Asia-Pacific Journal of Ophthalmology最新文献

{"title":"International consensuses and guidelines on diagnosing and managing cytomegalovirus (CMV) retinitis by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Professors of Ophthalmology (AAPPO) and the Asia-Pacific Society of Ocular Inflammation and Infection (APSOII).","authors":"De-Kuang Hwang, Danny S C Ng, Zhuyun Qian, Rupesh Agrawal, Anita S Y Chan, Jay Chhablani, Pitipol Choopong, Vishali Gupta, Alessandro Invernizzi, Peter McCluskey, Christopher Seungkyu Lee, Sundaram Natarajan, Rina La Distia Nora, Vicente Victor Ocampo, Ramandeep Singh, Thanapong Somkijrungroj, Koh-Hei Sonoda, Wenbin Wei, Ian Y H Wong, Dennis S C Lam, Yong Tao","doi":"10.1016/j.apjo.2025.100248","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100248","url":null,"abstract":"<p><p>With the paradigm changes in antiviral therapy, there are a myriad of emerging controversies in the management of cytomegalovirus retinitis (CMVR). A certain extent of variability exists in the management of CMVR among clinical practices worldwide. Hence, alignment in the management strategy is important towards optimizing the care of CMVR. An international panel of experts (IPE) formulated consensus statements for CMVR regarding to its 1) diagnosis, 2) screening, 3) treatment, 4) management in special populations and 5) emerging technologies. The clinical diagnosis of CMVR relies on patient's susceptibility due to compromised immune function and characteristic fundus manifestations. Polymerase chain reaction (PCR) of intraocular fluid for detection of CMV is indicated when confirmation is necessary. Oral valganciclovir is the preferred first-line treatment, and intravitreal ganciclovir injection when CMVR threatens to involve the posterior pole. Cessation of maintenance treatment can be considered after 6 months when CMVR remains inactive with immune reconstitution. Immune recovery uveitis (IRU) must be distinguished from CMVR relapse. Screening is recommended for high risk cases. Utilization of telemedicine and artificial intelligence-aided interpretation will help to alleviate the resources required for CMVR screening. Evidence for novel antiviral and immunotherapy have been appraised as second-line treatment options.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100248"},"PeriodicalIF":4.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative endophthalmitis rate associated with routine off-label reuse of single-use phacoemulsification cassettes in more than 1,000,000 consecutive surgeries.","authors":"David F Chang, Aravind Haripriya","doi":"10.1016/j.apjo.2025.100247","DOIUrl":"10.1016/j.apjo.2025.100247","url":null,"abstract":"<p><p>According to a 2025 APAO survey, reuse of phacoemulsification tubing and cassettes appears to be more common in Asian-Pacific countries compared to Europe and North America. We analyzed the phacoemulsification postoperative endophthalmitis (POE) rate from 2016 to 2024 at the Aravind Eye Care System's 15 hospital network. Single-use phacoemulsification cassettes were routinely reused all day (off label) at every facility during this 9-year period. The POE rate was 0.01 % in 1,133,959 consecutive cases. This rate was consistent from year to year and compared favorably with contemporaneous POE data from the American Academy of Ophthalmology Intelligent Research in Sight (IRIS) Registry (0.06 %), where presumably no reuse of phacoemulsification cassettes would have been allowed. We found no evidence that reusing the same phacoemulsification tubing and cassette all day increased the rate of POE.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100247"},"PeriodicalIF":4.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misdiagnosed ocular perforating injury with direct traumatic optic neuropathy from gun pellet confirmed intraoperatively.","authors":"Thibaud Garcin, Mathilde Kaspi, Nacim Bouheraoua, Vincent Borderie","doi":"10.1016/j.apjo.2025.100246","DOIUrl":"10.1016/j.apjo.2025.100246","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100246"},"PeriodicalIF":4.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does semaglutide increase the risk of non-arteritic anterior ischemic optic neuropathy? A systematic review and meta-analysis of emerging evidence.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1016/j.apjo.2025.100245","DOIUrl":"10.1016/j.apjo.2025.100245","url":null,"abstract":"<p><strong>Background: </strong>Semaglutide, a GLP-1 receptor agonist widely prescribed for type 2 diabetes and obesity, has recently been linked to rare ocular adverse events, including non-arteritic anterior ischemic optic neuropathy (NAION). Given the growing concerns and limited clarity, this systematic review and meta-analysis aims to critically assess the potential association between semaglutide use and NAION risk.</p><p><strong>Objectives: </strong>To evaluate the association between semaglutide use and the development of NAION.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted via different databases from inception to June 3rd, 2025. A reviewer screened the potential articles against prespecified eligibility criteria. The risk of bias in the eligible studies was then evaluated using the Newcastle Ottawa Scale (NOS). Data were then systematically extracted and analyzed.</p><p><strong>Results: </strong>The database search yielded 3539 records, of which 10 research articles investigating the association between Semaglutide and NAION were included in this study. Semaglutide use was associated with a significantly increased risk of NAION compared to control medications, with a pooled hazard ratio of 2.620 (95 % CI: 1.808-3.795, P < 0.001). Risk elevation showed time-dependency, becoming statistically significant after 2 years of exposure. Identified risk factors included older age, male sex, prolonged diabetes duration, elevated HbA1c, diabetic retinopathy, and obesity. Among GLP-1 receptor agonists, semaglutide accounted for 86.5 % of reported NAION cases. Clinical presentations featured optic disc edema, intraretinal fluid on OCT, and crowded optic discs. Cumulative incidence rates were substantially higher in semaglutide users versus non-GLP-1 receptor agonist comparators.</p><p><strong>Conclusions: </strong>Semaglutide use shows association with increased NAION risk, particularly with prolonged exposure and in patients with predisposing factors. Risk-benefit assessment and targeted ophthalmologic monitoring are recommended while maintaining appropriate therapeutic use.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100245"},"PeriodicalIF":4.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversy and consensus on the management of ocular toxoplasmosis: A joint statement by the Asia-Pacific Society of Ocular Inflammation and Infection (APSOII), the Asia-Pacific Vitreo-Retina Society (APVRS), the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and The Infectious Uveitis Treatment Algorithm Network (TITAN) Group.","authors":"Ikhwanuliman Putera, Carlos Cifuentes-González, William Rojas-Carabali, Zheng Xian Thng, Sivaraman Bala Murugan, Rachel Song, Liang Yao, Rubens Belfort, Andre Curi, Nicholas Jones, Jennifer E Thorne, Rina La Distia Nora, Alejandra de-la-Torre, Rupesh Agrawal","doi":"10.1016/j.apjo.2025.100244","DOIUrl":"10.1016/j.apjo.2025.100244","url":null,"abstract":"<p><p>This international consensus effort, convened by The Infectious Uveitis Treatment Algorithm Network (TITAN) group, brought together 103 uveitis experts to address long-standing controversies in the management of ocular toxoplasmosis (OT), a leading cause of infectious posterior uveitis worldwide. Despite the availability of advanced diagnostic tools, variability persists in clinical decision-making. Controversies were identified from previous surveys on OT management, which served as the foundation for developing the survey questions in this study. Using a two-round modified Delphi method, experts reviewed evidence and rated recommendations across three domains: diagnosis and investigations, treatment, and follow-up management. Key consensus findings include support for antiparasitic therapy in most active cases, selective use of polymerase chain reaction (PCR) testing for atypical presentations, and prophylactic therapy in high-risk scenarios. These expert-derived consensus provide a framework for best practices in OT clinical management and highlight priorities for future prospective studies.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100244"},"PeriodicalIF":4.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APAO survey of cataract surgeons' attitudes toward operating room waste.","authors":"David F Chang, Wendy See","doi":"10.1016/j.apjo.2025.100243","DOIUrl":"10.1016/j.apjo.2025.100243","url":null,"abstract":"<p><strong>Purpose: </strong>To determine Asia Pacific cataract surgeons' attitudes toward surgical waste and toward reusing supplies and pharmaceuticals.</p><p><strong>Design: </strong>Multinational survey of APAO members METHODS: An online survey link was distributed to APAO members through their national ophthalmology societies. Responses were deidentified and compared with those from identical survey questionnaires previously distributed to North American and European cataract surgeons.</p><p><strong>Results: </strong>Of 2095 total respondents, most were concerned about climate change (94 %), felt cataract surgical waste was excessive (96 %), and felt we should reduce unnecessary waste by safely reusing more surgical supplies and devices (80 %). Most identified manufacturers and regulatory agencies as the biggest drivers of single use products, rather than surgeons and patients. Most surgeons wanted more reusable instruments and supplies (92 %) and wanted greater discretion from manufacturers (92 %) andpolicymakers (90 %) to reuse many supplies, drugs, and devices; 89 % wanted their medical societies to advocate for reducing the waste and carbon footprint of cataract surgery. Far more APAO respondents (59 %) were currently reusing single-use instruments compared to North Americans (7 %) and Europeans (14 %). Many APAO respondents were currently reusing phacoemulsification tubing/cassettes (41 %), irrigation solution bottles (50 %), and intraocular drug solutions (41-55 %); 42 % were currently not changing surgical gowns between cases. These percentages were all higher compared to North American and European respondents.</p><p><strong>Conclusions: </strong>These universal and consensus opinions and preferences about willingness to reuse many cataract surgical products should inform and influence pharmaceutical and supply manufacturers, governmental policy makers, and health care institutions, such as hospitals and surgical facilities.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100243"},"PeriodicalIF":4.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies, Consensuses and Guidelines on Etiology, Diagnosis, Treatment, and Future Developments of Neovascular Age-Related Macular Degeneration (nAMD) by the Asia-Pacific Vitreo-retina Society (APVRS), the Asia-Pacific Ocular Imaging Society (APOIS) and the Academy of the Asia-Pacific Professors of Ophthalmology (AAPPO).","authors":"Timothy Y Y Lai, Keiko Kataoka, Yi-Ting Hsieh, Rajendra S Apte, Muna Bhende, Andrew Chang, Voraporn Chiakitmongkol, Youxin Chen, Li Jia Chen, Gemmy C M Cheung, Jay Chhablani, Kenneth C S Fong, Robyn H Guymer, Fumi Gomi, Suber S Huang, Judy E Kim, Gregg T Kokame, Adrian Koh, Xiaoxin Li, Danny S C Ng, Annabelle A Okada, Nishant V Radke, Srinivas R Sadda, Mariko Sasaki, Sobha Sivaprasad, Mahesh P Shanmugam, Lalit Verma, Tien-Yin Wong, Xinyuan Zhang, Dennis S C Lam","doi":"10.1016/j.apjo.2025.100242","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100242","url":null,"abstract":"<p><p>Neovascular age-related degeneration (nAMD) is one of the leading causes of visual impairment in older populations in the developed world. With the aging population, the incidence of nAMD is growing globally. Despite advancements in diagnostic investigations and treatment modalities over the past three decades, there remains considerable controversies in the pathogenesis, classification and optimal management strategies. An international panel of 35 experts from 13 countries/regions prepared and voted on consensus statements in five key areas: 1) etiology controversies; 2) diagnosis controversies; 3) treatment controversies; 4) future development controversies; and 5) healthcare deliveries controversies. Among the 31 consensus statements, 28 (90.3%) have achieved over 75% agreement. These statements can provide a practical guide for ophthalmologists to provide the optimal care of patients with nAMD and for planning future research priorities in order to address the unmet needs in nAMD.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100242"},"PeriodicalIF":4.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital health as a scalable strategy for equitable myopia management in East Asia.","authors":"Junhan Chen, Deokho Lee, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara","doi":"10.1016/j.apjo.2025.100241","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100241","url":null,"abstract":"<p><p>East Asia is facing a growing burden of myopia, with pronounced disparities in access to eye care between urban and rural populations. Digital health technologies present a scalable and cost-effective alternative to traditional myopia interventions that enhance early detection, risk stratification, behavioral modification, and public education. Artificial intelligence-assisted screening tools, wearable monitors, and mHealth initiatives, such as the World Health Organization-International Telecommunication Union MyopiaEd program, have demonstrated effectiveness in improving myopia prevention and health education accessibility. However, achieving a sustained impact requires rigorous validation, robust data governance, infrastructure investment, and integration with established clinical strategies. East Asia could be well-positioned to pioneer a comprehensive digital model for equitable myopia control.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100241"},"PeriodicalIF":4.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of prolonged use of topical glaucoma medications on gonioscopy-assisted transluminal trabeculotomy outcomes in juvenile open-angle glaucoma.","authors":"Zhixuan Wang, Zefeng Yang, Sujv Liu, Jinkun Liu, Chengjie Huang, Xiaoming Zhu, Guangfu Dang, Xiao Yang, Xiaojing Pan, Longfang Zhou, Guangxian Tang, Hengli Zhang, Sujie Fan, Liming Tao, Haijun Li, Aiguo Lv, Heting Liu, Jing Ren, Xiaowei Yan, Xiaoyan Li, Yuting Gao, Yunhe Song, Fengbin Lin, Dilimulati Xiaokaiti, Xiaoyi Liu, Zige Fang, Ling Jin, Yu Chen, Lin Xie, Li Tang, Yuhong Wang, Liuzhi Zeng, Xiulan Zhang","doi":"10.1016/j.apjo.2025.100240","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100240","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of prolonged use of topical glaucoma medications on the surgical outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in juvenile open-angle glaucoma (JOAG).</p><p><strong>Patients and methods: </strong>This multicenter retrospective study included 100 eyes of 77 JOAG patients who underwent GATT with at least 12 months of follow-up. Patients were categorized into the short-duration (≤ 1.5 years) and long-duration (> 1.5 years) groups. Intraocular pressure (IOP), glaucoma medications, and complications were recorded at baseline and the final visit. Success was defined as a postoperative IOP ≤ 21 mmHg (criterion A), ≤ 18 mmHg (criterion B), or ≤ 15 mmHg (criterion C). Complete and qualified successes were defined as meeting these criteria without and with medications, respectively.</p><p><strong>Results: </strong>The mean age of the participants was 23.2 ± 8.6 years with a mean follow-up of 14.2 ± 4.1 months. Qualified and complete success rates for the short-duration and long-duration groups were 98.0 % and 92.0 % (P = 0.369), 80.0 % and 66.0 % (P = 0.322) for criterion A; 92.0 %, and 68.0 % (P = 0.006), 78.0 % and 50.0 % (P = 0.021) for criterion B; 66.0 % and 40.0 % (P = 0.013), 58.0 % and 30.0 % (P = 0.015) for criterion C. The short-duration group had a significantly lower final IOP than the long-duration group (P = 0.011). No significant differences were observed in final medication and complications.</p><p><strong>Conclusions: </strong>Prolonged use of topical glaucoma medications may reduce the efficacy of GATT in achieving lower IOP in JOAG. Early surgical intervention may contribute to better postoperative outcomes.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100240"},"PeriodicalIF":4.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144940408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foveal actual defect (FAD): A novel OCT biomarker for prognosis and surgical decision support in idiopathic full-thickness macular hole.","authors":"Andrii Ruban, Vitalyi Prudyus, Anna Zolnikova, Beáta Éva Petrovski, Goran Petrovski, Andrzej Grzybowski, Lyubomyr M Lytvynchuk","doi":"10.1016/j.apjo.2025.100232","DOIUrl":"10.1016/j.apjo.2025.100232","url":null,"abstract":"<p><strong>Background: </strong>The current classification of idiopathic full thickness macular holes (IFTMH) based on the minimum linear diameter (MLD) parameter does not provide the surgeon with accurate prognostic information regarding the surgical outcome.</p><p><strong>Purpose: </strong>To investigate whether the preoperative Foveal Actual Defect (FAD) can predict postoperative macular hole outcomes and could be a key point in new Decision Support System for IFTMHs surgery.</p><p><strong>Patients and methods: </strong>Fifty-seven eyes of fifty-three patients with iFTMH, who underwent 25-gauge PPV, ILM peeling and gas tamponade (GT) were recruited for this retrospective, consecutive case, interventional study. The choice of additional surgical techniques was determined individually depending on the size of the FAD. Surgery outcome-related factors were also assessed.</p><p><strong>Results: </strong>The primary closure rate was 94.7 % (54/57). Three eyes (5.3 %) with persistent MHs required an additional surgery. In all of these eyes, the MH closed after the second surgery. Mean BCVA (logMAR) significantly improved after surgery from 0.8 ± 0.3 (ME = 0.7; IQR: 0.5-1.0) to 0.1 ± 0.2; (ME = 0.1; IQR: 0.1-0.2) (P = 0.0001). There is a statistically significant difference (U = 78.0; Р = 0.05) in the preoperative FAD indicators between groups with a primary closed holes at the first day (ME = 217; IQR: 140-391) and unclosed holes (ME = 370; IQR: 222-697). The probability of MH closing by 14 days after surgery with FAD < 400 µm increases 1.3 times (RR = 1.3, 95 %CI: 1.0-1.6; φ = 0.4; P = 0.02). The MLD indicator in the primary hole closing group at first postop day did not statistically significantly different from those who did not close, but in the group with a primary closed holes at 14-th postop day the MLD indicator statistically significantly (U = 10.0; P = 0.005) was less (ME = 390; IQR: 277 - 492) compared to the unclosed holes (ME = 642; IQR: 558 - 866). There is a statistically significant correlation between postoperative BCVA at 6 month and preoperative OCT parameters: BD - ρ = 0.23 (P = 0.02), MLD - ρ = 0.34 (P = 0.005), FAD - ρ = 0.37 (P = 0.002). The regression model showed that PreopBCVA, FAD, and BD were statistically significant: PostBCVA = 0.22 × PreBCVA + 0.00001 × BD + 0.00001 × FAD (σPreBCVA = 0.05, σBD = 0.000006, σFAD = 0.000005, R² = 0.75, P < 0.01).</p><p><strong>Conclusion: </strong>The proposed Decision Support System based on a new preoperative OCT-parameter Foveal Actual Defect (FAD) allows a personalized assessment of macular hole surgery.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100232"},"PeriodicalIF":4.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}