Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Exaggerated immune response to fungal keratitis post-COVID-19 vaccination","authors":"Isana Nakajima, Ken Fukuda, Tamaki Sumi, Kenji Yamashiro","doi":"10.1016/j.apjo.2024.100063","DOIUrl":"10.1016/j.apjo.2024.100063","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100063"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000586/pdfft?md5=0787111ba15b04d8bde508f7995cc33e&pid=1-s2.0-S2162098924000586-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concealed retro-iridic multi-cavitary melanoma revealed by ultrasound biomicroscopy","authors":"Miguel E. Hernandez-Emanuelli, Rolika Bansal, Thomas M. Catapano, Carol L. Shields","doi":"10.1016/j.apjo.2024.100049","DOIUrl":"10.1016/j.apjo.2024.100049","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100049"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000446/pdfft?md5=77e7d2e15a66e9202e418edc3df804fd&pid=1-s2.0-S2162098924000446-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial”","authors":"P. Connor Lentz , Leticia Checo , Isabella V. Wagner , Nithya Boopathiraj , Emily Dorairaj , Syril Dorairaj","doi":"10.1016/j.apjo.2024.100066","DOIUrl":"10.1016/j.apjo.2024.100066","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100066"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000677/pdfft?md5=22fcc65ad88d1bc96745c0cb9cad5d80&pid=1-s2.0-S2162098924000677-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of diabetic retinopathy screening for newly diagnosed type 2 diabetic patients: A nationwide population-based propensity score-matched cohort study","authors":"Yu-Chien Chung ,&nbsp;Yi-Wei Kao ,&nbsp;Yen-Chun Huang ,&nbsp;Pei-En Chen ,&nbsp;Shu-Chen Liao ,&nbsp;Chih-Kuang Liu ,&nbsp;Mingchih Chen","doi":"10.1016/j.apjo.2024.100071","DOIUrl":"10.1016/j.apjo.2024.100071","url":null,"abstract":"<div><h3>Aims</h3><p>This study investigated the association between the frequency of screening for diabetic retinopathy (DR) versus the development of DR and corresponding medical expenses among patients newly diagnosed with type 2 diabetes mellitus (T2DM).</p></div><div><h3>Methods</h3><p>This longitudinal, population-based study used the Taiwan National Health Insurance Research Database (2004 to 2020) as a data source. Propensity score matching (PSM) (sex, age, comorbidities and concurrent medication use) was employed in the grouping of T2DM patients according to different frequency of DR screening. Outcome measures included the proportion of patients who developed DR, who received DR treatment, and the associated medical expenses and hospitalizations.</p></div><div><h3>Results</h3><p>The 17-year cohort included 337,046 patients. After PSM, three groups each containing 35,739 patients were assembled and analyzed. Compared to low-frequency screening, high-frequency screening was more effective in detecting patients requiring treatment; however, the net cost for treatment was significantly lower. Standard-frequency screening appears to provide the best balance in terms of DR detection, diagnosis interval, the risk of DR-related hospitalization, and DR treatment costs.</p></div><div><h3>Conclusions</h3><p>In this real-world cohort study covering all levels of the healthcare system, infrequent screening was associated with delayed diagnosis and elevated treatment costs, while a fundus screening interval of 1–2 years proved optimal in terms of detection and medical expenditures.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100071"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000720/pdfft?md5=5325c510e97d01d39654289e634f6601&pid=1-s2.0-S2162098924000720-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and safety of posterior endoscopic cyclophotocoagulation in refractory glaucoma: A 5-year follow-up study at a tertiary eye center","authors":"Yuxin Fang,&nbsp;Pengfei Zheng,&nbsp;Xin Tang,&nbsp;Qiyan Li","doi":"10.1016/j.apjo.2024.100074","DOIUrl":"10.1016/j.apjo.2024.100074","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the long-term efficacy of endoscopic cyclophotocoagulation (ECP) via a pars plana approach in a large cohort of refractory glaucoma patients</p></div><div><h3>Design</h3><p>Single-center, retrospective, longitudinal, cohort study.</p></div><div><h3>Methods</h3><p>This study recruited patients who underwent ECP and consecutively visited and were followed up for at least 5 years at Beijing Tongren Eye Center, China from January 2013 to December 2017. All patients underwent a complete ophthalmic examination. Treatment success was defined as 6 mmHg ≤ IOP ≤ 21 mmHg with or without anti-glaucoma medications.</p></div><div><h3>Results</h3><p>A total of 121 eyes of 105 patients including 51 children and 54 adults were enrolled. The mean follow-up was 7.2 ± 1.3 years. The most common glaucoma diagnoses were secondary glaucoma (74 eyes, 61.1 %) and primary congenital glaucoma (19 eyes 15.7 %). The mean extent of the first ECP was 259 degrees. There was an overall decrease in IOP of 38.3 % from 33.3 ± 9.0 mmHg preoperatively to 20.5 ± 7.5 mmHg after surgery, which was statistically significant (<em>P</em> &lt; 0.001). The success rate after 1 or more ECP surgery was 65.3 %. After adjusting for sex, number of prior TCP surgeries and the extent of ECP degree, the failure of ECP was associated with being children (as compared with adults; <em>P</em> = 0.028; OR = 2.549) and higher preoperative IOP (<em>P</em> = 0.001; OR = 1.084).</p></div><div><h3>Conclusion</h3><p>ECP is an effective procedure for lowing IOP in refractory glaucoma, particularly in patients who are also candidates for vitreoretinal interventions. Hence, a collaborative approach between glaucoma and retinal specialists is of utmost importance in devising an optimal management strategy for glaucoma treatment.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100074"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000756/pdfft?md5=1d44ec0d02ae6453c527f61ddaf415d8&pid=1-s2.0-S2162098924000756-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for diabetic retinopathy, diabetic macular edema, and sight-threatening diabetic retinopathy","authors":"Guihua Zhang ,&nbsp;Weiqi Chen ,&nbsp;Haoyu Chen ,&nbsp;Jianwei Lin ,&nbsp;Ling-Ping Cen ,&nbsp;Peiwen Xie ,&nbsp;Yi Zheng ,&nbsp;Tsz Kin Ng ,&nbsp;Mårten Erik Brelén ,&nbsp;Mingzhi Zhang ,&nbsp;Chi Pui Pang","doi":"10.1016/j.apjo.2024.100067","DOIUrl":"10.1016/j.apjo.2024.100067","url":null,"abstract":"<div><h3>Objective</h3><p>To identify the risk factors for the development of diabetic retinopathy (DR), diabetic macular edema (DME), and sight-threatening DR (STDR) based on a city-wide diabetes screening program.</p></div><div><h3>Research design and methods</h3><p>Diabetic patients were prospectively recruited between June 2016 and December 2022. All patients underwent dilated fundus photography centered on the disc and macula or macular spectral domain optical coherence tomography (SD-OCT) scan. Complete medical history was documented. Systematic examination, blood analysis, and urinalysis were performed. Multivariate logistic regression analysis adjusting for age and sex was conducted.</p></div><div><h3>Results</h3><p>Out of 7274 diabetic patients, 6840 had gradable images, among which 3054 (42.0%) were graded as DR, 1153 (15.9%) as DME, and 1500 (20.6%) as STDR. The factors associated with DR, DME, and STDR included younger age (odds ratio [OR]: 0.96, 0.97, and 0.96 respectively), lower BMI (OR: 0.97, 0.95, and 0.95 respectively), longer duration of diabetes (OR: 1.07, 1.03, and 1.05 respectively) and positive of urinary albumin (OR: 2.22, 2.56, and 2.88 respectively). Other associated factors included elevated blood urea nitrogen (OR: 1.22, 1.28, and 1.27 respectively), higher LDL-cholesterol, lower blood hemoglobin (OR: 0.98, 0.98, and 0.98), insulin intake, presence of diabetic foot pathologies and diabetic peripheral neuropathy. We also identified novel risk factors, including high serum potassium (OR: 1.37, 1.46, and 1.55 respectively), high-serum sodium (OR: 1.02, 1.02, and 1.04 respectively). Better family income was a protective factor for DR, DME, and STDR. Alcohol consumption once a week was also identified as a protective factor for DR.</p></div><div><h3>Conclusions</h3><p>Similar risk factors for DR, DME, and STDR were found in this study. Our data also indicates high serum sodium, high serum potassium, low blood hemoglobin, and level of family income as novel associated factors for DR, DME, and STDR, which can help with DR monitoring and management.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100067"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000689/pdfft?md5=d2a990b0030a8bf37cf5bb7507b10252&pid=1-s2.0-S2162098924000689-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology including epigenetic defects of retinoblastoma","authors":"Linbin Zhou ,&nbsp;Yan Tong ,&nbsp;Bo Man Ho ,&nbsp;Jiahui Li ,&nbsp;Hoi Ying Emily Chan ,&nbsp;Tian Zhang ,&nbsp;Lin Du ,&nbsp;Jing Na He ,&nbsp;Li Jia Chen ,&nbsp;Clement C. Tham ,&nbsp;Jason C. Yam ,&nbsp;Chi Pui Pang ,&nbsp;Wai Kit Chu","doi":"10.1016/j.apjo.2024.100072","DOIUrl":"10.1016/j.apjo.2024.100072","url":null,"abstract":"<div><p>Retinoblastoma (RB), originating from the developing retina, is an aggressive intraocular malignant neoplasm in childhood. Biallelic loss of <em>RB1</em> is conventionally considered a prerequisite for initiating RB development in most RB cases. Additional genetic mutations arising from genome instability following <em>RB1</em> mutations are proposed to be required to promote RB development. Recent advancements in high throughput sequencing technologies allow a deeper and more comprehensive understanding of the etiology of RB that additional genetic alterations following <em>RB1</em> biallelic loss are rare, yet epigenetic changes driven by <em>RB1</em> loss emerge as a critical contributor promoting RB tumorigenesis. Multiple epigenetic regulators have been found to be dysregulated and to contribute to RB development, including noncoding RNAs, DNA methylations, RNA modifications, chromatin conformations, and histone modifications. A full understanding of the roles of genetic and epigenetic alterations in RB formation is crucial in facilitating the translation of these findings into effective treatment strategies for RB. In this review, we summarize current knowledge concerning genetic defects and epigenetic dysregulations in RB, aiming to help understand their links and roles in RB tumorigenesis.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100072"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000732/pdfft?md5=b4dfc704764d10f5c83d4504fe742792&pid=1-s2.0-S2162098924000732-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response: Comment on “Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial”","authors":"Yunhe Song,&nbsp;Fei Li,&nbsp;Xiulan Zhang","doi":"10.1016/j.apjo.2024.100076","DOIUrl":"10.1016/j.apjo.2024.100076","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100076"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S216209892400077X/pdfft?md5=078a02af33f311a5bab22e695a3dd5a5&pid=1-s2.0-S216209892400077X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141140741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic retinopathy","authors":"Jost B. Jonas","doi":"10.1016/j.apjo.2024.100077","DOIUrl":"10.1016/j.apjo.2024.100077","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100077"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000781/pdfft?md5=94c51c48644902d0c7e86dd6417f05b7&pid=1-s2.0-S2162098924000781-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of baseline factors with 1-year outcomes in the SB11-ranibizumab equivalence trial: A post hoc analysis","authors":"Se Joon Woo ,&nbsp;Jin Ah Jung ,&nbsp;Taehyung Kim ,&nbsp;Inkyung Oh ,&nbsp;Mercy Yeeun Kim ,&nbsp;Neil M. Bressler","doi":"10.1016/j.apjo.2024.100069","DOIUrl":"10.1016/j.apjo.2024.100069","url":null,"abstract":"<div><h3>Purpose</h3><p>To identify baseline factors associated with 1-year outcomes when treating neovascular age-related macular degeneration (nAMD) with ranibizumab biosimilar SB11 or reference ranibizumab (rRBZ), and to compare efficacy of the two products within subgroups judged to be clinically relevant.</p></div><div><h3>Design</h3><p>Post hoc analysis of a prospective, equivalence phase 3 randomized clinical trial (RCT)</p></div><div><h3>Methods</h3><p>705 patients with nAMD were randomized 1:1 to receive SB11 or rRBZ for 48 weeks. Pooled and randomized groups were used to identify baseline factors associated with clinical outcomes at Week 52 using multiple linear regression models. Significant factors identified in regression analyses were confirmed in analyses of variance. Subgroup analyses comparing best-corrected visual acuity (BCVA) changes between SB11 and rRBZ were conducted.</p></div><div><h3>Results</h3><p>634 (89.9%) participants completed the 52-week visit. Regression analyses showed that younger age, lower BCVA, and smaller total lesion area at baseline were associated with greater BCVA gain at Week 52, while older age, lower BCVA, and thicker central subfield thickness (CST) at baseline were predictors of greater CST reduction in the pooled group. Subgroup analyses demonstrated that BCVA outcomes appeared comparable for the SB11 and rRBZ groups.</p></div><div><h3>Conclusion</h3><p>Post hoc analyses of the SB11-rRBZ equivalence study showed that baseline age, BCVA, CST, and total lesion area were prognostic factors for visual or anatomical outcomes of nAMD, while subgroup analyses demonstrated comparable results for SB11 and rRBZ. Collectively, the results appear comparable to similar RCTs of anti-vascular endothelial growth factor reference products for nAMD and strengthen confidence in the biosimilarity of SB11.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 3","pages":"Article 100069"},"PeriodicalIF":4.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000707/pdfft?md5=c8cf11a3be79272bfc0b578ca7da56fc&pid=1-s2.0-S2162098924000707-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}