Avicenna Journal of Phytomedicine最新文献_第8页

Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study. 多菌株伊朗原生益生菌混合物对醋酸铅诱导的雄性大鼠肾脏毒性的保护作用：一项综合生化、分子和组织病理学研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24261

Mohsen Akbaribazm, Zahra Abdol Al Amir Mohammad Javad, Seyed Naser Alavi, Zahra Keshtmand

{"title":"Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study.","authors":"Mohsen Akbaribazm, Zahra Abdol Al Amir Mohammad Javad, Seyed Naser Alavi, Zahra Keshtmand","doi":"10.22038/AJP.2024.24261","DOIUrl":"https://doi.org/10.22038/AJP.2024.24261","url":null,"abstract":"Objective: In this study, the protective effects of native Iranian probiotics (Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus holoticus) on lead acetate (PbAc)-induced toxicity in the kidney of male rats were investigated using biochemical, molecular and histopathological approaches.Materials and methods: Twenty-one male Wistar rats were divided into three groups (n=7/group), including controls, PbAc recipient (10 mg/kg) and PbAc recipient (10 mg/kg) + probiotic mixture (109 CFU). PbAc and probiotics were gavage in the groups. On the 31st day, blood samples were used to measure serum concentrations of creatinine (Cr), blood urea nitrogen (BUN), sodium, total protein and potassium. Rats were dissected and renal tissues apoptotic and inflammatory genes were evaluated.Results: PbAc increased serum concentrations of Cr, sodium, and urea, and decreased total protein and potassium, while it enhanced interleukine-6 (IL-6) and tumor necrosis factor -α (TNF- α) gene expression in kidney tissue compared to the control group. Probiotic mixture decreased Cr, BUN, and malondialdehyde and increased activity of catalase and superoxide dismutase enzymes in kidney tissue.Conclusion: The results of the study showed that the native Iranian probiotics mixture can be used to protect the function and structure of the kidneys against toxic and oxidative damage induced by PbAc.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"632-664"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melissa officinalis extract improved high-fat-diet-induced anxiety-like behaviors, depression, and memory impairment by regulation of serum BDNF levels in rats. Melissa officinalis提取物通过调节大鼠血清BDNF水平改善高脂肪饮食诱导的焦虑样行为、抑郁和记忆障碍。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24343

Kazem Hatami, Majid Hassanpourezatti, Mohsen Khalili

{"title":"Melissa officinalis extract improved high-fat-diet-induced anxiety-like behaviors, depression, and memory impairment by regulation of serum BDNF levels in rats.","authors":"Kazem Hatami, Majid Hassanpourezatti, Mohsen Khalili","doi":"10.22038/AJP.2024.24343","DOIUrl":"https://doi.org/10.22038/AJP.2024.24343","url":null,"abstract":"Objective: Melissa officinalis (MO) hydroalcoholic extract has shown neuroprotective effects. We assess the possible therapeutic effects of Melissa officinalis extract (MOE) on blood biochemical and Brain-Derived Neurotrophic Factor (BDNF) levels as well as neurobehavioral consequences of high-fat-diet (HFD)-induced obese rats.Materials and methods: Eighty male Wistar rats weighing between 180 and 220 g were divided into two groups at the beginning of the experiment and fed with normal diet (ND) or HFD for 5 weeks. Then, each group was divided into four subgroups (10 rats in each group) and treated daily with MOE (50, 100, 150 mg/kg, intraperitoneal) or vehicle for another two weeks. At the end of the experiments, fasting blood glucose (FBG), blood lipid profile, and serum brain-derived neurotrophic factor (BDNF) levels were measured. The sucrose preference test (anhedonia and depression), open field test (locomotor), elevated plus maze (anxiety), Y-maze (working memory), and Morris water maze test (spatial memory) were done.Results: Feeding with HFD for 7 weeks caused obesity, anhedonia, anxiety, depression and learning and memory disorders in rats and a decrease in serum BDNF level. Administration of MOE at 100 or 150 mg/kg to HFD-fed rats decreased weight gain, FBG, and serum levels of total low-density lipoprotein cholesterol and increased serum BDNF levels. It also improved changes in locomotor activity, anxiety, depression, and learning and memory in HFD-fed rats.Conclusion: The results show that MOE has a therapeutic effect on model rats with HFD-induced metabolic and neurobehavioral abnormalities through regulation of BDNF secretion.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"617-631"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of Foeniculum vulgare fruit and Echium amoenum flower combination on the severity of physical and psychological symptoms of premenstrual syndrome. 小茴香果与菊苣花组合对经前综合征生理和心理症状严重程度的影响评价。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24208

Simin Sadat Motevalli Haghi, Amirhossein Sahebkar, Jamshid Jamali, Roshanak Salari, Maliheh Motavasselian

{"title":"Evaluation of the effect of Foeniculum vulgare fruit and Echium amoenum flower combination on the severity of physical and psychological symptoms of premenstrual syndrome.","authors":"Simin Sadat Motevalli Haghi, Amirhossein Sahebkar, Jamshid Jamali, Roshanak Salari, Maliheh Motavasselian","doi":"10.22038/AJP.2024.24208","DOIUrl":"https://doi.org/10.22038/AJP.2024.24208","url":null,"abstract":"Objective: Echium amoenum (EA) and Foeniculum vulgare (FV) might be beneficial for the management of Premenstrual syndrome (PMS) due to their possible effects on sex hormones and neurotransmitters such as serotonin. This study aimed to investigate the effect of a combination of Echium and Fennel on the severity of physical and psychological symptoms of PMS.Materials and methods: This triple-blinded, randomized, controlled trial was conducted on 80 women. The subjects were assigned to two groups of intervention (receiving EA 2 g/day and FV 1 g/day, in the second two weeks of the cycle, in two consecutive cycles) and placebo control. The data collection tools included the PSST, DRSP, and SF36 questionnaires.Results: Between-group differences in all subscales of DRSP were significant at one- and two-month time points (p<0.05). Bleeding volume was significantly increased in the intervention group, compared to the placebo group, two months after the intervention (p<0.05). Between-group comparison of the changes demonstrated significant differences in all subscales of SF36, except for limitations in usual role activities due to emotional problems (p=0.07).Conclusion: Consumption of EA and FV combination improved the quality of life in women with PMS and exerted favorable changes in PMS symptoms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"570-584"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heracleum persicum L. extract protects gentamicin-induced testicular toxicity. 仙桃提取物对庆大霉素致睾丸毒性的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24347

Elnaz Khordad, Mohsen Akbaribazm, Seyed Moein Hosseini

{"title":"Heracleum persicum L. extract protects gentamicin-induced testicular toxicity.","authors":"Elnaz Khordad, Mohsen Akbaribazm, Seyed Moein Hosseini","doi":"10.22038/AJP.2024.24347","DOIUrl":"https://doi.org/10.22038/AJP.2024.24347","url":null,"abstract":"Objective: The objective of this study was to assess the protective effects of Heracleum persicum L. leaves extract (HPE) against oxidative damage induced by gentamicin (GM) in the testes of rats through biochemical, histopathological, and immunohistochemical approaches.Materials and methods: Thirty-six male Wistar rats were divided into six groups (n=6/group) for 50 days. On day 51, the study assessed serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (TT), as well as antioxidant enzyme activity, nitric oxide levels, and various parameters related to testicular tissue (including the ferric reducing ability of plasma (FRAP), thiol, and thiobarbituric acid reactive substances (TBARS) levels). The stereological indices of seminiferous tubules were measured using serial sections of testicular tissue stained with hematoxylin and eosin, while the apoptosis rate of testicular parenchymal cells (p53, Caspase-3, and Bcl-2 positive cells) was also determined.Results: In the groups treated with HPE, particularly at 750 mg/kg, there was a significant increase (p<0.05) in LH, FSH, and TT hormone levels, an enhanced serum antioxidant enzyme activity and significantly reduced (p<0.05) nitric oxide levels. HPE inhibited the apoptotic pathway involving Bax/p53/Caspase-3 (significantly decreased (p<0.05) all three genes), thereby preserving the structure and function of the testicular tissue. Consequently, the number of p53 and Caspase-3 positive testicular cells decreased significantly (p<0.05), while the number of Bcl-2 positive cells increased.Conclusion: HPE demonstrated potential in protecting the function and structure of testis against toxic and oxidative damages.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"585-599"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Nigella sativa on dexamethasone-induced testicular toxicity in mice. 黑皮草对地塞米松致小鼠睾丸毒性的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2023.23584

Morteza Abouzaripour, Erfan Daneshi, Saeid Miri

{"title":"Effect of Nigella sativa on dexamethasone-induced testicular toxicity in mice.","authors":"Morteza Abouzaripour, Erfan Daneshi, Saeid Miri","doi":"10.22038/AJP.2023.23584","DOIUrl":"https://doi.org/10.22038/AJP.2023.23584","url":null,"abstract":"Objective: The aim of the current study was to assess the effects of Nigella sativa essential oil on testicular toxicity in mice induced by dexamethasone.Materials and methods: Forty NMRI mice were randomly divided into four groups. The first group (Sham) received 1 ml per day of normal saline by intraperitoneal (i.p.) injection for 7 days. The second group (Control) received (i.p) injection of 5 mg/kg dexamethasone for 7 days. The third group (Dexa+ N.S 5 mg/kg) received dexamethasone (5 mg/kg) and gavaged 5 mg/kg N. sativa essential oil for 7 days. The fourth group (N.S 5 mg/kg) for 7 days was gavaged 5 mg/kg N. sativa. Histopathology of testis, spermatogenesis, and sperm fertility rate were assessed.Results: The results of histopathology assessments showed that in the third group, all histopathology criteria were decreased compared to the second group. The number of seminiferous tubules that had abnormal spermatogenesis in Johnsen's score was slightly decreased in the third group compared to the second group. Furthermore, in the third group, embryo formation criteria were increased.Conclusion: The data of this research demonstrate that N. sativa improves spermatogenesis defects and sperm fertility in mice treated with dexamethasone.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"520-526"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual screening of natural products as potential inhibitors of SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp) and Spike Protein: Database design, molecular docking and molecular dynamic study. SARS-CoV-2主要蛋白酶、RNA依赖性RNA聚合酶（RdRp）和刺突蛋白潜在抑制剂天然产物的虚拟筛选：数据库设计、分子对接和分子动力学研究

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24271

Motahareh Boozari, Zeinab Amiri Tehranizadeh, Hossein Hosseinzadeh

{"title":"Virtual screening of natural products as potential inhibitors of SARS-CoV-2 main protease, RNA-dependent RNA polymerase (RdRp) and Spike Protein: Database design, molecular docking and molecular dynamic study.","authors":"Motahareh Boozari, Zeinab Amiri Tehranizadeh, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24271","DOIUrl":"https://doi.org/10.22038/AJP.2024.24271","url":null,"abstract":"Objective: COVID-19 is caused by the SARS-CoV-2 virus. In this study, around 300 herbal compounds were screened virtually to find the best anti-COVID-19 structures.Materials and methods: An extensive search in electronic databases was done. Around 300 herbal compounds, which were previously proven to be antiviral structures, were extracted from articles and considered our primary database. Then, molecular docking studies were performed to find the best inhibitors of the main SARS-COV-2 proteins, including spike protein (PDB 7BWJ), RNA-dependent RNA polymerase (PDB 6M71) and main protease (PDB 5R7Z).Results: The molecular docking and dynamics studies revealed that fangchinoline as an alkaloid could bind to the main protease of the virus more potent than lopinavir (-42.26 vs. -30.9 kJ/mol). Fangchinoline can be orally active based on drug-like properties. According to the molecular dynamic study, the complex between the fangchinoline and SARS-CoV-2 main protease is stable. chebulagic acid is a benzopyrene tannin that could inhibit RNA-dependent RNA polymerase (RdRp) better than remdesivir (-43.9 vs. -28.8 kJ/mol). The molecular dynamic study showed that chebulagic acid-RdRp interaction is stable and strong. Furthermore, suramin could neutralize different variants of COVID-19 spike proteins (wild type, and alpha and beta variants). However, suramin is not orally active but it is a potential inhibitor for different coronavirus spike proteins.Conclusion: According to the promising in silico results of this study, fangchinoline, chebulagic acid and suramin could be introduced as potential lead compounds for COVID-19 treatment. We are hopeful to find a reliable remedy shortly through natural compounds.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"600-616"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial. 芦荟补充剂可改善血液透析患者的心血管风险因素：一项随机、双盲、安慰剂对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-07-01 DOI: 10.22038/AJP.2023.23447

Akram Kooshki, Mohammad Reza Memarzadeh, Mohammad Hassan Rakhshani, Roya Akbarzadeh, Tahereh Tofighiyan, Elaheh Foroumandi

{"title":"Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial.","authors":"Akram Kooshki, Mohammad Reza Memarzadeh, Mohammad Hassan Rakhshani, Roya Akbarzadeh, Tahereh Tofighiyan, Elaheh Foroumandi","doi":"10.22038/AJP.2023.23447","DOIUrl":"10.22038/AJP.2023.23447","url":null,"abstract":"Objective: This study assessed the effects of Aloe vera supplementation on serum inflammatory factors, blood sugar and lipid profiles in hemodialysis patients.Materials and methods: Totally, 50 hemodialysis patients were allocated randomly to either Aloe vera or placebo groups. The Aloe vera group received 2 Aloe vera capsules daily for 8 weeks (500 mg/day). Serum C-reactive protein (hs- CRP), Fasting blood glucose (FBS), and lipid profiles levels were evaluated at the baseline and the end of the eighth week.Results: Aloe vera supplementation for 8 weeks was associated with a significant reduction of serum hs- CRP (p=0.004), total cholesterol (p=0.01), low density lipoprotein (LDL) (p=0.02) leves and increased high density lipoprotein (HDL) (p=0.002) concentration in the hemodialysis patients.Conclusion: Aloe vera supplementation is beneficial in improvement of cardiovascular risk factors in hemodialysis patients.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 4","pages":"422-430"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in vitro antiviral evaluation of punicalagin toward influenza A virus. 针对甲型流感病毒的体外抗病毒评估。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-07-01 DOI: 10.22038/AJP.2023.23389

Fatemeh Javadi-Farsani, Ali Karimi, Hadi Razavi Nikoo, Mohammad-Taghi Moradi, Alijan Tabarraei

{"title":"An in vitro antiviral evaluation of punicalagin toward influenza A virus.","authors":"Fatemeh Javadi-Farsani, Ali Karimi, Hadi Razavi Nikoo, Mohammad-Taghi Moradi, Alijan Tabarraei","doi":"10.22038/AJP.2023.23389","DOIUrl":"10.22038/AJP.2023.23389","url":null,"abstract":"Objective: Influenza complications are mild to serious, and can cause death in some cases. A great deal of attention has been paid in recent years to the development and use of new antiviral compounds to overcome drug resistance in certain strains of the influenza virus and treat the clinical implications. This study aimed to investigate the antiviral effect of punicalagin and its associated mechanism against influenza A (H1N1) virus in vitro.Materials and methods: the ant-influenza activity of punicalagin was studied in Madin-Darby Canine Kidney (MDCK) cells using influenza virus A/Puerto Rico/8/34 (H1N1) (PR8) using Hemagglutinin assay (HA) and 50% tissue culture infective dose (TCID50). Then, the inhibition of haemagglutination, virucidal activity, inhibitory effect at different times, replication of viral RNA and expression of viral genes were investigated.Results: Punicalagin could inhibit influenza virus infection with 50% inhibitory concentration (IC50) of 3.98 μg/ml and selectivity index (SI) value of 6.1. Punicalagin decreased virus titers with an inhibitory effect on virus hemagglutination (p<0.05). Punicalagin also inhibited viral adsorption. The results of virus RNA replication and viral mRNA (NS1 and HA) expression after treatment with punicalagin showed significant suppression of viral mRNA expression but no effect on replication of viral RNA.Conclusion: The results of the present study indicated that punicalagin was effective against influenza infection most probably via inhibition of haemagglutination activity and virus binding.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 4","pages":"496-504"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis. 草药和纳米草药：牙周炎治疗的新见解。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-07-01 DOI: 10.22038/AJP.2023.23261

Fatemeh Rezaei-Tazangi, Armita Forutan Mirhosseini, Amirhossein Fathi, Hossein Roghani-Shahraki, Reza Arefnezhad, Fateme Vasei

{"title":"Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis.","authors":"Fatemeh Rezaei-Tazangi, Armita Forutan Mirhosseini, Amirhossein Fathi, Hossein Roghani-Shahraki, Reza Arefnezhad, Fateme Vasei","doi":"10.22038/AJP.2023.23261","DOIUrl":"10.22038/AJP.2023.23261","url":null,"abstract":"Objective: Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle.Materials and methods: This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases.Results: According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs.Conclusion: Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 4","pages":"430-454"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial. 洛神花（木槿花）提取物作为缬沙坦的辅助药物用于轻度慢性肾病患者：双盲随机对照临床试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-07-01 DOI: 10.22038/AJP.2024.23871

Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar

{"title":"Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial.","authors":"Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar","doi":"10.22038/AJP.2024.23871","DOIUrl":"10.22038/AJP.2024.23871","url":null,"abstract":"Objective: The objective of this study was to evaluate the effectiveness of Hibiscus sabdariffa L. extract (HS) as an adjunct to valsartan in the treatment of high blood pressure in patients with mild chronic kidney disease (CKD).Materials and methods: This trial was conducted in Gorgan, Iran. Seventy-two participants with CKD and high blood pressure were randomly assigned to either the HS group, receiving a 350 mg pill every 12 hr for 90 days along with 40 mg of valsartan every 12 hr, or the control group (40 mg valsartan + 12.5 mg hydrochlorothiazide). The primary objective was to assess the improvement of hypertension, while secondary objectives included the evaluation of proteinuria, albuminuria, kidney function, lipid profile, and electrolyte levels. Molecular docking analysis was performed to examine the mechanisms of action of the isolated components of HS.Results: Out of 80 initial participants, 72 were included in the analysis. Both groups showed a significant reduction in blood pressure (p<0.001). The HS group demonstrated a statistically significant decrease in lipid profile (p<0.001). There were no statistically significant differences between the groups regarding the reduction of renal markers. Molecular docking analysis revealed that the compounds present in HS, particularly its anthocyanins and flavonoids, exhibited greater angiotensin-converting enzyme (ACE) inhibitory potential than hydrochlorothiazide in both domains. Moreover, the compounds met the criteria for drug likeness and Lipinski rules.Conclusion: Adjunctive therapy with HS showed promising results in reducing hypertension and improving lipid profile in patients with CKD.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 4","pages":"505-519"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0