Avicenna Journal of Phytomedicine最新文献

{"title":"The role of <i>Anvillea garcinii</i> and its compounds in health and disease: An overview.","authors":"Ali Zarei, Fatemeh Rasekh, Samaneh Ahmadpour Khorrami, Behnam Masmouei, Saeed Changizi-Ashtiyani, Majid Ramezani, Amirhossein Zarei","doi":"10.22038/ajp.2024.25131","DOIUrl":"10.22038/ajp.2024.25131","url":null,"abstract":"<p><strong>Objective: </strong>This scoping review aims to examine the potential health benefits of <i>Anvillea garcinii</i> and its compounds and provide recommendations based on available research. <i>A. garcinii</i> is a plant species in the daisy family that has demonstrated several therapeutic and preventive effects.</p><p><strong>Materials and methods: </strong>This review was conducted with a comprehensive approach. We meticulously searched multiple databases, including PubMed, Embase, Scopus, Cochrane, SID, and Magiran, using the keyword \"<i>A. garcinii</i> \" on October 4, 2023.</p><p><strong>Results: </strong>Research suggests that <i>A. garcinii</i> extract possesses several properties that could benefit health. These include anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory activities. The extract also displays anti-oxidant properties, enhances insulin sensitivity, and inhibits α-amylase and α-glucosidase. Additionally, it exhibits hepatoprotective activity, cytotoxic activity against cancerous cells, anti-fungal, anti-human immunodeficiency virus (HIV), anti-bacterial, anti-cholinesterase, and anti-tyrosinase activities.</p><p><strong>Conclusion: </strong>The diverse health benefits of <i>A. garcinii</i> extract and its active compounds, such as germacranolide and parthenolide, present significant potential for use in the food, cosmetic, and pharmaceutical industries. This potential, especially in treating diabetes, gastric ulcers, and cancer, opens up exciting possibilities for the future.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1113-1123"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of saffron supplementation on inflammatory factors and clinical outcomes in sepsis patients admitted to the intensive care unit (ICU): Study protocol for a double-blind randomized controlled clinical trial.","authors":"Shirin Hassanizadeh, Babak Alikiaii, Mohammad Hossein Rouhani, Zeinab Mokhtari, Mohammadreza Moznebiisfahani, Manoj Sharma, Mohammad Bagherniya","doi":"10.22038/ajp.2024.25221","DOIUrl":"10.22038/ajp.2024.25221","url":null,"abstract":"<p><strong>Objective: </strong>Research studies have examined saffron's effects on inflammation, infection, and oxidative stress. Nevertheless, the effects of saffron on sepsis patients in the intensive care units (ICUs) have not yet been studied. Hence, this study will examine the effects of saffron supplementation on oxidative stress biomarkers, inflammation factors, and clinical outcomes in critically ill septic patients.</p><p><strong>Materials and methods: </strong>Ninety patients with sepsis will participate in this parallel double-blind, randomized clinical controlled trial. In addition to usual care, the intervention group (n=45) will receive a daily tablet containing 100 mg/day saffron for 7 days, and the control group (n=45) will receive a placebo tablet containing 100 mg/day corn starch for the same duration. Acute Physiology and Chronic Health Evaluation II (APACHE II), the Sequential Organ Failure Assessment (SOFA), and the NUTRIC Score will be used to assess the patients' clinical and nutritional status at the beginning and end of the study. Inflammatory markers including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and IL-18, indicators of oxidative stress including malondialdehyde (MDA), glutathione peroxidase (GPx), catalase, superoxide dismutases (SODs), and total antioxidant capacity (TAC), level of Glasgow Coma Scale (GCS), complete blood count (CBC), and lactate dehydrogenase (LDH) will be evaluated at beginning and end of the study. Twenty-eight days after the start of the intervention mortality rates will be assessed.</p><p><strong>Discussion: </strong>Due to the anti-inflammatory, antioxidant, and antimicrobial effects, saffron might have beneficial effects in critically ill patients with sepsis.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 3","pages":"1137-1146"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Daucus carota</i> L. extract on spermiogram factors in men with idiopathic infertility: A double-blinded randomized clinical trial.","authors":"Abolhasan Mousavi Khorshidi, Ayesheh Enayati, Nasser Behnampour, Emadoddin Rezaei, Fatemeh Kolangi","doi":"10.22038/AJP.2024.25008","DOIUrl":"https://doi.org/10.22038/AJP.2024.25008","url":null,"abstract":"<p><strong>Objective: </strong>Male infertility is a common issue that affects people worldwide and presents challenges in terms of treatment. In recent times, there has been significant interest in the use of herbal remedies as a potential solution for male infertility. In this study, we aimed to assess and compare the effects of clomiphene, carrot seed, and education based on traditional Persian medicine on the sperm parameters in idiopathic male infertility.</p><p><strong>Materials and methods: </strong>Sixty male patients experiencing infertility were randomly divided into four groups: Clomiphene, Clomiphene + Carrot, Clomiphene + Lifestyle modification, and Clomiphene + Carrot + Lifestyle modification. In the herbal group, patients received four capsules of carrot seeds, for a total of 2 g daily for 90 days. Meanwhile, subjects in the Clomiphene group were administered one tablet of clomiphene, containing 50 mg, per day for a duration of 90 days. Sperm parameters were analyzed at the beginning and end of the study.</p><p><strong>Results: </strong>After the 90-day intervention, the groups that received clomiphene combined with carrot and lifestyle interventions showed significant improvements in various sperm parameters. These improvements were statistically significant compared to the control group.</p><p><strong>Conclusion: </strong>The combination of carrot seeds along with clomiphene and education based on traditional Persian medicine was found to improve sperm parameters in cases of idiopathic male infertility without any adverse effects.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"981-996"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-leishmanial effect of the hydroalcoholic extract of the leaves, roots and seeds of <i>Arctium lappa</i>.","authors":"Elham Maleki, Afsaneh Yegdaneh, Sakineh Akbari, Saberi Sedigheh","doi":"10.22038/AJP.2024.24940","DOIUrl":"https://doi.org/10.22038/AJP.2024.24940","url":null,"abstract":"<p><strong>Objective: </strong>Zoonotic cutaneous leishmaniasis is a common including endemic infectious disease in many parts of the world and Iran. Due to <i>Arctium lappa</i> wide therapeutic applications, the anti-leishmanial effect of the hydroalcoholic extract of its leaves (L), roots (R) and seeds (S) has been investigated in this research.</p><p><strong>Materials and methods: </strong>The leaves, seeds and roots of the greater burdock plant were extracted. In the <i>in vitro</i> phase, its cytotoxic and anti-leishmanial effects on promastigote and amastigote forms of <i>Leishmania major(L.major)</i> were investigated. In the in vivo stage, the leishmaniasis mouse model was dosed with concentrations of 50, 100, and 200 mg/kg and the liver and spleen parasite burden was checked.</p><p><strong>Results: </strong>The results of this research in the <i>in vitro</i> phase showed that the antileishmanial effect of the hydroalcoholic extract of leaves, roots and seeds on the promastigote and amastigote forms of <i>L. major</i> has a significant relationship with the increase in the concentration of the extract (for all p≤0.001). Also, exposure time and interaction effect of concentration and exposure time were significant. In the <i>in vivo</i> phase the significant effect of the increase in concentration (L: p≤0.001, R: p=0.02, S: p=0.03), exposure time (L: p≤0.001, R: p≤0.001, S: p≤0.01) and the interaction effect of these two factors (L: p=0.002, R: p≤0.001, S: p≤0.001) on reducing the size of the wound was shown.</p><p><strong>Conclusion: </strong>The investigation established that hydroalcoholic extract of the leaves, roots, and seeds of the greater burdock in high concentration exhibited beneficial inhibitory effects on the leishmanial lesions.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1030-1046"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anti-inflammatory effects of <i>Lavandula stoechas</i> L. extract on ovalbumin-induced acute asthma in BALB/c mice.","authors":"Nafiseh Erfanian, Faezeh Fazlpour, Hossein Safarpour, Sayyedeh Fatemeh Askari, Mohsen Foadoddini, Saeed Nasseri","doi":"10.22038/AJP.2024.25175","DOIUrl":"https://doi.org/10.22038/AJP.2024.25175","url":null,"abstract":"<p><strong>Objective: </strong>Asthma is an inflammatory disease of the respiratory system affecting over 300 million people worldwide. <i>Lavandula stoechas</i> L. (<i>L. stoechas</i>) has traditionally been used to manage inflammatory diseases and against multiple medical conditions. In this study, we aimed to explore the anti-inflammatory effects of the hydro-alcoholic extract of <i>L. stoechas</i> in a mice model of acute asthma.</p><p><strong>Materials and methods: </strong>Thirty-five male BALB/c mice were placed into five distinct study groups: (1) control, (2) ovalbumin (OVA) + Al(OH)3, (3) OVA + <i>L. stoechas</i> (200 mg/kg), (4) OVA + <i>L. stoechas</i> (300 mg/kg) and (5) OVA + dexamethasone. Sensitization of the mice involved intraperitoneal administration of 75 µg OVA + 2mg Al(OH)3 on days 1 and 8. Subsequently, between days 15 and 17, the mice underwent intranasal challenges with 50 µg of OVA. On days 13-18, the mice were administered either <i>L. stoechas</i> (200 and 300 mg/kg) orally or dexamethasone intraperitoneally (used as a positive control). On day 19, both bronchoalveolar lavage (BAL) fluid and lung tissue samples were collected for biochemical and immuno-histological analyses.</p><p><strong>Results: </strong>The <i>L. stoechas</i> extract-treated groups displayed notable reductions in histological alterations and inflammatory cell infiltration, surpassing the effects observed in the OVA group. Moreover, the <i>L. stoechas</i> treatment group exhibited lowered <i>TNF-α</i> and <i>IL-6</i> expression levels.</p><p><strong>Conclusion: </strong>Our results demonstrated the potential of <i>L. stoechas</i> as an anti-inflammatory agent in acute asthma.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"933-942"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible effects of royal jelly against neuronal injury in the hippocampus of ovariectomized rats with pentylenetetrazol-induced seizures: Role of luteinizing and follicle-stimulating hormones.","authors":"Asma Momeni, Mohammad Reza Salahshoor, Mohammadreza Afarinesh, Cyrus Jalili","doi":"10.22038/AJP.2024.25151","DOIUrl":"https://doi.org/10.22038/AJP.2024.25151","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential impact of royal jelly (RJ) on hippocampal neurons in an ovariectomized (OVX) rat model with pentylenetetrazol (PTZ)-induced seizures by assessing luteinizing (LH) and follicle-stimulating (FSH) hormones.</p><p><strong>Materials and methods: </strong>Fifty-six female rats (n=7/group) were divided into groups receiving saline (CTL, OVX, RJ, and OVX-RJ) and those undergoing PTZ-induced seizures (PTZ, PTZ-OVX, PTZ-RJ, and PTZ-OVX-RJ). OVX rats underwent bilateral ovary removal, followed by a 15-day RJ treatment at 300 mg/kg. The seizure model commenced 24 hours after the final RJ dose. Serum LH and FSH levels were measured, and Golgi staining assessed hippocampal neuron morphology.</p><p><strong>Results: </strong>The RJ group exhibited elevated LH and FSH levels compared to CTL. However, the PTZ-RJ group showed no significant changes in these hormones relative to the PTZ and CTL groups. In OVX-RJ rats, LH and FSH levels decreased compared to the RJ group, while PTZ-OVX-RJ rats showed increased levels. Dendritic spines remained unchanged in both the RJ and PTZ-RJ groups compared to the CTL and PTZ groups, respectively. Notably, OVX-RJ exhibited reduced spines compared to the RJ group, while PTZ-OVX-RJ showed an increase.</p><p><strong>Conclusion: </strong>RJ may protect against estrogen deficiency and seizure-related adverse effects on hippocampal neurons in OVX rats, highlighting its potential as a beneficial dietary supplement.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"1047-1058"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of lupeol on testicular lesions induced by cadmium chloride in rats.","authors":"Parmida Arabkarami, Pejman Mortazavi, Saeed Hesaraki","doi":"10.22038/AJP.2024.24716","DOIUrl":"https://doi.org/10.22038/AJP.2024.24716","url":null,"abstract":"<p><strong>Objective: </strong>Heavy metals and environmental pollutants, such as cadmium chloride, congenital disorders, and certain diseases, can lead to infertility in men. In this study, the effects of lupeol (an active pentacyclic triterpenoid with antioxidant properties) on testicular injuries induced by cadmium chloride were investigated in male rats.</p><p><strong>Materials and methods: </strong>Lupeol was obtained from Sigma-Aldrich, and the experiment included 40 male Wistar rats divided into 8 groups (healthy control, healthy rats treated with 100, 200, and 400 mg/kg of lupeol, cadmium chloride, and three groups that received cadmium chloride and were treated with 100, 200, and 400 mg/kg of lupeol). After oral treatment, rats were anesthetized, and blood and testicular tissue sampling was done. Subsequent analysis of oxidative stress enzymes, such as malondialdehyde (MDA) and superoxide dismutase (SOD), testosterone, sperm motility, and Aquaporin 9 (AQ9) levels was performed using ELISA, histopathology, and immunohistochemistry techniques, respectively. Immunohistochemistry staining was done for expression of Aquaporin 9 in seminiferous tubules.</p><p><strong>Results: </strong>The results showed that compared to the healthy control, cadmium chloride caused a significant decrease in SOD, testosterone, sperm motility, and sperm vitality, with severe destruction of spermatogenic tubes and a significant increase in MDA and AQ9 rate. Rats which were treated with cadmium chloride+400 mg/kg of lupeol showed a significant increase in SOD, testosterone, histopathology, sperm motility, and sperm vitality rate, and significant organization of spermatogenic tubes in testis tissue. There was also a decrease in MDA and AQ9 of rats that received high-dose lupeol. (p<0.001).</p><p><strong>Conclusion: </strong>This study suggests that lupeol has a high potential for improving male reproduction and antioxidants in rats exposed to oxidative stress.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 1","pages":"907-919"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial effectiveness of aqueous and alcoholic herbal extracts on <i>Streptococcus mutans</i>: A systematic review and meta-analysis of randomized controlled trials.","authors":"Kosar Ghandehari, Marzie Boskabadi, Alireza Sarraf Shirazi, Masoumeh Sadeghi, Taraneh Movahhed","doi":"10.22038/AJP.2024.24314","DOIUrl":"https://doi.org/10.22038/AJP.2024.24314","url":null,"abstract":"<p><strong>Objective: </strong>Debates about the efficacy of herbal products in oral care have inspired researchers to conduct a large number of trials. This systematic review and meta-analysis aimed to assess the antibacterial efficacy of aqueous and alcoholic herbal extracts against <i>Streptococcus mutans</i> (SM) as the main cariogenic microorganism.</p><p><strong>Materials and methods: </strong>Online databases PubMed, Scopus, Cochrane Library, Web of Science, and Magiran were searched for randomized controlled trials evaluating the efficacy of herbal products against SM published up to July 2023. Meta-analyses were performed for immediate and long-term effects based on random effect model.</p><p><strong>Results: </strong>Out of 57 studies that met the selection criteria for systematic review, 26 were subjected to meta-analysis. Considering both immediate and long-term effects on salivary SM, aqueous and alcoholic herbal extracts were significantly superior in the reduction of SM over non-herbal agents (immediate: SMD = -1.16; 95%CI: -2.03, -0.29, long-term: SMD = -0.76; 95%CI: -1.35, -0.17). However, the difference was not significant in the reduction of SM of plaque (SMD = -0.30, 95%CI: -1.25, 0.65). The subgroup analyses showed no significant difference compared to chlorhexidine (p>0.05). The overall quality of evidence was considered low based on GRADE tool.</p><p><strong>Conclusion: </strong>Current evidence suggests encouraging results for herbal extracts in reduction of SM, but not over chlorhexidine. However, there is still insufficient evidence to recommend them as the first option for oral care. High-quality randomized controlled trials are required to assert the safety and effectiveness of them for preventing dental caries.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"943-963"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of crocin on contrast-induced nephropathy in rats.","authors":"Mahnaz Zolfaghari Farajerdi, Fatemeh Rajabian, Bibi Marjan Razavi, Mahboobehr Ghasemzadeh Rahbarda, Abolfazl Khajavi Rad, Sakineh Amoueian, Hossein Hosseinzadeh","doi":"10.22038/AJP.2024.24786","DOIUrl":"https://doi.org/10.22038/AJP.2024.24786","url":null,"abstract":"<p><strong>Objective: </strong>Contrast-induced nephropathy (CIN) raises the risk of renal injury, but crocin, a saffron component, may improve kidney function. This study investigated crocin's protective effects against CIN in rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats were divided into eight groups: Sham, Control, Contrast medium (diatrizoate), Diatrizoate combined with crocin at 10, 20, or 40 mg/kg/day, Diatrizoate combined with N-acetylcysteine (NAC) at 125 mg/kg/day, and Crocin alone at 40 mg/kg/day. Water deprivation began on day 5 for 48 hr, except for the sham and crocin alone groups. Indomethacin and N(ω)-nitro-L-arginine methyl ester were administered after 40 hr of dehydration. Rats were sacrificed on the eighth day, and blood and kidney samples were collected.</p><p><strong>Results: </strong>Diatrizoate increased serum creatinine and blood urea nitrogen levels, elevated malondialdehyde levels, and reduced glutathione in renal tissue. Crocin reversed these effects. Diatrizoate caused severe tubular necrosis, proteinaceous casts, medullary congestion, and interstitial edema in kidney tissue. Crocin (20 and 40 mg/kg) significantly reduced tubular necrosis, and doses of 10 and 40 mg/kg reduced interstitial edema. NAC significantly improved histopathological damage, biochemical factors, and oxidative stress. The crocin alone group showed no significant changes.</p><p><strong>Conclusion: </strong>Diatrizoate induces nephrotoxicity by enhancing oxidative stress in rats, and crocin has a protective effect against it. Crocin mitigates both tissue and biochemical damage inflicted by diatrizoate.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"920-932"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of <i>Indigofera argentea</i> against acetic acid-induced inflammatory bowel disease are mediated by modulating antioxidant and inflammatory mediators.","authors":"Faraza Javaid, Qaiser Jabeen","doi":"10.22038/AJP.2024.24977","DOIUrl":"https://doi.org/10.22038/AJP.2024.24977","url":null,"abstract":"<p><strong>Objective: </strong>The plant <i>Indigofera argentea</i> Burm. f., belonging to the family Fabaceae, is locally known as Hathio, Jantar and Neel. This plant is commonly found in deserted habitat and used traditionally to treat inflammatory and gastric disorders. The current study was designed to evaluate the phytochemical profile, toxicity and intestinal anti-inflammatory effects of the whole plant crude extract against acetic acid-induced inflammatory bowel disease (IBD) in mice.</p><p><strong>Materials and methods: </strong>To study the phytochemical composition, preliminary phytochemical analysis along with HPLC and LCMS of the crude extract of <i>Indigofera argentea</i> (Ia.Cr) was performed. For the evaluation of intestinal anti-inflammatory activity, animals were divided into five groups (normal control, intoxicated, standard and two treatment groups) of six animals each and ulcerative colitis (UC) was induced by intrarectal administration of acetic acid (200 µl of 7.5%) and extent of damage caused by ulcerative colitis was measured by colonic mucosal damage index, disease activity index, and hematological and histological changes. Lipo-peroxide activity by malondialdehyde (MDA) and antioxidant enzyme glutathione peroxidase (GPX-1), catalase (CAT) and superoxide dismutase (SOD) levels were determined in colon tissues. Pro-inflammatory cytokines (IL-1, IL-6 and TNF-α) were quantified by ELISA immunoassay.</p><p><strong>Results: </strong>Pre-treatment with Ia.Cr significantly amended macroscopic damage, and hematological and histopathological alterations. Ia.Cr decreased oxidative parameters such as MDA and increased antioxidant activities of GPX-1, CAT and SOD. Ia.Cr also decreased the levels of pro-inflammatory biomarkers significantly.</p><p><strong>Conclusion: </strong>Results of this study indicated that Ia.Cr protected mice against acetic acid-induced inflammatory bowel disease by decreasing endogenous inflammatory biomarkers and oxidative damages.</p>","PeriodicalId":8677,"journal":{"name":"Avicenna Journal of Phytomedicine","volume":"15 2","pages":"964-980"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}