探讨橄榄叶和姜提取物对四氧嘧啶诱导的糖尿病大鼠肾脏和肝脏功能的潜在影响。

IF 1.9 Q3 CHEMISTRY, MEDICINAL
Shatha Alshaer, Mohammad A A Al-Najjar, Feras Darwish El-Hajji, Reem Abu-Tayeh
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引用次数: 0

摘要

目的:尽管药店货架上有许多治疗糖尿病的药物,但世界上许多人仍然使用草药制剂来治疗糖尿病。本研究以不同生理指标为指标,探讨了橄榄叶与姜提取物水溶液组合对1型糖尿病(T1DM)的影响。材料与方法:52只Wistar大鼠分为2组健康鼠和6组糖尿病鼠。40只大鼠腹腔单剂量四氧嘧啶(150 mg/kg)诱导T1DM。诱导后4天开始胰岛素治疗,包括加/不加单独提取物和联合提取物。提取物口服(500 mg/kg),胰岛素皮下注射(6 IU/kg),单剂量,每天1次。治疗一周后,采血测定空腹血糖(FBG)、谷丙转氨酶(ALT)、碱性磷酸酶(ALP)、肌酐。结果:两种提取物联合胰岛素治疗的糖尿病组在治疗14天后死亡率较低。接受橄榄叶提取物胰岛素治疗的糖尿病组ALT水平降至33.7 U/L (p=0.345), ALP水平维持在正常范围126.9 U/L (p=0.463)。分别服用橄榄油叶和生姜提取物和胰岛素的糖尿病组肌酐显著降低至1.1 mg/dl (p=0.028)和0.7 mg/dl (p=0.028)。结论:综上所述,与胰岛素联合使用对糖尿病大鼠的死亡率有较强的改善作用,且两种提取物单独使用均能降低肌酐水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the potential effects of olive leaves and ginger rhizome extracts on kidney and liver functions in alloxan-induced diabetic rats.

Objective: Although there are many drugs on the shelves of pharmacies to manage diabetes mellitus (DM), many people around the world still use herbal preparations to treat it. This study investigated the effect of an aqueous combination of olive leaves and ginger rhizome extracts on type 1 diabetes mellitus (T1DM) using various physiological markers.

Materials and methods: Fifty-two Wistar rats were distributed into 2 healthy and 6 diabetic groups. Forty rats were given alloxan (150 mg/kg) as an intraperitoneal single-dose to induce T1DM. Treatments including insulin with/without individual and combined extracts, were started 4-day post-induction. The extracts were administered orally (500 mg/kg) and insulin was administered subcutaneously (6 IU/kg) in single-doses once a day. After one week of treatment, the blood samples were collected to measure Fasting blood glucose (FBG), Alanine aminotransferase (ALT), Alkaline phosphatase (ALP), and creatinine.

Results: The diabetic group that received the combination of both extracts with insulin had a lower mortality rate after 14 days of treatment. The diabetic group receiving insulin with the olive leaves extract, demonstrated a decrease in ALT levels to 33.7 U/L (p=0.345) while maintaining the ALP levels within the normal range 126.9 U/L (p=0.463). Creatinine was significantly reduced to 1.1 mg/dl (p=0.028) and 0.7 mg/dl (p=0.028) in diabetic groups that received individual olive leaves and ginger extracts with insulin respectively.

Conclusion: To conclude, this combination with insulin had powerful effects to improve the mortality rate in diabetic rats over other groups, and the two extracts separately were able to decrease the creatinine levels.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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