Avicenna Journal of Phytomedicine最新文献

{"title":"Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells.","authors":"Mohammad Kamalabadi-Farahani, Fatemeh Jamshidi Adegani, Roqaye Karimi, Amir Atashi","doi":"10.22038/AJP.2024.24655","DOIUrl":"https://doi.org/10.22038/AJP.2024.24655","url":null,"abstract":"<p><strong>Objective: </strong>Brain metastasis in patients with breast cancer is considered a deadly event. The oleogum resins of Boswellia species, known as Frankincense has been found to have anti-cancer properties in many studies. The main purpose of our research was to evaluate these effects on brain metastatic cancer cells.</p><p><strong>Materials and methods: </strong>Primary (4T1T) and brain metastatic (4T1B) tumor cells were isolated from breast cancerous mice. Cytotoxic, apoptotic, and anti-metastatic effects of the methanolic extract of frankincense were evaluated with MTT assay, propidium iodide (PI) flow cytometric assay, and scratch test, respectively. Zymography assay was used to evaluate the effects of extract on the matrix metalloproteinases-2 and -9 (MMP-2 /9) expression/activity.</p><p><strong>Results: </strong>The methanolic extract of frankincense has significant cytotoxic and apoptotic effects on 4T1B cells (p<0.001). Interestingly, 4T1B cells are more prone to these effects than 4T1T cells. In 4T1B, the anti-metastatic effects of frankincense extract were confirmed. Frankincense suppressed MMP-2/9 protein expression both in 4T1T and 4T1B.</p><p><strong>Conclusion: </strong>Our findings indicated that frankincense extract has a potent cytotoxic effect on brain metastatic tumor cells and induces apoptosis in these cells. Unlike many anti-cancer drugs which have very little ability to combat and kill brain metastatic cancer cells, frankincense extract can be considered a suitable candidate to fight these cells.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"776-783"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic potential of Ma'aljobon, a whey product, in primary hypertension: A double-blind randomized controlled trial.","authors":"","doi":"10.22038/AJP.2024.24921","DOIUrl":"https://doi.org/10.22038/AJP.2024.24921","url":null,"abstract":"<p><strong>Objective: </strong>Ma'aljobon is used in Persian medicine (PM) as a natural antihypertensive product. This study aimed to evaluate the hypotensive effect of Ma'aljobon in patients with uncontrolled grade 1 primary hypertension (HTN).</p><p><strong>Materials and methods: </strong>This double-blind, placebo-controlled clinical trial included 114 patients (20-80 years) with uncontrolled grade 1 primary HTN. After obtaining informed consent, the participants were randomly divided into two groups and administered with 25g of Ma'aljobon or maltodextrin twice daily for six weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively) were analyzed.</p><p><strong>Results: </strong>A total of 97 patients (52.3±10.7 years, %53.6 female) completed the study. In the Ma'aljobon group, SBP decreased from 150.3±12.3 to 130.6±12.1 mm Hg, and DBP decreased from 93.3±8.2 to 80.1±6.6 mm Hg (p<0.001). In the control group, SBP decreased from 147.6±11.2 to 138.7±14.4 mm Hg, and DBP decreased from 86.6±7.7 to 82.2±8.2 mm Hg (p<0.001). There was a significant difference in the changes of SBP and DBP between the two groups over time (p<0.001). No adverse events were observed.</p><p><strong>Conclusion: </strong>Ma'aljobon has a stronger hypotensive effect than placebo in patients with HTN and can be recommended as an add-on therapy for uncontrolled HTN.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"848-859"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of wet cupping on reactive airway dysfunction syndrome (RADS) caused by early exposure to chlorine gas: A randomized clinical trial.","authors":"Khatereh Akbari Mashak, Khosro Agin, Elham Emaratkar, Mohammad Gholami Fesharaki, Hasan Namdar","doi":"10.22038/AJP.2024.25107","DOIUrl":"https://doi.org/10.22038/AJP.2024.25107","url":null,"abstract":"<p><strong>Objective: </strong>In the absence of targeted antidotes for chlorine gas poisoning, a common yet concerning problem, this study investigates the effect of Wet Cupping Therapy (WCT, or \"<i>Hijamat\"</i>) on the recovery process in chlorine-induced reactive airway dysfunction syndrome (RADS) patients.</p><p><strong>Materials and methods: </strong>This randomized controlled trial enrolled 24 patients experiencing acute inhalation of chlorine poisoning in Tehran, Iran (2020-2021). Patients were randomly divided into control (n=12, receiving conventional treatment) and intervention (n=12, receiving conventional treatment plus WCT) groups. Signs and symptoms were assessed pre-intervention, and in the first hour, first week, and first month post-intervention.</p><p><strong>Results: </strong>Medical records of 24 patients, including 3(12.5%) men and 21(87.5%) women, with a mean age of 42.92 years old, were evaluated. Baseline characteristics were similar between the groups. WCT significantly improved symptoms (dyspnea, cough, chest tightness, etc.) within the first hour (p=0.003) compared to the controls, with no future significant changes during the first week and first-month post-WCT. Comparison between the groups revealed substantial differences in the following variables: dyspnea scale (p=0.009), respiratory rate (p=0.026), cough (p=0.001), breath shortness (p=0.006), chest tightness (p=0.002), chest pain (p=0.010), substernal burning (p=0.015), throat sore (p=0.005) and hoarseness (p=0.027). Peak flow meter readings, reflecting lung function, were also significantly higher in the WCT group at all time-points (p<0.007).</p><p><strong>Conclusion: </strong>WCT may offer a rapid and sustained improvement in pulmonary and respiratory symptoms following acute chlorine inhalation injury.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"997-1015"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining efficacy and safety of ethyl acetate extract from <i>Allium hirtifolium</i> as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial.","authors":"Mansour Amin, Mandana Pouladzadeh, Mohammad Jaafar Yadyad, Roshanak Roshanfard, Mohamad Hasan Pipelzadeh, Afshin Talebi, Behzad Sharif Maakhmalzadeh, Mehdi Bijanzadeh, Nasrin Rakipour, Gholamreza Alizadehattar, Seyed Saeed Seyedian, Kambiz Ahmadi Angali, Parastoo Moradi Choghakabodi, Akbar Akbari, Fatemeh Maghsodi, Ebrahim Barzegari, Maryam Jamalan, Reza Aalizadeh, Mostafa Jamalan","doi":"10.22038/AJP.2024.24523","DOIUrl":"https://doi.org/10.22038/AJP.2024.24523","url":null,"abstract":"<p><strong>Objective: </strong>Given the apparent life-threatening nature of COVID-19, finding an effective treatment is under investigation.</p><p><strong>Materials and methods: </strong>We assessed effect of shallomin oral syrup (co IranAmin^®) as a complementary treatment to improve the clinical outcomes in COVID-19 patients. Patients in the control group received the approved treatment protocol (lopinavir/ritonavir), while those in the intervention group were treated with the oral syrup shallomin in addition to the approved treatment. Clinical status of treated patients was recorded and compared.</p><p><strong>Results: </strong>There were meaningful differences between the two groups regarding shortened length of hospital stay and the recovery time for cough, myalgia, sore throat, and shortness of breath. No side effect occurred in the intervention group compared to the control group in terms of biochemical and hematological factors.</p><p><strong>Conclusion: </strong>It seems that the treatment with shallomin syrup showed remarkable contribution to the recovery of COVID-19 induced symptoms in the patients under lopinavir/ritonavir therapy.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"699-710"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke.","authors":"Solmaz Najjary, Hossein Mostafavi, Hadi Feizi, Fatemeh Moradi, Mehdi Eskandari","doi":"10.22038/AJP.2024.24290","DOIUrl":"https://doi.org/10.22038/AJP.2024.24290","url":null,"abstract":"<p><strong>Objective: </strong>Brain ischemia generally results in irreversible brain damage or death. One of the most important features of an ischemic stroke is disruption of the Blood-brain barrier (BBB). In this study, we examined the effect of cinnamon hydroalcoholic extract consumption on BBB permeability and expression of some genes regulating its function.</p><p><strong>Materials and methods: </strong>Sixty male Wistar rats were divided into 5 groups; sham (high-fat diet+ sham surgery), Model (Middle Cerebral Artery Occlusion, MCAO+ high-fat diet), Lovastatin (high-fat diet + lovastatin + MCAO surgery), low and high dosage cinnamon (high-fat diet + cinnamon 130 or 260 mg, respectively+ MCAO surgery). The two doses of cinnamon (130 and 260 mg) were administered intraperitoneally. Twelve hours after ischemic stroke induction, brain right hemisphere tissues were collected and <i>calpain I, calpainII, occludin</i> and <i>VEGF</i> genes expression were quantified by Real-Time -PCR. Accordingly, p-selection protein levels were measured by ELISA method.</p><p><strong>Results: </strong>Cinnamon hydroalcoholic extract reduced the BBB permeability compared with the model group (p<0.05). Stroke increased <i>calpain</i> and <i>VEGF</i> genes while decreased <i>occludin</i> gene expression (p<0.001). Conversely, cinnamon administration increased <i>occludin</i> gene expression while <i>calpain</i> and <i>VEGF</i> genes were down-regulated (p<0.01). Pretreatment with cinnamon significantly diminished the P-Selectin protein levels as compared with the model group dose dependently (p<0.001).</p><p><strong>Conclusion: </strong>It seems that cinnamon restores BBB function by regulating the elements involved in its permeability.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"723-733"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors.","authors":"Zeinab Kordestani, Ahmad Beik, Hamid Najafipour, Zohreh Safi, Majid Askaripour, Soodeh Rajabi","doi":"10.22038/AJP.2024.24522","DOIUrl":"https://doi.org/10.22038/AJP.2024.24522","url":null,"abstract":"<p><strong>Objective: </strong>Pulmonary artery hypertension (PAH) is a devastating syndrome. Our previous studies showed that perillyl alcohol (P), berberine (B) and quercetin (Q) improve PAH. In this study, we investigated the effects of sub-effective doses of these derivatives in double and triple combination forms on PAH in rats.</p><p><strong>Materials and methods: </strong>Forty nine rats were divided into seven groups (n=7): 1) control, 2) monocrotaline (MCT), 3) MCT+vehicle (veh), 4) MCT+BP, 5) MCT+PQ, 6) MCT+BQ, and 7) MCT+BPQ. After three weeks of PAH induction with MCT (60 mg/kg), either vehicle (ethanol 5% in saline) or one of the above combinations (dose of 20 mg/kg for B, and doses of 20 and 10 mg/ kg for P and Q in vehicle) was administered for three weeks. Right ventricular (RV) pressure, contractility indices, lung pathology, miR-204 expression, oxidative stress markers, inflammation and apoptosis were assayed.</p><p><strong>Results: </strong>MCT increased RV systolic pressure and hypertrophy, and lung arteriole wall thickness, fibrosis and leukocyte infiltration in the MCT group compared to the CTL group. All treatments improved these effects significantly. Furthermore, MCT reduced antioxidant factors, Bax, P21 and miR-204 expression and increased Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6) and Bcl-2. All of these effects were recovered by combination treatments.</p><p><strong>Conclusion: </strong>The results showed that combination therapy with sub-effective/ineffective doses of these compounds had ameliorative effects against PAH.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"764-775"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects of <i>Allium ampeloprasum</i> Subsp <i>Iranicum</i> on cyclophosphamide-induced immunosuppression in NMRI Mice: A promising natural immunomodulator.","authors":"Fatemeh Abedi, Bahareh Sadat Yousefsani, Kobra Shirani","doi":"10.22038/AJP.2024.24595","DOIUrl":"https://doi.org/10.22038/AJP.2024.24595","url":null,"abstract":"<p><strong>Objective: </strong>Cyclophosphamide (CTX) is an effective anticancer drug, but toxic effects against normal human tissues are its dose-limiting drawback. The aim of this research was to investigate the <i>in vivo</i> immunomodulatory activities of <i>Allium ampeloprasum</i> Subsp <i>Iranicum</i> against CTX-induced toxicity in mice.</p><p><strong>Materials and methods: </strong>Extract of the whole plant of <i>A. ampeloprasum</i> Subsp <i>Iranicum</i> was obtained using the maceration technique, and its total phenolic and flavonoid contents were quantified through spectrophotometric analysis. Mice received daily oral administration (PO) of the extract (150 mg/kg) for a duration of 14 days, either as a standalone treatment or in conjunction with an intraperitoneal (IP) injection of 20 mg/kg CTX. The effects of the extract on body weight, spleen weight, white blood cell (WBC), serum antibody titer hemagglutination (HA), delayed-type hypersensitivity response (DTH), lymphocyte proliferation, cytokine production, and histopathological examinations were evaluated.</p><p><strong>Results: </strong><i>A. ampeloprasum</i> Subsp <i>Iranicum</i> restored several parameters including spleen weight (p<0.001), WBC (p<0.001), lymphocytes (p<0.05), and monocytes (p<0.01), HA titer (p<0.05), and DTH response (p<0.01). <i>A. ampeloprasum</i> Subsp <i>Iranicum</i> notably stimulated lymphocyte proliferation to PHA (p<0.01) and LPS (p<0.05) and recovered interferon (IFN)-γ (p<0.001) and interleukin (IL)-4 (p<0.001) levels in the immunosuppressed mice. Also, CTX-induced histopathological changes were reversed by <i>A. ampeloprasum</i> Subsp <i>Iranicum</i> <i>.</i></p><p><strong>Conclusion: </strong>Analyses revealed <i>A. ampeloprasum</i> Subsp <i>Iranicum</i> could regulate immunity and increase host immune responses. The observed strengthening effect can be attributed to the high amount of flavonoids and dipropyl trisulfide compounds present in <i>A. ampeloprasum</i> Subsp <i>Iranicum</i>.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"734-745"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The adjuvant therapy of edible herbal product including colchicum bulb, olive leaf, black cumin seeds, lavender flower, and ginger rhizome on the outcome of patients with severe and critical COVID-19: A double-blind randomized controlled clinical trial.","authors":"Vahid Sebghatollahi, Mansour Siavash Dastjerdi, Farzin Ghiasi, Babak Alikiaii, Morteza Pourahmad, Afsaneh Yegdaneh, Mojtaba Akbari, Reza Ghadiri","doi":"10.22038/AJP.2024.24633","DOIUrl":"https://doi.org/10.22038/AJP.2024.24633","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed at evaluating the effect of combination of medicinal plants, including <i>Colchicum autumnal</i> L., <i>Olea europaea</i> L.<i>,</i> <i>Nigella sativa</i> L., <i>Lavandula angustifolia</i> L., and <i>Zingiber officinale</i> Roscoe, on the recovery and outcome of COVID-19 patients.</p><p><strong>Materials and methods: </strong>This study was conducted on 150 COVID-19 patients. All patients received both pharmaceutical and supportive treatments. In addition to the standard care treatment, intervention group received two capsules of herbal medicine orally every 8 hours, while control group received placebo.</p><p><strong>Results: </strong>Oxygen saturation percentage (SpO2) of the intervention group (median:88.00) was significantly higher than that of the control group (median:86.00), while C-reactive protein (CRP) of the intervention group (median:20.00) was significantly lower than that of the control group (median:28.00) at the time of hospital discharge (p<0.05).</p><p><strong>Conclusion: </strong>The combination of studied medicinal plants could significantly reduce the oxygen requirement and oxygen therapy.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"686-698"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants used in traditional medicine to enhance immunity: A survey in the southeastern area of Morocco and a literature review.","authors":"Karima El-Yagoubi, Meryem Bakour, Badiaa Lyoussi","doi":"10.22038/AJP.2024.24096","DOIUrl":"https://doi.org/10.22038/AJP.2024.24096","url":null,"abstract":"<p><strong>Objective: </strong>The threat of immune escape and the discovery of antibiotic-resistant pathogens, as well as the failure of certain conventional drugs that are already in use for the symptomatic treatment of diseases, have prompted a re-evaluation of ancient therapeutic remedies such as phytotherapy, and aromatherapy. In this context, the present study aims to shed light on some medicinal plants mostly used by the population of the Daraa Tafilalet region to strengthen their immune systems, and to provide an up-to-date literature review on this subject.</p><p><strong>Materials and methods: </strong>A survey study was conducted using pre-prepared questionnaires addressed to the population of the Daraa Tafilalet region. MS Windows Excel and SPSS software were used for statistical analysis and results presentation. In addition, for the literature review, searches were conducted across several databases, including Google Scholar, Science Direct, Web of Science, PubMed, and Scopus, using medicinal plants, date products, enhance immunity, and essential oils as keywords.</p><p><strong>Results: </strong>Among 142 participants interviewed, 108 used medicinal plants to improve their immune systems. However, 34 interviewers prefer conventional medicine. Date palm fruits and oregano were the most commonly used medicinal plants by the Daraa Tafilalet population to enhance the immune system, followed by anise, lavender, rosemary, thyme, and pennyroyal. These results are supported by literature data.</p><p><strong>Conclusion: </strong>These results reflect the interesting traditional medical knowledge of this population, which merits being documented.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"666-685"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The preventive effects of <i>Zataria multiflora</i> and carvacrol and their co-administration with pioglitazolne on systemic inflammation and oxidative stress induced by paraquat inhalation in rats.","authors":"Mahla Mohammadi Mahjoob, Sima Beigoli, Arghavan Memarzia, Javad Ghasemi, Mohammad Hossein Boskabady","doi":"10.22038/AJP.2024.24272","DOIUrl":"https://doi.org/10.22038/AJP.2024.24272","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to assess the impact of the aqueous-ethanolic extract of <i>Zataria multiflora</i> (ZM), carvacrol (Car), and their co-administration with a PPAR activator, pioglitazone (Pio), on oxidative stress and inflammation induced by paraquat (PQ) inhalation at a systemic level.</p><p><strong>Materials and methods: </strong>The rats in the control group were exposed to saline and those of other groups to PQ (54 mg/m³) aerosols for 8 times on alternate days. Nine PQ groups were treated with saline, Car (20 and 80 mg/kg/day), ZM (200 and 800 mg/kg/day), Pio (5 mg/kg/day), dexamethasone (Dexa, 0.03 mg/kg/day), and low-dose ZM or Car + Pio for 16 days during the period of PQ exposure (n=6).</p><p><strong>Results: </strong>Differential and total WBC counts, and malondialdehyde (MDA), interleukin (IL)-10, and tumor necrosis factor (TNF)-α levels were enhanced but catalase (CAT), thiol, and superoxide dismutase (SOD) levels were reduced in the blood in the PQ group (p<0.01 to p<0.001). All measured variables improved in groups treated with both doses of ZM, Car, Pio, ZM + Pio, Car+Pio, and Dexa <i>vs</i> the PQ group (p<0.05 to p<0.001). Most variables were more improved in combined treatment groups in comparison with three agents alone. The combination of ZM or Car, and Pio showed an impact on PQ inhalation-induced systemic changes.</p><p><strong>Conclusion: </strong>The synergistic effect between Pio with ZM or Car indicates that these substances work together to enhance their individual effects.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"711-722"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}