Avicenna Journal of Phytomedicine最新文献_第6页

Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training. 原花青素和不同强度运动训练对心肌缺血Myh7和Myh6相关microRNA谱的调控

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24739

Safar Zarei, Farzaneh Taghian, Gholamreza Sharifi, Hassanali Abedi

{"title":"Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.","authors":"Safar Zarei, Farzaneh Taghian, Gholamreza Sharifi, Hassanali Abedi","doi":"10.22038/AJP.2024.24739","DOIUrl":"https://doi.org/10.22038/AJP.2024.24739","url":null,"abstract":"Objective: Myocardial ischemia (MI) and circulatory arrest are associated with unfavorable cardiovascular outcomes. This study aims to investigate the effects of proanthocyanidins (PC) and regular exercise with various intensity training protocols (low, moderate, and high) on cardiac protection in a rat model of MI induced by isoproterenol.Materials and methods: Based on bioinformatics, a pool of microRNAs and mRNAs was assessed according to significant differential expression in MI condition. Further, the networks of hub genes and mRNA-microRNAs were constructed. After 14 weeks of low, moderate, and high-intensity interval training and oral administration of 300 mg/kg of PC, MI was established in the rats by injecting isoproterenol. The real-time qPCR assessed the relative expressions.Results: Based on the in-silico analysis, Fn1 (fibronectin-1) and Myh7 (myosin heavy chain 7) are potentially druggable cut points to reduce cardiac tissue damage. High-intensity interval training (HIIT) and consumption of PC modified the relative expression of Myh6 (myosin heavy chain 6), Myh7, and Nf1. Moreover, High-intensity interval training and PC regulated the mir92a-3p, mir181a-5p, mir29a-3p, and mir133a-3p.Conclusion: Here, the data indicated that the HIIT protocol could have an effective strategy compared to low-intensity interval training (LIIT) and moderate-intensity interval training protocols (MIIT). Furthermore, HIIT and PC might have protective effects on the MI condition.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"874-889"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages. 苦参果实提取物对三氧化二砷致人淋巴细胞DNA氧化损伤的抗氧化作用及保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24842

Ablassé Rouamba, Vincent Ouedraogo, Maurice Ouédraogo, Martin Kiendrebeogo

{"title":"Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages.","authors":"Ablassé Rouamba, Vincent Ouedraogo, Maurice Ouédraogo, Martin Kiendrebeogo","doi":"10.22038/AJP.2024.24842","DOIUrl":"https://doi.org/10.22038/AJP.2024.24842","url":null,"abstract":"Objective: The integrity of the DNA is continously menaced by the harmful genotoxic compounds. The endogenous system responsible for preserving the DNA integrity, often fails following a massive influx of these genotoxic compounds. Reseaches on exogenous bioactive compounds from fruits and vegetables are necessary. This study was designed to evaluate the free radical scavenging activity and the DNA protection/repair potentiality of the extracts of Detarium microcarpum fruit pulp to protect against the arsenic trioxide-induced DNA oxidative degradation.Materials and methods: The ability of extracts to trap free radicals was assessed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide and hydroxyle radicals quenching assay. The comet assay was performed for evaluating the DNA protection/repair property of extracts to inhibit the DNA oxidative damage induced by arsenic trioxide.Results: All extracts at a final concentration of 50 µg/mL have quenched more than 50% of DPPH, nitric oxide and hydroxyle radicals. Moreover, all extracts have showed good DNA protection/repair activity against the arsenic trioxide-induced DNA oxidative damage compared to arsenic treatment alone (p<0.001). However, methanol fractions have exhibited the best DNA protection/repair activities by reducing considerably DNA fragmentations compared to arsenic treatment (p<0.001). The genoprotective activity of the extracts was positively correlated with their free radical scavenging abilities.Conclusion: The methanol fraction of D. microcarpum fruits have exhibited interesting DNA protection /repair properties probably due to its free radicals quenching ability. Further investigations are necessary to identify the phytomolecules responsible for these biological activities.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"837-847"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet. 香芹酚对高脂饮食诱导的肥胖雄性大鼠心脏细胞凋亡基因表达水平的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.25089

Mahdi Ahmadi, Sadegh Bagherzadeh, Mohammad Hossein Boskabady, Ali Vahabi, Sakhavat Abolhasani, Mohammad Reza Aslani

{"title":"The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet.","authors":"Mahdi Ahmadi, Sadegh Bagherzadeh, Mohammad Hossein Boskabady, Ali Vahabi, Sakhavat Abolhasani, Mohammad Reza Aslani","doi":"10.22038/AJP.2024.25089","DOIUrl":"https://doi.org/10.22038/AJP.2024.25089","url":null,"abstract":"Objective: Animal studies have revealed that lipid accumulation in obese mice fed with a high-fat diet (HFD) leads to alterations in the structural and functional properties of cardiovascular tissues. The current study aimed to investigate apoptosis/anti-apoptotic markers in the heart tissue of rats fed with a HFD.Materials and methods: Twenty-four male Wistar rats (weighing approximately 180 grams) were randomly divided into three groups (n=8 each group), including the control group (C), the high-fat diet group (HFD), and the high-fat diet + carvacrol group (HFD + Carva). Animals received a standard or HFD to induce obesity for three months. From day 61 to 90 in the HFD+Carva group, carvacrol was injected intraperitoneally (50 mg/kg) every other day. At the end of the study, the heart tissue was examined for pathological changes and the mRNA levels of TNF-α, Bcl2, Bax, and caspase3 in the heart tissue by Real Time-PCR.Results: HFD-induced obesity led to increased TNF-α, caspase-3, and Bax and decreased Bcl-2 expression levels in heart tissue. Furthermore, histopathological changes in intracytoplasmic vacuole accumulation were evident in the HFD-obese animals. Carvacrol treatment significantly decreased the expression of Bax, TNF-α, and caspase-3 and increased the expression of Bcl-2 in heart tissue.Conclusion: In the findings, carvacrol was found to decrease the histopathological changes caused by HFD in heart tissue by suppressing the expression of genes involved in the apoptosis pathway.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1059-1069"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells. 乳香甲醇提取物对脑转移性乳腺癌细胞的抗癌作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24655

Mohammad Kamalabadi-Farahani, Fatemeh Jamshidi Adegani, Roqaye Karimi, Amir Atashi

{"title":"Anti-cancer effects of frankincense methanolic extract on brain metastatic breast cancer cells.","authors":"Mohammad Kamalabadi-Farahani, Fatemeh Jamshidi Adegani, Roqaye Karimi, Amir Atashi","doi":"10.22038/AJP.2024.24655","DOIUrl":"https://doi.org/10.22038/AJP.2024.24655","url":null,"abstract":"Objective: Brain metastasis in patients with breast cancer is considered a deadly event. The oleogum resins of Boswellia species, known as Frankincense has been found to have anti-cancer properties in many studies. The main purpose of our research was to evaluate these effects on brain metastatic cancer cells.Materials and methods: Primary (4T1T) and brain metastatic (4T1B) tumor cells were isolated from breast cancerous mice. Cytotoxic, apoptotic, and anti-metastatic effects of the methanolic extract of frankincense were evaluated with MTT assay, propidium iodide (PI) flow cytometric assay, and scratch test, respectively. Zymography assay was used to evaluate the effects of extract on the matrix metalloproteinases-2 and -9 (MMP-2 /9) expression/activity.Results: The methanolic extract of frankincense has significant cytotoxic and apoptotic effects on 4T1B cells (p<0.001). Interestingly, 4T1B cells are more prone to these effects than 4T1T cells. In 4T1B, the anti-metastatic effects of frankincense extract were confirmed. Frankincense suppressed MMP-2/9 protein expression both in 4T1T and 4T1B.Conclusion: Our findings indicated that frankincense extract has a potent cytotoxic effect on brain metastatic tumor cells and induces apoptosis in these cells. Unlike many anti-cancer drugs which have very little ability to combat and kill brain metastatic cancer cells, frankincense extract can be considered a suitable candidate to fight these cells.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"776-783"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats. 玉米黄质对丙烯酰胺致Wistar大鼠神经毒性的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24950

Zoha Mortazavi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh

{"title":"Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats.","authors":"Zoha Mortazavi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24950","DOIUrl":"https://doi.org/10.22038/AJP.2024.24950","url":null,"abstract":"Objective: The Maillard reaction generates acrylamide (ACR), a toxic compound commonly found in laboratory and industrial settings. ACR exposure, both short-term and long-term, can damage various organs, notably the central nervous system, through oxidative stress, inflammation, and apoptosis. This study explores the potential neuroprotective effects of zeaxanthin (ZEA), known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, against ACR-induced toxicity in the rat cerebral cortex.Materials and methods: Rats were subjected to ACR exposure (50 mg/kg, intraperitoneal injection) for 11 days and subsequently, treated with ZEA (20-80 mg/kg, intragastric gavage) for either 11 or 20 days to assess both preventive and therapeutic effects. Locomotor behavior was evaluated using a gait score test, while biochemical analyses measured malondialdehyde (MDA) and glutathione (GSH) levels, inflammatory markers interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α), and apoptotic markers (cleaved caspase-3) in the cerebral cortex.Results: ACR exposure impaired locomotion in the animals, but ZEA treatment significantly improved gait scores when administered preventatively (from days 6-11) or therapeutically (from days 6-20). ACR also led to increased MDA levels and depleted GSH content in brain tissue, and it elevated IL-1β, TNF-α, and cleaved caspase-3 in the cerebral cortex. However, ZEA supplementation, along with vitamin E, effectively reversed these alterations compared to the ACR-exposed group.Conclusion: In conclusion, ZEA demonstrates both preventive and therapeutic effects against ACR-induced neurotoxicity. These findings suggest that ZEA could serve as an effective preventive agent by countering ACR-induced damage through its antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1016-1029"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of Ma'aljobon, a whey product, in primary hypertension: A double-blind randomized controlled trial. 乳清产品Ma'aljobon对原发性高血压的治疗潜力：一项双盲随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24921

{"title":"The therapeutic potential of Ma'aljobon, a whey product, in primary hypertension: A double-blind randomized controlled trial.","authors":"","doi":"10.22038/AJP.2024.24921","DOIUrl":"https://doi.org/10.22038/AJP.2024.24921","url":null,"abstract":"Objective: Ma'aljobon is used in Persian medicine (PM) as a natural antihypertensive product. This study aimed to evaluate the hypotensive effect of Ma'aljobon in patients with uncontrolled grade 1 primary hypertension (HTN).Materials and methods: This double-blind, placebo-controlled clinical trial included 114 patients (20-80 years) with uncontrolled grade 1 primary HTN. After obtaining informed consent, the participants were randomly divided into two groups and administered with 25g of Ma'aljobon or maltodextrin twice daily for six weeks. Systolic and diastolic blood pressures (SBP and DBP, respectively) were analyzed.Results: A total of 97 patients (52.3±10.7 years, %53.6 female) completed the study. In the Ma'aljobon group, SBP decreased from 150.3±12.3 to 130.6±12.1 mm Hg, and DBP decreased from 93.3±8.2 to 80.1±6.6 mm Hg (p<0.001). In the control group, SBP decreased from 147.6±11.2 to 138.7±14.4 mm Hg, and DBP decreased from 86.6±7.7 to 82.2±8.2 mm Hg (p<0.001). There was a significant difference in the changes of SBP and DBP between the two groups over time (p<0.001). No adverse events were observed.Conclusion: Ma'aljobon has a stronger hypotensive effect than placebo in patients with HTN and can be recommended as an add-on therapy for uncontrolled HTN.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"848-859"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of wet cupping on reactive airway dysfunction syndrome (RADS) caused by early exposure to chlorine gas: A randomized clinical trial. 湿罐对早期接触氯气引起的反应性气道功能障碍综合征（RADS）的影响：一项随机临床试验

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.25107

Khatereh Akbari Mashak, Khosro Agin, Elham Emaratkar, Mohammad Gholami Fesharaki, Hasan Namdar

{"title":"The effect of wet cupping on reactive airway dysfunction syndrome (RADS) caused by early exposure to chlorine gas: A randomized clinical trial.","authors":"Khatereh Akbari Mashak, Khosro Agin, Elham Emaratkar, Mohammad Gholami Fesharaki, Hasan Namdar","doi":"10.22038/AJP.2024.25107","DOIUrl":"https://doi.org/10.22038/AJP.2024.25107","url":null,"abstract":"Objective: In the absence of targeted antidotes for chlorine gas poisoning, a common yet concerning problem, this study investigates the effect of Wet Cupping Therapy (WCT, or \"Hijamat\") on the recovery process in chlorine-induced reactive airway dysfunction syndrome (RADS) patients.Materials and methods: This randomized controlled trial enrolled 24 patients experiencing acute inhalation of chlorine poisoning in Tehran, Iran (2020-2021). Patients were randomly divided into control (n=12, receiving conventional treatment) and intervention (n=12, receiving conventional treatment plus WCT) groups. Signs and symptoms were assessed pre-intervention, and in the first hour, first week, and first month post-intervention.Results: Medical records of 24 patients, including 3(12.5%) men and 21(87.5%) women, with a mean age of 42.92 years old, were evaluated. Baseline characteristics were similar between the groups. WCT significantly improved symptoms (dyspnea, cough, chest tightness, etc.) within the first hour (p=0.003) compared to the controls, with no future significant changes during the first week and first-month post-WCT. Comparison between the groups revealed substantial differences in the following variables: dyspnea scale (p=0.009), respiratory rate (p=0.026), cough (p=0.001), breath shortness (p=0.006), chest tightness (p=0.002), chest pain (p=0.010), substernal burning (p=0.015), throat sore (p=0.005) and hoarseness (p=0.027). Peak flow meter readings, reflecting lung function, were also significantly higher in the WCT group at all time-points (p<0.007).Conclusion: WCT may offer a rapid and sustained improvement in pulmonary and respiratory symptoms following acute chlorine inhalation injury.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"997-1015"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial. 葱乙酸乙酯提取物辅助治疗COVID-19的疗效和安全性：一项随机、多中心、对照临床试验

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24523

Mansour Amin, Mandana Pouladzadeh, Mohammad Jaafar Yadyad, Roshanak Roshanfard, Mohamad Hasan Pipelzadeh, Afshin Talebi, Behzad Sharif Maakhmalzadeh, Mehdi Bijanzadeh, Nasrin Rakipour, Gholamreza Alizadehattar, Seyed Saeed Seyedian, Kambiz Ahmadi Angali, Parastoo Moradi Choghakabodi, Akbar Akbari, Fatemeh Maghsodi, Ebrahim Barzegari, Maryam Jamalan, Reza Aalizadeh, Mostafa Jamalan

{"title":"Examining efficacy and safety of ethyl acetate extract from Allium hirtifolium as complementary therapy in COVID-19: A randomized, multicenter, controlled clinical trial.","authors":"Mansour Amin, Mandana Pouladzadeh, Mohammad Jaafar Yadyad, Roshanak Roshanfard, Mohamad Hasan Pipelzadeh, Afshin Talebi, Behzad Sharif Maakhmalzadeh, Mehdi Bijanzadeh, Nasrin Rakipour, Gholamreza Alizadehattar, Seyed Saeed Seyedian, Kambiz Ahmadi Angali, Parastoo Moradi Choghakabodi, Akbar Akbari, Fatemeh Maghsodi, Ebrahim Barzegari, Maryam Jamalan, Reza Aalizadeh, Mostafa Jamalan","doi":"10.22038/AJP.2024.24523","DOIUrl":"https://doi.org/10.22038/AJP.2024.24523","url":null,"abstract":"Objective: Given the apparent life-threatening nature of COVID-19, finding an effective treatment is under investigation.Materials and methods: We assessed effect of shallomin oral syrup (co IranAmin®) as a complementary treatment to improve the clinical outcomes in COVID-19 patients. Patients in the control group received the approved treatment protocol (lopinavir/ritonavir), while those in the intervention group were treated with the oral syrup shallomin in addition to the approved treatment. Clinical status of treated patients was recorded and compared.Results: There were meaningful differences between the two groups regarding shortened length of hospital stay and the recovery time for cough, myalgia, sore throat, and shortness of breath. No side effect occurred in the intervention group compared to the control group in terms of biochemical and hematological factors.Conclusion: It seems that the treatment with shallomin syrup showed remarkable contribution to the recovery of COVID-19 induced symptoms in the patients under lopinavir/ritonavir therapy.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"699-710"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke. 肉桂预处理调节大鼠中风模型中紧密连接蛋白的基因表达。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24290

Solmaz Najjary, Hossein Mostafavi, Hadi Feizi, Fatemeh Moradi, Mehdi Eskandari

{"title":"Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke.","authors":"Solmaz Najjary, Hossein Mostafavi, Hadi Feizi, Fatemeh Moradi, Mehdi Eskandari","doi":"10.22038/AJP.2024.24290","DOIUrl":"https://doi.org/10.22038/AJP.2024.24290","url":null,"abstract":"Objective: Brain ischemia generally results in irreversible brain damage or death. One of the most important features of an ischemic stroke is disruption of the Blood-brain barrier (BBB). In this study, we examined the effect of cinnamon hydroalcoholic extract consumption on BBB permeability and expression of some genes regulating its function.Materials and methods: Sixty male Wistar rats were divided into 5 groups; sham (high-fat diet+ sham surgery), Model (Middle Cerebral Artery Occlusion, MCAO+ high-fat diet), Lovastatin (high-fat diet + lovastatin + MCAO surgery), low and high dosage cinnamon (high-fat diet + cinnamon 130 or 260 mg, respectively+ MCAO surgery). The two doses of cinnamon (130 and 260 mg) were administered intraperitoneally. Twelve hours after ischemic stroke induction, brain right hemisphere tissues were collected and calpain I, calpainII, occludin and VEGF genes expression were quantified by Real-Time -PCR. Accordingly, p-selection protein levels were measured by ELISA method.Results: Cinnamon hydroalcoholic extract reduced the BBB permeability compared with the model group (p<0.05). Stroke increased calpain and VEGF genes while decreased occludin gene expression (p<0.001). Conversely, cinnamon administration increased occludin gene expression while calpain and VEGF genes were down-regulated (p<0.01). Pretreatment with cinnamon significantly diminished the P-Selectin protein levels as compared with the model group dose dependently (p<0.001).Conclusion: It seems that cinnamon restores BBB function by regulating the elements involved in its permeability.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"723-733"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors. 紫苏醇、槲皮素和小檗碱联合治疗改善实验性肺动脉高压：对肺miR-204表达、重塑和炎症因子的影响

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-11-01 DOI: 10.22038/AJP.2024.24522

Zeinab Kordestani, Ahmad Beik, Hamid Najafipour, Zohreh Safi, Majid Askaripour, Soodeh Rajabi

{"title":"Perillyl alcohol, quercetin, and berberine combination therapy ameliorates experimental pulmonary arterial hypertension: Effects on the lung miR-204 expression, remodeling, and inflammatory factors.","authors":"Zeinab Kordestani, Ahmad Beik, Hamid Najafipour, Zohreh Safi, Majid Askaripour, Soodeh Rajabi","doi":"10.22038/AJP.2024.24522","DOIUrl":"https://doi.org/10.22038/AJP.2024.24522","url":null,"abstract":"Objective: Pulmonary artery hypertension (PAH) is a devastating syndrome. Our previous studies showed that perillyl alcohol (P), berberine (B) and quercetin (Q) improve PAH. In this study, we investigated the effects of sub-effective doses of these derivatives in double and triple combination forms on PAH in rats.Materials and methods: Forty nine rats were divided into seven groups (n=7): 1) control, 2) monocrotaline (MCT), 3) MCT+vehicle (veh), 4) MCT+BP, 5) MCT+PQ, 6) MCT+BQ, and 7) MCT+BPQ. After three weeks of PAH induction with MCT (60 mg/kg), either vehicle (ethanol 5% in saline) or one of the above combinations (dose of 20 mg/kg for B, and doses of 20 and 10 mg/ kg for P and Q in vehicle) was administered for three weeks. Right ventricular (RV) pressure, contractility indices, lung pathology, miR-204 expression, oxidative stress markers, inflammation and apoptosis were assayed.Results: MCT increased RV systolic pressure and hypertrophy, and lung arteriole wall thickness, fibrosis and leukocyte infiltration in the MCT group compared to the CTL group. All treatments improved these effects significantly. Furthermore, MCT reduced antioxidant factors, Bax, P21 and miR-204 expression and increased Tumor Necrosis Factor alpha (TNF-α), Interleukin 6 (IL-6) and Bcl-2. All of these effects were recovered by combination treatments.Conclusion: The results showed that combination therapy with sub-effective/ineffective doses of these compounds had ameliorative effects against PAH.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"14 6","pages":"764-775"},"PeriodicalIF":1.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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