Avicenna Journal of Phytomedicine最新文献_第9页

The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial. 补充苏木（Rhus coriaria L.）粉对超重或肥胖的非酒精性脂肪肝患者的生化指标和人体测量指标的疗效：双盲随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23927

Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi

{"title":"The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.","authors":"Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi","doi":"10.22038/AJP.2024.23927","DOIUrl":"10.22038/AJP.2024.23927","url":null,"abstract":"Objective: This study aimed to assess the effect of sumac supplement in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease.Materials and methods: In this double-blind randomized controlled trial, 45 NAFLD patients were randomly divided into two groups. The intervention group received sumac capsules (3 g/day) with a balanced diet for 8 weeks, while the placebo group received placebo with a balanced diet. Anthropometric indices, lipid profile, fasting blood glucose, insulin, Homeostatic Model Assessment for Insulin Resistance, aspartate transaminase, alanine aminotransferase, high sensitivity C-reactive protein and malondialdehyde were measured at baseline and at the end of the study.Results: The results revealed a significant decrease in anthropometric indices (weight (p=0.001), body mass index (p=0.001), waist circumference (p=0.001), body fat mass (p=0.001), body fat percentage (p=0.001), visceral fat score (p=0.001), biochemical levels of total cholesterol (p=0.007), fasting blood sugar (p=0.006), insulin (p=0.004) and HOMA-IR (p=0.002)) after the intervention compared to the baseline. However, no significant difference was observed between the two groups concerning anthropometric and biochemical indices.Conclusion: In this study, no significant differences were observed between the two groups regarding anthropometric and biochemical indices. Thus, further studies with larger sample sizes are recommended to be conducted on the issue.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 3","pages":"338-348"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin may reduce the risk of developing the symptoms of COVID-19. 槲皮素可降低出现 COVID-19 症状的风险。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22920

Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab

{"title":"Quercetin may reduce the risk of developing the symptoms of COVID-19.","authors":"Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab","doi":"10.22038/AJP.2023.22920","DOIUrl":"10.22038/AJP.2023.22920","url":null,"abstract":"Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.Materials and methods: Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: \"corona or coronavirus or COVID or COVID-19 or viral or virus\" AND \"nutrient or flavonoid or Quercetin\".Results: The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.Conclusion: Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"189-201"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial. Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( 对 COVID-19 患者的影响：随机临床试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22800

Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi

{"title":"The effect of Phytopaj ) Ferula assa-foetida L. oleo gum resin and tragacanth( in patients with COVID-19: A randomized clinical trial.","authors":"Hamid Reza Bahrami-Taghanaki, Hamidreza Hoseinzadeh, Shokouhsadat Hamedi, Majid Jafari Nejad-Bajestani, Nayereh Esmaeilzadeh, Hasan Abdollahzadeh, Seyedehmasoume Hoseini-Asil, Gholamreza Haghighi, Amin Bojdi","doi":"10.22038/AJP.2023.22800","DOIUrl":"10.22038/AJP.2023.22800","url":null,"abstract":"Objective: Exogenous hydrogen sulfide (H2S) has a positive effect on respiratory diseases. Oleo-gum of Ferula assa-foetida contains this compound. This study assessed the effects of Ferula assa-foetida L. oleo gum resin and tragacanth (Phytopaj) on patients with COVID-19.Materials and methods: A randomized, single-blinded, controlled trial (RCT) phase 2 was conducted in Mashhad on hospitalized COVID-19 patients. In this RCT, 122 patients were randomly assigned to either receive a 14-day oral phytopaj plus ordinary treatment or ordinary treatment only. Changes in peripheral blood lymphocyte count (LC) and blood oxygen saturation (PO2) were the endpoints.Results: Mean±SD of PO2 in Phytopaj comparison ordinary treatment before intervention was 91.86±4.62 and 91.41±9.18, after the intervention it was 93.22±4.26 and 91.91±5.92 mmHg; before intervention, mean±SD of peripheral blood lymphocyte count was 1015.90±500.55, and 1104.28±543.61, and after intervention, it was 1652.27±921.38 and 1326.12±719.28/μL respectively.Conclusion: Phyopaj is most useful in moderate stages of Covid19, and it is not recommended for elderly patients and patients with comorbidity until more insight is gained.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"152-165"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial. 评估口服纳米姜黄素对支气管非变应性哮喘患者呼吸功能和生活质量的疗效：随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22826

Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi

{"title":"Evaluation of oral nano-curcumin efficacy on respiratory function and quality of life in patients with bronchial non-atopic asthma: A randomized controlled trial.","authors":"Shahrzad Mohammadzadeh Lari, Amir Hooshang Mohamadpour, Davood Attaran, Mahmodreza Jafari, Omid Arasteh, Maryam Emadzadeh, Mahnaz Mozdourian, Soroush Attaran, Zahra Javidarabshahi","doi":"10.22038/AJP.2023.22826","DOIUrl":"10.22038/AJP.2023.22826","url":null,"abstract":"Objective: Asthma is a common disease and curcumin has modest effect in inflammatory disorders. This study investigated the efficacy of nano-curcumin on asthma.Materials and methods: In this double-blinded randomized clinical trial, 60 patients with non-atopic bronchial asthma were randomly stratified in two groups of intervention (N=30) and control (N=30) groups. Apart from their standard treatment, the intervention group received 40 mg nano-curcumin (soft gel) three times daily while the control group received placebo. During the 60-day study, patients were assessed using spirometry to measure Forced expiratory volume in first second (FEV1). Asthma control test (ACT) was completed every 30 days and asthma quality of life questionnaire (AQLQ) was completed at the first and end of the study.Results: Totally, 31 patients (51.7%) were male and the mean age was 51.45±12.58 years. FEV1 was improved but there was no significant difference between intervention and control groups. ACT and AQLQ domains scores significantly improved. However, it was not statistically different between control and intervention groups.Conclusion: Nano-curcumin at administered dosage had no additive effect on the standard treatment in asthmatic patients.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"229-241"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial. 新型抗病毒草药制剂对入住ICU的COVID-19患者的疗效和安全性：III期双盲对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23259

{"title":"Efficacy and safety of a novel antiviral herbal preparation in ICU-admitted patients with COVID-19: A phase III double-blinded controlled trial.","authors":"","doi":"10.22038/AJP.2023.23259","DOIUrl":"10.22038/AJP.2023.23259","url":null,"abstract":"Objective: Despite an increasing number of studies, there is as yet no definite treatment developed for the coronavirus disease 2019 (COVID-19). In this clinical trial, we examined the efficacy of a novel herbal antiviral preparation in critically ill COVID-19 patients.Materials and methods: A total number of 120 ICU-admitted patients with a diagnosis of COVID-19 pneumonia were recruited to the trial. Participants were equally randomized to receive either the novel antiviral preparation sublingually, for up to two consecutive weeks or till discharge, or placebo. Clinical and laboratory parameters as well as survival rates were compared between the two groups.Results: The cumulative incidence of death throughout the study period was 8.33% in the intervention group and 60% in the placebo group (risk ratio: 0.14; 95% confidence interval [CI], 0.05 to 0.32; p<0.001). On day 7, several parameters including white blood cells (WBCs) count, C-reactive protein, and SpO2 were improved for the treatment group compared with the placebo group (p-values of 0.05, 0.01, and <0.001, respectively).Conclusion: This preparation might be suggested as a potentially promising COVID-19 treatment.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"215-228"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study. 肉桂诱导多囊卵巢综合征妇女的代谢和内分泌变化：一项试点研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23357

Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki

{"title":"Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study.","authors":"Sepideh Peivandi, Sahar Heydari-Latibari, Fatemeh Ghasemzadeh, Marzieh Zamaniyan, Adele Bahar, Hadi Majidi, Behnam Maleki","doi":"10.22038/AJP.2023.23357","DOIUrl":"10.22038/AJP.2023.23357","url":null,"abstract":"Objective: Most polycystic ovary syndrome (PCOS) patients have metabolic abnormalities in which insulin resistance (IR) plays a pivotal role. Cinnamon is a herbal medicine with insulinotropic properties. This pilot study aimed to evaluate the effects of cinnamon on ovarian volume, androgenic profile, and metabolic and anthropometric parameters in women with PCOS.Materials and methods: A single-center, double-blind, randomized, placebo-controlled trial was carried out on 39 overweight / obese women with PCOS. For six months, subjects in the cinnamon (500 mg) (n=19) and placebo (n=20) groups were given three capsules daily. Before and after the intervention, the variables were assessed. The data was analyzed using the GraphPad Prism software.Results: After the intervention, the two intervention and control groups had significant differences in abdominal subcutaneous fat and ovarian volume, but they did not differ significantly in terms of body mass index (BMI). Also, after the intervention, no significant difference was observed between the two groups in terms of lipid profile and the concentration of androgenic biomarkers of insulin resistance.Conclusion: Cinnamon supplementation improves ovarian volume and subcutaneous abdominal fat but has no effect on anthropometric parameters, lipid profile, insulin resistance, or androgen hormones.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"242-251"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the effects of bean extract on axillary hair reduction. 评估豆类提取物对减少腋毛的作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22888

Fereshteh Zamiri, Hassan Rakhshandeh, Bita Kiafar, Syed Mohammad Naqvi, Maryam Emadzadeh, Sara Fakhraei, Masoud Maleki

{"title":"Assessment of the effects of bean extract on axillary hair reduction.","authors":"Fereshteh Zamiri, Hassan Rakhshandeh, Bita Kiafar, Syed Mohammad Naqvi, Maryam Emadzadeh, Sara Fakhraei, Masoud Maleki","doi":"10.22038/AJP.2023.22888","DOIUrl":"10.22038/AJP.2023.22888","url":null,"abstract":"Objective: Body hair removal plays an important role in beauty standards, particularly for women. Finding a method that is easy to use, cheap, and can be done without supervision can significantly affect long-term hair reduction and reduce the side effects of hair removal. The present study investigated the impact of a containing 20% broad bean (Vicia faba) extract cream on axillary hair removal.Materials and methods: Twenty-five female volunteers were randomly divided into A (right axillary intervention - left axillary placebo) and B (right axillary placebo - left axillary intervention). Depending on the group, each person used a cream containing 20% broad bean extract )\"The extract made from the seeds and pods of broad beans.\") on one side and a placebo on the other twice a day for three months. Volunteers shaved their axillary hairs three days before each visit and took pictures of both sides on the day of the visit with a trichoscope (to check the diameter and thickness of the hairs).Results: We found a decrease in thickness on the intervention group (the axilla where a cream containing broad bean extract was applied); however, this difference was not significant between the intervention side and the placebo. In terms of the number of hairs, the difference between the two groups was significant only in the second month despite the decrease on the intervention side. Evaluation based on the personal judgment of the volunteers showed that there was a substantial difference in terms of the number of hairs (p=0.012) and thinning of hair (p=0.02).Conclusion: Our findings showed that 20% broad bean extract cream could potentially reduce axillary hair growth.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"268-277"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats. 同时服用白藜芦醇和阻力训练可改善丙烯酰胺诱导的大鼠空间学习障碍。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22937

Shaghayegh Hemat Jouy, Jafar Shahraki, Ramin Rezaee, Vahideh Ghorani, Mandana Gholami

{"title":"Concomitant administration of resveratrol and resistance training ameliorates acrylamide-induced spatial learning impairment in rats.","authors":"Shaghayegh Hemat Jouy, Jafar Shahraki, Ramin Rezaee, Vahideh Ghorani, Mandana Gholami","doi":"10.22038/AJP.2023.22937","DOIUrl":"10.22038/AJP.2023.22937","url":null,"abstract":"Objective: The present study examined effects of resistance training (RT) and resveratrol (RES) alone and together on acrylamide (AC)-induced memory impairment in rats.Materials and methods: Animals were divided into 6 groups: (1) Control group which received normal saline intraperitoneally (ip) daily for 8 weeks; (2) Scopolamine (SCO) group which received SCO (1 mg/kg/day, ip) for 8 weeks; (3) AC group which received AC (5 mg/kg/day, ip) for 8 weeks; (4) AC + RT group which received AC (5 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks); (5) AC + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks; and (6) AC + RT + RES group which received AC (5 mg/kg/day, ip) and RES (1 mg/kg/day, ip) for 8 weeks and performed RT (5 days a week for 8 weeks). On day 53, animal training began in the Morris Water Maze (MWM) and 24 hr after the last training, the probe test was performed.Results: RT and RES alone did not significantly affect escape latency or traveled distance increased by AC. However, concomitant RES and RT treatment significantly reduced these parameters compared to the AC group. Co-treatment with RES and RT also significantly increased the time spent in the target quadrant compared to the AC group. Lipid peroxidation was reduced in the AC+RES and AC+RT+RES groups compared to the AC group.Conclusion: It seems that daily co-treatment with RES and RT for 8 weeks ameliorates the memory-impairing effects of AC.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"177-188"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats. 莪术可减轻大鼠因接触双酚 A 而引起的心血管和肾脏氧化应激毒性。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23367

Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Israel Mark Osawere, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Odunayo Ibraheem Azeez, Ayobami Deborah Obisesan, Ademola Adetokunbo Oyagbemi, Olufunke Eunice Ola-Davies, Temidayo Olutayo Omobowale, Adebowale Benard Saba, Adeolu Alex Adedapo, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju

{"title":"Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats.","authors":"Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Israel Mark Osawere, Moses Olusola Adetona, Oluwasanmi Olayinka Aina, Odunayo Ibraheem Azeez, Ayobami Deborah Obisesan, Ademola Adetokunbo Oyagbemi, Olufunke Eunice Ola-Davies, Temidayo Olutayo Omobowale, Adebowale Benard Saba, Adeolu Alex Adedapo, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju","doi":"10.22038/AJP.2023.23367","DOIUrl":"10.22038/AJP.2023.23367","url":null,"abstract":"Objective: Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage.Materials and methods: Sixty rats were randomly selected, and grouped as control, BPA (100 mg/ kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined.Results: Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups.Conclusion: C. longa ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"202-214"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of Melissa officinalis L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: A study on anti-inflammatory and antioxidant effects. Melissa officinalis L. 水醇提取物和迷迭香酸在大鼠哮喘模型中的治疗潜力：抗炎和抗氧化作用研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.23321

Vahideh Abbasnia, Delaram Eslimi Esfahani, Mohammad Reza Khazdair, Shahrbanoo Oryan, Mohsen Foadoddini

{"title":"The therapeutic potential of Melissa officinalis L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: A study on anti-inflammatory and antioxidant effects.","authors":"Vahideh Abbasnia, Delaram Eslimi Esfahani, Mohammad Reza Khazdair, Shahrbanoo Oryan, Mohsen Foadoddini","doi":"10.22038/AJP.2023.23321","DOIUrl":"10.22038/AJP.2023.23321","url":null,"abstract":"Objective: The article studies how Melissa officinalis L. extract and rosmarinic acid (RA) affect lung inflammation, pathology, and oxidative stress in rats with ovalbumin-induced asthma.Materials and methods: Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received M. officinalis extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.Results: In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).Conclusion: This study showed that M. officinalis and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 2","pages":"252-267"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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