Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Association of residential air pollution with visual impairment in adults: The UK Biobank study.","authors":"Ebenezer Zaabaar, Yuzhou Zhang, Ka Wai Kam, Yingan Li, Xiu Juan Zhang, Mary Ho, Dong Liu, Mandy Ph Ng, Patrick Ip, Alvin Young, Chi Pui Pang, Clement C Tham, Mei-Po Kwan, Li Jia Chen, Jason C Yam","doi":"10.1016/j.apjo.2025.100209","DOIUrl":"10.1016/j.apjo.2025.100209","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association of joint exposure to residential air pollutants with different severities of visual impairment (VI) in adults.</p><p><strong>Methods: </strong>Exposure to particulate matter and oxides of nitrogen were evaluated in 95,246 adults aged 40-70 years. Joint exposure to the pollutants was calculated using principal component analysis to create an air pollution score. Subjects were categorized by distance visual acuity into bilateral normal vision, near normal vision, unilateral VI, socially significant VI, and blindness and low vision.</p><p><strong>Results: </strong>A unit rise in air pollution score was associated with 9.2 %, 4.1 %, and 1.8 % increased risks of blindness and low vision, adjusted OR (AOR) = 1.092 (95 % CI, 1.057-1.129); socially significant VI, AOR = 1.041 (95 % CI, 1.016-1.066); and unilateral VI, AOR = 1.018 (95 % CI, 1.007-1.029), respectively. Compared to subjects in the lowest quartile of air pollution score, those in the highest quartile had 69.2 %, 30.5 %, and 9.9 % greater risks of blindness and low vision, AOR = 1.692 (95 % CI, 1.355-2.114), socially significant VI, AOR = 1.305 (95 % CI, 1.127-1.513), and unilateral VI, AOR = 1.099 (95 % CI, 1.035-1.167), respectively while those in the third quartile had 40.5 % and 25.6 % higher risks of blindness and low vision, AOR = 1.405 (95 % CI, 1.121-1.760) and socially significant VI, AOR = 1.256 (95 % CI, 1.086-1.453), respectively. There was a significant trend of increasing risk of blindness and low vision, as well as socially significant VI, as pollution levels rose.</p><p><strong>Conclusion: </strong>Joint exposure to air pollutants increased the risks of poor vision and blindness, suggesting that reducing such exposure could alleviate the disease burden of VI.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100209"},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of the Japanese version of the Impact of Vision Impairment (IVI) questionnaire using Rasch analysis.","authors":"Saiko Matsumura, Eva K Fenwick, Momoko Kawakami, Seiji Takagi, Ecosse L Lamoureux, Yuichi Hori","doi":"10.1016/j.apjo.2025.100204","DOIUrl":"10.1016/j.apjo.2025.100204","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100204"},"PeriodicalIF":3.7,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital twins in ophthalmology: Concepts, applications, and challenges.","authors":"Kezheng Xu, Xiaolan Chen, Bowen Liu, Kai Jin, Mingguang He, Danli Shi","doi":"10.1016/j.apjo.2025.100205","DOIUrl":"10.1016/j.apjo.2025.100205","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100205"},"PeriodicalIF":3.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal toxicity after intracameral cefuroxime following cataract surgery.","authors":"Xuejuan Cheng, Lu Qiu, Fei Cong, Lei Gao","doi":"10.1016/j.apjo.2025.100206","DOIUrl":"10.1016/j.apjo.2025.100206","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100206"},"PeriodicalIF":3.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"24-month prospective randomized comparison of ab externo penetrating canaloplasty versus trabeculectomy in primary angle-closure glaucoma","authors":"Wenqing Ye ,&nbsp;Shaodan Zhang ,&nbsp;Shuqing Zhu ,&nbsp;Jinxin Li ,&nbsp;Juan Gu ,&nbsp;Mian Zhao ,&nbsp;Kaiting Jiang ,&nbsp;Yanqian Xie ,&nbsp;Rongrong Le ,&nbsp;Weihe Zhou ,&nbsp;Clement C. Tham ,&nbsp;Mingguang He ,&nbsp;Yuanbo Liang ,&nbsp;Ningli Wang","doi":"10.1016/j.apjo.2025.100167","DOIUrl":"10.1016/j.apjo.2025.100167","url":null,"abstract":"<div><h3>Purpose</h3><div>To report the 24-month efficacy and safety of ab externo penetrating canaloplasty compared with trabeculectomy in the treatment of primary angle-closure glaucoma (PACG).</div></div><div><h3>Methods</h3><div>This is a prospective, randomized, controlled trial. Patients with PACG and inadequately controlled intraocular pressure (IOP) were recruited. Patients enrolled were randomized to either ab externo penetrating canaloplasty (PCP group) or trabeculectomy (TRAB group). The main outcome measures were intraocular pressure (IOP), number of glaucoma medications, success rate and ocular surface disease index (OSDI) questionnaire. Surgical success (definition 1) was defined as 6 mm Hg ≤ IOP ≤ 21 mm Hg with an IOP reduction of ≥ 20 % without glaucoma medications (complete success) or regardless of glaucoma medications (qualified success).</div></div><div><h3>Results</h3><div>A total of 52 eyes (44 patients) were finally enrolled with 25 eyes in PCP group and 27 eyes in TRAB group. PCP group (85.0 %) had a similar qualified success rate compared with TRAB group (87.0 %) with definition 1 at 24 months in intention to treat (ITT) analysis (P = 1.000). In per protocol (PP) analysis, the qualified success with definition 1 were 81.3 % in PCP group and 87.0 % in TRAB group (P = 0.972). But PCP group had a lower success rate in postoperative IOP ≤ 15 mm Hg with an IOP reduction of ≥ 20 % than in TRAB group, in ITT analysis with complete success (PCP 35.0 % vs TRAB 65.2 %, P = 0.048) and PP analysis with qualified success (PCP 31.3 % vs. TRAB 69.6 %, P = 0.025). The mean OSDI score was equal in PCP group (11.9 ± 8.5) and TRAB group (16.6 ± 14.3) (P = 0.302). Hypotony-associated complications were the main complications in PCP group and TRAB group (24.0 % vs. 33.3 %, P = 0.458).</div></div><div><h3>Conclusions</h3><div>Compared with trabeculectomy, ab externo penetrating canaloplasty had a similar qualified success rate and comparable complications at 24 months. Without frequent bleb interventions, penetrating canaloplasty may be a promising surgery for PACG patients especially with early or mild stages.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100167"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term green space exposure and dry eye in China","authors":"Weijing Cheng ,&nbsp;Hanyou Wu ,&nbsp;Zhenyu Wang,&nbsp;Lingyi Liang","doi":"10.1016/j.apjo.2025.100165","DOIUrl":"10.1016/j.apjo.2025.100165","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the association between green space exposure and dry eye.</div></div><div><h3>Design</h3><div>Part I: case-control study. Part II: cross-sectional study.</div></div><div><h3>Methods</h3><div>Part I: The study contained 450 patients with dry eye and 900 controls recruited from Electronic Health Records. Logistic regression analysis was employed to investigate the relationship between green space exposure and the occurrence of dry eye. Part II: This study included 140 diabetic participants recruited from the community registry in Guangzhou, China. Linear regression analysis was used to assess the association between green space exposure and quantitative measures of the tear meniscus.</div></div><div><h3>Results</h3><div>Part I: A total of 1350 individuals were included in the study. On average individuals aged 31.07 ± 4.58 years and 59.33 % were female. Higher 10-year green space exposure was significantly associated with lower odds of dry eye (OR = 0.96; 95 % confidence interval [CI], 0.94, 0.97; p &lt; 0.001) after adjusting for age, sex, rainfall, temperature, particulate matter, and other factors. Part II: A total of 140 diabetic patients were included in the study. On average individuals aged 64.48 ± 8.19 years and 53.57 % were female. Greater 10-year green space exposure was associated with a higher tear meniscus area (β = 0.07, 95 % CI, 0.02, 0.11; p = 0.007) after adjusting for age, sex, rainfall, temperature, particulate matter, and other factors.</div></div><div><h3>Conclusions</h3><div>Our findings suggest an association between green space exposure and diagnosis of dry eye and tear meniscus, offering novel insights into the strategies for preventing dry eye.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100165"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic atrophy: Understanding the relationship between structure and function","authors":"Antoine Huang ,&nbsp;Zhichao Wu ,&nbsp;Georg Ansari ,&nbsp;Leon Von Der Emde ,&nbsp;Maximilian Pfau ,&nbsp;Steffen Schmitz-Valckenberg ,&nbsp;Monika Fleckenstein ,&nbsp;Tiarnán D.L. Keenan ,&nbsp;Srinivas R. Sadda ,&nbsp;Robyn H. Guymer ,&nbsp;Chui Ming Gemmy Cheung ,&nbsp;Usha Chakravarthy","doi":"10.1016/j.apjo.2025.100207","DOIUrl":"10.1016/j.apjo.2025.100207","url":null,"abstract":"<div><h3>Purpose</h3><div>This review explores the complex relationship between anatomical alterations and functional consequences in geographic atrophy (GA), the advanced non-neovascular form of age-related macular degeneration. We examine the natural history, progression patterns, structural biomarkers, functional assessments, and structure-function correlations in GA.</div></div><div><h3>Methods</h3><div>Experts contributed specialized knowledge on GA pathophysiology, imaging biomarkers, and functional assessment methods. We synthesized an understanding of the relationship between structural changes (including fundus autofluorescence patterns, optical coherence tomography markers, and novel biomarkers) and functional outcomes (visual acuity, microperimetry, reading performance, and patient-reported outcomes), drawing from authors' research expertise and relevant literature.</div></div><div><h3>Results</h3><div>While GA is defined by visible areas of outer retinal atrophy, the structure-function relationship is complex and often discordant. Visual acuity incompletely reflects the functional impact of GA, as it may remain preserved until foveal involvement occurs. Microperimetric assessments reveal functional deficits extending beyond visible atrophic borders, with varying degrees of correlation between structural and functional metrics. Different fundus autofluorescence patterns demonstrate distinct functional implications and progression rates. Recent innovations in imaging and visual function testing offer enhanced characterization of disease progression.</div></div><div><h3>Conclusions</h3><div>The complex relationship between structural and functional measures in GA reflects underlying pathophysiological mechanisms and has important implications for clinical trial endpoints and patient management. Multimodal assessment incorporating both structural and functional parameters is essential for the comprehensive evaluation and management of GA, particularly as novel therapeutic approaches emerge.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100207"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey: Practice patterns of intravitreal injection in Japan","authors":"Kazuki Matsuura,&nbsp;Shin-ichi Sasaki,&nbsp;Hidenori Inoue,&nbsp;Takafumi Mori,&nbsp;Kazunobu Sugihara","doi":"10.1016/j.apjo.2025.100169","DOIUrl":"10.1016/j.apjo.2025.100169","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100169"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"70 MHz ultrahigh frequency ultrasound imaging in spontaneous sclerocorneal fistula","authors":"Mathilde Kaspi ,&nbsp;Jean Luc Perrot ,&nbsp;Vincent Borderie ,&nbsp;Thibaud Garcin","doi":"10.1016/j.apjo.2025.100171","DOIUrl":"10.1016/j.apjo.2025.100171","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100171"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics","authors":"William Rojas-Carabali ,&nbsp;Kevin Chan ,&nbsp;Carlos Cifuentes-Gonzalez ,&nbsp;Manisha Agarwal ,&nbsp;Alok Sen ,&nbsp;Jyotirmay Biswas ,&nbsp;Ranju Kharel (Sitaula) ,&nbsp;Rina La Distia Nora ,&nbsp;Anna Utami ,&nbsp;Anadi Khatri ,&nbsp;Padmamalini Mahendradas ,&nbsp;Ariel Schlaen ,&nbsp;Chitaranjan Mishra ,&nbsp;Yan Guex-Crosier ,&nbsp;Edmund Tsui ,&nbsp;Apoorva Ayachit ,&nbsp;Sapna Gangaputra ,&nbsp;John H. Kempen ,&nbsp;Vishali Gupta ,&nbsp;Alejandra de-la-Torre ,&nbsp;Sagun Narayan Joshi","doi":"10.1016/j.apjo.2025.100199","DOIUrl":"10.1016/j.apjo.2025.100199","url":null,"abstract":"<div><h3>Purpose</h3><div>The Programme for Ocular Inflammation &amp; Infection Translational Research (PROTON) registry collects real-world data on infectious and non-infectious ocular inflammatory diseases (OID) to enhance understanding of disease progression and treatment outcomes. This report presents the baseline characteristics of patients enrolled in two international multicentric studies, OASIS 1 and OASIS 2, over the first two years.</div></div><div><h3>Design</h3><div>A cross-sectional observational study.</div></div><div><h3>Methods</h3><div>PROTON is an observational ambispective cohort registry comprising OASIS 1, a retrospective study (2000–2021), and OASIS 2, a prospective study (2021 onwards). Data is collected at multiple intervals over a 10-year period, focusing on various OID. Participants include patients diagnosed with anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis, scleritis, retinal vasculitis, and neuroretinitis. Baseline characteristics, ocular examinations, and treatment outcomes are recorded.</div></div><div><h3>Results</h3><div>A total of 2640 patients (3642 eyes) have been recruited across 17 centers worldwide. Infectious was the most common etiology (31.6 %), followed by idiopathic (28.1 %), undetermined (21.7 %), and non-infectious (16.0 %). Most patients (54.8 %) were male, with anterior uveitis being the most common anatomical location (37.5 %). Visual impairment was present in 53.2 % of cases, with 18.8 % experiencing moderate (0.5–1.0 LogMAR) and 22.6 % severe impairment (&gt;1.0 LogMAR). Tuberculosis (64.0 %) and toxoplasmosis (13.5 %) were the leading infectious causes, while HLA-B27-associated uveitis accounted for 19.4 % of non-infectious cases.</div></div><div><h3>Conclusions</h3><div>The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importance of research on this topic. As the registry evolves, it will help refine clinical management strategies and improve patient outcomes globally.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100199"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}