{"title":"草药和纳米草药:牙周炎治疗的新见解。","authors":"Fatemeh Rezaei-Tazangi, Armita Forutan Mirhosseini, Amirhossein Fathi, Hossein Roghani-Shahraki, Reza Arefnezhad, Fateme Vasei","doi":"10.22038/AJP.2023.23261","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle.</p><p><strong>Materials and methods: </strong>This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases.</p><p><strong>Results: </strong>According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs.</p><p><strong>Conclusion: </strong>Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 4","pages":"430-454"},"PeriodicalIF":1.9000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179182/pdf/","citationCount":"0","resultStr":"{\"title\":\"Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis.\",\"authors\":\"Fatemeh Rezaei-Tazangi, Armita Forutan Mirhosseini, Amirhossein Fathi, Hossein Roghani-Shahraki, Reza Arefnezhad, Fateme Vasei\",\"doi\":\"10.22038/AJP.2023.23261\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle.</p><p><strong>Materials and methods: </strong>This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases.</p><p><strong>Results: </strong>According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs.</p><p><strong>Conclusion: </strong>Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently.</p>\",\"PeriodicalId\":8677,\"journal\":{\"name\":\"Avicenna Journal of Phytomedicine\",\"volume\":\"14 4\",\"pages\":\"430-454\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179182/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Avicenna Journal of Phytomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22038/AJP.2023.23261\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Avicenna Journal of Phytomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22038/AJP.2023.23261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
目的:牙周炎是一种常见的慢性炎症性疾病,会导致牙龈、牙槽骨和牙周韧带等支撑牙齿的组织功能失调。虽然抗生素疗法是治疗牙周炎的常用方法,但这种方法会对这些患者造成一些不良影响。因此,寻找一种副作用小的有效治疗方案仍是一个难题:通过搜索谷歌学者、PubMed、Scopus、Web of Science、Science Direct 和科学信息数据库等不同数据库,对草药和纳米草药治疗牙周炎的效果进行了叙述性综述:根据已发表的研究,一些常用的草药配方,如芦荟、姜黄素、互叶白千层和黄芩,可有效治疗牙周炎。然而,这些草药产品可能存在一些药理限制,如生物利用度低、不稳定、水溶性弱等。另一方面,利用纳米草药制剂可以提高生物利用度,降低毒性,并避免重复给药:草药和纳米草药产品可为有效治疗牙周炎创造良好的机会。
Herbal and nano-based herbal medicine: New insights into their therapeutic aspects against periodontitis.
Objective: Periodontitis is a type of prevalent chronic inflammatory disorder resulting in a failure in the function of tissues supporting the tooth, like gingiva, alveolar bone, and periodontal ligament. Although antibiotic therapy is a common therapy for periodontitis cases, this approach can cause some adverse effects in these patients. Thus, finding an effective curative option with low side effects is still a puzzle.
Materials and methods: This narrative review was conducted on the effects of herbal and nano-based herbal medicine against periodontitis by searching different databases such as Google Scholar, PubMed, Scopus, Web of Science, Science Direct, and Scientific Information Databases.
Results: According to published studies, some popular herbal formulations, such as Aloe vera, curcumin, Melaleuca alternifolia, and Scutellaria baicalensis Georgi, can be effective in periodontitis treatment. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the other hand, harnessing nano-based herbal formulations can elevate the bioavailability, diminish toxicity, and omit repeated administration of drugs.
Conclusion: Herbal and nano-based herbal products can create a good chance to treat periodontitis efficiently.