英国生物银行的一般认知能力因子。

IF 2.6 4区医学 Q2 BEHAVIORAL SCIENCES

Behavior Genetics Pub Date : 2023-03-01 DOI:10.1007/s10519-022-10127-6

Camille Michèle Williams, Ghislaine Labouret, Tobias Wolfram, Hugo Peyre, Franck Ramus

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引用次数: 4

摘要

英国生物银行的参与者没有高质量的智力测量或智力多基因评分(pgs)来同时检查智力的遗传和神经基础。我们创建了一种相对于英国人口的通用智力(g因子)的标准化测量方法，并估计了其质量。在对UK Biobank参与者(N = 187,288)运行g因子质量良好且没有神经影像学数据的GWAS (N = 187,288)后，我们导出了具有神经影像学数据的UK Biobank参与者的ggs。对于至少进行过一次认知测试的个体，来自8次认知测试的g因子(N = 501,650)解释了29%的认知测试表现差异。具有神经成像数据的英国个体的PGS (N = 27174)解释了7.6%的g方差。我们为大多数英国生物样本库参与者提供了高质量的g因子估计，并为具有神经成像数据的英国生物样本库参与者提供了g因子PGS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A General Cognitive Ability Factor for the UK Biobank.

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A General Cognitive Ability Factor for the UK Biobank.

UK Biobank participants do not have a high-quality measure of intelligence or polygenic scores (PGSs) of intelligence to simultaneously examine the genetic and neural underpinnings of intelligence. We created a standardized measure of general intelligence (g factor) relative to the UK population and estimated its quality. After running a GWAS of g on UK Biobank participants with a g factor of good quality and without neuroimaging data (N = 187,288), we derived a g PGS for UK Biobank participants with neuroimaging data. For individuals with at least one cognitive test, the g factor from eight cognitive tests (N = 501,650) explained 29% of the variance in cognitive test performance. The PGS for British individuals with neuroimaging data (N = 27,174) explained 7.6% of the variance in g. We provided high-quality g factor estimates for most UK Biobank participants and g factor PGSs for UK Biobank participants with neuroimaging data.

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来源期刊

Behavior Genetics 生物-行为科学

CiteScore

4.90

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavior Genetics - the leading journal concerned with the genetic analysis of complex traits - is published in cooperation with the Behavior Genetics Association. This timely journal disseminates the most current original research on the inheritance and evolution of behavioral characteristics in man and other species. Contributions from eminent international researchers focus on both the application of various genetic perspectives to the study of behavioral characteristics and the influence of behavioral differences on the genetic structure of populations.