Avicenna Journal of Phytomedicine最新文献_第3页

Protective effect of Henna (Lawsonia inermis L.) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats. 波斯药物制剂指甲花固定油对大鼠醋酸致溃疡性结肠炎的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-07-01 DOI: 10.22038/ajp.2024.25298

Raheleh Zareshahi, Samane Jahanabadi, Sadaf Rafiyan, Maryam Yadegary, Roohollah Edalatkhah, Hamed Mahmoodian

{"title":"Protective effect of Henna (Lawsonia inermis L.) fixed oil (a Persian medicine preparation) on acetic acid-induced ulcerative colitis in rats.","authors":"Raheleh Zareshahi, Samane Jahanabadi, Sadaf Rafiyan, Maryam Yadegary, Roohollah Edalatkhah, Hamed Mahmoodian","doi":"10.22038/ajp.2024.25298","DOIUrl":"10.22038/ajp.2024.25298","url":null,"abstract":"Objective: Ulcerative colitis is a chronic recurrent inflammatory bowel disease of unknown etiology. The anti-inflammatory, immunomodulatory, and antioxidant characteristics of Henna ( Lawsonia inermis) fixed oil (HFO) imply that it may be advantageous for the treatment of colitis.Materials and methods: In this research, the effect of HFO in a Wistar albino rat model of acetic acid (AA)-induced ulcerative colitis, was examined. The animals received daily oral administration of either normal saline (10 ml/kg), HFO (100, 400, and 1600 µl/kg), or dexamethasone (2 mg/kg) for 5 days. A single intracolonic injection of 2 ml of a 4% (v/v) acetic acid solution was used to induce colitis. The levels of myeloperoxidase (MPO) and tumor necrosis factor-alpha (TNF-α) were measured.Results: The administration of HFO at doses 400 and 1600 μl/kg showed a significant enhancement in the weight-to-length ratio of colon tissue in comparison to the control group. Furthermore, the increased amounts of HFO (400 and 1600 μl/kg) were associated with a significant reduction in ulcer severity, area, and index. However, examination of tissue samples revealed a decrease in the overall colitis index suggesting fewer inflammatory cells invaded the colonic regions of rats treated with HFO at doses of 400 and 1600 μl/kg. Moreover, the elevated MPO levels and TNF-α were significantly decreased following the administration of the fixed oil at these doses.Conclusion: These findings indicate that HFO could potentially decrease the manifestations of experimental colitis in a dose-dependent manner.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 4","pages":"1241-1251"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracts of Apium graveolens (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf2-antioxidant signaling pathways. 芹菜提取物通过激活nrf2 -抗氧化信号通路，减轻庆大霉素引起的小鼠肝肾损伤。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-07-01 DOI: 10.22038/ajp.2024.25338

Arnaud Fondjo Kouam, Mayelle Mepa Mokam, Eleonore Ngounou, Ferdinand Elombo Kouoh, Rodrigue Fifen, Kerinyuy Juliene Kongnyuy, Elisabeth Menkem Zeuko'o, Nembu Erastus Nembo, Pascal Dieudonné Chuisseu Djamen, Frédéric Nico Njayou, Paul Fewou Moundipa, Emmanuel Acha Asongalem

{"title":"Extracts of Apium graveolens (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf2-antioxidant signaling pathways.","authors":"Arnaud Fondjo Kouam, Mayelle Mepa Mokam, Eleonore Ngounou, Ferdinand Elombo Kouoh, Rodrigue Fifen, Kerinyuy Juliene Kongnyuy, Elisabeth Menkem Zeuko'o, Nembu Erastus Nembo, Pascal Dieudonné Chuisseu Djamen, Frédéric Nico Njayou, Paul Fewou Moundipa, Emmanuel Acha Asongalem","doi":"10.22038/ajp.2024.25338","DOIUrl":"10.22038/ajp.2024.25338","url":null,"abstract":"Objective: This study aimed at investigating the protective effect of extracts from Apium graveolens against gentamicin-induced hepato-renal toxicity.Materials and methods: The aqueous and hydro-ethanolic extracts of A. graveolens designated respectively as WAG and HAG were tested for their in vitro antioxidant activities. Then, their cytoprotective effects were assessed against gentamicin-induced cytotoxicity in primary mouse hepatocytes. Finally, mice were administered with gentamicin (20 mg/kg) and co-treated with HAG for 14 days, and histopathology, biochemical and molecular parameters related to gentamicin-induced toxicity were evaluated.Results: HAG exhibited outstanding chemical antioxidant activities and preserved hepatocytes from gentamicin-induced cytotoxicity. HAG relieved liver and kidney histopathological and biochemical changes, and enhanced the mRNA level of Nrf2 and its target gene HO-1 in gentamicin-intoxicated mice.Conclusion: HAG attenuates hepato-renal injuries induced by 14-days administration of gentamicin in mice through the activation of Nrf2-antioxidant signaling pathways.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 4","pages":"1341-1357"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation. 甘草提取物和卡贝诺洛酮通过调节caspase-3和PARP的激活来保护PC12细胞免受血清/葡萄糖剥夺诱导的凋亡。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-07-01 DOI: 10.22038/ajp.2024.25252

Hossein Hosseinzadeh, Elham Ramazani, Soheyla Bakhshi, Zahra Tayarani-Najaran

{"title":"Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation.","authors":"Hossein Hosseinzadeh, Elham Ramazani, Soheyla Bakhshi, Zahra Tayarani-Najaran","doi":"10.22038/ajp.2024.25252","DOIUrl":"10.22038/ajp.2024.25252","url":null,"abstract":"Objective: Serum/glucose deprivation in cultured PC12 cells is considered an appropriate model for investigating detailed mechanisms of ischemia-induced brain injury. Here, we aimed to study the anti-apoptotic effects of licorice (Glycyrrhiza glabra L.) root extract and carbenoxolone on PC12 cells cultured in the serum/glucose deprivation (SGD) condition.Materials and methods: Cells were incubated with the different concentrations of the G. glabra methanol extract (5-320 µg/ml) and carbenoxolone (0.5-32 µM) for 2 hr before being deprived of serum/glucose. Protection against cytotoxicity, increase in reactive oxygen species (ROS), and apoptosis was analyzed with resazurin, dichlorofluorescein diacetate (DCFH-DA), and western blot, respectively.Results: Serum/glucose deprivation induced cell death and apoptosis in PC12 cells. Pretreatment with the G. glabra methanol extract at 5-20 µg/ml and carbenoxolone at 0.5-2 µM for 2 hr significantly decreased the cytotoxicity (p<0.05), and pretreatment with the G. glabra methanol extract (5-160 µg/ml) and carbenoxolone (0.5 μM) significantly decreased the ROS content. Pretreatment with the G. glabra methanol extract and carbenoxolone at 5-20 µg/ml significantly prevented from the Poly (ADP-ribose) polymerase (PARP) and caspase-3 cleavage.Conclusion: Taken together, this study confirms the protective and free radical-scavenging potency of licorice extract and carbenoxolone in in vitro model of ischemia. Overall, it seems that pretreatment with the licorice extract and carbenoxolone may potentially slow the progression of brain ischemia.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 4","pages":"1252-1263"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relaxant effect of the extract of Crocus sativus petal on Wistar rats airway smooth muscle and its possible mechanisms. 番红花花瓣提取物对Wistar大鼠气道平滑肌的松弛作用及其可能机制。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-07-01 DOI: 10.22038/ajp.2024.25150

Sepide Behrouz, Arghavan Memarzia, Mohammad Hossein Eshaghi Ghalibaf, Amir Hossein Yazdi, Mohammad Hossein Boskabady

{"title":"The relaxant effect of the extract of Crocus sativus petal on Wistar rats airway smooth muscle and its possible mechanisms.","authors":"Sepide Behrouz, Arghavan Memarzia, Mohammad Hossein Eshaghi Ghalibaf, Amir Hossein Yazdi, Mohammad Hossein Boskabady","doi":"10.22038/ajp.2024.25150","DOIUrl":"10.22038/ajp.2024.25150","url":null,"abstract":"Objective: Obstructive pulmonary diseases are characterized by airflow limitation secondary to airway wall thickening, airway narrowing and increased mucus secretion. Saffron (Crocus sativus L.) has shown different effects including anti-inflammatory, antioxidant, and immunomodulatory properties and promising effects for treating multiple disorders. In this study, the contribution of calcium and potassium channels, muscarinic and histamine (H1) receptors in the relaxant effect of the C. sativus petal extract on tracheal smooth muscle (TSM) was assessed.Materials and methods: Fifty-four male Wistar rats divided in 8 groups, were studied. TSM was contracted by 10 μM methacholine or 60 mM KCl for 5 min, and the relaxant effects of cumulative concentrations of C. sativus petal extract (0.1, 0.2, 0.4 and 0.8 mg/ml), theophylline (0.2, 0.4, 0.6 and 0.8 mM) or 1 mL normal saline were tested. In non-incubated TSM and in TSM groups incubated with diltiazem, chlorpheniramine, propranolol, glibenclamide, atropine and indomethacin, the relaxant effects of the extract were evaluated.Results: The concentration-dependent relaxant effects of C. sativus petal extract on non-incubated TSM contracted by methacholine or KCl, were observed (for all, p<0.001). The relaxant effects of C. sativus petal extract in TSM incubated with chlorpheniramine and indomethacin, were significantly reduced compared to non-incubated tissues (p<0.05 to p<0.001).Conclusion: The results showed an obvious relaxation effect of the petal of C. sativus extract on TSM and suggest that inhibition of cyclooxygenase pathway and histamine receptors contribute to the extract relaxant effect of the extract.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 4","pages":"1358-1365"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of an Aloe-based polyherbal formulation on fertility parameters in male rats. 芦荟复方对雄性大鼠生育参数的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.25197

Fahimeh Safaeinejad, Mojgan Tansaz, Farkhonde Sarhaddi, Vahid Esmaeili, Fatemeh Jafari, Akram Shahhosseini, Behnaz Keramatian, Homa Hajimehdipoor

{"title":"The effects of an Aloe-based polyherbal formulation on fertility parameters in male rats.","authors":"Fahimeh Safaeinejad, Mojgan Tansaz, Farkhonde Sarhaddi, Vahid Esmaeili, Fatemeh Jafari, Akram Shahhosseini, Behnaz Keramatian, Homa Hajimehdipoor","doi":"10.22038/ajp.2024.25197","DOIUrl":"10.22038/ajp.2024.25197","url":null,"abstract":"Objective: Aloe dry juice as a purgative agent is widely used in phytotherapy. In Iranian traditional medicine to decrease Aloe side effects, some plants are added, and this polyherbal formulation is named \"Ayarij-e-Faiqra\" (AF). Based on the anti-fertility properties of Aloe, this study investigates the anti-fertility effects of Aloe-based polyherbal formulation to find the impact of accompanying plants on the anti-fertility effects of Aloe.Materials and methods: In this study, forty male rats were classified into the following groups: the control group, the sham group receiving only busulfan carrier solution (DMSO 50%) on days 1 and 21 via intraperitoneal injection, the busulfan group received intraperitoneally 10 mg/kg of busulfan on days 1 and 21, the Aloe group received 25 mg/kg of Aloe-dry juice, and the AF group was administered with 71 mg/kg (containing 25 mg/kg of Aloe dry juice). Treatment was performed by gavage for 56 days. Testis weight and histological alterations, sexual hormone levels (testosterone, estrogen, and progesterone), and classical and functional sperm parameters were examined.Results: Our findings showed that AF negatively affects testicular tissue architecture and sperm quality such as count, motility, morphology, and viability which were accompanied by an imbalance of testosterone, estrogen, and progesterone hormones. In addition, reaction oxygen species (ROS) and apoptosis increased in the sperm cells of the AF group while decreasing their mitochondrial membrane potential.Conclusion: The plants presented in the formulation of AF cannot cover the anti-fertility side effects of Aloe.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1228-1240"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the potential effects of olive leaves and ginger rhizome extracts on kidney and liver functions in alloxan-induced diabetic rats. 探讨橄榄叶和姜提取物对四氧嘧啶诱导的糖尿病大鼠肾脏和肝脏功能的潜在影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.24986

Shatha Alshaer, Mohammad A A Al-Najjar, Feras Darwish El-Hajji, Reem Abu-Tayeh

{"title":"Investigating the potential effects of olive leaves and ginger rhizome extracts on kidney and liver functions in alloxan-induced diabetic rats.","authors":"Shatha Alshaer, Mohammad A A Al-Najjar, Feras Darwish El-Hajji, Reem Abu-Tayeh","doi":"10.22038/ajp.2024.24986","DOIUrl":"10.22038/ajp.2024.24986","url":null,"abstract":"Objective: Although there are many drugs on the shelves of pharmacies to manage diabetes mellitus (DM), many people around the world still use herbal preparations to treat it. This study investigated the effect of an aqueous combination of olive leaves and ginger rhizome extracts on type 1 diabetes mellitus (T1DM) using various physiological markers.Materials and methods: Fifty-two Wistar rats were distributed into 2 healthy and 6 diabetic groups. Forty rats were given alloxan (150 mg/kg) as an intraperitoneal single-dose to induce T1DM. Treatments including insulin with/without individual and combined extracts, were started 4-day post-induction. The extracts were administered orally (500 mg/kg) and insulin was administered subcutaneously (6 IU/kg) in single-doses once a day. After one week of treatment, the blood samples were collected to measure Fasting blood glucose (FBG), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and creatinine.Results: The diabetic group that received the combination of both extracts with insulin had a lower mortality rate after 14 days of treatment. The diabetic group receiving insulin with the olive leaves extract, demonstrated a decrease in ALT levels to 33.7 U/L (p=0.345) while maintaining the ALP levels within the normal range 126.9 U/L (p=0.463). Creatinine was significantly reduced to 1.1 mg/dl (p=0.028) and 0.7 mg/dl (p=0.028) in diabetic groups that received individual olive leaves and ginger extracts with insulin respectively.Conclusion: To conclude, this combination with insulin had powerful effects to improve the mortality rate in diabetic rats over other groups, and the two extracts separately were able to decrease the creatinine levels.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1124-1136"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study. 旱金莲水醇提取物保护抑制肝和肾毒性细胞凋亡和炎症途径：一项体内研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.25213

Sevil Soudkhah, Sahar Keyghobadi, Amir Shadboorestan, Mahdi Gholami, Behnam Omidi Sarajar, Armin Salek Maghsoudi, Mahmoud Omidi, Saeed Mohammadi Motamed, Saeid Akbarzadeh Kolahi, Nima Rastegar-Pouyani, Shokoufeh Hassani

{"title":"The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study.","authors":"Sevil Soudkhah, Sahar Keyghobadi, Amir Shadboorestan, Mahdi Gholami, Behnam Omidi Sarajar, Armin Salek Maghsoudi, Mahmoud Omidi, Saeed Mohammadi Motamed, Saeid Akbarzadeh Kolahi, Nima Rastegar-Pouyani, Shokoufeh Hassani","doi":"10.22038/ajp.2024.25213","DOIUrl":"10.22038/ajp.2024.25213","url":null,"abstract":"Objective: Nasturtium officinale (N. officinale (NO)) has been widely used in traditional medicine. This study investigates the protective effects of NO against hepatic and renal damage induced by CCl4 and gentamicin, respectively, in rats.Materials and methods: Male Wistar rats were divided into two arms: A (CCl4-induced hepatotoxicity) and B (gentamicin-induced nephrotoxicity). Seventeen groups were formed by dividing arms A and B, with nine groups in arm A and eight groups in arm B (n=5). Rats were daily treated with various doses (50, 100, and 200 mg/kg BW) of N. officinale extract (NOE) (Total extract; Oral gavage) for 14 and 28 days in arm A and B, respectively. Biochemical and histopathological evaluations and gene expression analyses were conducted on blood, liver, and kidney tissues.Results: NOE treatment significantly modulated B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and B-cell lymphoma protein 2 (Bcl-2) expression in kidney tissue, reducing Bax (p<0.01) and increasing Bcl-2 (p<0.05). In liver tissue, NOE inhibited tumor necrosis factor alpha (TNF-α) (p<0.01) and Interleukin-1 beta (IL-1β) (p<0.001), while reducing AST and ALT activity (p<0.001). Additionally, blood urea nitrogen (BUN) levels significantly decreased (p<0.05) in nephrotoxic rats.Conclusion: Our findings highlight the capability of NOE as a promising therapeutic against liver and kidney damage induced by CCl4 and gentamicin, respectively, in animal models.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1177-1192"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: An open-label, randomized, controlled clinical trial. 与奥美拉唑相比，漆树水提取物和饮食改变对功能性消化不良症状的影响：一项开放标签、随机对照临床试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.25239

Mahdi Saravani, Zahra Memariani, Nasser Behnampour, Mohammadreza Seyyedmajidi, Fatemeh Kolangi

{"title":"Effects of sumac aqueous extract along with eating and drinking modification on functional dyspepsia symptoms in comparison with omeprazole: An open-label, randomized, controlled clinical trial.","authors":"Mahdi Saravani, Zahra Memariani, Nasser Behnampour, Mohammadreza Seyyedmajidi, Fatemeh Kolangi","doi":"10.22038/ajp.2024.25239","DOIUrl":"10.22038/ajp.2024.25239","url":null,"abstract":"Objective: Functional dyspepsia (FD), a common gastrointestinal problem. The aim of the study was to evaluate the influence of Rhus coriaria L. (sumac) on FD.Materials and methods: This randomized controlled clinical trial study included 104 patients aged 18 to 60 years diagnosed with FD according to the ROME IV criteria. Four groups were formed: A) sumac extract + dietary changes, B) dietary changes, C) sumac extract and D) omeprazole. During the present eight-week study, patients' FD symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) in four sessions. The Nepean Dyspepsia Index (NDI-10) was used to measure the impact of the interventions on patients' quality of life.Results: The study employed generalized estimating equation (GEE) analysis and found that symptom severity decreased across all groups during the intervention period. At the fourth week, no notable difference was noted between the omeprazole group and others. After the intervention, the severity of symptoms increased, especially in the omeprazole group, resulting in a significant difference compared to other groups.Conclusion: It seems that as a complementary treatment in FD, sumac might be effective with a more lasting effect with a significantly less recurrence of symptoms.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1147-1166"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of menthol against diethylnitrosamine-induced hepatocellular carcinoma in mice by downregulating CTNNB1 and HIF-1α. 薄荷醇通过下调CTNNB1和HIF-1α对二乙基亚硝胺诱导的小鼠肝癌的保护作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.25230

Zahra Mollaei, Masoumeh Asle-Rousta, Golnaz Asaadi Tehrani

{"title":"Protective effect of menthol against diethylnitrosamine-induced hepatocellular carcinoma in mice by downregulating CTNNB1 and HIF-1α.","authors":"Zahra Mollaei, Masoumeh Asle-Rousta, Golnaz Asaadi Tehrani","doi":"10.22038/ajp.2024.25230","DOIUrl":"10.22038/ajp.2024.25230","url":null,"abstract":"Objective: This study examined the impact of menthol, a natural monoterpene, on diethylnitrosamine (DEN)-induced molecular and histopathological changes in the livers of male mice.Materials and methods: Forty male mice were divided into four groups: Control, Menthol (M), DEN, and DEN-M. The DEN and DEN-M groups received an intraperitoneal injection of DEN (25 mg/kg) at the age of 14 days. The M and DEN-M groups were also given menthol (50 mg/kg, three times a week for six months) via gavage. The expression of genes related to liver carcinoma was analyzed using real-time PCR. Subsequently, the liver tissue was microscopically examined following staining with hematoxylin-eosin.Results: After one month, menthol reduced the infiltration of inflammatory cells in the liver tissue of mice injected with DEN. It also prevented the increase in the expression of alpha-fetoprotein (AFP) (p<0.001), programmed cell death 6 (p<0.05), hypoxia-inducible factor-1 alpha (HIF-1α) (p<0.001), and vascular endothelial growth factor (VEGF) (p<0.001) in DEN-M animals compared with DEN group. After six months of session, the expression of AFP (p<0.05), HIF-1α (p<0.05), secreted frizzled-related protein 1 (p<0.001), and catenin beta 1 (p<0.01) was lower in group DEN-M compared with group DEN. Menthol also partially prevented DEN-induced various histopathological changes in the liver after six months of treatment.Conclusion: We concluded that menthol inhibits Wnt signaling and suppresses the expression of HIF-1α and VEGF in the liver of DEN-injected mice. It is probably a suitable option for the prevention and treatment of hepatocellular carcinoma.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1167-1176"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic effects of Peganum harmala seed extract on streptozotocin-induced diabetes in rats. 苦参籽提取物对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2025-05-01 DOI: 10.22038/ajp.2024.25241

Mozafar Khazaei, Mohammadali Meskaraf-Asadabadi, Elham Ghanbari, Amir Hossein Khazaei

{"title":"Antidiabetic effects of Peganum harmala seed extract on streptozotocin-induced diabetes in rats.","authors":"Mozafar Khazaei, Mohammadali Meskaraf-Asadabadi, Elham Ghanbari, Amir Hossein Khazaei","doi":"10.22038/ajp.2024.25241","DOIUrl":"10.22038/ajp.2024.25241","url":null,"abstract":"Objective: Diabetes, a chronic metabolic disease, has many complex complications and an increasing prevalence in various societies. Despite conventional drug treatments and limited surgical and tissue transplant methods, a definitive diabetes treatment remains to be found. Restoring damaged beta cells to insulin production or prompting other pancreatic cells to secrete insulin is an essential goal of diabetes research. The present study investigated the antidiabetic and regenerative effects of Peganum harmala seed extract (PHSE) on streptozotocin (STZ)-induced diabetes in rats.Materials and methods: In this experimental in vivo study, male Wistar rats (200±10 g) were placed in 5 groups: control, untreated diabetic and diabetic groups treated with 100, 200, and 400 mg/kg doses of PHSE. Fasting blood sugar (FBS), C-peptide, insulin, and antioxidant parameters (total antioxidant capacity (TAC) and nitric oxide (NO)) of serum were measured. Pancreatic tissue was used for histologic staining and assessment of the expression of genes related to beta cell regeneration.Results: PHSE significantly improved FBS, weight loss, insulin, c-peptide, TAC, NO, and expression of pancreatic genes (insulin, PDX1 and neurogenin-3) (p<0.05). It also increased the number of pancreatic beta cells.Conclusion: PHSE has considerable regenerative and antidiabetic effects on changes caused by diabetes in rats' serum and pancreas.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1193-1203"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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