Avicenna Journal of Phytomedicine最新文献_第2页

Naringenin modifies T-helper responses and macrophage activities in BALB/c mice. 柚皮苷可改变 BALB/c 小鼠的 T 辅助反应和巨噬细胞活性。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23382

Fatemeh Keivan, Seyyed Meysam Abtahi Froushani

{"title":"Naringenin modifies T-helper responses and macrophage activities in BALB/c mice.","authors":"Fatemeh Keivan, Seyyed Meysam Abtahi Froushani","doi":"10.22038/AJP.2023.23382","DOIUrl":"10.22038/AJP.2023.23382","url":null,"abstract":"Objective: Naringenin is a naturally occurring flavonoid found in citrus fruits. This study was done to compare the oral immunomodulatory effects of naringenin and prednisolone.Materials and methods: The effect of one-month oral administration of naringenin (10, 20, and 40 mg/kg) and prednisolone (2 mg/kg) on peritoneal macrophage was compared in the first set of experiments. Separate evaluations were conducted on the effects of naringenin on in vivo and ex vivoT-helper (Th) lymphocyte responses and their subsets in mice immunized with ovalbumin (OVA). Animals challenged with OVA received oral doses of naringenin or prednisolone from two days prior to immunization to 28 days after immunization.Results: Naringenin and prednisolone increased macrophages' respiratory burst, and nitric oxide and interleukin (IL)-10 production while decreasing IL-12 production. Macrophages isolated from mice administered with 40 mg/kg naringenin had greater phagocytic potential than those isolated from mice administered with prednisolone. OVA-challenged mice treated with 40 mg/kg naringenin or prednisolone had decreased delayed-type hypersensitivity comparable to control mice. The splenocyte proliferation index was lower in the prednisolone-treated group than the naringenin-treated group, even at 40 mg/kg. In the splenocyte cultures, both agents decreased T-bet expression. Naringenin, in contrast to prednisolone, did not affect GATA3expression. The 40 mg/kg naringenin dose reduced RORγt more effectively than prednisolone.Conclusion: All these findings indicate the potential of naringenin as a modifying agent of immune responses. Consequently, naringenin may be beneficial in controlling some immunopathological conditions.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auraptene inhibits migration, invasion and metastatic behavior of human malignant glioblastoma cells: An in vitro and in silico study. 金合欢烯能抑制人类恶性胶质母细胞瘤细胞的迁移、侵袭和转移行为：一项体外和硅学研究。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23586

Seyed Hadi Mousavi, Mohammad Jalili-Nik, Mohammad Soukhtanloo, Arash Soltani, Farzaneh Abbasinezhad-Moud, Hamid Mollazadeh, Farzaneh Shakeri, Bahram Bibak, Amirhossein Sahebkar, Amir R Afshari

{"title":"Auraptene inhibits migration, invasion and metastatic behavior of human malignant glioblastoma cells: An in vitro and in silico study.","authors":"Seyed Hadi Mousavi, Mohammad Jalili-Nik, Mohammad Soukhtanloo, Arash Soltani, Farzaneh Abbasinezhad-Moud, Hamid Mollazadeh, Farzaneh Shakeri, Bahram Bibak, Amirhossein Sahebkar, Amir R Afshari","doi":"10.22038/AJP.2023.23586","DOIUrl":"10.22038/AJP.2023.23586","url":null,"abstract":"Objective: The present work examined the anti-metastatic effects of auraptene and their underlying mechanisms of action in U87 Glioblastoma multiforme (GBM) cells.Materials and methods: To test the hypothesis, cell culture, Matrigel invasion assay, scratch wound healing assay, gelatin zymography assay, qRT-PCR, and western blot experiments were conducted.Results: At sublethal concentrations of 12.5 and 25 µg/ml, auraptene exhibited a significant reduction in cell invasion and migration of U87 cells, as assessed using scratch wound healing and Transwell tests, respectively. The qRT-PCR and zymography experiments demonstrated a significant decrease in both mRNA expression and activities of MMP-2 and MMP-9 following auraptene treatment. Western blot analysis also showed that MMP-2 protein level and phosphorylation of metastasis-related proteins (p-JNK and p-mTOR) decreased in auraptene-treated cells. Molecular docking studies consistently demonstrated that auraptene exhibits a significant affinity towards MMP-2/-9, the ATP binding site of mTOR and JNK1/2/3.Conclusion: Auraptene inhibited the migration and invasion of GBM cells. This inhibitory effect was induced by modulating specific mechanisms, including suppressing MMPs, JNK, and mTOR activities.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A preliminary report comparing the effect of Asafoetida with oral contraceptive on polycystic ovarian syndrome in a double-blind randomized trial. 在一项双盲随机试验中，初步报告比较了 Asafoetida 和口服避孕药对多囊卵巢综合症的影响。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23122

Najmeh Dehparvar, Ahia Garshasbi, Amir Niasari-Naslaji, Fatemeh Alijaniha, Mohammad Gholami-Fesharaki, Farzaneh Ghaffari, Mohsen Naseri

{"title":"A preliminary report comparing the effect of Asafoetida with oral contraceptive on polycystic ovarian syndrome in a double-blind randomized trial.","authors":"Najmeh Dehparvar, Ahia Garshasbi, Amir Niasari-Naslaji, Fatemeh Alijaniha, Mohammad Gholami-Fesharaki, Farzaneh Ghaffari, Mohsen Naseri","doi":"10.22038/AJP.2023.23122","DOIUrl":"10.22038/AJP.2023.23122","url":null,"abstract":"Objective: Polycystic ovarian syndrome (PCOS) is the most common cause of infertility and endocrine disorders in women of childbearing age. In Persian medicine, Ferula assafoetida L. (Asafoetida) was recommended for treating PCOS. The present study was conducted to compare the effect of Asafoetida with oral contraceptive tablets on PCOS patients.Materials and methods: Patients with PCOS (n=30) were enrolled in a double-blind randomized clinical trial. On Day 5 of the menstrual cycle, patients received two periods of 21-day treatment, with 7 days rest between the two treatments. On a daily basis, half of the patients (n=15) received Asafoetida (1 g), and the rest received low dose oral contraceptive (LD; one tablet). Menstrual status, anthropometric characteristics, hematology and biochemistry parameters, ovarian ultrasound examination and hirsutism were evaluated prior to the initiation of the experiment and 14 days after the end of treatment. The occurrence of menstrual cycles and pregnancy was assessed eight months after the end of treatment.Results: The incidence of pregnancy was greater in patients who received Asafoetida compared to those who received LD (p=0.019). The time intervals between menstrual cycles became shorter in both groups (p<0.05). The occurrence of regular menstrual cycles remained longer in the Asafoetida compared to the LD group (p=0.001). Concentrations of triglycerides, cholesterol, HDL and LDL were significantly increased after treating with LD (p<0.05).Conclusion: In PCOS patients, the occurrence of regular menstrual cycles and the incidence of pregnancy were improved following treatment with Asafoetida. This medicament could be considered a safe treatment for patients with PCOS.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of Wild Bitter Melon to ameliorate muscle atrophy in a murine model. 野生苦瓜在小鼠模型中改善肌肉萎缩的治疗潜力。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.24011

Sima Seifi, Seyedeh Elnaz Nazari, Amir Avan, Nima Khalili-Tanha, Fatemeh Babaei, Saman Soleimanpour, Fereshteh Asgharzadeh, Mousa-Al-Reza Hajzadeh, Majid Khazaei, Abdoljalal Marjani

{"title":"The therapeutic potential of Wild Bitter Melon to ameliorate muscle atrophy in a murine model.","authors":"Sima Seifi, Seyedeh Elnaz Nazari, Amir Avan, Nima Khalili-Tanha, Fatemeh Babaei, Saman Soleimanpour, Fereshteh Asgharzadeh, Mousa-Al-Reza Hajzadeh, Majid Khazaei, Abdoljalal Marjani","doi":"10.22038/AJP.2024.24011","DOIUrl":"10.22038/AJP.2024.24011","url":null,"abstract":"Objective: Muscle atrophy due to immobility is a common complication of many diseases and a consequence of therapeutic processes. Immobility and inactivity have been shown to be associated with increased inflammation. The aim of this study was to investigate the therapeutic potential of Wild Bitter Melon (WBM) (Momordica charantia Linn) on muscle atrophy due to immobility in a mouse model.Materials and methods: This study was performed in two phases of atrophy and recovery on male BALB/c mice which were divided into 3 groups: control, immobilized, and experimental. The treatment period with WBM at a dose of 400 mg/kg daily by gavage was 17 days, including 7 days of being immobilized and 10 days of recovery. At the end of each phase, half of the mice from each group were examined regarding the four limb grip strength, and then histological and biochemical analyses were done.Results: The tissue level of malondialdehyde (MDA) oxidative stress index in the atrophy phase in the atrophy group (5.4567±0.522) nmol/g compared to the control group (3.455±0.065) nmol significantly (p 0.001) <) increased. Also, the tissue level of MDA in the WBM group (3.87±0.035) showed a significant decrease compared to the atrophy group (p<0.01). The strength percentage of four limbs in the mice of the treatment group (-23.46±2.45) was significantly higher than that of the atrophy group (-30.60±3.15) at the end of the atrophy phase.Conclusion: The results suggest that the use of WBM reduces the degree of inflammation, oxidative stress and muscle damage, as well as muscle atrophy, which may improve the muscle atrophy in mice.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potency of curcumin on radiodermatitis: A systematic review. 姜黄素对放射性皮炎的疗效：系统综述。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23175

Hossein Abdeahad, Nikoo Saeedi, Afsane Bahrami, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Amir Avan, Majid Khazaei, Elnaz Ghorbani, Mikhail Ryzhikov, Seyed Mahdi Hassanian

{"title":"Therapeutic potency of curcumin on radiodermatitis: A systematic review.","authors":"Hossein Abdeahad, Nikoo Saeedi, Afsane Bahrami, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Amir Avan, Majid Khazaei, Elnaz Ghorbani, Mikhail Ryzhikov, Seyed Mahdi Hassanian","doi":"10.22038/AJP.2023.23175","DOIUrl":"10.22038/AJP.2023.23175","url":null,"abstract":"Objective: Radiodermatitis (RD) is a frequent adverse event of radiotherapy (RT). Currently, there is no consensus and approved protocol for the treatment of RD. Curcumin (CUR) is a natural polyphenol obtained from turmeric and it has low intrinsic toxicity in humans. The aim of this systematic review was to explore the efficacy of CUR for prevention and treatment of RD.Materials and methods: A systematic literature review was performed in the following online databases: Cochrane library, PubMed, Scopus, Web of Science, MEDLINE, and EMBASE. Among the 5 selected records, 3 had a randomized clinical trial (RCT)-design and the other had a pilot and controlled study designed. The included studies were performed on breast cancer (N=3), head and neck cancers (N=1) and different types of cancer (N=1).Results: Four of the studies reported that the application of curcumin in cancer patients undergoing radiotherapy is associated with decreased intensity of radiodermatitis. However, one study did not report any significant effect of CUR on radiodermatitis. This review provides substantial evidence which confirm the clinical value of CUR in cancer supportive care.Conclusion: Further prospective clinical trials in larger scales are warranted in order to determine the \" supplemental form and dose of CUR\" for RD prevention and treatment in patients receiving radiotherapy.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia. Pistacia vera果皮的亲水提取物可防止苯肼引起的肝毒性和溶血性贫血。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23925

Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour

{"title":"Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia.","authors":"Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour","doi":"10.22038/AJP.2024.23925","DOIUrl":"10.22038/AJP.2024.23925","url":null,"abstract":"Objective: Pistacia vera is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of Pistacia vera pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.Materials and methods: PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice. 研究巴豆素对电磁场诱发的雄性 Balb/c 小鼠小脑损伤的神经保护作用

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2023.23005

Mehrdad Hajinejad, Abdolreza Narouiepour, Fatemeh Alipour, Alireza Ebrahimzadeh Bideskan

{"title":"Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice.","authors":"Mehrdad Hajinejad, Abdolreza Narouiepour, Fatemeh Alipour, Alireza Ebrahimzadeh Bideskan","doi":"10.22038/AJP.2023.23005","DOIUrl":"10.22038/AJP.2023.23005","url":null,"abstract":"Objective: Mobile devices are sources of electromagnetic fields (EMFs) that cause increasing concern among scientists about human health, especially with the long-term use of mobile phones. With regard to this issue, the potential adverse health effects, particularly on brain function have raised public concern. There is considerable evidence that natural compounds have neuro-protective effects due to their antioxidant and anti-inflammatory properties. Growing evidence suggests that crocin as a natural bioactive compound can be considered a potential therapeutic agent against various neurologic disorders. Therefore, the present study investigated the effects of crocin on the cerebellum after exposure to EMF.Materials and methods: Twenty-four Male Balb/c mice were divided into control group, EMF group (2100 MHZ), EMF +Crocin group (2100 MHZ+50 mg/kg), and crocin group (50 mg/kg). The animals in the EMF and EMF+Crocin groups were exposed continuously for 30 days to an EMF 120 min/day. After 30 days, cerebellar cortex was evaluated by histomorphometric and immunohistochemical methods.Results: The results showed that 30 days of exposure to EMF had no significant effect on Purkinje cell size. However, EMF reduced significantly the diameter of astrocytes and increased Glial fibrillary acidic protein (GFAP) expression compared to the controls (p<0.05). Our findings also indicated that crocin treatment could improve the diameter of astrocytes and normalize GFAP expression (p<0.05).Conclusion: This study concluded that 2100-MHz EMF caused adverse eﬀects on the cerebellum through astrocyte damage and crocin could partially reverse the EMF-related adverse effects.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats. 纳米水飞蓟素和水飞蓟素对高脂饮食诱发的成年雄性大鼠脂肪肝的影响比较。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23734

Reza Mohebbati, Mohammad Amin Momeni-Moghaddam, Rokhsareh Asghari, Abbasali Abbasnezhad, Alireza Ebrahim Zadeh Bideskan, Davoud Salarbashi, Nasim Khajavian

{"title":"The comparison of the effects of nano-silymarin and silymarin on high-fat diet-induced fatty liver of adult male rats.","authors":"Reza Mohebbati, Mohammad Amin Momeni-Moghaddam, Rokhsareh Asghari, Abbasali Abbasnezhad, Alireza Ebrahim Zadeh Bideskan, Davoud Salarbashi, Nasim Khajavian","doi":"10.22038/AJP.2024.23734","DOIUrl":"10.22038/AJP.2024.23734","url":null,"abstract":"Objective: Considering the high prevalence of non-alcoholic fatty liver disease and its complications, this study aims to determine and compare the effect of nano-silymarin and silymarin on non-alcoholic fatty liver in rats.Materials and methods: Rats were divided into 5 groups: Control, high-fat diet, high-fat diet and atorvastatin, high-fat diet and silymarin, and high-fat diet and nano-silymarin. After 12 weeks, blood samples were taken to measure cholesterol, triglyceride, HDL, LDL, ALT and AST. The animals were killed and the liver tissue was removed to examine the histopathological changes.Results: Feeding with a high-fat diet caused a significant increase in cholesterol, triglyceride and LDL-C in serum of rats compared to the control. Nano-silymarin and silymarin could significantly reduce serum triglyceride compared to negative group but the reduction of cholesterol, LDL-C, AST and ALT by nano-silymarin was not significant as compared to silymarin. The liver histology evaluation mainly showed that in the group receiving nano-silymarin, a significant decrease in the percentage of fat vacuoles and degree of steatosis was observed compared to the negative group. In the positive group, the percentage of fat vacuoles and the degree of steatosis showed a significant decrease compared to the negative group. Group receiving atorvastatin showed a greater protective effect than silymarin and nano-silymarin.Conclusion: The use of nano-silymarin similar to silymarin in rats treated with a high-fat diet led to a decrease in the percentage of fat vacuoles and the degree of hepatic steatosis mainly and can be used to prevent non-alcoholic fatty liver disease.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial. 补充苏木（Rhus coriaria L.）粉对超重或肥胖的非酒精性脂肪肝患者的生化指标和人体测量指标的疗效：双盲随机对照试验。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI: 10.22038/AJP.2024.23927

Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi

{"title":"The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.","authors":"Mohsen Mohit, Mohammadali Nejati, Najmeh Hejazi, Shayan Modaresi","doi":"10.22038/AJP.2024.23927","DOIUrl":"10.22038/AJP.2024.23927","url":null,"abstract":"Objective: This study aimed to assess the effect of sumac supplement in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease.Materials and methods: In this double-blind randomized controlled trial, 45 NAFLD patients were randomly divided into two groups. The intervention group received sumac capsules (3 g/day) with a balanced diet for 8 weeks, while the placebo group received placebo with a balanced diet. Anthropometric indices, lipid profile, fasting blood glucose, insulin, Homeostatic Model Assessment for Insulin Resistance, aspartate transaminase, alanine aminotransferase, high sensitivity C-reactive protein and malondialdehyde were measured at baseline and at the end of the study.Results: The results revealed a significant decrease in anthropometric indices (weight (p=0.001), body mass index (p=0.001), waist circumference (p=0.001), body fat mass (p=0.001), body fat percentage (p=0.001), visceral fat score (p=0.001), biochemical levels of total cholesterol (p=0.007), fasting blood sugar (p=0.006), insulin (p=0.004) and HOMA-IR (p=0.002)) after the intervention compared to the baseline. However, no significant difference was observed between the two groups concerning anthropometric and biochemical indices.Conclusion: In this study, no significant differences were observed between the two groups regarding anthropometric and biochemical indices. Thus, further studies with larger sample sizes are recommended to be conducted on the issue.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin may reduce the risk of developing the symptoms of COVID-19. 槲皮素可降低出现 COVID-19 症状的风险。

IF 1.9

Avicenna Journal of Phytomedicine Pub Date : 2024-03-01 DOI: 10.22038/AJP.2023.22920

Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab

{"title":"Quercetin may reduce the risk of developing the symptoms of COVID-19.","authors":"Marjan Ajami, Mohammadjavad Sotoudeheian, Anahita Houshiar-Rad, Mina Esmaili, Fatemeh Naeini, Fatemeh Mohammadi Nasrabadi, Saied Doaei, Ali Milani-Bonab","doi":"10.22038/AJP.2023.22920","DOIUrl":"10.22038/AJP.2023.22920","url":null,"abstract":"Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.Materials and methods: Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: \"corona or coronavirus or COVID or COVID-19 or viral or virus\" AND \"nutrient or flavonoid or Quercetin\".Results: The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.Conclusion: Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted.","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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