Avicenna Journal of Phytomedicine最新文献

{"title":"Preventive and therapeutic effects of <i>Nasturtium officinale</i> hydroalcoholic extract on cyclophosphamide-induced testicular toxicity in rats.","authors":"Hamideh Aboutalebi, Fatemeh Alipour, Alireza Ebrahimzadeh-Bideskan","doi":"10.22038/ajp.2025.25887","DOIUrl":"10.22038/ajp.2025.25887","url":null,"abstract":"<p><strong>Objective: </strong>Cyclophosphamide (Cy) as an alkylating chemotherapeutic agent with broad-spectrum efficacy in cancer treatment. Despite its wide spectrum of clinical usage, off-target multiple organ toxicity such as sperm and testicular injury is one of its toxic side effects. Since the <i>Nasturtium officinale</i> L. hydroalcoholic extract (NOE) contains a wide range of phytochemicals with various biological functions, the current study was designed to explore the protective potential of NOE on testicular toxicity caused by Cy in rats.</p><p><strong>Materials and methods: </strong>Forty-eight adult male Wistar rats were randomly allocated into eight groups (n=6): control, Cy [received a single dose of 75 mg/kg, intraperitoneal (i.p)], NOE+Cy (Prevention): received NOE 500 and 1000 mg/kg/day, orally for 21 consecutive days and on the last day received Cy, Cy+NOE (Treatment): received NOE 500 and 1000 mg/kg/day, orally for 7 days after Cy administration for 21 consecutive days, and NOE (500 and 1000 mg/kg/day). After experiments, the testicular weight and volume, testosterone level, and sperm parameters as well as histologic and histomorphometric changes of testis were examined.</p><p><strong>Results: </strong>Base on the results, Cy caused significant decreases in testicular weight and volume, decreased testosterone level and reduced sperm count, and motility whereas increased sperm abnormality (p<0.05). Cy significantly reduced seminiferous tubules diameter, and height of the seminiferous epithelium (p<0.05). Furthermore, disorganization of seminiferous tubules diameter was increased in Cy group (p<0.05). Interestingly, pre and post-treatment with NOE could effectively improve testicular weight and volume, and testosterone level as well as sperm parameters. Furthermore, NOE administration ameliorated seminiferous tubules diameter diameter, seminiferous epithelium height (p<0.05).</p><p><strong>Conclusion: </strong>It is concluded that NOE may provide a potential protective effect for Cy-induced testicular damage.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1091-1101"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAS/RAF/MEK/MAPK signaling pathway as a therapeutic target in breast cancer: Emphasis on a novel carrier for tamoxifen and digestion behaviors.","authors":"Niloofar Mansouri, Melika Daneshgar, Farzaneh Khojasteh, Zahra Modaresi, Reza Taheri, Parisa Mokaberi, Mohammad Reza Saberi, Jamshidkhan Chamani","doi":"10.22038/ajp.2024.25253","DOIUrl":"10.22038/ajp.2024.25253","url":null,"abstract":"<p><strong>Objective: </strong>This research attempted to increase the bioactivity and solubility and reduce the side effects of Tamoxifen (TMX) by using the cellulose nanocrystals (CNCs) extracted from walnut shells as a carrier and studied the interaction behavior of CNCs-TMX with hemoglobin.</p><p><strong>Materials and methods: </strong>The synthesized CNCs and CNCs-TMX were analyzed through the usage of XRD, FTIR, TEM, SEM, and multi-spectroscopic techniques. A real-time PCR assay was also conducted to further unravel the underlying mechanism of CNCs- TMX.</p><p><strong>Results: </strong>Our synthesized products including CNCs and CNCs- TMX had spherical morphologies in small sizes of 17.42 nm and 56.38 nm, respectively. The changes in FTIR spectrum signified the induced alterations in the samples functional group during the steps of preparation, while the crystallinity index of CNCs was 71.35%. Fluorescence spectroscopy confirmed the quencher functionality of CNCs-TMX along with the dominance of static quenching mechanism. Also, synchronous fluorescence displayed its binding to Hb in the vicinity of Tryptophanresidue. FRET was applied to calculate the interaction energy transfer of 0.18 nm. Next to achieving satisfactory results from oxygen-hemoglobin dissociation studies, the presence of CNCs-TMX caused a reduction in hemoglobin affinity for oxygen.</p><p><strong>Conclusion: </strong>Our findings pointed out the remarkable potential of TMX-loaded CNCs, derived from walnut shell, in suppressing the proliferation, migration, and invasion of breast cancer cells by quelling the RAS/RAF/MEK/MAPK signaling pathways. The gathered data approved the promising applicability of the obtained CNCs from walnut shell in the delivery system of anti-cancer drugs throughout pharmaceutical applications.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1204-1227"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of hesperidin and auraptene on 6-hydroxydopamine-induced neurodegeneration in SH-SY5Y cells.","authors":"Malihe Mehrparvar Tajoddini, Elaheh Gheybi, Mehdi Rostami, Seyed Hadi Mousavi, Seyed Isaac Hashemy, Roghayeh Rashidi, Mohammad Soukhtanloo","doi":"10.22038/ajp.2024.25214","DOIUrl":"10.22038/ajp.2024.25214","url":null,"abstract":"<p><strong>Objective: </strong>Destruction of dopaminergic neurons causes diseases. Various compounds with neuroprotective and antioxidant properties have been identified, including Hesperidin (HES) and Auraptene (AUR). We aimed in this study to evaluate the <i>in vitro</i> protective effects of these compounds in SH-SY5Y neuroblastoma cell line against the induced neurotoxicity of 6-hydroxydopamine (6-OHDA).</p><p><strong>Materials and methods: </strong>The MTT test to assess cell viability was used. Flow cytometry was conducted for the cell cycle analysis using propidium iodide (PI) stain. The intracellular production of reactive oxygen species (ROS) was assessed using 2, 7'-dichlorofluorescein diacetate (DCFDA) probe and fluorimetry.</p><p><strong>Results: </strong>Following 6-OHDA treatment, cell viability decreased, and G2/M arrest and ROS levels increased. Our intervention demonstrated that only HES has neuroprotective effects against 6-OHDA-induced toxicity.</p><p><strong>Conclusion: </strong>HES protects SH-SY5Y cells against 6-OHDA-induced neural damage via inhibiting G2/M arrest, reducing the amount of ROS, and increasing cell viability. However, the different effects and more precise mechanisms are still unknown, and requires new research on animal and human models.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1082-1090"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atorvastatin and flaxseed dietary treatments improve dyslipidemia and liver injuries in a diet-induced rat model of non-alcoholic fatty liver disease.","authors":"Zahra Eslami, Hamidreza Joshaghani, Abdorreza Eghbal Moghanlou, Alireza Norouzi, Seyed Javad Mirghani","doi":"10.22038/ajp.2024.25220","DOIUrl":"10.22038/ajp.2024.25220","url":null,"abstract":"<p><strong>Objective: </strong>Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease is associated with metabolic disorders including dysregulated lipid and glucose metabolism. There is no approved drug treatment for NAFLD; thus, new therapies are needed. We studied the antidyslipidemic effects of atorvastatin and/or possibly hepatoprotective effects of flaxseed/ flaxseed oil in a rat model of NAFLD.</p><p><strong>Materials and methods: </strong>Fifty-six male Wistar rats were divided randomly into seven groups: 1) control, 2) high-fructose diet (HFD), 3) HFD +atorvastatin (20 mg/kg), 4) HFD+ flaxseed (40 g/kg), 5) HFD+ flaxseed oil (40 mg/kg), 6) HFD+flaxseed (40 g/kg) + atorvastatin (20 mg/kg) and 7) HFD+flaxseed oil (40 g/kg) +atorvastatin (20 mg/kg). The interventions were done for 23 weeks, after which anthropometric indices, lipid profile, liver enzymes, fasting blood glucose, and kidney indices were analyzed. Scoring of hematoxylin-eosin-stained liver sections was used to assess the severity of NAFLD.</p><p><strong>Results: </strong>All the treatments reduced mesenteric fat mass, and the amount of fat around the liver, except in HFD+ flaxseed +atorvastatin group. The interventions improved NAFLD activity score, which considers steatosis, lobular inflammation, and hepatocyte ballooning. However, atorvastatin was most efficient in reducing inflammation and hepatocyte ballooning. While atorvastatin reduced only Gamma-glutamyltransferase (GGT) levels, flaxseed or flaxseed oil mono- and combination therapies reduced serum levels of all liver enzymes. The interventions improved the serum lipid profile and all, except atorvastatin decreased fasting blood glucose.</p><p><strong>Conclusion: </strong>Flaxseed therapies improved NAFLD-associated liver injuries and dyslipidemia, while atorvastatin mostly reduced hepatocyte ballooning and lobular inflammation.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1102-1112"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of <i>Anvillea garcinii</i> and its compounds in health and disease: An overview.","authors":"Ali Zarei, Fatemeh Rasekh, Samaneh Ahmadpour Khorrami, Behnam Masmouei, Saeed Changizi-Ashtiyani, Majid Ramezani, Amirhossein Zarei","doi":"10.22038/ajp.2024.25131","DOIUrl":"10.22038/ajp.2024.25131","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review aims to examine the potential health benefits of <i>Anvillea garcinii</i> and its compounds and provide recommendations based on available research. <i>A. garcinii</i> is a plant species in the daisy family that has demonstrated several therapeutic and preventive effects.</p><p><strong>Materials and methods: </strong>This review was conducted with a comprehensive approach. We meticulously searched multiple databases, including PubMed, Embase, Scopus, Cochrane, SID, and Magiran, using the keyword \"<i>A. garcinii</i> \" on October 4, 2023.</p><p><strong>Results: </strong>Research suggests that <i>A. garcinii</i> extract possesses several properties that could benefit health. These include anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory activities. The extract also displays anti-oxidant properties, enhances insulin sensitivity, and inhibits α-amylase and α-glucosidase. Additionally, it exhibits hepatoprotective activity, cytotoxic activity against cancerous cells, anti-fungal, anti-human immunodeficiency virus (HIV), anti-bacterial, anti-cholinesterase, and anti-tyrosinase activities.</p><p><strong>Conclusion: </strong>The diverse health benefits of <i>A. garcinii</i> extract and its active compounds, such as germacranolide and parthenolide, present significant potential for use in the food, cosmetic, and pharmaceutical industries. This potential, especially in treating diabetes, gastric ulcers, and cancer, opens up exciting possibilities for the future.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1113-1123"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of saffron supplementation on inflammatory factors and clinical outcomes in sepsis patients admitted to the intensive care unit (ICU): Study protocol for a double-blind randomized controlled clinical trial.","authors":"Shirin Hassanizadeh, Babak Alikiaii, Mohammad Hossein Rouhani, Zeinab Mokhtari, Mohammadreza Moznebiisfahani, Manoj Sharma, Mohammad Bagherniya","doi":"10.22038/ajp.2024.25221","DOIUrl":"10.22038/ajp.2024.25221","url":null,"abstract":"<p><strong>Objective: </strong>Research studies have examined saffron's effects on inflammation, infection, and oxidative stress. Nevertheless, the effects of saffron on sepsis patients in the intensive care units (ICUs) have not yet been studied. Hence, this study will examine the effects of saffron supplementation on oxidative stress biomarkers, inflammation factors, and clinical outcomes in critically ill septic patients.</p><p><strong>Materials and methods: </strong>Ninety patients with sepsis will participate in this parallel double-blind, randomized clinical controlled trial. In addition to usual care, the intervention group (n=45) will receive a daily tablet containing 100 mg/day saffron for 7 days, and the control group (n=45) will receive a placebo tablet containing 100 mg/day corn starch for the same duration. Acute Physiology and Chronic Health Evaluation II (APACHE II), the Sequential Organ Failure Assessment (SOFA), and the NUTRIC Score will be used to assess the patients' clinical and nutritional status at the beginning and end of the study. Inflammatory markers including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-18, indicators of oxidative stress including malondialdehyde (MDA), glutathione peroxidase (GPx), catalase, superoxide dismutases (SODs), and total antioxidant capacity (TAC), level of Glasgow Coma Scale (GCS), complete blood count (CBC), and lactate dehydrogenase (LDH) will be evaluated at beginning and end of the study. Twenty-eight days after the start of the intervention mortality rates will be assessed.</p><p><strong>Discussion: </strong>Due to the anti-inflammatory, antioxidant, and antimicrobial effects, saffron might have beneficial effects in critically ill patients with sepsis.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1137-1146"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Daucus carota</i> L. extract on spermiogram factors in men with idiopathic infertility: A double-blinded randomized clinical trial.","authors":"Abolhasan Mousavi Khorshidi, Ayesheh Enayati, Nasser Behnampour, Emadoddin Rezaei, Fatemeh Kolangi","doi":"10.22038/AJP.2024.25008","DOIUrl":"https://doi.org/10.22038/AJP.2024.25008","url":null,"abstract":"<p><strong>Objective: </strong>Male infertility is a common issue that affects people worldwide and presents challenges in terms of treatment. In recent times, there has been significant interest in the use of herbal remedies as a potential solution for male infertility. In this study, we aimed to assess and compare the effects of clomiphene, carrot seed, and education based on traditional Persian medicine on the sperm parameters in idiopathic male infertility.</p><p><strong>Materials and methods: </strong>Sixty male patients experiencing infertility were randomly divided into four groups: Clomiphene, Clomiphene + Carrot, Clomiphene + Lifestyle modification, and Clomiphene + Carrot + Lifestyle modification. In the herbal group, patients received four capsules of carrot seeds, for a total of 2 g daily for 90 days. Meanwhile, subjects in the Clomiphene group were administered one tablet of clomiphene, containing 50 mg, per day for a duration of 90 days. Sperm parameters were analyzed at the beginning and end of the study.</p><p><strong>Results: </strong>After the 90-day intervention, the groups that received clomiphene combined with carrot and lifestyle interventions showed significant improvements in various sperm parameters. These improvements were statistically significant compared to the control group.</p><p><strong>Conclusion: </strong>The combination of carrot seeds along with clomiphene and education based on traditional Persian medicine was found to improve sperm parameters in cases of idiopathic male infertility without any adverse effects.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"981-996"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-leishmanial effect of the hydroalcoholic extract of the leaves, roots and seeds of <i>Arctium lappa</i>.","authors":"Elham Maleki, Afsaneh Yegdaneh, Sakineh Akbari, Saberi Sedigheh","doi":"10.22038/AJP.2024.24940","DOIUrl":"https://doi.org/10.22038/AJP.2024.24940","url":null,"abstract":"<p><strong>Objective: </strong>Zoonotic cutaneous leishmaniasis is a common including endemic infectious disease in many parts of the world and Iran. Due to <i>Arctium lappa</i> wide therapeutic applications, the anti-leishmanial effect of the hydroalcoholic extract of its leaves (L), roots (R) and seeds (S) has been investigated in this research.</p><p><strong>Materials and methods: </strong>The leaves, seeds and roots of the greater burdock plant were extracted. In the <i>in vitro</i> phase, its cytotoxic and anti-leishmanial effects on promastigote and amastigote forms of <i>Leishmania major(L.major)</i> were investigated. In the in vivo stage, the leishmaniasis mouse model was dosed with concentrations of 50, 100, and 200 mg/kg and the liver and spleen parasite burden was checked.</p><p><strong>Results: </strong>The results of this research in the <i>in vitro</i> phase showed that the antileishmanial effect of the hydroalcoholic extract of leaves, roots and seeds on the promastigote and amastigote forms of <i>L. major</i> has a significant relationship with the increase in the concentration of the extract (for all p≤0.001). Also, exposure time and interaction effect of concentration and exposure time were significant. In the <i>in vivo</i> phase the significant effect of the increase in concentration (L: p≤0.001, R: p=0.02, S: p=0.03), exposure time (L: p≤0.001, R: p≤0.001, S: p≤0.01) and the interaction effect of these two factors (L: p=0.002, R: p≤0.001, S: p≤0.001) on reducing the size of the wound was shown.</p><p><strong>Conclusion: </strong>The investigation established that hydroalcoholic extract of the leaves, roots, and seeds of the greater burdock in high concentration exhibited beneficial inhibitory effects on the leishmanial lesions.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1030-1046"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anti-inflammatory effects of <i>Lavandula stoechas</i> L. extract on ovalbumin-induced acute asthma in BALB/c mice.","authors":"Nafiseh Erfanian, Faezeh Fazlpour, Hossein Safarpour, Sayyedeh Fatemeh Askari, Mohsen Foadoddini, Saeed Nasseri","doi":"10.22038/AJP.2024.25175","DOIUrl":"https://doi.org/10.22038/AJP.2024.25175","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is an inflammatory disease of the respiratory system affecting over 300 million people worldwide. <i>Lavandula stoechas</i> L. (<i>L. stoechas</i>) has traditionally been used to manage inflammatory diseases and against multiple medical conditions. In this study, we aimed to explore the anti-inflammatory effects of the hydro-alcoholic extract of <i>L. stoechas</i> in a mice model of acute asthma.</p><p><strong>Materials and methods: </strong>Thirty-five male BALB/c mice were placed into five distinct study groups: (1) control, (2) ovalbumin (OVA) + Al(OH)3, (3) OVA + <i>L. stoechas</i> (200 mg/kg), (4) OVA + <i>L. stoechas</i> (300 mg/kg) and (5) OVA + dexamethasone. Sensitization of the mice involved intraperitoneal administration of 75 µg OVA + 2mg Al(OH)3 on days 1 and 8. Subsequently, between days 15 and 17, the mice underwent intranasal challenges with 50 µg of OVA. On days 13-18, the mice were administered either <i>L. stoechas</i> (200 and 300 mg/kg) orally or dexamethasone intraperitoneally (used as a positive control). On day 19, both bronchoalveolar lavage (BAL) fluid and lung tissue samples were collected for biochemical and immuno-histological analyses.</p><p><strong>Results: </strong>The <i>L. stoechas</i> extract-treated groups displayed notable reductions in histological alterations and inflammatory cell infiltration, surpassing the effects observed in the OVA group. Moreover, the <i>L. stoechas</i> treatment group exhibited lowered <i>TNF-α</i> and <i>IL-6</i> expression levels.</p><p><strong>Conclusion: </strong>Our results demonstrated the potential of <i>L. stoechas</i> as an anti-inflammatory agent in acute asthma.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"933-942"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible effects of royal jelly against neuronal injury in the hippocampus of ovariectomized rats with pentylenetetrazol-induced seizures: Role of luteinizing and follicle-stimulating hormones.","authors":"Asma Momeni, Mohammad Reza Salahshoor, Mohammadreza Afarinesh, Cyrus Jalili","doi":"10.22038/AJP.2024.25151","DOIUrl":"https://doi.org/10.22038/AJP.2024.25151","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential impact of royal jelly (RJ) on hippocampal neurons in an ovariectomized (OVX) rat model with pentylenetetrazol (PTZ)-induced seizures by assessing luteinizing (LH) and follicle-stimulating (FSH) hormones.</p><p><strong>Materials and methods: </strong>Fifty-six female rats (n=7/group) were divided into groups receiving saline (CTL, OVX, RJ, and OVX-RJ) and those undergoing PTZ-induced seizures (PTZ, PTZ-OVX, PTZ-RJ, and PTZ-OVX-RJ). OVX rats underwent bilateral ovary removal, followed by a 15-day RJ treatment at 300 mg/kg. The seizure model commenced 24 hours after the final RJ dose. Serum LH and FSH levels were measured, and Golgi staining assessed hippocampal neuron morphology.</p><p><strong>Results: </strong>The RJ group exhibited elevated LH and FSH levels compared to CTL. However, the PTZ-RJ group showed no significant changes in these hormones relative to the PTZ and CTL groups. In OVX-RJ rats, LH and FSH levels decreased compared to the RJ group, while PTZ-OVX-RJ rats showed increased levels. Dendritic spines remained unchanged in both the RJ and PTZ-RJ groups compared to the CTL and PTZ groups, respectively. Notably, OVX-RJ exhibited reduced spines compared to the RJ group, while PTZ-OVX-RJ showed an increase.</p><p><strong>Conclusion: </strong>RJ may protect against estrogen deficiency and seizure-related adverse effects on hippocampal neurons in OVX rats, highlighting its potential as a beneficial dietary supplement.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1047-1058"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}