Avicenna Journal of Phytomedicine最新文献_第4页

The protective properties of resveratrol against glycerol-induced acute kidney injury in rats. 白藜芦醇对甘油致大鼠急性肾损伤的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24649

Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh

{"title":"The protective properties of resveratrol against glycerol-induced acute kidney injury in rats.","authors":"Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24649","DOIUrl":"https://doi.org/10.22038/AJP.2024.24649","url":null,"abstract":"Objective: After rhabdomyolysis, muscle tissue releases substances such as myoglobin, creatine kinase, and electrolytes into the bloodstream, potentially leading to acute kidney injury (AKI). Resveratrol (RSV) is a polyphenol compound with anti-inflammatory and antioxidant effects and it is found in various plants. This research evaluated the protective effects of RSV in rhabdomyolysis-induced AKI in rat kidneys.Materials and methods: Thirty-six male Wistar rats were randomly assigned to six groups (n=6): 1) control (normal saline), 2) glycerol only (10 ml/kg, intramuscular), 3, 4, and 5) glycerol +RSV (5, 10, and 25 mg/kg, intraperitoneal injection) and 6) RSV (25 mg/kg). After 4 days, pathological alterations and the level of blood urea nitrogen (BUN) and serum creatinine were determined. Malondialdehyde (MDA), glutathione (GSH), neutrophil gelatinase-associated lipocalin (NGAL), and tumor necrosis factor-α (TNF-α) proteins were investigated in rat kidneys.Results: Injection of 50% glycerol (10 ml/kg, IM) resulted in pathological lesions, elevated levels of MDA (p<0.001), BUN (p<0.01), serum creatinine (p<0.001), TNF-α (p<0.01), and NGAL protein (p<0.001), and decreased GSH content (p<0.001) compared to the control animals. These findings indicated AKI induced by rhabdomyolysis. RSV (25 mg/kg) administration significantly decreased serum creatinine, BUN, MDA, NGAL, and TNF-α levels compared to the glycerol group. Histopathologically, tubule necrosis, myoglobin cast formation and glomerular atrophy increased in the glycerol group and reduced in animals that received RSV.Conclusion: In the glycerol-induced AKI rat model, RSV administration alleviated renal dysfunction by reducing oxidative stress and inflammatory responses.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"860-873"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine. 药用植物油在儿科相关疾病中的局部应用：一篇基于传统波斯医学的比较综述文章。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24303

Maryam Mohammadian-Dameski, AhmadShah Farhat, Maliheh Motavasselian, Vahid Reza Askari

{"title":"Topical application of medicinal plant oils in pediatric-related disorders: A comparative review article based on traditional Persian medicine.","authors":"Maryam Mohammadian-Dameski, AhmadShah Farhat, Maliheh Motavasselian, Vahid Reza Askari","doi":"10.22038/AJP.2024.24303","DOIUrl":"https://doi.org/10.22038/AJP.2024.24303","url":null,"abstract":"Objective: Researchers have considered medicinal oils to prevent and treat pediatric diseases. In the traditional Persian medicine (TPM) doctrine, anointment is widely used in order to avoid and treat diseases. This study aimed to evaluate and reconcile the uses of anointment in children in TPM and the new studies.Materials and methods: Accordingly, TPM documents were scrutinized for anointments and their applications in pediatric disorders. Moreover, new studies were reviewed in Google scholar, PubMed, Medline, Scopus, and Web of Science until June 2022.Results: In the health preservation field, TPM scholars have recommended daily anointment with some oils like sweet almonds in the early months after birth to improve growth, strengthen the body, and prevent dry skin, and new studies have confirmed the effectiveness of some oils accordingly. In the treatment field, various oils are recommended, namely sweet almond oil for weight disorders, violet oil for insomnia, olive oil and chamomile oil for functional constipation, infantile colic and enuresis, and olive oil for diaper rash and atopic dermatitis and new studies have shown their effectiveness. Sweet almond, chamomile, violet, olive, and rose oils are among the most widely used oils in Persian medicine for children, which we have discussed in this study.Conclusion: Due to the non-invasive nature of anointment and the observation of minimal adverse effects in studies, it can be given attention for maintaining pediatric health and treating their diseases.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"794-815"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effect of a herbal cream containing rose essence in an animal model of eczema. 研究含有玫瑰精华的草本乳膏对湿疹动物模型的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.25132

Ali Reza Malayeri, Anayatollah Salimi, Fariba Iraji, Susan Sabbagh, Neda Shakerian, Mobin Khaledi

{"title":"Investigating the effect of a herbal cream containing rose essence in an animal model of eczema.","authors":"Ali Reza Malayeri, Anayatollah Salimi, Fariba Iraji, Susan Sabbagh, Neda Shakerian, Mobin Khaledi","doi":"10.22038/AJP.2024.25132","DOIUrl":"https://doi.org/10.22038/AJP.2024.25132","url":null,"abstract":"Objective: Eczema, a common inflammatory skin condition characterized by itching and dermatitis, can significantly impact the quality of life. While conventional treatments exist, there is interest in exploring natural alternatives. This study investigates the efficacy of a rosehip extract-based cream in mitigating eczema symptoms in a mouse model.Materials and methods: Thirty-five mice were divided into five groups: control, dinitrochlorobenzene (DNCB)-induced eczema (model group), and treatment groups receiving placebo, betamethasone cream (positive control), or rosehip extract cream. Following topical treatment for four weeks, the animals were euthanized, and their skin was evaluated for inflammation, moisture, and thickness. Histopathological analysis was performed using hematoxylin and eosin (H&E) staining.Results: Compared to the control group, DNCB treatment significantly increased inflammation, erythema (redness), dryness, and epidermal thickness. Notably, topical application of the rosehip extract cream significantly reduced these eczema-associated parameters, demonstrating efficacy comparable to the positive control (betamethasone cream).Conclusion: This study suggests that a topical cream formulated with rosehip extract may be a promising therapeutic strategy for alleviating eczema symptoms. The anti-inflammatory and potentially regenerative properties of rose extract warrant further investigation for the development of natural eczema treatments.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1070-1081"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats. γ -米甲醇对慢性限制性应激大鼠雄性生殖功能的抗氧化和抗凋亡作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24819

Mahsan Alizadeh, Sina Moshtagh, Shahabaddin Abdolalizadeh Amir, Mostafa Jeddi, Sepehr Tahmasebzadeh, Ghazal Radman, Amin Bagheri, Yasin Bagheri, Nazanin Shahabinejad

{"title":"Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats.","authors":"Mahsan Alizadeh, Sina Moshtagh, Shahabaddin Abdolalizadeh Amir, Mostafa Jeddi, Sepehr Tahmasebzadeh, Ghazal Radman, Amin Bagheri, Yasin Bagheri, Nazanin Shahabinejad","doi":"10.22038/AJP.2024.24819","DOIUrl":"https://doi.org/10.22038/AJP.2024.24819","url":null,"abstract":"Objective: This study investigates the effects of GO on depressive behaviors and reproductive parameters in rats exposed to CRS.Materials and methods: Rats were divided into three groups: sham, CRS-control, and CRS-GO. Behavioral assessments using the SPT and measurements of body and testes weights were conducted. Reproductive potential was evaluated by ELISA for testosterone, LH, and FSH levels, as well as sperm characteristics. Oxidative stress levels were assessed through MDA measurements and antioxidant enzyme activities. Additionally, apoptotic and signaling pathway proteins were analyzed by measuring cleaved caspase-3 and Nrf-2 levels in the testes using western blot analysis.Results: GO mitigated depressive behaviors and reduced serum corticosterone levels compared to the CRS-control group. GO increased testosterone, LH, and FSH levels and improved sperm parameters. GO supplementation reduced MDA levels and enhanced antioxidant enzyme activities compared to the CRS-control group. The analysis showed that GO down-regulated cleaved caspase-3 levels and up-regulated Nrf-2 protein levels in the testes of CRS rats compared to the CRS-control group.Conclusion: The administration of GO treatment can contribute to the recovery from male reproductive complications by regulating oxidative stress and apoptotic pathways.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"890-906"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study. 缬草茶对健康志愿者交感迷走神经张力和心功能影响的半实验研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24974

Seyed Mehran Hosseini, Shahab Zanganeh, Marzieh Qaraaty

{"title":"The effect of Valeriana officinalis tea on sympathovagal tone and cardiac function in healthy volunteers: A semi-experimental study.","authors":"Seyed Mehran Hosseini, Shahab Zanganeh, Marzieh Qaraaty","doi":"10.22038/AJP.2024.24974","DOIUrl":"https://doi.org/10.22038/AJP.2024.24974","url":null,"abstract":"Objective: The use of herbal teas can affect some physiological parameters of the body. Valerian has been used as a valuable medicinal plant. There are reports about sedative and sleep-inducing effects of Valeriana officinalis L. (VOT) on the nervous system. But in relation to its possible effect on the autonomic nervous system, the available information is limited. This study aimed to determine the effect of VOT on sympathovagal tone based on heart rate variability indices.Materials and methods: In this semi-experimental study, 12 healthy volunteers were enrolled. At first, the participants received 50 ml of water as the control group, and then after the clearance time, they received VOT with a dilution of 50% with the same temperature and volume and were considered the intervention group. Assessment of sympathovagal tone was performed in terms of heart rate variability indices. There were 5 recording steps: baseline, after drinking water, and 5, 20, and 30 minutes after drinking VOT.Results: The mean±SD of the average heart rate per minute at the five recording steps after VOT was 65.4±15.5, 63.5 ±14.6, 62.7±15.6, 61.8±16.09, and 60.9 15.2, respectively (p<0.05). The average arterial systolic pressure at the five recording steps after VOT was 119.4±7.4, 117.9± 9, 114.3±7.9, 113.8±8.6, and 114±6.5 mmHg, respectively.Conclusion: A single cup of VOT significantly decreased the heart rate. This effect may be associated with a decrease in sympathetic activity and an increase in parasympathetic activity.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"784-793"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet. 香芹酚对高脂饮食诱导的肥胖雄性大鼠心脏细胞凋亡基因表达水平的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.25089

Mahdi Ahmadi, Sadegh Bagherzadeh, Mohammad Hossein Boskabady, Ali Vahabi, Sakhavat Abolhasani, Mohammad Reza Aslani

{"title":"The effects of carvacrol on the cardiac apoptosis gene expression levels in heart tissue of obese male rats induced by high-fat diet.","authors":"Mahdi Ahmadi, Sadegh Bagherzadeh, Mohammad Hossein Boskabady, Ali Vahabi, Sakhavat Abolhasani, Mohammad Reza Aslani","doi":"10.22038/AJP.2024.25089","DOIUrl":"https://doi.org/10.22038/AJP.2024.25089","url":null,"abstract":"Objective: Animal studies have revealed that lipid accumulation in obese mice fed with a high-fat diet (HFD) leads to alterations in the structural and functional properties of cardiovascular tissues. The current study aimed to investigate apoptosis/anti-apoptotic markers in the heart tissue of rats fed with a HFD.Materials and methods: Twenty-four male Wistar rats (weighing approximately 180 grams) were randomly divided into three groups (n=8 each group), including the control group (C), the high-fat diet group (HFD), and the high-fat diet + carvacrol group (HFD + Carva). Animals received a standard or HFD to induce obesity for three months. From day 61 to 90 in the HFD+Carva group, carvacrol was injected intraperitoneally (50 mg/kg) every other day. At the end of the study, the heart tissue was examined for pathological changes and the mRNA levels of TNF-α, Bcl2, Bax, and caspase3 in the heart tissue by Real Time-PCR.Results: HFD-induced obesity led to increased TNF-α, caspase-3, and Bax and decreased Bcl-2 expression levels in heart tissue. Furthermore, histopathological changes in intracytoplasmic vacuole accumulation were evident in the HFD-obese animals. Carvacrol treatment significantly decreased the expression of Bax, TNF-α, and caspase-3 and increased the expression of Bcl-2 in heart tissue.Conclusion: In the findings, carvacrol was found to decrease the histopathological changes caused by HFD in heart tissue by suppressing the expression of genes involved in the apoptosis pathway.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1059-1069"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training. 原花青素和不同强度运动训练对心肌缺血Myh7和Myh6相关microRNA谱的调控

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24739

Safar Zarei, Farzaneh Taghian, Gholamreza Sharifi, Hassanali Abedi

{"title":"Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.","authors":"Safar Zarei, Farzaneh Taghian, Gholamreza Sharifi, Hassanali Abedi","doi":"10.22038/AJP.2024.24739","DOIUrl":"https://doi.org/10.22038/AJP.2024.24739","url":null,"abstract":"Objective: Myocardial ischemia (MI) and circulatory arrest are associated with unfavorable cardiovascular outcomes. This study aims to investigate the effects of proanthocyanidins (PC) and regular exercise with various intensity training protocols (low, moderate, and high) on cardiac protection in a rat model of MI induced by isoproterenol.Materials and methods: Based on bioinformatics, a pool of microRNAs and mRNAs was assessed according to significant differential expression in MI condition. Further, the networks of hub genes and mRNA-microRNAs were constructed. After 14 weeks of low, moderate, and high-intensity interval training and oral administration of 300 mg/kg of PC, MI was established in the rats by injecting isoproterenol. The real-time qPCR assessed the relative expressions.Results: Based on the in-silico analysis, Fn1 (fibronectin-1) and Myh7 (myosin heavy chain 7) are potentially druggable cut points to reduce cardiac tissue damage. High-intensity interval training (HIIT) and consumption of PC modified the relative expression of Myh6 (myosin heavy chain 6), Myh7, and Nf1. Moreover, High-intensity interval training and PC regulated the mir92a-3p, mir181a-5p, mir29a-3p, and mir133a-3p.Conclusion: Here, the data indicated that the HIIT protocol could have an effective strategy compared to low-intensity interval training (LIIT) and moderate-intensity interval training protocols (MIIT). Furthermore, HIIT and PC might have protective effects on the MI condition.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"874-889"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fertility-enhancing effects of Prunus amygdalas oil on reproductive functions of male rats: A two-generation study. 核桃油对雄性大鼠生殖功能的促生育作用：两代研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24590

Sadia Suri Kashif, Sadaf Naeem, Saira Saeed Khan, Aisha Razzaque

{"title":"Fertility-enhancing effects of Prunus amygdalas oil on reproductive functions of male rats: A two-generation study.","authors":"Sadia Suri Kashif, Sadaf Naeem, Saira Saeed Khan, Aisha Razzaque","doi":"10.22038/AJP.2024.24590","DOIUrl":"https://doi.org/10.22038/AJP.2024.24590","url":null,"abstract":"Objective: Prunus amygdalas (Almond; PA) has extensively been used in traditional medicine and has been the source of robust phenolic compounds. The current study intended to evaluate the fertility-enhancing effect of PA on male rats infertility and reproductive performance of two successive generations of rats namely, F0 and F1.Materials and methods: Chemical composition of the oil was established with the aid of Gas Chromatography-Mass Spectrometry (GC-MS). The oil was then subjected to in-vitro antioxidant assay via DPPH (1,1-diphenyl-2-picrylhydrazyl) and ROS (reactive oxygen species), followed by in vivo toxicity testing. In the fertility assessment, 1 and 2 ml/kg of PA oil was given to rats up to pre-cohabitation, cohabitation, gestation and lactation period. The reproductive performance along with hormonal and antioxidant markers of F1 generation was estimated and histopathological evaluation of both sex organs was done. Further, ethanol-induced male infertility model was established and sex hormones, antioxidant markers (superoxide dismutase (SOD), Glutathione peroxidase (GPx) and lipid profile were assessed along with histopathology of male sex organs.Results: The PA oil supplementation showed pronounced fertility outcomes in terms of raised litter size, sex hormones and antioxidant markers in both generations. Moreover, in ethanol-induced male infertility model, PA oil significantly restored sex hormones, ROS and GPx levels. Histological findings also endorsed better spermatogenesis with enhanced architecture.Conclusion: These results strongly suggest that PA oil rich in PUFA (poly-unsaturated fatty acids) might be a promising treatment option in future for male/female sterility.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"816-837"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages. 苦参果实提取物对三氧化二砷致人淋巴细胞DNA氧化损伤的抗氧化作用及保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24842

Ablassé Rouamba, Vincent Ouedraogo, Maurice Ouédraogo, Martin Kiendrebeogo

{"title":"Antioxidant effects and protective potential of fruit extracts of Detarium microcarpum against arsenic trioxide-induced human lymphocytes DNA oxidative damages.","authors":"Ablassé Rouamba, Vincent Ouedraogo, Maurice Ouédraogo, Martin Kiendrebeogo","doi":"10.22038/AJP.2024.24842","DOIUrl":"https://doi.org/10.22038/AJP.2024.24842","url":null,"abstract":"Objective: The integrity of the DNA is continously menaced by the harmful genotoxic compounds. The endogenous system responsible for preserving the DNA integrity, often fails following a massive influx of these genotoxic compounds. Reseaches on exogenous bioactive compounds from fruits and vegetables are necessary. This study was designed to evaluate the free radical scavenging activity and the DNA protection/repair potentiality of the extracts of Detarium microcarpum fruit pulp to protect against the arsenic trioxide-induced DNA oxidative degradation.Materials and methods: The ability of extracts to trap free radicals was assessed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide and hydroxyle radicals quenching assay. The comet assay was performed for evaluating the DNA protection/repair property of extracts to inhibit the DNA oxidative damage induced by arsenic trioxide.Results: All extracts at a final concentration of 50 µg/mL have quenched more than 50% of DPPH, nitric oxide and hydroxyle radicals. Moreover, all extracts have showed good DNA protection/repair activity against the arsenic trioxide-induced DNA oxidative damage compared to arsenic treatment alone (p<0.001). However, methanol fractions have exhibited the best DNA protection/repair activities by reducing considerably DNA fragmentations compared to arsenic treatment (p<0.001). The genoprotective activity of the extracts was positively correlated with their free radical scavenging abilities.Conclusion: The methanol fraction of D. microcarpum fruits have exhibited interesting DNA protection /repair properties probably due to its free radicals quenching ability. Further investigations are necessary to identify the phytomolecules responsible for these biological activities.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"837-847"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats. 玉米黄质对丙烯酰胺致Wistar大鼠神经毒性的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-01-01 DOI: 10.22038/AJP.2024.24950

Zoha Mortazavi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh

{"title":"Protective role of zeaxanthin on acrylamide-induced neurotoxicity in Wistar rats.","authors":"Zoha Mortazavi, Mahboobeh Ghasemzadeh Rahbardar, Soghra Mehri, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24950","DOIUrl":"https://doi.org/10.22038/AJP.2024.24950","url":null,"abstract":"Objective: The Maillard reaction generates acrylamide (ACR), a toxic compound commonly found in laboratory and industrial settings. ACR exposure, both short-term and long-term, can damage various organs, notably the central nervous system, through oxidative stress, inflammation, and apoptosis. This study explores the potential neuroprotective effects of zeaxanthin (ZEA), known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, against ACR-induced toxicity in the rat cerebral cortex.Materials and methods: Rats were subjected to ACR exposure (50 mg/kg, intraperitoneal injection) for 11 days and subsequently, treated with ZEA (20-80 mg/kg, intragastric gavage) for either 11 or 20 days to assess both preventive and therapeutic effects. Locomotor behavior was evaluated using a gait score test, while biochemical analyses measured malondialdehyde (MDA) and glutathione (GSH) levels, inflammatory markers interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α), and apoptotic markers (cleaved caspase-3) in the cerebral cortex.Results: ACR exposure impaired locomotion in the animals, but ZEA treatment significantly improved gait scores when administered preventatively (from days 6-11) or therapeutically (from days 6-20). ACR also led to increased MDA levels and depleted GSH content in brain tissue, and it elevated IL-1β, TNF-α, and cleaved caspase-3 in the cerebral cortex. However, ZEA supplementation, along with vitamin E, effectively reversed these alterations compared to the ACR-exposed group.Conclusion: In conclusion, ZEA demonstrates both preventive and therapeutic effects against ACR-induced neurotoxicity. These findings suggest that ZEA could serve as an effective preventive agent by countering ACR-induced damage through its antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1016-1029"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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