.1007/s10519-022-10115-w

Jared V. Balbona, Yongkang Kim, Matt Keller, J. Hewitt

引用次数: 0

Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation. 主成分分析减少了多基因分数效应大小估计中的对撞机偏差。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-09-01 Epub Date: 2022-06-08 DOI: 10.1007/s10519-022-10104-z

Nathaniel S Thomas, Peter Barr, Fazil Aliev, Mallory Stephenson, Sally I-Chun Kuo, Grace Chan, Danielle M Dick, Howard J Edenberg, Victor Hesselbrock, Chella Kamarajan, Samuel Kuperman, Jessica E Salvatore

{"title":"Principal Component Analysis Reduces Collider Bias in Polygenic Score Effect Size Estimation.","authors":"Nathaniel S Thomas, Peter Barr, Fazil Aliev, Mallory Stephenson, Sally I-Chun Kuo, Grace Chan, Danielle M Dick, Howard J Edenberg, Victor Hesselbrock, Chella Kamarajan, Samuel Kuperman, Jessica E Salvatore","doi":"10.1007/s10519-022-10104-z","DOIUrl":"10.1007/s10519-022-10104-z","url":null,"abstract":"In this study, we test principal component analysis (PCA) of measured confounders as a method to reduce collider bias in polygenic association models. We present results from simulations and application of the method in the Collaborative Study of the Genetics of Alcoholism (COGA) sample with a polygenic score for alcohol problems, DSM-5 alcohol use disorder as the target phenotype, and two collider variables: tobacco use and educational attainment. Simulation results suggest that assumptions regarding the correlation structure and availability of measured confounders are complementary, such that meeting one assumption relaxes the other. Application of the method in COGA shows that PC covariates reduce collider bias when tobacco use is used as the collider variable. Application of this method may improve PRS effect size estimation in some cases by reducing the effect of collider bias, making efficient use of data resources that are available in many studies.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"52 4-5","pages":"268-280"},"PeriodicalIF":2.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103419/pdf/nihms-1884763.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Capital Mediates Natural Selection in Contemporary Humans. 人力资本对当代人类自然选择的中介作用。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-09-01 Epub Date: 2022-07-06 DOI: 10.1007/s10519-022-10107-w

David Hugh-Jones, Abdel Abdellaoui

{"title":"Human Capital Mediates Natural Selection in Contemporary Humans.","authors":"David Hugh-Jones, Abdel Abdellaoui","doi":"10.1007/s10519-022-10107-w","DOIUrl":"10.1007/s10519-022-10107-w","url":null,"abstract":"Natural selection has been documented in contemporary humans, but little is known about the mechanisms behind it. We test for natural selection through the association between 33 polygenic scores and fertility, across two generations, using data from UK Biobank (N = 409,629 British subjects with European ancestry). Consistently over time, polygenic scores that predict higher earnings, education and health also predict lower fertility. Selection effects are concentrated among lower SES groups, younger parents, people with more lifetime sexual partners, and people not living with a partner. The direction of natural selection is reversed among older parents, or after controlling for age at first live birth. These patterns are in line with the economic theory of fertility, in which earnings-increasing human capital may either increase or decrease fertility via income and substitution effects in the labour market. Studying natural selection can help us understand the genetic architecture of health outcomes: we find evidence in modern day Great Britain for multiple natural selection pressures that vary between subgroups in the direction and strength of their effects, that are strongly related to the socio-economic system, and that may contribute to health inequalities across income groups.","PeriodicalId":8715,"journal":{"name":"Behavior Genetics","volume":"52 4-5","pages":"205-234"},"PeriodicalIF":2.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Human Capital Mediates Natural Selection in Contemporary Humans. 更正:人力资本在当代人类中调节自然选择。

IF 2.6 4区医学

Behavior Genetics Pub Date : 2022-09-01 DOI: 10.1007/s10519-022-10110-1

David Hugh-Jones, Abdel Abdellaoui

引用次数: 0