Avicenna Journal of Phytomedicine最新文献

{"title":"Investigation of the effects of alcoholic frankincense extract on oxidative stress and inflammatory parameters in C57BL/6 mice with induced autoimmune encephalomyelitis.","authors":"Abdolghader Tane, Yaser Mohammadi, Mohsen Naseri, Gholamreza Anani Sarab, Hamidreza Safari, Niloofar Honari","doi":"10.22038/ajp.2026.27390","DOIUrl":"10.22038/ajp.2026.27390","url":null,"abstract":"<p><strong>Objective: </strong>Multiple sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation and demyelination. Frankincense, a natural oleo-gum-resin obtained from the genus <i>Boswellia</i> (family Burseraceae), possesses anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the therapeutic effects of alcoholic frankincense extract in an experimental model of MS.</p><p><strong>Materials and methods: </strong>Female C57BL/6 mice were randomly assigned to three groups (n = 5). Experimental autoimmune encephalomyelitis (EAE) was induced by subcutaneous immunization with MOG_35-55/CFA and intraperitoneal injection of pertussis toxin. Mice were treated orally with alcoholic frankincense extract (200 mg/kg) for 33 days. Serum levels of IL-17A, IL-23, transforming growth factor-β (TGF-β), and total antioxidant capacity (TAC) were measured, and brain tissues were examined histopathologically.</p><p><strong>Results: </strong>EAE induction caused significant weight loss, severe clinical symptoms, increased IL-17A and IL-23 levels, reduced TGF-β and TAC, and marked neuroinflammation with myelin damage. Frankincense treatment significantly improved clinical scores and body weight, decreased proinflammatory cytokines, enhanced antioxidant capacity, and attenuated inflammatory infiltration and myelin degradation in brain tissue.</p><p><strong>Conclusion: </strong>Alcoholic frankincense extract ameliorated EAE-associated inflammation and oxidative stress and exerted a protective effect on myelin integrity, suggesting its potential as a complementary therapeutic approach for MS. Further studies are warranted to confirm its clinical applicability.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"972-983"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and laboratory findings in patients with castor bean (<i>Ricinus communis</i> L.) poisoning referred to Imam Reza hospital in northeast of Iran, from April 2015 to March 2020.","authors":"Mohammad Moshiri, Yeganeh Ramazani, Nilofar Akhgar, Bita Dadpour, Leila Etemad","doi":"10.22038/ajp.2025.26942","DOIUrl":"10.22038/ajp.2025.26942","url":null,"abstract":"<p><strong>Objective: </strong>Castor bean (CB) (<i>Ricinus communis</i>) contains a highly toxic natural compound called ricin. We retrospectively reviewed the documents of CB-poisoned cases referred to the clinical toxicology department of Imam Reza Hospital affiliated with Mashhad University of Medical Sciences, Mashhad, Iran.</p><p><strong>Materials and methods: </strong>Patients' data including epidemiological variables, rout and amount of CB ingestion, clinical and laboratory findings, and type of treatment were extracted from hospital documents.</p><p><strong>Results: </strong>Twelve cases of CB ingestion, with mean age 29.42 ± 21.19 years (4 to 70 years), 4 children (33.3%), and two elderly people (16.7%), were included in the study. All of them were intoxicated by oral ingestion of CB. The mean number of ingested CBs was 4.83 ± 3.16 seeds (range 1-10, median 5 seeds). The most common complaint of the cases (n = 11, 91.67%) was frequent vomiting, followed by nausea (n = 7, 41.7%) and diarrhea (n = 4, 33.3%). Vomiting more commonly occurred up to the second hour after seeds ingestion and at a frequency of 8 to 21 times. The vital signs of all cases were in normal ranges and no tachycardia, hypotension, or tachypnea was recorded. Also, all laboratory results were normal, except metabolic acidosis (pH 7.3) in one case (8.3%). All cases were discharged in good condition with conservative treatment after 19.5 ± 15.3 hr (12-45 hr, median = 22 hr). None of them reported any problem in follow-up.</p><p><strong>Conclusion: </strong>The majority of our cases were mild. Gastrointestinal problems, especially frequent vomiting, were the most common complaints. Conservative management was effective in mild to moderate cases.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"811-818"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant efficacy of <i>Cotoneaster nummularius</i> in phenylhydrazine-induced hyperbilirubinemia: A rat model study.","authors":"Faezeh Valipour, Akbar Safipour Afshar, Mohammad Azadbakht, Hamidreza Mohammadi, Rahele Zhiani","doi":"10.22038/ajp.2025.26368","DOIUrl":"10.22038/ajp.2025.26368","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the hepatoprotective effects of <i>Cotoneaster nummularius</i> manna extract (CNE) against phenylhydrazine (PHZ)-induced hyperbilirubinemia and oxidative stress in a neonatal rat model.</p><p><strong>Materials and methods: </strong>Fifty neonatal Wistar rats (2 weeks old) were divided into five groups (n=10): a control group, a PHZ-only group, and three PHZ-treated groups receiving CNE (1, 2.5, and 5 mg/kg, orally, thrice daily for 10 days). PHZ was used to induce hemolysis and hyperbilirubinemia. Markers of liver function, oxidative stress, and antioxidant capacity were analyzed, alongside β-glucuronidase activity.</p><p><strong>Results: </strong>CNE significantly mitigated PHZ-induced hyperbilirubinemia by reducing serum bilirubin levels and dose-dependently decreasing oxidative stress markers, including reactive oxygene species ROS, malondialdehyde (MDA), and protein carbonylation. It also restored glutathione (GSH) levels and total antioxidant capacity. The highest CNE dose (5 mg/kg) demonstrated the most pronounced effects. Furthermore, CNE inhibited β-glucuronidase activity, contributing to its hepatoprotective action. Hierarchical clustering and heatmap analyses corroborated the dose-dependent antioxidant and hepatoprotective properties of CNE.</p><p><strong>Conclusion: </strong>These findings highlight the hepatoprotective potential of <i>C. nummularius</i> extract in reducing oxidative stress and hyperbilirubinemia. CNE dose-dependent effects, particularly at 5 mg/kg, suggest its promise as a therapeutic agent for neonatal liver dysfunction and oxidative damage. Further clinical studies are warranted to explore its potential applications in managing liver disorders.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 1","pages":"169-183"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of trans sodium crocetinate and crocetin on reperfusion injury in acute myocardial infarction with ST-segment elevation: A double-blind, randomized, placebo-controlled clinical trial.","authors":"Ghazaleh Elahabadi, Arash Gholoobi, Javad Ramezani, Ali Eshraghi, Reza Javidi Dasht Bayaz, Vahid Ghavami, Majid Sezavar Dokht Faroughi, Amir Hooshang Mohammadpour, Hossein Hosseinzadeh","doi":"10.22038/ajp.2025.26046","DOIUrl":"10.22038/ajp.2025.26046","url":null,"abstract":"<p><strong>Objective: </strong>This randomized, double-blind trial evaluated trans sodium crocetinate (TSC)-a crocetin-derived antioxidant and crocetin with potential cardioprotective effects-on reperfusion injury in 90 ST-elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PPCI).</p><p><strong>Materials and methods: </strong>Patients received either TSC (0.5 mg/kg injection pre-PPCI + 7.5 mg crocetin tablets for 3 days) or placebo. The primary outcome was ≥ 70% ST-segment resolution 1-hr post-PPCI. Secondary outcomes included corrected thrombolysis in myocardial infarction frame count (CTIMIFC), arrhythmia rates, and echocardiographic parameters (left ventricular ejection fraction (LVEF) and LV size).</p><p><strong>Results: </strong>ST-segment resolution occurrence was significantly higher in the TSC group versus placebo (p=0.018). There was no difference in CTIMIFC between the two groups. Echocardiographic parameters were similar between the TSC and placebo groups. Although not statistically significant, the frequency of supraventricular and ventricular arrhythmias was lower in the TSC group. Adverse drug effects were comparable between the two groups.</p><p><strong>Conclusion: </strong>TSC (0.5 mg/kg injection pre-PPCI + 7.5 mg crocetin tablets for 3 days) administration improved myocardial reperfusion, as evidenced by enhanced ST-segment resolution, suggesting reduced reperfusion injury in STEMI patients post-PPCI. While no benefits were observed in CTIMIFC or cardiac remodeling, the safety profile and primary outcome results support further investigation. Larger trials are needed to confirm efficacy and assess long-term clinical impacts.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 1","pages":"130-141"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review.","authors":"Somaihe Sabzali, Seifollah Bahramikia, Kiana Shahzamani","doi":"10.22038/ajp.2025.26851","DOIUrl":"10.22038/ajp.2025.26851","url":null,"abstract":"<p><strong>Objective: </strong>Today, applying herbal extracts to treat skin damage has become widespread and it is supported by numerous studies that confirmed their effectiveness. Due to fewer side effects, diversity of active compounds in them, and lower costs, herbal extracts are an important therapeutic method for skin lesions. Additionally, nanoparticles are important for stimulating the body's ability to recover and treat wounds.</p><p><strong>Materials and methods: </strong>This review article aims to evaluate how combining herbal extracts with nanoparticles and advanced drug carriers (like liposomes and nanofibers) creates synergistic effects that enhance the treatment of bacterial skin infections and wounds. By improving bioavailability, targeting delivery, and reducing required dosages, these formulated combinations offer a more effective, faster-healing, and potentially safer alternative to conventional therapies.</p><p><strong>Results: </strong>Based on the discussed studies, therapy using a combination of medicinal herbs and nanotechnology increases the effectiveness of treatment, accelerates recovery, and decreases the use of each material, thereby reducing the toxicity of each in infection and skin damage treatment.</p><p><strong>Conclusion: </strong>This review conclusively demonstrates that the strategic formulation of herbal extracts with nanoparticles and advanced drug carriers-such as liposomes, nanofibers, and polymeric nanoparticles-unlocks unprecedented synergistic potential for treating bacterial skin infections and accelerating wound and burn healing. By enhancing bioavailability, enabling targeted delivery, and reducing therapeutic doses (thereby minimizing toxicity), these nano-herbal hybrids represent a paradigm shift toward safer, faster, and more cost-effective regenerative therapies that can combat antibiotic resistance and revolutionize modern dermatological care.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"834-846"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesperidin attenuates cisplatin-induced cardiotoxicity in rats through regulating autophagy.","authors":"Hoori Heidari Kahkesh, Negin Amini, Mohammad Badavi, Mahin Dianat, Fereshteh Nejaddehbashi, Khojasteh Hoseinynejad","doi":"10.22038/ajp.2026.27360","DOIUrl":"10.22038/ajp.2026.27360","url":null,"abstract":"<p><strong>Objective: </strong>Cisplatin is a well-known anticancer drug whose use has been limited due to a variety of side effects. Evidence has confirmed that cisplatin consumption is associated with cardiac toxicity. Unfortunately, no drug has yet been found to treat cardiac toxicity or reduce the side effects caused by cisplatin. However, hesperidin has been identified as an antioxidant agent which has protective effects on the heart tissue. This study explored the impact of hesperidin on cisplatin-induced cardiac toxicity through its antioxidant effect and adjustment of autophagy.</p><p><strong>Materials and methods: </strong>It included male Wistar rats allocated into five groups: sham, cisplatin: animals treated with cisplatin (7.5 mg/kg intraperitoneally) on the 4^th day; and four groups which received hesperidin (50, 100, and 200 mg/kg, gavage, 1 week) along with cisplatin on the 4^th day. A mixture of ketamine and xylazine was used to anesthetize all animals on day 8 to obtain blood and tissue samples and to record ECG.</p><p><strong>Results: </strong>The findings indicated that cisplatin led to an increase in creatine kinase-MB, lactate dehydrogenase, and malondialdehyde levels, and a reduction in total antioxidant capacity in heart tissue. Moreover, it reduced the expression of microtubule-associated protein light chain (LC3-II) and beclin-1. ECG parameters included: Heart rate (HR) and QRS voltage complex which were reduced by cisplatin. However, hesperidin (100, and 200 mg/kg) reversed these changes.</p><p><strong>Conclusion: </strong>Hesperidin could protect cardiac tissue against cisplatin administration by exerting its antioxidant effect and regulating autophagy in a dose-dependent manner.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"946-956"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of standardized hydroalcoholic extract of oat grains (<i>Avena sativa</i> L.) capsules as an adjunctive treatment on allergic rhinitis.","authors":"Farzad Nasrpour Tahouneh, Mehdi Ansari Dogaheh, Fariba Sharififar, Fatemeh Dabaghzadeh, Nasrin Bazargan, Sarehossadat Ebrahimi, Tania Dehesh, Faraz Ahmad","doi":"10.22038/ajp.2025.26055","DOIUrl":"10.22038/ajp.2025.26055","url":null,"abstract":"<p><strong>Objective: </strong>Allergic rhinitis is a chronic inflammatory disease which exists throughout people's lives. <i>Avena sativa</i> L. (oat) belongs to the Poaceae family and has antihistamine, anti-inflammatory, and antioxidant effects. The aim of this study was to evaluate the effects of standardized hydroalcoholic extract of oat grains capsules as an adjunctive treatment on allergic rhinitis.</p><p><strong>Materials and methods: </strong>Hard gelatin capsules of the dried extract of oat grains were prepared, and characterized for key physico-chemical properties. Patients diagnosed with allergic rhinitis were recruited for the clinical trial to assess the effectiveness of these capsules, and were randomly divided into treatment and control groups. The participating subjects received one oat extract or placebo capsule twice daily for two weeks. All the subjects (in the control and treatment groups) also received oral antihistamines and glucocorticoid nasal spray as the standard treatment. The patients' total nasal symptom scores and the presence of allergic rhinitis symptoms were recorded at the baseline and at the end of the second week.</p><p><strong>Results: </strong>After two weeks of intervention, the patients' total nasal symptom scores and the prevalence of allergic rhinitis symptoms significantly decreased in all of them. However, supplementation with oat grain extract capsules was associated with significantly higher improvements in the outcomes in the treatment group compared with the control group.</p><p><strong>Conclusion: </strong>The dried extract of oat grains (<i>Avena sativa</i> L.) capsules was an effective adjunctive therapy to improve allergic rhinitis symptoms.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 1","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of <i>Asparagus racemosus</i> extract (ARova5X) supplementation on postmenopausal discomfort.","authors":"Kumar Guru Mishra, Nabnita Patnaik, Adityananda Mohapatra, Nihar Ranjan Pradhan","doi":"10.22038/ajp.2025.26850","DOIUrl":"10.22038/ajp.2025.26850","url":null,"abstract":"<p><strong>Objective: </strong>Menopause is a critical physiological transition often associated with a spectrum of health challenges such as sexual dysfunction, vasomotor symptoms, and increased oxidative stress. This study aimed to evaluate the efficacy of a hydroalcoholic extract of <i>Asparagus racemosus</i> root (ARova5X), standardized to contain 5% shatavarins, in improving health outcomes among postmenopausal women.</p><p><strong>Materials and methods: </strong>A randomized, double-blind, placebo-controlled clinical trial was conducted at Apollo Hospitals, Hyderabad, India, during January 2024-2025. A total of 214 postmenopausal women were randomly assigned to receive either ARova5X (250 mg/day) or placebo for 90 days (n=107 per group). Outcome measures were assessed at baseline and post-intervention using validated tools including the Sexual Quotient-Female (SQ-F) questionnaire, the Female Intervention Efficacy Index (FIEI), oxidative stress markers, and anthropometric parameters. Primary endpoints included changes in sexual function, menopausal symptoms, oxidative stress, and weight-related measures.</p><p><strong>Results: </strong>Participants receiving ARova5X showed significant improvements in multiple domains of sexual function including desire (p<0.001), foreplay (p=0.002), arousal (p<0.001), and satisfaction (p=0.004) compared to the placebo group. Vaginal lubrication improved by 84.11% in the intervention group compared to 13.08% in the placebo group. Oxidative stress levels were markedly reduced, with 39.25% of women in the ARova5X group reaching minimal stress levels. Clinical obesity prevalence decreased from 42.99% to 29.91%. Menopausal symptoms such as hot flashes, fatigue, and irritability were also significantly alleviated.</p><p><strong>Conclusion: </strong>ARova5X appears to be a safe, effective natural intervention for improving sexual health, reducing oxidative stress, and supporting weight management in postmenopausal women.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 5","pages":"860-872"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy with bone marrow-derived mesenchymal stem cell transplantation and propolis improves streptozotocin-induced kidney injury in diabetic rats.","authors":"Fatemeh Salami, Sara Hosseinian, Elahe Mahdipour, Samira Shahraki, Mohammad Hossein Rigi, Zahra Samadi Noshahr, Hossein Hosseinzadeh, Abolfaz L Khajavi Rad","doi":"10.22038/ajp.2025.26229","DOIUrl":"10.22038/ajp.2025.26229","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the current study was to determine the therapeutic effects of combination therapy with propolis extract and rat bone marrow mesenchymal stem cells (MSCs) in streptozotocin (STZ)-induced diabetic rats.</p><p><strong>Materials and methods: </strong>Firstly, characterization of MSCs was performed and MTT assay was done to determine the optimum concentration of propolis for incubation with MSCs. Rats were divided into 8 groups: Control, diabetic , diabetic+propolis, diabetic+metformin, diabetic+MSCs, diabetic+MSCs+ propolis, diabetic+ MSCs pre-incubated with propolis. MSCs were transplanted via the tail vein on the 7^th and 21^st days of the study. Renal function tests and histopathologic examination were performed for all groups.</p><p><strong>Results: </strong>Serum glucose concentration in all propolis and MSCs treatment groups was significantly lower than that of the STZ group on the 21^st and 42^nd days of the study. On the 42^nd day, the concentration of serum albumin in the STZ group was significantly lower than the control. Serum albumin concentration in all diabetic groups treated with propolis and MSCs was significantly higher than the diabetic animals. On the 42^nd day, the concentrations of creatinine and urea in the STZ group were significantly higher than all the treatment and control groups. The renal index and histopathological parameters improved in all treatment groups compared with the STZ group.</p><p><strong>Conclusion: </strong>Our findings demonstrated, MSCs, propolis, and their combination demonstrate positive effects on renal function, kidney index, and histopathology in all treated animals compared with the STZ diabetic rats. These beneficial effects are comparable to those of metformin.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 1","pages":"155-168"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of training and <i>Tribulus terrestris</i> extract on the antioxidant system and telomere functional markers in the liver tissue of rats exposed to stanozolol.","authors":"Najmeh Kiani, Saeed Keshavarz, Seyed Ali Hosseini, Jamshid Banai","doi":"10.22038/ajp.2025.26403","DOIUrl":"10.22038/ajp.2025.26403","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to assess the effect of training along with administration of <i>Tribulus terrestris</i> (T) on the antioxidant system and telomere functional markers in the liver tissue of rats exposed to stanozolol.</p><p><strong>Materials and methods: </strong>Forty- nine male rats, with average age and weight of 8-10 weeks and 180-220 g respectively, were randomly divided into 7 groups of seven rats: 1) Sh: Sham, 2) S: stanozolol, 3) S+T50: stanozolol+ 50 mg/kg <i>T. terrestris</i>, 4) S+T100: stanozolol+ 100 mg/kg <i>T. terrestris</i>, 5) S+RT: stanozolol + resistance training, 6) S+RT+T50: stanozolol + resistance training + 50 mg/kg <i>T. terrestris</i>, and 7) S+RT+T100: stanozolol + resistance training + 100 mg/kg <i>T. terrestris</i>. Rats in the S groups received 5 mg/kg stanozolol intraperitoneally (25 mg/kg/wk). Groups 5 (R+T), 6 (S+RT+T50), and 7 (S+RT+T100) performed resistance trainings three sessions per week with an intensity of 30-100 percent of body weight for eight weeks. Also, groups 3 (S+T50), 4 (S+T100), 6 (S+RT+T50) and 7 (S+RT+T100) received daily ethanolic extract of T with doses of 50 and 100 mg/kg intraperitoneally.</p><p><strong>Results: </strong>In the S+RT, S+T50, S+T100, S+RT+T50, and S+RT+T100 groups, malondialdehyde (MDA) levels were significantly lower and gene expression of phosphoinositide 3-kinases <i>(PI3K</i>), protein kinase B (<i>Akt</i>), and telomerase reverse transcriptase (<i>TERT</i>) levels were higher than the S group. Also, <i>phosphatase and tensin homolog</i> (<i>PTEN</i>) and <i>TERT</i> gene expression levels in the S+T100 group were significantly higher than the S+T50 group.</p><p><strong>Conclusion: </strong>Training and T have a positive effect on the transcription pathway of antioxidants and telomere protection.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"16 1","pages":"184-194"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}