Avicenna Journal of Phytomedicine最新文献

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Effect of lupeol on testicular lesions induced by cadmium chloride in rats. 芦皮酮对氯化镉致大鼠睾丸损伤的影响。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24716
Parmida Arabkarami, Pejman Mortazavi, Saeed Hesaraki
{"title":"Effect of lupeol on testicular lesions induced by cadmium chloride in rats.","authors":"Parmida Arabkarami, Pejman Mortazavi, Saeed Hesaraki","doi":"10.22038/AJP.2024.24716","DOIUrl":"https://doi.org/10.22038/AJP.2024.24716","url":null,"abstract":"<p><strong>Objective: </strong>Heavy metals and environmental pollutants, such as cadmium chloride, congenital disorders, and certain diseases, can lead to infertility in men. In this study, the effects of lupeol (an active pentacyclic triterpenoid with antioxidant properties) on testicular injuries induced by cadmium chloride were investigated in male rats.</p><p><strong>Materials and methods: </strong>Lupeol was obtained from Sigma-Aldrich, and the experiment included 40 male Wistar rats divided into 8 groups (healthy control, healthy rats treated with 100, 200, and 400 mg/kg of lupeol, cadmium chloride, and three groups that received cadmium chloride and were treated with 100, 200, and 400 mg/kg of lupeol). After oral treatment, rats were anesthetized, and blood and testicular tissue sampling was done. Subsequent analysis of oxidative stress enzymes, such as malondialdehyde (MDA) and superoxide dismutase (SOD), testosterone, sperm motility, and Aquaporin 9 (AQ9) levels was performed using ELISA, histopathology, and immunohistochemistry techniques, respectively. Immunohistochemistry staining was done for expression of Aquaporin 9 in seminiferous tubules.</p><p><strong>Results: </strong>The results showed that compared to the healthy control, cadmium chloride caused a significant decrease in SOD, testosterone, sperm motility, and sperm vitality, with severe destruction of spermatogenic tubes and a significant increase in MDA and AQ9 rate. Rats which were treated with cadmium chloride+400 mg/kg of lupeol showed a significant increase in SOD, testosterone, histopathology, sperm motility, and sperm vitality rate, and significant organization of spermatogenic tubes in testis tissue. There was also a decrease in MDA and AQ9 of rats that received high-dose lupeol. (p<0.001).</p><p><strong>Conclusion: </strong>This study suggests that lupeol has a high potential for improving male reproduction and antioxidants in rats exposed to oxidative stress.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"907-919"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial effectiveness of aqueous and alcoholic herbal extracts on Streptococcus mutans: A systematic review and meta-analysis of randomized controlled trials. 水和酒精草药提取物对变形链球菌的抗菌效果:随机对照试验的系统回顾和荟萃分析。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24314
Kosar Ghandehari, Marzie Boskabadi, Alireza Sarraf Shirazi, Masoumeh Sadeghi, Taraneh Movahhed
{"title":"Antimicrobial effectiveness of aqueous and alcoholic herbal extracts on <i>Streptococcus mutans</i>: A systematic review and meta-analysis of randomized controlled trials.","authors":"Kosar Ghandehari, Marzie Boskabadi, Alireza Sarraf Shirazi, Masoumeh Sadeghi, Taraneh Movahhed","doi":"10.22038/AJP.2024.24314","DOIUrl":"https://doi.org/10.22038/AJP.2024.24314","url":null,"abstract":"<p><strong>Objective: </strong>Debates about the efficacy of herbal products in oral care have inspired researchers to conduct a large number of trials. This systematic review and meta-analysis aimed to assess the antibacterial efficacy of aqueous and alcoholic herbal extracts against <i>Streptococcus mutans</i> (SM) as the main cariogenic microorganism.</p><p><strong>Materials and methods: </strong>Online databases PubMed, Scopus, Cochrane Library, Web of Science, and Magiran were searched for randomized controlled trials evaluating the efficacy of herbal products against SM published up to July 2023. Meta-analyses were performed for immediate and long-term effects based on random effect model.</p><p><strong>Results: </strong>Out of 57 studies that met the selection criteria for systematic review, 26 were subjected to meta-analysis. Considering both immediate and long-term effects on salivary SM, aqueous and alcoholic herbal extracts were significantly superior in the reduction of SM over non-herbal agents (immediate: SMD = -1.16; 95%CI: -2.03, -0.29, long-term: SMD = -0.76; 95%CI: -1.35, -0.17). However, the difference was not significant in the reduction of SM of plaque (SMD = -0.30, 95%CI: -1.25, 0.65). The subgroup analyses showed no significant difference compared to chlorhexidine (p>0.05). The overall quality of evidence was considered low based on GRADE tool.</p><p><strong>Conclusion: </strong>Current evidence suggests encouraging results for herbal extracts in reduction of SM, but not over chlorhexidine. However, there is still insufficient evidence to recommend them as the first option for oral care. High-quality randomized controlled trials are required to assert the safety and effectiveness of them for preventing dental caries.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"943-963"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the effect of crocin on contrast-induced nephropathy in rats. 评价藏红花素对造影剂肾病大鼠的影响。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24786
Mahnaz Zolfaghari Farajerdi, Fatemeh Rajabian, Bibi Marjan Razavi, Mahboobehr Ghasemzadeh Rahbarda, Abolfazl Khajavi Rad, Sakineh Amoueian, Hossein Hosseinzadeh
{"title":"Evaluating the effect of crocin on contrast-induced nephropathy in rats.","authors":"Mahnaz Zolfaghari Farajerdi, Fatemeh Rajabian, Bibi Marjan Razavi, Mahboobehr Ghasemzadeh Rahbarda, Abolfazl Khajavi Rad, Sakineh Amoueian, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24786","DOIUrl":"https://doi.org/10.22038/AJP.2024.24786","url":null,"abstract":"<p><strong>Objective: </strong>Contrast-induced nephropathy (CIN) raises the risk of renal injury, but crocin, a saffron component, may improve kidney function. This study investigated crocin's protective effects against CIN in rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats were divided into eight groups: Sham, Control, Contrast medium (diatrizoate), Diatrizoate combined with crocin at 10, 20, or 40 mg/kg/day, Diatrizoate combined with N-acetylcysteine (NAC) at 125 mg/kg/day, and Crocin alone at 40 mg/kg/day. Water deprivation began on day 5 for 48 hr, except for the sham and crocin alone groups. Indomethacin and N(ω)-nitro-L-arginine methyl ester were administered after 40 hr of dehydration. Rats were sacrificed on the eighth day, and blood and kidney samples were collected.</p><p><strong>Results: </strong>Diatrizoate increased serum creatinine and blood urea nitrogen levels, elevated malondialdehyde levels, and reduced glutathione in renal tissue. Crocin reversed these effects. Diatrizoate caused severe tubular necrosis, proteinaceous casts, medullary congestion, and interstitial edema in kidney tissue. Crocin (20 and 40 mg/kg) significantly reduced tubular necrosis, and doses of 10 and 40 mg/kg reduced interstitial edema. NAC significantly improved histopathological damage, biochemical factors, and oxidative stress. The crocin alone group showed no significant changes.</p><p><strong>Conclusion: </strong>Diatrizoate induces nephrotoxicity by enhancing oxidative stress in rats, and crocin has a protective effect against it. Crocin mitigates both tissue and biochemical damage inflicted by diatrizoate.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"920-932"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of Indigofera argentea against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators. 靛蓝对醋酸诱导的炎症性肠病的保护作用是通过调节抗氧化和炎症介质介导的。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24977
Faraza Javaid, Qaiser Jabeen
{"title":"Protective effects of <i>Indigofera argentea</i> against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators.","authors":"Faraza Javaid, Qaiser Jabeen","doi":"10.22038/AJP.2024.24977","DOIUrl":"https://doi.org/10.22038/AJP.2024.24977","url":null,"abstract":"<p><strong>Objective: </strong>The plant <i>Indigofera argentea</i> Burm. f., belonging to the family Fabaceae, is locally known as Hathio, Jantar and Neel. This plant is commonly found in deserted habitat and used traditionally to treat inflammatory and gastric disorders. The current study was designed to evaluate the phytochemical profile, toxicity and intestinal anti-inflammatory effects of the whole plant crude extract against acetic acid-induced inflammatory bowel disease (IBD) in mice.</p><p><strong>Materials and methods: </strong>To study the phytochemical composition, preliminary phytochemical analysis along with HPLC and LCMS of the crude extract of <i>Indigofera argentea</i> (Ia.Cr) was performed. For the evaluation of intestinal anti-inflammatory activity, animals were divided into five groups (normal control, intoxicated, standard and two treatment groups) of six animals each and ulcerative colitis (UC) was induced by intrarectal administration of acetic acid (200 µl of 7.5%) and extent of damage caused by ulcerative colitis was measured by colonic mucosal damage index, disease activity index, and hematological and histological changes. Lipo-peroxide activity by malondialdehyde (MDA) and antioxidant enzyme glutathione peroxidase (GPX-1), catalase (CAT) and superoxide dismutase (SOD) levels were determined in colon tissues. Pro-inflammatory cytokines (IL-1, IL-6 and TNF-α) were quantified by ELISA immunoassay.</p><p><strong>Results: </strong>Pre-treatment with Ia.Cr significantly amended macroscopic damage, and hematological and histopathological alterations. Ia.Cr decreased oxidative parameters such as MDA and increased antioxidant activities of GPX-1, CAT and SOD. Ia.Cr also decreased the levels of pro-inflammatory biomarkers significantly.</p><p><strong>Conclusion: </strong>Results of this study indicated that Ia.Cr protected mice against acetic acid-induced inflammatory bowel disease by decreasing endogenous inflammatory biomarkers and oxidative damages.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"964-980"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The protective properties of resveratrol against glycerol-induced acute kidney injury in rats. 白藜芦醇对甘油致大鼠急性肾损伤的保护作用。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24649
Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh
{"title":"The protective properties of resveratrol against glycerol-induced acute kidney injury in rats.","authors":"Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24649","DOIUrl":"https://doi.org/10.22038/AJP.2024.24649","url":null,"abstract":"<p><strong>Objective: </strong>After rhabdomyolysis, muscle tissue releases substances such as myoglobin, creatine kinase, and electrolytes into the bloodstream, potentially leading to acute kidney injury (AKI). Resveratrol (RSV) is a polyphenol compound with anti-inflammatory and antioxidant effects and it is found in various plants. This research evaluated the protective effects of RSV in rhabdomyolysis-induced AKI in rat kidneys.</p><p><strong>Materials and methods: </strong>Thirty-six male Wistar rats were randomly assigned to six groups (n=6): 1) control (normal saline), 2) glycerol only (10 ml/kg, intramuscular), 3, 4, and 5) glycerol +RSV (5, 10, and 25 mg/kg, intraperitoneal injection) and 6) RSV (25 mg/kg). After 4 days, pathological alterations and the level of blood urea nitrogen (BUN) and serum creatinine were determined. Malondialdehyde (MDA), glutathione (GSH), neutrophil gelatinase-associated lipocalin (NGAL), and tumor necrosis factor-α (TNF-α) proteins were investigated in rat kidneys.</p><p><strong>Results: </strong>Injection of 50% glycerol (10 ml/kg, IM) resulted in pathological lesions, elevated levels of MDA (p<0.001), BUN (p<0.01), serum creatinine (p<0.001), TNF-α (p<0.01), and NGAL protein (p<0.001), and decreased GSH content (p<0.001) compared to the control animals. These findings indicated AKI induced by rhabdomyolysis. RSV (25 mg/kg) administration significantly decreased serum creatinine, BUN, MDA, NGAL, and TNF-α levels compared to the glycerol group. Histopathologically, tubule necrosis, myoglobin cast formation and glomerular atrophy increased in the glycerol group and reduced in animals that received RSV.</p><p><strong>Conclusion: </strong>In the glycerol-induced AKI rat model, RSV administration alleviated renal dysfunction by reducing oxidative stress and inflammatory responses.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"860-873"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine. 药用植物油在儿科相关疾病中的局部应用:一篇基于传统波斯医学的比较综述文章。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24303
Maryam Mohammadian-Dameski, AhmadShah Farhat, Maliheh Motavasselian, Vahid Reza Askari
{"title":"Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine.","authors":"Maryam Mohammadian-Dameski, AhmadShah Farhat, Maliheh Motavasselian, Vahid Reza Askari","doi":"10.22038/AJP.2024.24303","DOIUrl":"https://doi.org/10.22038/AJP.2024.24303","url":null,"abstract":"<p><strong>Objective: </strong>Researchers have considered medicinal oils to prevent and treat pediatric diseases. In the traditional Persian medicine (TPM) doctrine, anointment is widely used in order to avoid and treat diseases. This study aimed to evaluate and reconcile the uses of anointment in children in TPM and the new studies.</p><p><strong>Materials and methods: </strong>Accordingly, TPM documents were scrutinized for anointments and their applications in pediatric disorders. Moreover, new studies were reviewed in Google scholar, PubMed, Medline, Scopus, and Web of Science until June 2022.</p><p><strong>Results: </strong>In the health preservation field, TPM scholars have recommended daily anointment with some oils like sweet almonds in the early months after birth to improve growth, strengthen the body, and prevent dry skin, and new studies have confirmed the effectiveness of some oils accordingly. In the treatment field, various oils are recommended, namely sweet almond oil for weight disorders, violet oil for insomnia, olive oil and chamomile oil for functional constipation, infantile colic and enuresis, and olive oil for diaper rash and atopic dermatitis and new studies have shown their effectiveness. Sweet almond, chamomile, violet, olive, and rose oils are among the most widely used oils in Persian medicine for children, which we have discussed in this study.</p><p><strong>Conclusion: </strong>Due to the non-invasive nature of anointment and the observation of minimal adverse effects in studies, it can be given attention for maintaining pediatric health and treating their diseases.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"794-815"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the effect of a herbal cream containing rose essence in an animal model of eczema. 研究含有玫瑰精华的草本乳膏对湿疹动物模型的影响。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.25132
Ali Reza Malayeri, Anayatollah Salimi, Fariba Iraji, Susan Sabbagh, Neda Shakerian, Mobin Khaledi
{"title":"Investigating the effect of a herbal cream containing rose essence in an animal model of eczema.","authors":"Ali Reza Malayeri, Anayatollah Salimi, Fariba Iraji, Susan Sabbagh, Neda Shakerian, Mobin Khaledi","doi":"10.22038/AJP.2024.25132","DOIUrl":"https://doi.org/10.22038/AJP.2024.25132","url":null,"abstract":"<p><strong>Objective: </strong>Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cream in mitigating eczema symptoms in a mouse model.</p><p><strong>Materials and methods: </strong>Thirty-five mice were divided into five groups: control, dinitrochlorobenzene (DNCB)-induced eczema (model group), and treatment groups receiving placebo, betamethasone cream (positive control), or rosehip extract cream. Following topical treatment for four weeks, the animals were euthanized, and their skin was evaluated for inflammation, moisture, and thickness. Histopathological analysis was performed using hematoxylin and eosin (H&E) staining.</p><p><strong>Results: </strong>Compared to the control group, DNCB treatment significantly increased inflammation, erythema (redness), dryness, and epidermal thickness. Notably, topical application of the rosehip extract cream significantly reduced these eczema-associated parameters, demonstrating efficacy comparable to the positive control (betamethasone cream).</p><p><strong>Conclusion: </strong>This study suggests that a topical cream formulated with rosehip extract may be a promising therapeutic strategy for alleviating eczema symptoms. The anti-inflammatory and potentially regenerative properties of rose extract warrant further investigation for the development of natural eczema treatments.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1070-1081"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats. γ -米甲醇对慢性限制性应激大鼠雄性生殖功能的抗氧化和抗凋亡作用。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24819
Mahsan Alizadeh, Sina Moshtagh, Shahabaddin Abdolalizadeh Amir, Mostafa Jeddi, Sepehr Tahmasebzadeh, Ghazal Radman, Amin Bagheri, Yasin Bagheri, Nazanin Shahabinejad
{"title":"Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats.","authors":"Mahsan Alizadeh, Sina Moshtagh, Shahabaddin Abdolalizadeh Amir, Mostafa Jeddi, Sepehr Tahmasebzadeh, Ghazal Radman, Amin Bagheri, Yasin Bagheri, Nazanin Shahabinejad","doi":"10.22038/AJP.2024.24819","DOIUrl":"https://doi.org/10.22038/AJP.2024.24819","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the effects of GO on depressive behaviors and reproductive parameters in rats exposed to CRS.</p><p><strong>Materials and methods: </strong>Rats were divided into three groups: sham, CRS-control, and CRS-GO. Behavioral assessments using the SPT and measurements of body and testes weights were conducted. Reproductive potential was evaluated by ELISA for testosterone, LH, and FSH levels, as well as sperm characteristics. Oxidative stress levels were assessed through MDA measurements and antioxidant enzyme activities. Additionally, apoptotic and signaling pathway proteins were analyzed by measuring cleaved caspase-3 and Nrf-2 levels in the testes using western blot analysis.</p><p><strong>Results: </strong>GO mitigated depressive behaviors and reduced serum corticosterone levels compared to the CRS-control group. GO increased testosterone, LH, and FSH levels and improved sperm parameters. GO supplementation reduced MDA levels and enhanced antioxidant enzyme activities compared to the CRS-control group. The analysis showed that GO down-regulated cleaved caspase-3 levels and up-regulated Nrf-2 protein levels in the testes of CRS rats compared to the CRS-control group.</p><p><strong>Conclusion: </strong>The administration of GO treatment can contribute to the recovery from male reproductive complications by regulating oxidative stress and apoptotic pathways.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"890-906"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study. 缬草茶对健康志愿者交感迷走神经张力和心功能影响的半实验研究。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24974
Seyed Mehran Hosseini, Shahab Zanganeh, Marzieh Qaraaty
{"title":"The effect of <i>Valeriana officinalis</i> tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study.","authors":"Seyed Mehran Hosseini, Shahab Zanganeh, Marzieh Qaraaty","doi":"10.22038/AJP.2024.24974","DOIUrl":"https://doi.org/10.22038/AJP.2024.24974","url":null,"abstract":"<p><strong>Objective: </strong>The use of herbal teas can affect some physiological parameters of the body. Valerian has been used as a valuable medicinal plant. There are reports about sedative and sleep-inducing effects of <i>Valeriana officinalis</i> L. (VOT) on the nervous system. But in relation to its possible effect on the autonomic nervous system, the available information is limited. This study aimed to determine the effect of VOT on sympathovagal tone based on heart rate variability indices.</p><p><strong>Materials and methods: </strong>In this semi-experimental study, 12 healthy volunteers were enrolled. At first, the participants received 50 ml of water as the control group, and then after the clearance time, they received VOT with a dilution of 50% with the same temperature and volume and were considered the intervention group. Assessment of sympathovagal tone was performed in terms of heart rate variability indices. There were 5 recording steps: baseline, after drinking water, and 5, 20, and 30 minutes after drinking VOT.</p><p><strong>Results: </strong>The mean±SD of the average heart rate per minute at the five recording steps after VOT was 65.4±15.5, 63.5 ±14.6, 62.7±15.6, 61.8±16.09, and 60.9 15.2, respectively (p<0.05). The average arterial systolic pressure at the five recording steps after VOT was 119.4±7.4, 117.9± 9, 114.3±7.9, 113.8±8.6, and 114±6.5 mmHg, respectively.</p><p><strong>Conclusion: </strong>A single cup of VOT significantly decreased the heart rate. This effect may be associated with a decrease in sympathetic activity and an increase in parasympathetic activity.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"784-793"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertility-enhancing effects of Prunus amygdalas oil on reproductive functions of male rats: A two-generation study. 核桃油对雄性大鼠生殖功能的促生育作用:两代研究。
IF 1.9
Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24590
Sadia Suri Kashif, Sadaf Naeem, Saira Saeed Khan, Aisha Razzaque
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