Avicenna Journal of Phytomedicine最新文献_第5页

Hormetic effects of curcumin on oxidative stress injury induced by trivalent arsenic in isolated rat hepatocytes. 姜黄素对三价砷诱导的离体大鼠肝细胞氧化应激损伤的激素效应

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22634

Marzieh Amirmostofian, Fahimeh Akbari, Mahmoud Hashemzaei, Fahimeh Safaeinejad, Kaveh Tabrizian, Halimeh Arbab, Ramin Rezaee, Shaghayegh Hemat Jouy, Vahideh Ghorani, Jafar Shahraki

{"title":"Hormetic effects of curcumin on oxidative stress injury induced by trivalent arsenic in isolated rat hepatocytes.","authors":"Marzieh Amirmostofian, Fahimeh Akbari, Mahmoud Hashemzaei, Fahimeh Safaeinejad, Kaveh Tabrizian, Halimeh Arbab, Ramin Rezaee, Shaghayegh Hemat Jouy, Vahideh Ghorani, Jafar Shahraki","doi":"10.22038/AJP.2023.22634","DOIUrl":"https://doi.org/10.22038/AJP.2023.22634","url":null,"abstract":"Objective: Arsenic (As) poisoning is a worldwide public health problem. Arsenic can cause cancer, diabetes, hepatic problems, etc. Hence, we investigated possible hepatoprotective properties of curcumin against As3+-induced liver damages in freshly isolated rat hepatocytes.Materials and methods: Isolation of hepatocytes was done by the two-step liver perfusion method using collagenase. The EC50 concentration of As3+ was used in toxicity assessments and curcumin (2, 5, and 10 µM) was added 15 min before As3+ addition to isolated hepatocytes. Curcumin impact was assessed in terms of cytotoxicity, lipid peroxidation induction, reactive oxygen species (ROS) levels, and mitochondrial membrane potential.Results: As3+ significantly increased cytotoxicity, malondialdehyde and ROS levels and induced mitochondrial membrane damage and hepatocyte membrane lysis after 3 hr incubation. Curcumin 2 µM significantly prevented lipid peroxidation induction, ROS formation, and mitochondrial membrane damage; while curcumin 5 µM had no apparent effect on these parameters, curcumin 10 µM potentiated them.Conclusion: Curcumin only at low doses could ameliorate oxidative stress injury induced by As3+ in isolated rat hepatocytes.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal plants and foods with metaphorical concepts in Rumi's "Masnavi Manavi": The psychosomatic approach to human health. 鲁米《玛斯纳维 Manavi》中具有隐喻概念的药用植物和食物：人类健康的心身医学方法。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.71710.3309

{"title":"Medicinal plants and foods with metaphorical concepts in Rumi's \"Masnavi Manavi\": The psychosomatic approach to human health.","authors":"","doi":"10.22038/AJP.2023.71710.3309","DOIUrl":"https://doi.org/10.22038/AJP.2023.71710.3309","url":null,"abstract":"Objective: \"Masnavi Manavi\" is one of the most valuable texts of Persian literature. In this book, Rumi (Mevlana) with a unique method and in the form of moral stories teaches life lessons, mystical truths and even therapeutic advices to people. The aim of this study is to highlight the medicinal plants and foods that had been applied both in somatic and spiritual concept in \"Masnavi Manavi' poems.Materials and methods: For this purpose, a library-based, descriptive and analytical method was used.Results: Some medicinal plants and food terms such as rose-water, vinegar, honey, oxymel, common reed, grape, onion, garlic and wheat are mentioned in this study to show Rumi's metaphorical and therapeutic approach as a doctor who treats both soul and body. In fact, Rumi's intention to apply these terms was to express his ideas and views about the inseparability of physical and spiritual aspects in human health and well-being.Conclusion: Rumi focus in \"Masnavi Manavi\" moral stories is the soul health and consider body as carrier of the soul. Therefore, because of this psychosomatic approach to human disease, he selects the most suitable herbs and foods for explaining spiritual and somatic medicine.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ellagic acid alleviates motor, cognitive and hippocampal electrical activity deficits in the male rats with 2-vessel occlusion cerebral ischemia/reperfusion. 鞣花酸可缓解双血管闭塞性脑缺血/再灌注雄性大鼠的运动、认知和海马电活动障碍。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22787

Khadijeh Hassonizadeh Falahieh, Alireza Sarkaki, Mohammadamin Edalatmanesh, Mohammad Kazem Gharib Naseri, Yaghoob Farbood

{"title":"Ellagic acid alleviates motor, cognitive and hippocampal electrical activity deficits in the male rats with 2-vessel occlusion cerebral ischemia/reperfusion.","authors":"Khadijeh Hassonizadeh Falahieh, Alireza Sarkaki, Mohammadamin Edalatmanesh, Mohammad Kazem Gharib Naseri, Yaghoob Farbood","doi":"10.22038/AJP.2023.22787","DOIUrl":"https://doi.org/10.22038/AJP.2023.22787","url":null,"abstract":"Objective: Cerebral ischemia/reperfusion (I/R) has been known as a major cause of inability and mortality worldwide. Ellagic acid (EA) has many pharmacological effects including antioxidant, antithrombotic and neurorestoration activities. The aim of this study was evaluation of the effects of EA on motor and cognitive behaviors, hippocampal local field potential (LFP), brain oxidative stress in male rats with cerebral 2-vessel occlusion ischemia/reperfusion (2VO I/R).Materials and methods: Forty-eight male Wistar rats (250-300 g) were assigned into six groups. 1) The Sham: rats were treated with DMSO10%/normal saline as solvent of EA 3 times daily for 1 week; 2) I/R+Veh; I/R rats received vehicle; 3-5) EA-treated groups: I/R rats received 50, 75, or 100 mg/kg EA; and 6) Cont+EA100: intact rats received EA. The cerebral 2VO I/R was made by the bilateral common carotid arteries closing for 20 min followed by reperfusion. The behavioral tests and hippocampal LFP recording were performed after treatment with EA. The oxidative stress parameters were assayed by special ELISA kits.Results: Cerebral 2VO I/R significantly decreased motor coordination, memory and hippocampal LFP and significantly increased oxidative stress. Treatment with EA improved all I/R complications.Conclusion: The current findings showed that treatment of I/R rats with EA could reverse cognitive and motor functions, and improve the LFP and oxidative stress markers. So, effects of EA on cognitive and motor function may at least in part, be due to its antioxidative actions.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The methanolic extract of Hibiscus sabdariffa downregulates the relative expression of Kiss1 gene in the hypothalamus of Wistar rats: A preliminary report. 木槿甲醇提取物能下调 Wistar 大鼠下丘脑 Kiss1 基因的相对表达：初步报告

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22692

Izuchukwu Azuka Okafor, Smart Ikechukwu Mbagwu, Uchenna Somtochukwu Okafor, Johnson Okwudili Nweke, Kingsley Chinemerem Ibeabuchi, Samuel Nduka Ogbonna

{"title":"The methanolic extract of Hibiscus sabdariffa downregulates the relative expression of Kiss1 gene in the hypothalamus of Wistar rats: A preliminary report.","authors":"Izuchukwu Azuka Okafor, Smart Ikechukwu Mbagwu, Uchenna Somtochukwu Okafor, Johnson Okwudili Nweke, Kingsley Chinemerem Ibeabuchi, Samuel Nduka Ogbonna","doi":"10.22038/AJP.2023.22692","DOIUrl":"https://doi.org/10.22038/AJP.2023.22692","url":null,"abstract":"Objective: Kiss1 gene expression in the rat hypothalamus was investigated following administration of methanolic extract of Hibiscus sabdariffa (MEHS) to provide mechanistic evidence for the reproductive effect of the MEHS as a potential regulator of Kiss1 gene (which directly controls the hypogonadal axis).Materials and methods: This experiment was done using fifteen (15) male rats with average weight of 148 g, randomly grouped into three (3) groups (A-C). Group A was the control group and received no treatment. Group B and C were orally administered with 200 mg/kg and 400 mg/kg of MEHS, respectively. The animals received the extract once a day for twenty-one (21) days. The hypothalamus was harvested on the last day of administration to investigate antioxidant levels, histopathology, and Kiss1 gene expression.Results: The relative expression of Kiss1 gene in the group C was downregulated compared to the control group (p=0.023). No significant changes were seen in the antioxidant levels of the groups treated with MEHS when compared to the control. MEHS had no histopathological effects in the hypothalamus at both low (200 mg/kg) and high (400 mg/kg) doses.Conclusion: High-dose MEHS lowers the expression of the Kiss1 gene in the hypothalamus. However, this effect could not be explained by the oxidative profile or histology of the hypothalamus.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial. 姜黄素补充剂对经前综合征和痛经年轻女性失眠和白天嗜睡的影响：随机临床试验。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.21916

Saman Seyedabadi, Zahra Sadat Hoseini, Gordon A Ferns, Afsane Bahrami

{"title":"Effects of curcumin supplementation on insomnia and daytime sleepiness in young women with premenstrual syndrome and dysmenorrhea: A randomized clinical trial.","authors":"Saman Seyedabadi, Zahra Sadat Hoseini, Gordon A Ferns, Afsane Bahrami","doi":"10.22038/AJP.2023.21916","DOIUrl":"https://doi.org/10.22038/AJP.2023.21916","url":null,"abstract":"Objective: Premenstrual syndrome and primary dysmenorrhea are common gynecological complaints that are associated with psychological disorders. There is increasing evidence for the neuroprotective properties of curcumin, a polyphenolic natural product. This study aimed to assess the effects of curcumin on sleep complications in women with premenstrual syndrome and dysmenorrhea.Materials and methods: This triple-masked, placebo-controlled clinical trial comprised 124 patients with both premenstrual syndrome and dysmenorrhea. Participants were randomly assigned to curcumin (n=57) or control (n=60) groups. Each participant received one capsule containing either 500 mg of curcumin plus piperine or placebo, daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Insomnia and sleepiness were assessed using standard questionnaires.Results: Scores for insomnia and daytime sleepiness were directly correlated with the Premenstrual Syndrome Screening Tool (PSST) score (p<0.05), but not with the visual analogue scale (VAS) score at baseline (p>0.05). There was a non-significant reduction in insomnia and sleepiness scores in both curcumin and placebo groups after the study intervention. Whilst, improvement rate of insomnia status, daytime sleepiness severity, short sleep duration and difficult sleep initiation was not statistically significant between the curcumin and placebo groups.Conclusion: Curcumin does not significantly affect sleep disorders in young women with premenstrual syndrome and dysmenorrhea.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Lilium ledebourii antiproliferative compounds against skin, bone and oral cancer cells. 鉴定百合花抗皮肤癌、骨癌和口腔癌细胞增殖的化合物。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22875

Nastaran Partovi, Hassan Hassani Kumleh, Ebrahim Mirzajani, Mohsen Farhadpour

{"title":"Identification of Lilium ledebourii antiproliferative compounds against skin, bone and oral cancer cells.","authors":"Nastaran Partovi, Hassan Hassani Kumleh, Ebrahim Mirzajani, Mohsen Farhadpour","doi":"10.22038/AJP.2023.22875","DOIUrl":"https://doi.org/10.22038/AJP.2023.22875","url":null,"abstract":"Objective: This study aimed at the evaluation of anti antiproliferative activity of Lonicera nummularifolia, Lilium ledebourii, Campsis radicans and Parthenocissus quinquefolia extracts.Materials and methods: The extract was taken from the fresh leaves and bulbs of the plants by maceration method in the dark. After separating the solvent, the remaining dry matter was added to the culture medium containing G292, A431 and KB cancer and HGF-1 normal cells. Cytotoxicity tests, as well as cell cycle and apoptosis tests were performed on cells treated with dry substances and untreated cells. Finally, the most effective extract was separated into fractions by preparative HPLC and the effective fraction was characterized by Triple-Quad LC/MS connected to the UHPLC system.Results: All extracts significantly enhanced cell death rate in the three cancer cell lines more than the HGF-1 line. The Methanolic extract of L. ledebourii bulbs exhibited considerable efficacy on apoptosis induction in the cancer cell lines. It seems that the mode of action for L. ledebourii methanolic extract is mediated through increased BID/MAPK14 expression and decreased MDM2/BCL2/MYC expression, which led to activation of the p53 protein-induced apoptosis. It was also determined that the effective fraction of L. ledebourii methanolic extract consists of substances such as caffeic acid, ferulic acid, coumarin acid, catechin and apigenin.Conclusion: Overall, the findings suggest that L. ledebourii is a promising source of bioactive compounds with anticancer properties.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD). 纳米微粒姜黄素对肝酶的影响：治疗非酒精性脂肪肝（NAFLD）的新方法。

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.21919

Ali Beheshti Namdar, Mitra Ahadi, Seyed Mousalreza Hoseini, Hassan Vosoghinia, Hosein Rajablou, Salman Farsi, Amirsadra Zangouei, Hamid Reza Rahimi

{"title":"Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD).","authors":"Ali Beheshti Namdar, Mitra Ahadi, Seyed Mousalreza Hoseini, Hassan Vosoghinia, Hosein Rajablou, Salman Farsi, Amirsadra Zangouei, Hamid Reza Rahimi","doi":"10.22038/AJP.2023.21919","DOIUrl":"https://doi.org/10.22038/AJP.2023.21919","url":null,"abstract":"Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of 160 mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=33) and placebo (n=33) groups and at the end of the study, the data of 56 participants who completed the 2-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received 160 mg/day of nano-micelle curcumin in two divided doses for 60 days. The 2 groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p<0.01) as well as a significant difference between the groups before and after the intervention in curcumin group (p<0.05). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p<0.01).Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats. 评估可可油对卵巢切除大鼠学习和行为障碍的神经保护作用

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22724

Ali Balderan, Yasamin Farrokhifar, Mahmoud Hosseini, Elnaz Khordad, Saeedeh Askarian, Samaneh Kakhki, Farimah Beheshti

{"title":"Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats.","authors":"Ali Balderan, Yasamin Farrokhifar, Mahmoud Hosseini, Elnaz Khordad, Saeedeh Askarian, Samaneh Kakhki, Farimah Beheshti","doi":"10.22038/AJP.2023.22724","DOIUrl":"https://doi.org/10.22038/AJP.2023.22724","url":null,"abstract":"Objective: The current study aimed to investigate whether Cocos nucifera L. oil (CO) is effective on menopause-related memory dysfunction in ovariectomized (OVX) rats.Materials and methods: Fifty healthy female Wistar rats were randomly selected and classified into five groups as control, OVX rats, and three OVX groups of rats which received three different doses (100, 200, and 400 mg/kg/day) of CO for five consecutive weeks by gavage. To assess the effect of CO, neurobehavioral tests such as Morris water maze (MWM) and Passive avoidance (PA) were done and then the animals were sacrificed to remove cortical and hippocampal tissues for biochemical analysis.Results: In both behavioral tests including MWM and PA, treatment with CO particularly two higher doses of 200, and 400 mg/kg demonstrated significant improvement in comparison with OVX group. Furthermore, antioxidant biomarkers such as total thiol content, catalase and superoxide dismutase (SOD) activities were significantly higher in the OVX-CO groups versus the OVX group. On the contrary, malondialdehyde (MDA) concentration as an oxidative stress biomarker was remarkably lower in the OVX-CO200 and 400 mg groups than the OVX group.Conclusion: The present study demonstrated the significant improvement of CO on learning and memory impairment induced by ovariectomy. Although the exact mechanism needs further investigation, it might have occurred due to the anti-oxidative effect of CO.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silibinin effects on cognitive disorders: Hope or treatment? Silibinin 对认知障碍的影响：希望还是治疗？

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.21959

Zahra Akhoond-Ali, Alireza Rahimi, Atiyeh Ghorbani, Fatemeh Forouzanfar, Sara Hosseinian, Hamed Ghazavi, Farzaneh Vafaee

{"title":"Silibinin effects on cognitive disorders: Hope or treatment?","authors":"Zahra Akhoond-Ali, Alireza Rahimi, Atiyeh Ghorbani, Fatemeh Forouzanfar, Sara Hosseinian, Hamed Ghazavi, Farzaneh Vafaee","doi":"10.22038/AJP.2023.21959","DOIUrl":"https://doi.org/10.22038/AJP.2023.21959","url":null,"abstract":"Objective: Almost all diseases of the nervous system are related to neuroinflammation, oxidative stress, neuronal death, glia activation, and increased pro-inflammatory cytokines. Cognitive disorders are one of the common complications of nervous system diseases. The role of some plant compounds in reducing or preventing cognitive disorders has been determined. Silibinin is a plant bioflavonoid and exhibits various effects on cognitive functions. This article discusses the different mechanisms of the effect of silibinin on cognitive disorders in experimental studies.Materials and methods: Databases, including ISI, , Google Scholar, Scopus, Medline and PubMed, were investigated from 2000 to 2021, using related keywords to find required articles.Results: Silibinin can improve cognitive disorders by different pathways such as reducing neuroinflammation and oxidative stress, activation of reactive oxygen species- Brain-derived neurotrophic factor- Tropomyosin receptor kinase B (ROS-BDNF-TrkB) pathway in the hippocampus, an increase of dendritic spines in the brain, inhibition of hyperphosphorylation of tau protein and increasing the expression of insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R), inhibiting inflammatory responses and oxidative stress in the hippocampus and amygdala, and decrease of Homovanillic acid/Dopamine (HVA/DA) ratio and 3,4-Dihydroxyphenylacetic acid + Homovanillic acid/Dopamine (DOPAC+ HVA/DA) ratio in the prefrontal cortex and 5-hydroxyindoleacetic acid/5-hydroxytryptamine (5-HIAA/5-HT) ratio in the hippocampus.Conclusion: These results suggest that silibinin can be considered a therapeutic agent for the symptom reduction of cognitive disorders, and it acts by affecting various mechanisms such as inflammation, programmed cell death, and oxidative stress.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis. 香根草精油对铜绿素多发性硬化大鼠模型中胼胝体脱髓鞘的预防作用

IF 2.2

Avicenna Journal of Phytomedicine Pub Date : 2023-11-01 DOI: 10.22038/AJP.2023.22784

Valiollah Moradi, Seyed Mostafa Ghanadian, Bahman Rashidi, Nazem Ghasemi, Gholamreza Dashti, Ebrahim Esfandiari

{"title":"The preventive effect of Zingiber officinale essential oil on demyelination of corpus callosum in a cuprizone rat model of multiple sclerosis.","authors":"Valiollah Moradi, Seyed Mostafa Ghanadian, Bahman Rashidi, Nazem Ghasemi, Gholamreza Dashti, Ebrahim Esfandiari","doi":"10.22038/AJP.2023.22784","DOIUrl":"https://doi.org/10.22038/AJP.2023.22784","url":null,"abstract":"Objective: Multiple sclerosis (MS) is the most prevalent neurological disability among young adults. Anti-inflammatory drugs have shown to be effective in MS. The anti-inflammatory and antioxidative properties of Zingiber officinale (ginger) have been shown and proven in many phytotherapy studies. This study aimed to evaluate effects of ginger essential oil on preventing myelin degradation in a rat model of MS.Materials and methods: In this study, we divided 49 rats into 7 groups; 4 control and 3 experimental groups that received 3 different dose of ginger essential oil (50, 100, and 150 mg/kg/day) for treatment of cuprizone-induced demyelinated rats. Basket test and transmission electron microscopy were performed in this study. Olig2 and Mbp genes and proteins were respectively evaluated by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).Results: Histologically, cuprizone created demyelination in the corpus callosum fibers. Remyelination of fibers was seen in the group treated with the medium dose of ginger essence, by toluidine blue staining. transmission electron microscopy (TEM) revealed increased thickness of the myelin of fibers in all 3 treated groups (p<0.05). Feeding by the medium dose of ginger essence significantly increased the levels of Mbp and Olig2 genes (p<0.05). ELISA test showed that 100 mg/kg/day of ginger caused a significant difference between experimental and the cuprizone-induced groups (p<0.05).Conclusion: Our findings suggested that administration of ginger essential oil prevented demyelination and improved remyelination of rats` corpus callusom and can be used as an effective substance in the prevention of MS.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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