Avicenna Journal of Phytomedicine最新文献_第10页

Therapeutic potency of curcumin on radiodermatitis: A systematic review. 姜黄素对放射性皮炎的疗效：系统综述。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23175

Hossein Abdeahad, Nikoo Saeedi, Afsane Bahrami, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Amir Avan, Majid Khazaei, Elnaz Ghorbani, Mikhail Ryzhikov, Seyed Mahdi Hassanian

{"title":"Therapeutic potency of curcumin on radiodermatitis: A systematic review.","authors":"Hossein Abdeahad, Nikoo Saeedi, Afsane Bahrami, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Amir Avan, Majid Khazaei, Elnaz Ghorbani, Mikhail Ryzhikov, Seyed Mahdi Hassanian","doi":"10.22038/AJP.2023.23175","DOIUrl":"10.22038/AJP.2023.23175","url":null,"abstract":"Objective: Radiodermatitis (RD) is a frequent adverse event of radiotherapy (RT). Currently, there is no consensus and approved protocol for the treatment of RD. Curcumin (CUR) is a natural polyphenol obtained from turmeric and it has low intrinsic toxicity in humans. The aim of this systematic review was to explore the efficacy of CUR for prevention and treatment of RD.Materials and methods: A systematic literature review was performed in the following online databases: Cochrane library, PubMed, Scopus, Web of Science, MEDLINE, and EMBASE. Among the 5 selected records, 3 had a randomized clinical trial (RCT)-design and the other had a pilot and controlled study designed. The included studies were performed on breast cancer (N=3), head and neck cancers (N=1) and different types of cancer (N=1).Results: Four of the studies reported that the application of curcumin in cancer patients undergoing radiotherapy is associated with decreased intensity of radiodermatitis. However, one study did not report any significant effect of CUR on radiodermatitis. This review provides substantial evidence which confirm the clinical value of CUR in cancer supportive care.Conclusion: Further prospective clinical trials in larger scales are warranted in order to determine the \" supplemental form and dose of CUR\" for RD prevention and treatment in patients receiving radiotherapy.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"297-304"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia. Pistacia vera果皮的亲水提取物可防止苯肼引起的肝毒性和溶血性贫血。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23925

Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour

{"title":"Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia.","authors":"Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour","doi":"10.22038/AJP.2024.23925","DOIUrl":"10.22038/AJP.2024.23925","url":null,"abstract":"Objective: Pistacia vera is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of Pistacia vera pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.Materials and methods: PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"375-387"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice. 研究巴豆素对电磁场诱发的雄性 Balb/c 小鼠小脑损伤的神经保护作用

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23005

Mehrdad Hajinejad, Abdolreza Narouiepour, Fatemeh Alipour, Alireza Ebrahimzadeh Bideskan

{"title":"Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice.","authors":"Mehrdad Hajinejad, Abdolreza Narouiepour, Fatemeh Alipour, Alireza Ebrahimzadeh Bideskan","doi":"10.22038/AJP.2023.23005","DOIUrl":"10.22038/AJP.2023.23005","url":null,"abstract":"Objective: Mobile devices are sources of electromagnetic fields (EMFs) that cause increasing concern among scientists about human health, especially with the long-term use of mobile phones. With regard to this issue, the potential adverse health effects, particularly on brain function have raised public concern. There is considerable evidence that natural compounds have neuro-protective effects due to their antioxidant and anti-inflammatory properties. Growing evidence suggests that crocin as a natural bioactive compound can be considered a potential therapeutic agent against various neurologic disorders. Therefore, the present study investigated the effects of crocin on the cerebellum after exposure to EMF.Materials and methods: Twenty-four Male Balb/c mice were divided into control group, EMF group (2100 MHZ), EMF +Crocin group (2100 MHZ+50 mg/kg), and crocin group (50 mg/kg). The animals in the EMF and EMF+Crocin groups were exposed continuously for 30 days to an EMF 120 min/day. After 30 days, cerebellar cortex was evaluated by histomorphometric and immunohistochemical methods.Results: The results showed that 30 days of exposure to EMF had no significant effect on Purkinje cell size. However, EMF reduced significantly the diameter of astrocytes and increased Glial fibrillary acidic protein (GFAP) expression compared to the controls (p<0.05). Our findings also indicated that crocin treatment could improve the diameter of astrocytes and normalize GFAP expression (p<0.05).Conclusion: This study concluded that 2100-MHz EMF caused adverse eﬀects on the cerebellum through astrocyte damage and crocin could partially reverse the EMF-related adverse effects.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"289-296"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats. 纳米水飞蓟素和水飞蓟素对高脂饮食诱发的成年雄性大鼠脂肪肝的影响比较。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23734

Reza Mohebbati, Mohammad Amin Momeni-Moghaddam, Rokhsareh Asghari, Abbasali Abbasnezhad, Alireza Ebrahim Zadeh Bideskan, Davoud Salarbashi, Nasim Khajavian

{"title":"The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats.","authors":"Reza Mohebbati, Mohammad Amin Momeni-Moghaddam, Rokhsareh Asghari, Abbasali Abbasnezhad, Alireza Ebrahim Zadeh Bideskan, Davoud Salarbashi, Nasim Khajavian","doi":"10.22038/AJP.2024.23734","DOIUrl":"10.22038/AJP.2024.23734","url":null,"abstract":"Objective: Considering the high prevalence of non-alcoholic fatty liver disease and its complications, this study aims to determine and compare the effect of nano-silymarin and silymarin on non-alcoholic fatty liver in rats.Materials and methods: Rats were divided into 5 groups: Control, high-fat diet, high-fat diet and atorvastatin, high-fat diet and silymarin, and high-fat diet and nano-silymarin. After 12 weeks, blood samples were taken to measure cholesterol, triglyceride, HDL, LDL, ALT and AST. The animals were killed and the liver tissue was removed to examine the histopathological changes.Results: Feeding with a high-fat diet caused a significant increase in cholesterol, triglyceride and LDL-C in serum of rats compared to the control. Nano-silymarin and silymarin could significantly reduce serum triglyceride compared to negative group but the reduction of cholesterol, LDL-C, AST and ALT by nano-silymarin was not significant as compared to silymarin. The liver histology evaluation mainly showed that in the group receiving nano-silymarin, a significant decrease in the percentage of fat vacuoles and degree of steatosis was observed compared to the negative group. In the positive group, the percentage of fat vacuoles and the degree of steatosis showed a significant decrease compared to the negative group. Group receiving atorvastatin showed a greater protective effect than silymarin and nano-silymarin.Conclusion: The use of nano-silymarin similar to silymarin in rats treated with a high-fat diet led to a decrease in the percentage of fat vacuoles and the degree of hepatic steatosis mainly and can be used to prevent non-alcoholic fatty liver disease.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"365-375"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial. 补充苏木（Rhus coriaria L.）粉对超重或肥胖的非酒精性脂肪肝患者的生化指标和人体测量指标的疗效：双盲随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23927

Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi

{"title":"The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.","authors":"Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi","doi":"10.22038/AJP.2024.23927","DOIUrl":"10.22038/AJP.2024.23927","url":null,"abstract":"Objective: This study aimed to assess the effect of sumac supplement in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease.Materials and methods: In this double-blind randomized controlled trial, 45 NAFLD patients were randomly divided into two groups. The intervention group received sumac capsules (3 g/day) with a balanced diet for 8 weeks, while the placebo group received placebo with a balanced diet. Anthropometric indices, lipid profile, fasting blood glucose, insulin, Homeostatic Model Assessment for Insulin Resistance, aspartate transaminase, alanine aminotransferase, high sensitivity C-reactive protein and malondialdehyde were measured at baseline and at the end of the study.Results: The results revealed a significant decrease in anthropometric indices (weight (p=0.001), body mass index (p=0.001), waist circumference (p=0.001), body fat mass (p=0.001), body fat percentage (p=0.001), visceral fat score (p=0.001), biochemical levels of total cholesterol (p=0.007), fasting blood sugar (p=0.006), insulin (p=0.004) and HOMA-IR (p=0.002)) after the intervention compared to the baseline. However, no significant difference was observed between the two groups concerning anthropometric and biochemical indices.Conclusion: In this study, no significant differences were observed between the two groups regarding anthropometric and biochemical indices. Thus, further studies with larger sample sizes are recommended to be conducted on the issue.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"338-348"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin may reduce the risk of developing the symptoms of COVID-19. 槲皮素可降低出现 COVID-19 症状的风险。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22920

Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab

{"title":"Quercetin may reduce the risk of developing the symptoms of COVID-19.","authors":"Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab","doi":"10.22038/AJP.2023.22920","DOIUrl":"10.22038/AJP.2023.22920","url":null,"abstract":"Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.Materials and methods: Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: \"corona or coronavirus or COVID or COVID-19 or viral or virus\" AND \"nutrient or flavonoid or Quercetin\".Results: The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.Conclusion: Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"189-201"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial. Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( 对 COVID-19 患者的影响：随机临床试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22800

Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi

{"title":"The effect of Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial.","authors":"Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi","doi":"10.22038/AJP.2023.22800","DOIUrl":"10.22038/AJP.2023.22800","url":null,"abstract":"Objective: Exogenous hydrogen sulfide (H2S) has a positive effect on respiratory diseases. Oleo-gum of Ferula assa-foetida contains this compound. This study assessed the effects of Ferula assa-foetida L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19.Materials and methods: A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO2) were the endpoints.Results: Mean±SD of PO2 in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively.Conclusion: Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"152-165"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial. 评估口服纳米姜黄素对支气管非变应性哮喘患者呼吸功能和生活质量的疗效：随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22826

Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi

{"title":"Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial.","authors":"Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi","doi":"10.22038/AJP.2023.22826","DOIUrl":"10.22038/AJP.2023.22826","url":null,"abstract":"Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.Materials and methods: In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV1). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.Results: Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV1 was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"229-241"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial. 新型抗病毒草药制剂对入住ICU的COVID-19患者的疗效和安全性：III期双盲对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23259

{"title":"Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial.","authors":"","doi":"10.22038/AJP.2023.23259","DOIUrl":"10.22038/AJP.2023.23259","url":null,"abstract":"Objective: Despite an increasing number of studies, there is as yet no definite treatment developed for the coronavirus disease 2019 (COVID-19). In this clinical trial, we examined the efficacy of a novel herbal antiviral preparation in critically ill COVID-19 patients.Materials and methods: A total number of 120 ICU-admitted patients with a diagnosis of COVID-19 pneumonia were recruited to the trial. Participants were equally randomized to receive either the novel antiviral preparation sublingually, for up to two consecutive weeks or till discharge, or placebo. Clinical and laboratory parameters as well as survival rates were compared between the two groups.Results: The cumulative incidence of death throughout the study period was 8.33% in the intervention group and 60% in the placebo group (risk ratio: 0.14; 95% confidence interval [CI], 0.05 to 0.32; p<0.001). On day 7, several parameters including white blood cells (WBCs) count, C-reactive protein, and SpO2 were improved for the treatment group compared with the placebo group (p-values of 0.05, 0.01, and <0.001, respectively).Conclusion: This preparation might be suggested as a potentially promising COVID-19 treatment.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"215-228"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study. 肉桂诱导多囊卵巢综合征妇女的代谢和内分泌变化：一项试点研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23357

Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki

{"title":"Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study.","authors":"Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki","doi":"10.22038/AJP.2023.23357","DOIUrl":"10.22038/AJP.2023.23357","url":null,"abstract":"Objective: Most polycystic ovary syndrome (PCOS) patients have metabolic abnormalities in which insulin resistance (IR) plays a pivotal role. Cinnamon is a herbal medicine with insulinotropic properties. This pilot study aimed to evaluate the effects of cinnamon on ovarian volume, androgenic profile, and metabolic and anthropometric parameters in women with PCOS.Materials and methods: A single-center, double-blind, randomized, placebo-controlled trial was carried out on 39 overweight / obese women with PCOS. For six months, subjects in the cinnamon (500 mg) (n=19) and placebo (n=20) groups were given three capsules daily. Before and after the intervention, the variables were assessed. The data was analyzed using the GraphPad Prism software.Results: After the intervention, the two intervention and control groups had significant differences in abdominal subcutaneous fat and ovarian volume, but they did not differ significantly in terms of body mass index (BMI). Also, after the intervention, no significant difference was observed between the two groups in terms of lipid profile and the concentration of androgenic biomarkers of insulin resistance.Conclusion: Cinnamon supplementation improves ovarian volume and subcutaneous abdominal fat but has no effect on anthropometric parameters, lipid profile, insulin resistance, or androgen hormones.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"242-251"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0