Avicenna Journal of Phytomedicine最新文献_第6页

Apoptotic and anti-migratory activity of Citrus limon rind essential oil encapsulated in niosome against human breast cancer cells. 膜小体包封柠檬皮精油对人乳腺癌细胞的凋亡和抗迁移作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24656

Mohammad Mehdi Yaghoobi, Toktam Deylami, Masoud Torkzadeh-Mahani

{"title":"Apoptotic and anti-migratory activity of Citrus limon rind essential oil encapsulated in niosome against human breast cancer cells.","authors":"Mohammad Mehdi Yaghoobi, Toktam Deylami, Masoud Torkzadeh-Mahani","doi":"10.22038/AJP.2024.24656","DOIUrl":"https://doi.org/10.22038/AJP.2024.24656","url":null,"abstract":"Objective: This study aimed to formulate Citrus limon fruit rind's essential oil (EO) and to analyze its impact on breast cancer cells.Materials and methods: Initially, the cytotoxicity of EO (0.09-9 µg/ml) and doxorubicin (0.5-5 µM) on MCF-7, SK-BR-3, and MDA-MB-231 breast cancer cells was assessed using the MTT assay following 24-72 hr treatment. The cells were then treated with niosomes containing 4.5 µg/ml EO and 0.5 µM doxorubicin for 48 hr. Flow cytometry, migration assay, and RT-qPCR were used to study the cell behavior.Results: MTT results indicated that both EO and doxorubicin alone exhibited severe cytotoxicity (viability ≤ 30%) towards all three cells after 48 hr . When treated with encapsulated EO, the apoptotic death rate in MCF-7, MDA-MB-231, and SK-BR-3 cells was substantially diminished to 14%, 28%, and 9%, respectively. Similarly, encapsulated doxorubicin induced mild apoptotic death in these cells. Encapsulated EO and doxorubicin significantly prevented the migration of all cells. Following treatment with the encapsulated EO, a notable reduction in the expression of VIM, SLUG, SNAIL, and JUN, which are promoters of cancer cell invasion, was seen. Conversely, the expression of the FAS receptor, an active participant in the extrinsic apoptosis pathway, increased (p˂0.01).Conclusion: Lemon EO has apoptotic and anti-migratory effects on breast cancer cells, comparable to that of doxorubicin. Utilizing niosome as an efficient delivery modality effectively mitigates the adverse effects of EO and can be used for in vivo delivery of it to cancer cells.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"749-763"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of hair growth promoting effect of transferosomes containing red clover extract and caffeine alone or in combination. 含红三叶草提取物和咖啡因单独或联合的转移体的制备及促发效果评价。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24304

Valiollah Hajhashemi, Azade Taheri, Farnaz Karimian, Omid Hajihashemi, Ardeshir Talebi

{"title":"Preparation and evaluation of hair growth promoting effect of transferosomes containing red clover extract and caffeine alone or in combination.","authors":"Valiollah Hajhashemi, Azade Taheri, Farnaz Karimian, Omid Hajihashemi, Ardeshir Talebi","doi":"10.22038/AJP.2024.24304","DOIUrl":"https://doi.org/10.22038/AJP.2024.24304","url":null,"abstract":"Objective: Trifolium pratense L. (Red clover) belongs to the Leguminosae family. This study was designed to develop transferosome formulations containing red clover extract or caffeine alone or in combination and evaluate their effects on hair growth in mice.Materials and methods: Thin-lipid film hydration technique was used to make transferosomes. Six groups (n=6) of male Swiss mice (28-32 g) were used. One group was normal control. The second group received transferosome without drug. Groups 3 to 5 received 100 µl of transferosomes containing red clover extract (1%) or caffeine (0.002%) alone or in combination. The sixth group received minoxidil (2%). Treatments continued six days per week for 3 weeks and each week, the hair growth scores were recorded. At the end, sections of the skin were prepared for determining the percent of follicles in the anagen phase.Results: Encapsulation efficiency was 84.3, 81.6 and 89.1% for red clover, caffeine and red clover+caffeine transferosomes respectively. After 24 hr, the cumulative release of red clover and caffeine formulations was 77.6 and 76.9%, respectively. Treatments produced no significant change in hair growth after two weeks but at the end of the third week, all treatments significantly increased the hair growth and the effects were comparable with minoxidil. The combination of red clover and caffeine was not more effective than either alone.Conclusion: Transferosome formulations of caffeine and red clover alone demonstrated hair growth effect but their combination had no additive effect which might be due to a physicochemical or pharmacodynamic interaction.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"645-652"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effect of zeaxanthin on olanzapine-induced metabolic disorders in rats. 探讨玉米黄质对奥氮平所致大鼠代谢紊乱的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24352

Anahita Salehsari, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Hossein Hosseinzadeh

{"title":"Investigating the effect of zeaxanthin on olanzapine-induced metabolic disorders in rats.","authors":"Anahita Salehsari, Mahboobeh Ghasemzadeh Rahbardar, Bibi Marjan Razavi, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24352","DOIUrl":"https://doi.org/10.22038/AJP.2024.24352","url":null,"abstract":"Objective: Olanzapine (OLZ) is used by some patients with bipolar disorder and schizophrenia. Some of its side effects include weight gain and metabolic syndrome. Zeaxanthin (Zx), a yellow pigment found in egg yolk as well as some yellow and orange plants and fruits, is an anti-obesity factor that aids in the treatment of metabolic disorders. The effects of Zx on metabolic disorders caused by OLZ were investigated in this study.Materials and methods: Female Wistar rats were randomly divided into seven groups (n=6): 1. control (vehicle); 2. OLZ (5 mg/kg, 14 days, intraperitoneal (i.p.)); 3-5. OLZ + Zx (12.5, 25, and 50 mg/kg, 14 days, gavage); 6. OLZ+ metformin (100 mg/kg, 14 days, i.p.); and 7. Zx (50 mg/kg, 14 days). Weight changes were checked every 3 days and food intake was monitored every day. Systolic blood pressure, insulin, blood sugar, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and leptin levels were evaluated on the last day of the study.Results: OLZ caused an increase in weight (84.5% increase on day 15), food intake, blood pressure, triglyceride, LDL, insulin, blood sugar, and leptin compared to the control group (p<0.01 and p<0.001). The use of different doses of Zx (12.5, 25, and 50 mg/kg) and metformin decreased weight (the percentages of weigh reduction on day 15 were 91.92% for Zx (50 mg/kg) and 59.39% for metformin), food intake, systolic blood pressure, triglyceride, LDL, insulin, blood sugar, and leptin compared to the OLZ group. The amounts of cholesterol and HDL were not different in different groups.Conclusion: Zx alleviates metabolic abnormalities including hypertension, hyperglycemia, and dyslipidemia in rats.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"653-665"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study. 月见草油对青春期女孩多囊卵巢综合征患者的影响：一项双盲安慰剂对照随机研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24342

Laila Mohammadlo, Kaveh Rahimi, Masomeh Rezaie, Nasrin Soufizadeh, Fariba Seyedoshohadaei, Khaled Rahmani, Reza Bekhradi

{"title":"The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study.","authors":"Laila Mohammadlo, Kaveh Rahimi, Masomeh Rezaie, Nasrin Soufizadeh, Fariba Seyedoshohadaei, Khaled Rahmani, Reza Bekhradi","doi":"10.22038/AJP.2024.24342","DOIUrl":"https://doi.org/10.22038/AJP.2024.24342","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is a common disorder among women of reproductive age. The goal of the current study was to evaluate the effect of evening primrose oil (EPO) (Oenothera biennis) in adolescent girls with PCOS.Materials and methods: In the current double-blind and randomized controlled research, 76 patients completed the study in two groups (38 in the placebo and 38 in the EPO groups). The patients were asked to take oral placebo or EPO (1000 mg/day) for 12 weeks. Biochemical, clinical, and ultrasonography assessments were performed. The data was analyzed using SPSS statistical software.Results: After the intervention, the regulation of the menstrual cycle in the EPO group was different from that of the placebo group (p=0.04). The levels of insulin, testosterone, and free androgen index (FAI) in the EPO group were lower than those of the placebo group (p<0.05). The sex hormone binding globulin (SHBG) levels in the EPO group were higher than those of the placebo group (p=0.01). While the number of immature follicles decreased in the EPO group, this difference was not statistically significant (p=0.8).Conclusion: Overall, EPO administration for 12 weeks in young women with PCOS regulated the irregular menstrual cycle. In addition, the levels of insulin, testosterone, FAI, and SHBG changed. Therefore, EPO may be effective in improving hormonal and menstrual irregularities.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"561-569"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy of Terminalia chebula Retz. 5% cream compared to hydroquinone 2% cream in the treatment of melasma. 评价5% chebula Retz乳膏与2%对苯二酚乳膏治疗黄褐斑的疗效。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.23932

Amir Emad Kheirieh, Fariba Sharififar, Mehdi Ansari Dogaheh, Fatemeh Dabaghzadeh, Simin Shamsi Meymandi, Behnoush Bakhshoudeh

{"title":"Evaluating the efficacy of Terminalia chebula Retz. 5% cream compared to hydroquinone 2% cream in the treatment of melasma.","authors":"Amir Emad Kheirieh, Fariba Sharififar, Mehdi Ansari Dogaheh, Fatemeh Dabaghzadeh, Simin Shamsi Meymandi, Behnoush Bakhshoudeh","doi":"10.22038/AJP.2024.23932","DOIUrl":"https://doi.org/10.22038/AJP.2024.23932","url":null,"abstract":"Objective: Melasma is a multifactorial, chronic, acquired skin disorder of hyperpigmentation. Terminalia chebula Retz. (T. chebula) has shown antioxidant, anti-inflammatory and tyrosinase enzyme inhibitory activities. So, the present study was designed to evaluate the efficacy of T. chebula 5% cream compared to hydroquinone 2% cream in treating patients with melasma.Materials and methods: The formulation of T. chebula 5% cream was prepared. The stability and release study of the cream were performed. In this randomized, controlled, triple-blind clinical trial, participants with facial melasma were randomly assigned to receive T. chebula 5% cream or hydroquinone 2% cream at bedtime for 12 weeks. Modified Melasma Area and Severity Index (mMASI) scores were recorded for all the participants at the baseline and 4, 8, and 12 weeks after initiating the study.Results: No statistically significant differences regarding mMASI scores were detected between T. chebula and hydroquinone groups at each time point. The reduction in mMASI scores was statistically significant (p<0.05) in T. chebula group 4, 8, and 12 weeks after initiating the study. However, it reached statistical significance (p<0.05) in hydroquinone group 8, and 12 weeks after the study initiation. The frequencies of side effects especially skin irritation were significantly (p<0.05) lower in T. chebula group.Conclusion: T. chebula 5% cream could be as effective as hydroquinone 2% cream in treating melasma with fewer side effects.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"527-536"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and clinical studies on pharmacological actions of the genus Achillea: A comprehensive and updated review. 阿喀琉斯属植物药理作用的实验与临床研究综述。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.23711

Saeideh Saadat, Mojgan Rajabi, Mohammad Hossein Boskabady

{"title":"Experimental and clinical studies on pharmacological actions of the genus Achillea: A comprehensive and updated review.","authors":"Saeideh Saadat, Mojgan Rajabi, Mohammad Hossein Boskabady","doi":"10.22038/AJP.2024.23711","DOIUrl":"https://doi.org/10.22038/AJP.2024.23711","url":null,"abstract":"Objective: Species of the genus Achillea (from the family Compositae or Asteraceae) are widely used for their numerous pharmacological properties. The present paper reviews pharmacological actions and their possible underlying molecular mechanisms reported for various species of Achillea.Materials and methods: Various databases including PubMed, Science Direct, and Scopus were used.Results: Immunosuppressive, anti-inflammatory and anti-oxidant effects were shown for these plants. In addition, it was shown that these plants pose wound-healing properties and antimicrobial effects on various bacteria as well as antitumor effects on different cell lines. Achillea species showed anti-arrhythmic, anti-thrombotic, vasorelaxant, anti-hyperlipidemic, anti-hypertensive, hepatoprotective and gastroprotective effects. In addition, the plants showed different endocrine effects such as anti-diabetic, estrogenic and anti-spermatogenic properties. Neurological effects of the plants also included anti-nociceptive and anti-anxiety actions. Clinical studies also indicated therapeutic effect of A. millefolium on multiple sclerosis, chemotherapy-induced oral mucositis in cancer patients, and dysmenorrhea but did not affect atopic dermatitis.Conclusion: Achillea species could be of therapeutic potential for treating of a wide range of diseases but further investigations are needed regarding the other properties of Achillea plants.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"530-560"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study. 多菌株伊朗原生益生菌混合物对醋酸铅诱导的雄性大鼠肾脏毒性的保护作用：一项综合生化、分子和组织病理学研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24261

Mohsen Akbaribazm, Zahra Abdol Al Amir Mohammad Javad, Seyed Naser Alavi, Zahra Keshtmand

{"title":"Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study.","authors":"Mohsen Akbaribazm, Zahra Abdol Al Amir Mohammad Javad, Seyed Naser Alavi, Zahra Keshtmand","doi":"10.22038/AJP.2024.24261","DOIUrl":"https://doi.org/10.22038/AJP.2024.24261","url":null,"abstract":"Objective: In this study, the protective effects of native Iranian probiotics (Lactobacillus rhamnosus, Lactobacillus casei and Lactobacillus holoticus) on lead acetate (PbAc)-induced toxicity in the kidney of male rats were investigated using biochemical, molecular and histopathological approaches.Materials and methods: Twenty-one male Wistar rats were divided into three groups (n=7/group), including controls, PbAc recipient (10 mg/kg) and PbAc recipient (10 mg/kg) + probiotic mixture (109 CFU). PbAc and probiotics were gavage in the groups. On the 31st day, blood samples were used to measure serum concentrations of creatinine (Cr), blood urea nitrogen (BUN), sodium, total protein and potassium. Rats were dissected and renal tissues apoptotic and inflammatory genes were evaluated.Results: PbAc increased serum concentrations of Cr, sodium, and urea, and decreased total protein and potassium, while it enhanced interleukine-6 (IL-6) and tumor necrosis factor -α (TNF- α) gene expression in kidney tissue compared to the control group. Probiotic mixture decreased Cr, BUN, and malondialdehyde and increased activity of catalase and superoxide dismutase enzymes in kidney tissue.Conclusion: The results of the study showed that the native Iranian probiotics mixture can be used to protect the function and structure of the kidneys against toxic and oxidative damage induced by PbAc.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"632-664"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melissa officinalis extract improved high-fat-diet-induced anxiety-like behaviors, depression, and memory impairment by regulation of serum BDNF levels in rats. Melissa officinalis提取物通过调节大鼠血清BDNF水平改善高脂肪饮食诱导的焦虑样行为、抑郁和记忆障碍。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24343

Kazem Hatami, Majid Hassanpourezatti, Mohsen Khalili

{"title":"Melissa officinalis extract improved high-fat-diet-induced anxiety-like behaviors, depression, and memory impairment by regulation of serum BDNF levels in rats.","authors":"Kazem Hatami, Majid Hassanpourezatti, Mohsen Khalili","doi":"10.22038/AJP.2024.24343","DOIUrl":"https://doi.org/10.22038/AJP.2024.24343","url":null,"abstract":"Objective: Melissa officinalis (MO) hydroalcoholic extract has shown neuroprotective effects. We assess the possible therapeutic effects of Melissa officinalis extract (MOE) on blood biochemical and Brain-Derived Neurotrophic Factor (BDNF) levels as well as neurobehavioral consequences of high-fat-diet (HFD)-induced obese rats.Materials and methods: Eighty male Wistar rats weighing between 180 and 220 g were divided into two groups at the beginning of the experiment and fed with normal diet (ND) or HFD for 5 weeks. Then, each group was divided into four subgroups (10 rats in each group) and treated daily with MOE (50, 100, 150 mg/kg, intraperitoneal) or vehicle for another two weeks. At the end of the experiments, fasting blood glucose (FBG), blood lipid profile, and serum brain-derived neurotrophic factor (BDNF) levels were measured. The sucrose preference test (anhedonia and depression), open field test (locomotor), elevated plus maze (anxiety), Y-maze (working memory), and Morris water maze test (spatial memory) were done.Results: Feeding with HFD for 7 weeks caused obesity, anhedonia, anxiety, depression and learning and memory disorders in rats and a decrease in serum BDNF level. Administration of MOE at 100 or 150 mg/kg to HFD-fed rats decreased weight gain, FBG, and serum levels of total low-density lipoprotein cholesterol and increased serum BDNF levels. It also improved changes in locomotor activity, anxiety, depression, and learning and memory in HFD-fed rats.Conclusion: The results show that MOE has a therapeutic effect on model rats with HFD-induced metabolic and neurobehavioral abnormalities through regulation of BDNF secretion.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"617-631"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effect of Foeniculum vulgare fruit and Echium amoenum flower combination on the severity of physical and psychological symptoms of premenstrual syndrome. 小茴香果与菊苣花组合对经前综合征生理和心理症状严重程度的影响评价。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24208

Simin Sadat Motevalli Haghi, Amirhossein Sahebkar, Jamshid Jamali, Roshanak Salari, Maliheh Motavasselian

{"title":"Evaluation of the effect of Foeniculum vulgare fruit and Echium amoenum flower combination on the severity of physical and psychological symptoms of premenstrual syndrome.","authors":"Simin Sadat Motevalli Haghi, Amirhossein Sahebkar, Jamshid Jamali, Roshanak Salari, Maliheh Motavasselian","doi":"10.22038/AJP.2024.24208","DOIUrl":"https://doi.org/10.22038/AJP.2024.24208","url":null,"abstract":"Objective: Echium amoenum (EA) and Foeniculum vulgare (FV) might be beneficial for the management of Premenstrual syndrome (PMS) due to their possible effects on sex hormones and neurotransmitters such as serotonin. This study aimed to investigate the effect of a combination of Echium and Fennel on the severity of physical and psychological symptoms of PMS.Materials and methods: This triple-blinded, randomized, controlled trial was conducted on 80 women. The subjects were assigned to two groups of intervention (receiving EA 2 g/day and FV 1 g/day, in the second two weeks of the cycle, in two consecutive cycles) and placebo control. The data collection tools included the PSST, DRSP, and SF36 questionnaires.Results: Between-group differences in all subscales of DRSP were significant at one- and two-month time points (p<0.05). Bleeding volume was significantly increased in the intervention group, compared to the placebo group, two months after the intervention (p<0.05). Between-group comparison of the changes demonstrated significant differences in all subscales of SF36, except for limitations in usual role activities due to emotional problems (p=0.07).Conclusion: Consumption of EA and FV combination improved the quality of life in women with PMS and exerted favorable changes in PMS symptoms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"570-584"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heracleum persicum L. extract protects gentamicin-induced testicular toxicity. 仙桃提取物对庆大霉素致睾丸毒性的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-09-01 DOI: 10.22038/AJP.2024.24347

Elnaz Khordad, Mohsen Akbaribazm, Seyed Moein Hosseini

{"title":"Heracleum persicum L. extract protects gentamicin-induced testicular toxicity.","authors":"Elnaz Khordad, Mohsen Akbaribazm, Seyed Moein Hosseini","doi":"10.22038/AJP.2024.24347","DOIUrl":"https://doi.org/10.22038/AJP.2024.24347","url":null,"abstract":"Objective: The objective of this study was to assess the protective effects of Heracleum persicum L. leaves extract (HPE) against oxidative damage induced by gentamicin (GM) in the testes of rats through biochemical, histopathological, and immunohistochemical approaches.Materials and methods: Thirty-six male Wistar rats were divided into six groups (n=6/group) for 50 days. On day 51, the study assessed serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (TT), as well as antioxidant enzyme activity, nitric oxide levels, and various parameters related to testicular tissue (including the ferric reducing ability of plasma (FRAP), thiol, and thiobarbituric acid reactive substances (TBARS) levels). The stereological indices of seminiferous tubules were measured using serial sections of testicular tissue stained with hematoxylin and eosin, while the apoptosis rate of testicular parenchymal cells (p53, Caspase-3, and Bcl-2 positive cells) was also determined.Results: In the groups treated with HPE, particularly at 750 mg/kg, there was a significant increase (p<0.05) in LH, FSH, and TT hormone levels, an enhanced serum antioxidant enzyme activity and significantly reduced (p<0.05) nitric oxide levels. HPE inhibited the apoptotic pathway involving Bax/p53/Caspase-3 (significantly decreased (p<0.05) all three genes), thereby preserving the structure and function of the testicular tissue. Consequently, the number of p53 and Caspase-3 positive testicular cells decreased significantly (p<0.05), while the number of Bcl-2 positive cells increased.Conclusion: HPE demonstrated potential in protecting the function and structure of testis against toxic and oxidative damages.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 5","pages":"585-599"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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