洛神花(木槿花)提取物作为缬沙坦的辅助药物用于轻度慢性肾病患者:双盲随机对照临床试验。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar
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引用次数: 0

摘要

研究目的本研究旨在评估木槿提取物(HS)作为缬沙坦的辅助药物治疗轻度慢性肾病(CKD)患者高血压的有效性:该试验在伊朗戈尔甘进行。72 名患有慢性肾脏病和高血压的参与者被随机分配到 HS 组(每 12 小时服用 350 毫克药片,同时每 12 小时服用 40 毫克缬沙坦,持续 90 天)或对照组(40 毫克缬沙坦 + 12.5 毫克氢氯噻嗪)。首要目标是评估高血压的改善情况,次要目标包括评估蛋白尿、白蛋白尿、肾功能、血脂和电解质水平。为研究 HS 分离成分的作用机制,进行了分子对接分析:在最初的 80 名参与者中,有 72 人参与了分析。两组患者的血压均有明显降低(p 结论:HS 的辅助治疗显示出良好的效果:HS 的辅助治疗在降低慢性肾脏病患者的高血压和改善血脂状况方面显示出良好的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial.

Objective: The objective of this study was to evaluate the effectiveness of Hibiscus sabdariffa L. extract (HS) as an adjunct to valsartan in the treatment of high blood pressure in patients with mild chronic kidney disease (CKD).

Materials and methods: This trial was conducted in Gorgan, Iran. Seventy-two participants with CKD and high blood pressure were randomly assigned to either the HS group, receiving a 350 mg pill every 12 hr for 90 days along with 40 mg of valsartan every 12 hr, or the control group (40 mg valsartan + 12.5 mg hydrochlorothiazide). The primary objective was to assess the improvement of hypertension, while secondary objectives included the evaluation of proteinuria, albuminuria, kidney function, lipid profile, and electrolyte levels. Molecular docking analysis was performed to examine the mechanisms of action of the isolated components of HS.

Results: Out of 80 initial participants, 72 were included in the analysis. Both groups showed a significant reduction in blood pressure (p<0.001). The HS group demonstrated a statistically significant decrease in lipid profile (p<0.001). There were no statistically significant differences between the groups regarding the reduction of renal markers. Molecular docking analysis revealed that the compounds present in HS, particularly its anthocyanins and flavonoids, exhibited greater angiotensin-converting enzyme (ACE) inhibitory potential than hydrochlorothiazide in both domains. Moreover, the compounds met the criteria for drug likeness and Lipinski rules.

Conclusion: Adjunctive therapy with HS showed promising results in reducing hypertension and improving lipid profile in patients with CKD.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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