Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Rationale and protocol paper for the Asia Pacific Network for inherited eye diseases","authors":"Wendy M. Wong ,&nbsp;Yih Chung Tham ,&nbsp;Matthew P. Simunovic ,&nbsp;Fred Kuanfu Chen ,&nbsp;Chi D. Luu ,&nbsp;Haoyu Chen ,&nbsp;Zi-Bing Jin ,&nbsp;Ren-Juan Shen ,&nbsp;Shiying Li ,&nbsp;Ruifang Sui ,&nbsp;Chen Zhao ,&nbsp;Liping Yang ,&nbsp;Muna Bhende ,&nbsp;Rajiv Raman ,&nbsp;Parveen Sen ,&nbsp;Arkasubhra Ghosh ,&nbsp;B. Poornachandra ,&nbsp;Muhammad Bayu Sasongko ,&nbsp;Alia Arianti ,&nbsp;Valen Chia ,&nbsp;Hwei Wuen Chan","doi":"10.1016/j.apjo.2023.100030","DOIUrl":"10.1016/j.apjo.2023.100030","url":null,"abstract":"<div><h3>Purpose</h3><p>There are major gaps in our knowledge of hereditary ocular conditions in the Asia-Pacific population, which comprises approximately 60% of the world's population. Therefore, a concerted regional effort is urgently needed to close this critical knowledge gap and apply precision medicine technology to improve the quality of lives of these patients in the Asia-Pacific region.</p></div><div><h3>Design</h3><p>Multi-national, multi-center collaborative network.</p></div><div><h3>Methods</h3><p>The Research Standing Committee of the Asia-Pacific Academy of Ophthalmology and the Asia-Pacific Society of Eye Genetics fostered this research collaboration, which brings together renowned institutions and experts for inherited eye diseases in the Asia-Pacific region. The immediate priority of the network will be inherited retinal diseases (IRDs), where there is a lack of detailed characterization of these conditions and in the number of established registries.</p></div><div><h3>Results</h3><p>The network comprises 55 members from 35 centers, spanning 12 countries and regions, including Australia, China, India, Indonesia, Japan, South Korea, Malaysia, Nepal, Philippines, Singapore, Taiwan, and Thailand. The steering committee comprises ophthalmologists with experience in consortia for eye diseases in the Asia-Pacific region, leading ophthalmologists and vision scientists in the field of IRDs internationally, and ophthalmic geneticists.</p></div><div><h3>Conclusions</h3><p>The Asia Pacific Inherited Eye Disease (APIED) network aims to (1) improve genotyping capabilities and expertise to increase early and accurate genetic diagnosis of IRDs, (2) harmonise deep phenotyping practices and utilization of ontological terms, and (3) establish high-quality, multi-user, federated disease registries that will facilitate patient care, genetic counseling, and research of IRDs regionally and internationally.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100030"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000300/pdfft?md5=e6c9bf41d8332b424fdfd963f3895da3&pid=1-s2.0-S2162098923000300-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phacogoniotomy: An alternative treatment for advanced primary angle-closure glaucoma with cataract","authors":"Poemen P.M. Chan,&nbsp;Enne Hiu Ying Leung,&nbsp;Jost B. Jonas,&nbsp;Dennis S.C. Lam","doi":"10.1016/j.apjo.2024.100034","DOIUrl":"10.1016/j.apjo.2024.100034","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100034"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S216209892400001X/pdfft?md5=de4fe09c0f8680455153030cf09e5b23&pid=1-s2.0-S216209892400001X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139566399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative intense pulsed light to prevent and improve symptoms of post-laser corneal refractive surgery dry eye. A randomized clinical trial","authors":"María C. Martínez-Hergueta ,&nbsp;Mario Cantó-Cerdán ,&nbsp;Maria A. Amesty ,&nbsp;M. Jose García-Corral ,&nbsp;Laura Casanova-Blanquer ,&nbsp;Ana B. Plaza-Puche ,&nbsp;Jorge L. Alió ,&nbsp;Jorge L. Alió del Barrio","doi":"10.1016/j.apjo.2023.100029","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100029","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the efficacy of perioperative IPL therapy in preventing postoperative ocular surface disorders in patients undergoing corneal laser refractive surgery.</p></div><div><h3>Design</h3><p>randomized, controlled, clinical trial with triple-blinding.</p></div><div><h3>Methods</h3><p><em>Setting</em>: Vissum Miranza - Alicante; <em>Study population</em>: 61 patients randomized in two groups: 31 study patients (perioperative IPL + laser refractive surgery) and 30 control patients (perioperative placebo + laser refractive surgery). Follow-up was conducted over a 6-month period; <em>Intervention:</em> Each participants underwent three IPL sessions with a two-week interval between each session (pre-surgery, post-surgery week-one, and post-surgery week-three). For controls, placebo was administered following the same protocol. <em>Main outcomes measures</em>: visual outcomes and refraction, slit-lamp examination, corneal topography, visual analogue scale questionnaire and Oculus Keratograph 5 M including tear meniscus height, non-invasive tear break- up time, ocular redness, infrared meibography and Ocular Surface Disease Index (OSDI) questionnaire.</p></div><div><h3>Results</h3><p>61 randomized eyes were included. No significant differences were observed in terms of uncorrected and corrected distance visual acuity (UDVA, CDVA), refractive error or corneal aberrations. A statistically significant improvement in OSDI score (change −8.47, p = 0.043), tear meniscus (change 0.05 mm, p = 0.004) and Meibography (change −0.42, p = 0.012) was observed at the third postoperative month in the study group. Additionally, at the sixth postoperative month, there were statistically significant improvements in tear meniscus (change 0.06 mm, p = 0.018), tear break-up-time (change 1.68 s, p = 0.039) and Meibography (change −0.37, p = 0.030).</p></div><div><h3>Conclusions</h3><p>Results suggest that perioperative IPL therapy applied to laser corneal refractive surgery improves objective and subjective ocular surface parameters over non-IPL-treated control patients and early postoperative dry eye symptoms.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100029"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000294/pdfft?md5=1085007efef0299aa01c2f92ff7a82ae&pid=1-s2.0-S2162098923000294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Comment on \"Central Retinal Artery Occlusion in Rhino-Orbital-Cerebral Mucormycosis: An Inflammatory-Prothrombotic State\".","authors":"Damir Bosnar, Mira Knežić Zagorec, Mladen Bušić","doi":"10.1016/j.apjo.2023.100019","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100019","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100019"},"PeriodicalIF":4.4,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Glaucoma Surgery: Latest Developments and Future Challenges.","authors":"Poemen P M Chan, Mark D Larson, Jaime E Dickerson, Karl Mercieca, Victor Teck Chang Koh, Ridia Lim, Enne Hiu Ying Leung, Thomas W Samuelson, Christine L Larsen, Alison Harvey, Marc Töteberg-Harms, Frances Meier-Gibbons, Nicole Shu-Wen Chan, Jessica Belle Sy, Kaweh Mansouri, Xiulan Zhang, Dennis S C Lam","doi":"10.1097/APO.0000000000000646","DOIUrl":"10.1097/APO.0000000000000646","url":null,"abstract":"<p><p>The development of minimally invasive glaucoma surgeries (MIGSs) was intended to provide safe and modestly efficacious modalities for early intervention of mild-to-moderate glaucoma, with minimal trauma and rapid recovery. They were mainly ab interno procedures that reduce intraocular pressure by facilitating the aqueous outflow by bypassing the trabecular meshwork resistance, reinforcing the uveoscleral flow via the supraciliary space, and reducing aqueous production by the ciliary body. While the cumulating evidence helps shape the role of the available MIGS, the exponential new development and advancement in this field has expanded the territory of MIGS. Apart from developing subconjunctival MIGS filtration devices (Xen gel stent and PRESERFLO MicroShunt), there is a tendency to revisit the \"traditional\" MIGS for alternative use and to modify the procedures with consideration of the fundamental aqueous outflow physiology. Combined MIGS has also been suggested, based on the theory that their different mechanisms may provide additive or synergistic effects. The advancement of laser procedures is also promising and could supplement unmet needs along the glaucoma treatment algorithm. This review examines the broad array of MIGS, updates the recent findings, discusses their potential alternative applications, and explores future challenges.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"12 6","pages":"537-564"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Corneal Biomechanical Alteration Detected In Early Keratoconus Based on Corneal Deformation Using Artificial Intelligence.","authors":"Xuan Chen, Zuoping Tan, Yan Huo, Jiaxin Song, Qiang Xu, Can Yang, Vishal Jhanji, Jing Li, Jie Hou, Haohan Zou, Gauhar Ali Khan, Mohammad Alzogool, Riwei Wang, Yan Wang","doi":"10.1097/APO.0000000000000644","DOIUrl":"10.1097/APO.0000000000000644","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a novel method to diagnose early keratoconus by detecting localized corneal biomechanical changes based on dynamic deformation videos using machine learning.</p><p><strong>Design: </strong>Diagnostic research study.</p><p><strong>Methods: </strong>We included 917 corneal videos from the Tianjin Eye Hospital (Tianjin, China) and Shanxi Eye Hospital (Xi'an, China) from February 6, 2015, to August 25, 2022. Scheimpflug technology was used to obtain dynamic deformation videos under forced puffs of air. Fourteen new pixel-level biomechanical parameters were calculated based on a spline curve equation fitting by 115,200-pixel points from the corneal contour extracted from videos to characterize localized biomechanics. An ensemble learning model was developed, external validation was performed, and the diagnostic performance was compared with that of existing clinical diagnostic indices. The performance of the developed machine learning model was evaluated using precision, recall, F1 score, and the area under the receiver operating characteristic curve.</p><p><strong>Results: </strong>The ensemble learning model successfully diagnosed early keratoconus (area under the curve = 0.9997) with 95.73% precision, 95.61% recall, and 95.50% F1 score in the sample set (n=802). External validation on an independent dataset (n=115) achieved 91.38% precision, 92.11% recall, and 91.18% F1 score. Diagnostic accuracy was significantly better than that of existing clinical diagnostic indices (from 86.28% to 93.36%, all P <0.01).</p><p><strong>Conclusions: </strong>Localized corneal biomechanical changes detected using dynamic deformation videos combined with machine learning algorithms were useful for diagnosing early keratoconus. Focusing on localized biomechanical changes may guide ophthalmologists, aiding the timely diagnosis of early keratoconus and benefiting the patient's vision.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"574-581"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Glaucoma Surgery: A New Era in Glaucoma Treatment.","authors":"Xiulan Zhang, Fengbin Lin, Fei Li, Jacky W Y Lee, Clement C Tham","doi":"10.1097/APO.0000000000000648","DOIUrl":"10.1097/APO.0000000000000648","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"12 6","pages":"509-511"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Strabismus Measurement Using a Video Oculagraphy System and Alternate Prism Cover Test.","authors":"Mario Cantó-Cerdán, Antonio Martínez-Abad, Ana Siverio-Colomina, Rosa Díez, María A Amesty","doi":"10.1097/APO.0000000000000641","DOIUrl":"10.1097/APO.0000000000000641","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to compare distance vision measurements obtained with video oculography (VOG) and an alternate prism cover test (APCT).</p><p><strong>Design: </strong>Single-center, retrospective, and cross-sectional.</p><p><strong>Methods: </strong>Eighty-seven subjects with strabismus were included. All patients underwent an optometric examination. The measurement of strabismus in distance vision was performed with the best optical correction using the APCT and the VOG GazeLab. Subjects were divided according to the type of strabismus; 41 were esotropic and 46 were exotropic.</p><p><strong>Results: </strong>The general comparison of APCT and VOG showed a mean difference of 0.60±2.74 prism diopters (Δ), not observing statistical differences between both methods ( P =0.059) and presenting a correlation of 0.976 ( P <0.001). Using APCT, the mean amount of esotropia for the group was 18.31±11.64 Δ and that of exotropia was 19.62±8.80 Δ. Compared with the VOG, the mean value of esotropia for the group was 18.65±11.65 Δ and that of exotropia was 19.48±8.62 Δ. The means are statistically different for the esotropia group ( P =0.005) but not for the exotropia group ( P =0.318). There was a high direct correlation between the methods of measurement for both the esotropic ( R =0.980; P <0.001) and exotropic patients ( R =0.975; P <0.001). Bland-Altman analysis shows a mean difference of 1.37±2.76 Δ for the esotropia patients and 0.31±2.66 Δ for the exotropic patients, respectively.</p><p><strong>Conclusions: </strong>This study demonstrated comparable results in measuring strabismus between VOG and APTC for esotropia and exotropia, with an excellent correlation between both methods and good agreement, especially in subjects with exotropia.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"582-590"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the Retina: A New Phenotype and its Differential Diagnosis.","authors":"Marc J Sirks, Elon H C van Dijk, Laurenz J B Pauleikhoff, Roselie M H Diederen, Camiel J F Boon","doi":"10.1097/APO.0000000000000645","DOIUrl":"10.1097/APO.0000000000000645","url":null,"abstract":"<p><strong>Purpose: </strong>The presence of peripapillary intraretinal fluid (IRF) has a broad differential diagnosis, including several types of neovascular and pachychoroid-related diseases. However, the clinician may encounter cases without signs of neovascular or pachychoroid disease, or any other previously described diagnosis. For these patients, we propose the term NOn-Pachychoroid PEripapillary Schisis (NOPPES) of the retina, and we discuss the differential diagnosis.</p><p><strong>Design: </strong>A retrospective chart study set in a tertiary referral center for retinal diseases in Amsterdam, the Netherlands.</p><p><strong>Methods: </strong>Using multimodal imaging, cases suspected of peripapillary pachychoroid syndrome were reviewed. Cases without signs of neovascular or pachychoroid disease were included in this study. These cases were discussed in a group of senior retinal specialists to establish a diagnosis, and if there was no evidence for any previously described diagnostic entity, these cases were categorized as NOPPES.</p><p><strong>Results: </strong>Four cases of NOPPES were identified, 3 female patients and 1 male patient, aged between 58 and 75 years. Two patients were myopic, and 1 patient had a mild hyperopia. Three out of 4 cases showed unilateral peripapillary IRF, and 1 case had bilateral IRF. No improvement was seen after intravitreal bevacizumab or aflibercept, nepafenac eye drops, oral acetazolamide, vitrectomy with internal limiting membrane peeling, or surgery for carotid stenosis. One case showed a reduction in IRF after starting prednisolone eye drops.</p><p><strong>Conclusions: </strong>We describe NOPPES, a new form of peripapillary schisis-like IRF. NOPPES seems relatively therapy-resistant. More research is needed to delineate the clinical spectrum of NOPPES and its pathogenesis and treatment.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"614-621"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus Disease 2019 Pandemic and Infodemic: Separating the Signal From the Noise.","authors":"Kelvin H Wan, Nishant Vijay Radke, Raymond L M Wong, Jost B Jonas","doi":"10.1097/APO.0000000000000649","DOIUrl":"10.1097/APO.0000000000000649","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"12 6","pages":"507-508"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138795749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}