Avicenna Journal of Phytomedicine最新文献_第10页

The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke. 菊苣叶水醇提取物对吸烟大鼠睾丸芳烃受体表达的影响。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.21307

Maryam Hashemi, Mahnaz Azarnia, Zahra Hajebrahimi, Samad Nejad Ebrahimi

{"title":"The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke.","authors":"Maryam Hashemi, Mahnaz Azarnia, Zahra Hajebrahimi, Samad Nejad Ebrahimi","doi":"10.22038/AJP.2022.21307","DOIUrl":"10.22038/AJP.2022.21307","url":null,"abstract":"Objective: Cigarette smoke (CS) contains compounds such as reactive oxygen species (ROS). Oxidative stress caused by excessive ROS eventually leads to germ cell apoptosis and male infertility. The leaves of Cichorium intybus (chicory) are rich in natural antioxidants, but their protective effects on the adverse effects of CS on testicular tissue have not been studied.Materials and methods: 24 Wistar rats were classified into four groups: control, extract: treatment with chicory extract (200 mg/kg body weight/day) for 13 weeks, smoke: exposed to CS for 13 weeks, and smoke + extract: exposed to CS and treated with the C. intybus extract. Histological and biochemical analyses and apoptosis assay were done, and Ahr, and Cyp1a1 expression was determined.Results: Treatment with C. intybus compensated for the reduction of Sertoli cells, spermatogonia, spermatocytes, and spermatids caused by CS. Chicory extract reduced free radicals and improved antioxidant status. The lowest and highest percentage of apoptotic cells was observed in the extract and smoke groups, respectively, while simultaneous treatment with C. intybus extract led to a significant reduction of apoptotic cells. The mean Ahr levels in the control, extract, smoke and smoke + extract groups were 1.00±0.57, 1.93±0.25, 5.98±0.42, and 0.62±0.22, respectively (p˂0.05). The mean levels of Cyp1a1 expression in the control, extract, smoke and smoke + extract groups were 1.00±0.31, 2.28±0.65, 5.55±0.40, and 0.21±0.23 (p˂0.05).Conclusion: The C. intybus extract probably affected Cyp1a1 expression by downregulation of Ahr. These led to a decrease in free radicals and apoptosis, and an improvement in antioxidant status.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"13 1","pages":"58-69"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia. 马齿苋甲醇和水提取物在苯肼贫血模型中的造血潜力。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.20965

Kobra Shirani, Bamdad Riahi-Zanjani, Seyed Navid Omidkhoda, Samira Barangi, Gholamreza Karimi

{"title":"The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia.","authors":"Kobra Shirani, Bamdad Riahi-Zanjani, Seyed Navid Omidkhoda, Samira Barangi, Gholamreza Karimi","doi":"10.22038/AJP.2022.20965","DOIUrl":"10.22038/AJP.2022.20965","url":null,"abstract":"Objective: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia.Materials and methods: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated.Results: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine.Conclusion: In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"13 1","pages":"85-96"},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial. 补充植物体姜黄素对偏头痛患者临床症状、炎症和氧化应激生物标志物的影响：一项随机双盲安慰剂对照试验的方案。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.21242

Mehrnaz Shojaei, Amirhossein Sahebkar, Fariborz Khorvash, Soheil Fallahpour, Gholamreza Askari, Mohammad Bagherniya

{"title":"The effects of phytosomal curcumin supplementation on clinical symptoms, and inflammatory and oxidative stress biomarkers in patients with migraine: A protocol for a randomized double-blind placebo-controlled trial.","authors":"Mehrnaz Shojaei, Amirhossein Sahebkar, Fariborz Khorvash, Soheil Fallahpour, Gholamreza Askari, Mohammad Bagherniya","doi":"10.22038/AJP.2022.21242","DOIUrl":"10.22038/AJP.2022.21242","url":null,"abstract":"Objective: Migraine is one of the most common diseases. Curcumin with anti-oxidative and anti-neuroinflammatory properties might have beneficial effects in migraine patients. This study will be conducted to evaluate the effects of a phytosomal preparation of curcumin on clinical signs, oxidative stress, and inflammatory parameters in patients with migraine.Materials and methods: This is a randomized, double-blind, placebo-controlled, clinical trial in which, 60 patients with migraine will be assigned to receive a daily dose of 250 mg of phytosomal curcumin for 8 weeks (intervention group) or 250 mg maltodextrin as a placebo for the same duration (control group). Before and after the study, frequency, duration, and severity of the attacks, quality of life and sleep, mood status, high-sensitivity C-reactive protein (hs-CRP), Nitric Oxide (NO), and oxidative stress factors will be measured.Conclusion: It seems that phytosomal formulation of curcumin (a solid dispersion preparation of curcumin with phosphatidylserine) with high bioavailability, can cross the blood-brain barrier (BBB) and result in decreased neuroinflammation, oxidative stress, and neurotoxicity. This way, phytosomal curcumin might lead to reduction of headaches and other complications of migraine and increase the quality of life of patients with migraine.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"13 1","pages":"45-57"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10677166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Antidiabetic effects of Eryngium billardieri hydrosol in the treatment of type 2 diabetic patients: A double-blind randomized clinical trial. 双盲随机临床试验：比拉氏杏鲍水溶胶治疗2型糖尿病患者的抗糖尿病作用。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.21175

Zahra Hamami Chamgordani, Mohammad Mazaheri, Bijan Iraj, Hojjat Baghshahi, Fakhri Sabouhi

{"title":"Antidiabetic effects of Eryngium billardieri hydrosol in the treatment of type 2 diabetic patients: A double-blind randomized clinical trial.","authors":"Zahra Hamami Chamgordani, Mohammad Mazaheri, Bijan Iraj, Hojjat Baghshahi, Fakhri Sabouhi","doi":"10.22038/AJP.2022.21175","DOIUrl":"10.22038/AJP.2022.21175","url":null,"abstract":"Objective: Medicinal plants with fewer side effects and low cost than synthetic medicines are increasingly advised to treat diseases. The present study aimed to identify Eryngium billardieri compounds and evaluate the plant's effects on hyperglycemic and hyperlipidemia indices, and liver, and kidney function.Materials and methods: Following identification of Eryngium billardieri using GC/MS method, 72 participants were randomly divided into two groups (n=36 per group), receiving oral hypoglycemic medication (metformin) with or without 50 ml hydrosol twice a day for three months as intervention and placebo control, respectively. Body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), total cholesterol, triglyceride, HDL-C, and LDL-C levels were measured at the beginning and end of the experiment. Also, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine levels were measured to assess adverse effects on liver and kidney functions.Results: The main components were terpenes with 46.69% of the total ingredients of E. billardieri essential oil. Other prominent compounds identified included octanoic acid (12.14 %) and isoxazole (6.72 %). Intergroup changes in blood parameters showed that E. billardieri hydrosol for three months could significantly reduce HbA1C and blood cholesterol levels but did not affect other measured parameters. Also, there were no adverse effects on kidney or liver function.Conclusion: The present findings showed that the consumption of 50 ml of E. billardieri hydrosol as a complementary treatment in diabetic patients reduced HbA1C and cholesterol levels without adverse effects on the liver or kidneys functions.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"13 1","pages":"34-44"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10622335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Letter to Editor on: "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney" by Akbari et al. 致编辑的信：Akbari等人的“生姜提取物可上调NRF2和TNFα的肾脏表达，并防止乙醇诱导的大鼠肾脏毒性”。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.21187

Perumal Elumalai, Devaraj Ezhilarasan, Subramanian Raghunandhakumar

引用次数: 0

Reply to Letter to Editor by Elumalai et al. re : "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney". 回复Elumalai等人给编辑的信：“生姜提取物可以上调NRF2和TNFα的肾脏表达，并防止乙醇诱导的大鼠肾脏毒性”。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.66674.3146

Abolfazl Akbari

引用次数: 4

The protective effect of curcumin on thrombin-induced hyper-permeability. 姜黄素对凝血酶诱导的高渗透性的保护作用。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI: 10.22038/AJP.2022.21025

Farzad Rahmani, Hossein Abdeahad, Najmeh Jaberi, Reyhane Hanaie, Atena Soleimani, Amir Avan, Majid Khazaei, Seyed Mahdi Hassanian

{"title":"The protective effect of curcumin on thrombin-induced hyper-permeability.","authors":"Farzad Rahmani, Hossein Abdeahad, Najmeh Jaberi, Reyhane Hanaie, Atena Soleimani, Amir Avan, Majid Khazaei, Seyed Mahdi Hassanian","doi":"10.22038/AJP.2022.21025","DOIUrl":"10.22038/AJP.2022.21025","url":null,"abstract":"Objective: Thrombin is a proinflammatory and pro-coagulant agent which is upregulated in several human diseases. Thrombin has a critical role in promoting cell proliferation and microvascular leakage in malignant cells, resulting in cancer growth and progression. Here, we explored the potential therapeutic value of curcumin on permeability induced by thrombin in mice.Materials and methods: To assess the activity of curcumin on thrombin-induced vascular permeability mice model, C57BL / 6 mice were randomly divided into four groups: (1) control (2) Thrombin (3) Thrombin + Curcumin and (4) Thrombin + Metformin. Thirty minutes after treatment, Evans blue was injected intravenously through the tail vein to mice. Then, animals were sacrificed and the dye was extracted from the skin tissue by incubation with formamide. Heatmap and correlation map were generated and protein-protein interaction network of the hub genes was drawn by Cytoscape software.Results: Hub DEG expression rate showed that Heat shock protein a1 (Hspa1) family (comprised of HSPa1a, b, and HSPa5), caspase 3, and minichromosome maintenance complex component 2 were overexpressed after treatment with curcumin. Functional modules of curcumin enriched through Enrich gene biological process and revealed positive association of gene expression of apoptosis process with the therapy. Curcumin was also found to reduce leucocyte migration in murine tissues. Additionally, treatment with curcumin resulted in downregulation of heat shock proteins and proinflammatory cytokines such as monocyte chemotactic protein 1, interleukin-6 and chemokine (C-X-C motif) ligand 3.Conclusion: Curcumin inhibited the proinflammatory cytokines and inflammatory HSPs in endothelial cells and reduced thrombin-induced barrier destabilization in vivo.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"13 1","pages":"97-108"},"PeriodicalIF":2.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840778/pdf/AJP-13-97.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10622336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters. 芝麻酚对受损周围神经的影响:功能、组织学、分子和氧化应激参数的评估。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2022-11-01 DOI: 10.22038/AJP.2022.20663

Nastaran Amerian, Athar Talebi, Manouchehr Safari, Hamid Reza Sameni, Ali Ghanbari, Parisa Hayat, Moslem Mohammadi, Maryam Ardekanian, Sam Zarbakhsh

{"title":"Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters.","authors":"Nastaran Amerian, Athar Talebi, Manouchehr Safari, Hamid Reza Sameni, Ali Ghanbari, Parisa Hayat, Moslem Mohammadi, Maryam Ardekanian, Sam Zarbakhsh","doi":"10.22038/AJP.2022.20663","DOIUrl":"https://doi.org/10.22038/AJP.2022.20663","url":null,"abstract":"Objective: Peripheral nerve injury is a clinical problem that may cause sensory and motor inabilities. Sesamol is an antioxidant that can help in repairing damaged central nervous system (CNS) and other organs. The present study aimed to investigate whether the antioxidant effects of sesamol could improve the function, structure, and myelination in rats' damaged peripheral nervous system (PNS).Materials and methods: In this study, 28 adult male Wistar rats were randomly divided into four groups. In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. The control received DMSO (solvent) and the two experimental groups received 50 or 100 mg/kg sesamol intraperitoneally for 28 days after sciatic nerve crush injury, respectively. Next, sciatic function index (SFI), superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, expression of nerve growth factor (NGF) and myelin protein zero (MPZ) proteins in the sciatic nerve, and histological indices of the sciatic nerve and gastrocnemius muscle were evaluated.Results: The results showed that sesamol reduced oxidative stress parameters, increased expression of NGF and MPZ proteins, and improved function and regeneration of the damaged sciatic nerve. Furthermore, a significant regeneration was observed in the gastrocnemius muscle after treatment with sesamol. Although administration of both doses of sesamol was useful, the 100 mg/kg dose was more effective than the 50 mg/kg one.Conclusion: The results suggest that sesamol may be effective in improving damaged peripheral nerves in rats by reducing oxidative stress and increasing the expression of NGF and MPZ proteins.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"12 6","pages":"602-613"},"PeriodicalIF":2.2,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10446807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indian traditional medicinal plants in ophthalmic diseases. 印度传统眼科药用植物。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2022-11-01 DOI: 10.22038/AJP.2022.20345

Sana Nafees, Jamal Akhtar, Jasbir Kaur

{"title":"Indian traditional medicinal plants in ophthalmic diseases.","authors":"Sana Nafees, Jamal Akhtar, Jasbir Kaur","doi":"10.22038/AJP.2022.20345","DOIUrl":"https://doi.org/10.22038/AJP.2022.20345","url":null,"abstract":"Objective: Traditional herbal plants have been in use since ancient times to treat ophthalmic conditions; so, the aim of this study is to evaluate some potent Indian traditional medicinal plants used in ophthalmic diseases in order to summarize their potential effect in ophthalmology along with their mechanism of action.Materials and methods: Databases PubMed, Google Scholar, and Embase were extensively explored. Additionally, relevant textbooks and literatures were consulted to summarize most of the considerable scientific literature for the review. Search term included ophthalmology, glaucoma, cataract, trachoma, conjunctivitis, traditional medicines, Unani drugs, and ayurvedic drugs were used. Around 80 review articles were consulted from the year 1982 to 2021.Results: The traditional medicinal plants are easily available, cost-effective and have no associated side effects in comparison to current conventional treatments. Moreover, these drugs in oppose to modern medicine, have an inherent potential to accelerate the body's own immunity to fight against any infection. A large volume of scientific studies has reported the beneficial effects of traditional drugs in ophthalmology.Conclusion: This review, therefore, describes the potential benefits and uses of some traditional medicinal plants used in ophthalmic diseases.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"12 6","pages":"566-575"},"PeriodicalIF":2.2,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10446810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial. 评价藏红花素对冠状动脉旁路移植术或心脏瓣膜置换术后房颤的预防作用:一项双盲、随机、安慰剂对照试验。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2022-11-01 DOI: 10.22038/AJP.2022.20908

Seyyed Hamed Hashemi Shahri, Ghasem Soltani, Mohammad Abbasi Teshnizi, Aliasghar Moeinipour, Mohammad Tayyebi, Reza Javidi Dasht Bayaz, Farshad Abedi, Vahid Ghavami, Shahram Amini, Amir Hooshang Mohammadpour

{"title":"Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial.","authors":"Seyyed Hamed Hashemi Shahri, Ghasem Soltani, Mohammad Abbasi Teshnizi, Aliasghar Moeinipour, Mohammad Tayyebi, Reza Javidi Dasht Bayaz, Farshad Abedi, Vahid Ghavami, Shahram Amini, Amir Hooshang Mohammadpour","doi":"10.22038/AJP.2022.20908","DOIUrl":"https://doi.org/10.22038/AJP.2022.20908","url":null,"abstract":"Objective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and methods: 100 patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant-antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.Results: POAF developed in 7 patients in the treatment group versus 18 patients in the control (p=0.02). PAB levels were significantly lower in the crocin group (p<0.001), while differences in CRP levels were insignificant (p=0.39).Conclusion: It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"12 6","pages":"589-601"},"PeriodicalIF":2.2,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10446806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0