Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Barriers to MIGS adoption among glaucoma specialists in India: Insights from a targeted survey.","authors":"Sahebaan Sethi, Shweta Tripathi, Maneesh Singh, Nagalekshmi Ganesh, Mayav Movdawalla, Shahinur Tayab","doi":"10.1016/j.apjo.2025.100195","DOIUrl":"10.1016/j.apjo.2025.100195","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100195"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and projections of the burden of visual impairment in Asia: Findings from the Global Burden of Disease Study 2021.","authors":"Shengsong Xu, Jianqi Chen, Xiao Wang, Xiaohua Zhuo, Yanbin Wang, Jinyi Xu, Chuqi Xiang, Mingxin Lu, Jingfeng Mu, Xiao Yang","doi":"10.1016/j.apjo.2025.100196","DOIUrl":"10.1016/j.apjo.2025.100196","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to examine the trends in the burden of visual impairment across Asia from 1990 to 2021 and to project the burden through 2040.</p><p><strong>Methods: </strong>This population-based study used data from the latest Global Burden of Disease 2021 study. Prevalence and years lived with disability (YLDs) were the main outcomes. The trends were analyzed by calculating the average annual percentage change (AAPC) using joinpoint regression analysis. The projection was performed by Bayesian age-period-cohort modeling.</p><p><strong>Results: </strong>The prevalence of visual impairment in Asia increased from 1990 to 2021, with AAPCs of 0.77 (95 % confidence interval [CI], 0.44-1.11), while YLD rates decreased with AAPCs of - 0.21 (95 % CI, - 0.38 to - 0.03). Near vision loss was the main contributor to visual impairment in Asia. Notably, the prevalence in the working-age population (20-54 years) increased significantly from 1990 to 2021 (AAPC = 2.11 [95 % CI, 1.70-2.53]), which was accord with the YLDs (AAPC = 1.07 [95 % CI, 0.83-1.32]), whereas for children and adolescents (< 20 years) and the elderly (≥ 55 years) it has decreased. According to the projection, the burden was predicted to significantly increase across all Asian sub-regions, especially in East Asia and South Asia.</p><p><strong>Conclusion: </strong>The burden of visual impairment in Asia has been substantially increasing from 1990 to 2021. This trend is anticipated to persist significantly soon, especially in East Asia and South Asia, underlining the urgent need for concentrated attention and robust policy support for these regions.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100196"},"PeriodicalIF":3.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flourishing index measures among ophthalmologists in the Asia-Pacific region.","authors":"Joanna Ng, Loh Kai-Lyn, Marvinash Rao, Nazli Gul, Arjun Shrestha, Ng Hong Kee, Raymond N Regalado, Anna Cs Tan, Claire L Peterson, Rachel S Chong","doi":"10.1016/j.apjo.2025.100193","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100193","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100193"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long anterior lens zonules in cataract surgery.","authors":"Jiancheng Mu, Feng Xu, Wei Fan","doi":"10.1016/j.apjo.2025.100194","DOIUrl":"10.1016/j.apjo.2025.100194","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100194"},"PeriodicalIF":3.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Saffron Repron® in counteracting the progression of retinitis pigmentosa: Neuroprotection and resilience.","authors":"Francesca Corsi, Alessia Galante, Maria Anna Maggi, Raffaele Mazziotti, Silvia Bisti, Ilaria Piano, Claudia Gargini","doi":"10.1016/j.apjo.2025.100192","DOIUrl":"10.1016/j.apjo.2025.100192","url":null,"abstract":"<p><p>The mutations observed in the various forms of retinitis pigmentosa (RP) affect genes coding for rod-specific proteins and direct the progression of different forms of dystrophy toward total blindness. The present investigation aims to explore the protective effects of Saffron Repron®, in a mouse model of RP. Saffron was administered orally to pregnant females and weaned pups for 120 days. At different time points (P30, P60, P90, and P120), visual function, retinal function, cone lifespan, morphology, gene expression, and protein level were analyzed. The results indicate that chronic saffron treatment effectively slows the progression of long-term damage caused by genetic mutations in both the morphology and function of retinal neurons. Cellular mechanisms responsible for this action appear complex and, probably, due to coordinated and synergistic activities by its chemical components. Here we provide evidence that saffron is able to modulate the epigenetic pathway involved in neuroinflammation. Biochemical and molecular measures suggest that early saffron treatment may induce a form of adaptation known as acquired resilience.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100192"},"PeriodicalIF":3.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced visualization and removal of epithelial ingrowth after SMILE and LASIK using a fiberoptic illuminator.","authors":"Yi-Ting Hou, Le-Yu Chen, I-Hung Lin, Wei-Li Chen","doi":"10.1016/j.apjo.2025.100172","DOIUrl":"10.1016/j.apjo.2025.100172","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100172"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperreflective foci and subretinal fluid predicts microglia activation involved in the breakdown of outer blood-retinal barrier in treatment-naïve patients with diabetic macular edema.","authors":"Yiyang Shu, Chaoyang Zhang, Yanlong Bi, Jingfa Zhang","doi":"10.1016/j.apjo.2025.100168","DOIUrl":"10.1016/j.apjo.2025.100168","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the correlation between hyperreflective foci (HRF), the biomarker of activated microglia, and subretinal fluid (SRF), representing the dysfunction of retinal pigment epithelium (RPE), in treatment-naïve patients with diabetic macular edema (DME).</p><p><strong>Methods: </strong>Sixty-one treatment-naïve patients (61 eyes) with DME were included in the research. Participants were divided into two categories based on the presence or absence of SRF. Basic characteristics were recorded. The parameters, including the HRF number in inner and outer retina, central macular thickness (CMT), intraretinal cyst (IRC), as well as the width, height and area of SRF, were analyzed with optical coherence tomography angiography (OCTA). The correlations between HRF and the parameters including SRF, IRC and CMT were analyzed accordingly.</p><p><strong>Results: </strong>The mean CMT in DME with SRF group was much thicker than that in DME without SRF group (P < 0.0001). The mean HRF number in the outer retina and whole retina was markedly higher in DME patients with the presence of IRC or SRF when compared to those without IRC or SRF (P < 0.05). Further analysis showed that the width, height and area of SRF were positively correlated with the HRF number in the outer retina and the ratio of outer/whole retina HRFs (P < 0.05).</p><p><strong>Conclusion: </strong>The positive correlation between the increased number of HRF, especially in the outer retina, and the formation of SRF in patients with DME supports the hypothesis that microglia activation represented by HRF might cause the dysfunction of RPE and the breakdown of the outer blood-retinal barrier (oBRB), which leads to the increased fluid leakage in subretinal space.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100168"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent polypoidal lesions after achieving inactive polypoidal choroidal vasculopathy following 1-year fixed-dosing aflibercept treatments","authors":"Voraporn Chaikitmongkol ,&nbsp;Wantip Tadadoltip ,&nbsp;Direk Patikulsila ,&nbsp;Titipol Srisomboon ,&nbsp;Chanusnun Narongchai ,&nbsp;Janejit Choovuthayakorn ,&nbsp;Nawat Watanachai ,&nbsp;Paradee Kunavisarut ,&nbsp;Apisara Sangkaew ,&nbsp;Phit Upaphong ,&nbsp;Neil M. Bressler","doi":"10.1016/j.apjo.2025.100176","DOIUrl":"10.1016/j.apjo.2025.100176","url":null,"abstract":"<div><h3>Purpose</h3><div>Polypoidal choroidal vasculopathy (PCV) may have frequent recurrences after fluid resolution, but time to recurrence is unclear. This study explored time to first polypoidal recurrence after 1-year fixed-dosing aflibercept treatments.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Methods</h3><div>Treatment-naïve PCV eyes treated between April 2015 to May 2019 were identified and included with criteria including: (1) received fixed-dosing 2 mg aflibercept in the first year, (2) became “inactive” (absence of both intraretinal and subretinal fluid on OCT) at post-treatment year-1 (PTY1) and managed as needed (PRN) thereafter, (3) FU ≥ 12 months after PTY1. Fundus photography, indocyanine green angiography (ICGA), and OCT graded to identify timing and risk factors for recurrence (defined as fluid on OCT).</div></div><div><h3>Results</h3><div>Of 37 study eyes [37 patients; median age was 64 years (IQR 59–69); median aflibercept injection number was 8 (IQR 8–8); median FU 38 months (IQR, 30–50 months)]; 18 eyes (49 %) had recurrence during FU. Fourteen (78 %) of 18 had recurrence within 12 months after PTY1 visit. Risk factors for recurrence included: incomplete polypoidal regression on post-treatment ICGA [<em>P</em> = .004, Hazard ratio (HR) = 4.4, 95 % confidence interval (CI) 1.6–11.9] and PED with internal heterogeneous reflectivity on post-treatment OCT (<em>P</em> = .04, HR = 2.7, 95 % CI 1.1–6.9).</div></div><div><h3>Conclusions</h3><div>Nearly half of inactive PCV eyes following 1-year fixed-dosing aflibercept treatments had recurrent polypoidal lesions. Eyes with high-risk features for recurrence, some of which can be detected with OCT without the need for ICGA, may warrant close monitoring.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100176"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing generative AI in ophthalmic medical paper writing: Applications, limitations, and practical tools","authors":"Fang-Yu Hu ,&nbsp;Le-Yu Chen ,&nbsp;Pin-Jung Cheng,&nbsp;Jen-Yu Liu,&nbsp;Jo-Hsuan Wu,&nbsp;Wei-Li Chen","doi":"10.1016/j.apjo.2025.100174","DOIUrl":"10.1016/j.apjo.2025.100174","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100174"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in choroidal thickness in pre-myopic children after repeated low-level red-light therapy and their role in predicting myopia prevention and controlling myopic shift","authors":"Kaidi Xiang ,&nbsp;Jingjing Wang ,&nbsp;Zhuoting Zhu ,&nbsp;Xinzi Zhang ,&nbsp;Bo Zhang ,&nbsp;Jun Chen ,&nbsp;Jinliuxing Yang ,&nbsp;Linlin Du ,&nbsp;Zhijian Ai ,&nbsp;Xiangui He ,&nbsp;Xun Xu","doi":"10.1016/j.apjo.2024.100115","DOIUrl":"10.1016/j.apjo.2024.100115","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate longitudinal changes in choroidal thickness (ChT) after 1-year treatment of repeated low-level red-light (RLRL) and their predictive value in efficacy on myopia prevention and myopic shift among pre-myopic children.</div></div><div><h3>Methods</h3><div>278 pre-myopic (-0.50 D &lt; spherical equivalent refraction, SER ≤ 0.50 D) participants were assigned to the RLRL group and control group randomly and evenly. The OCT, visual acuity, AL, SER and other parameters were measured before enrollment and every 3 months after intervention. The data from both eyes of the included participants were analyzed.</div></div><div><h3>Results</h3><div>A total of 463 eyes were analyzed. Due to the COVID-19 pandemic, 176 participants in the RLRL group had treatment interrupted. The continued RLRL group, interrupted RLRL group and control group were well balanced in baseline characteristics. In the continued and interrupted RLRL group, the average ChT increased significantly at 3-month visit (all <em>P</em> &lt; 0.001) and the subfoveal ChT thickened evidently. The area under the curve (AUC) for the models including gender and 3-month change in ChT to predict satisfactory myopia prevention at 12 months was 0.983. The efficacy of the models that also used the combined indicators of baseline age, gender and the 3-month change in ChT to predict AL progression control over 12 months reached 0.944.</div></div><div><h3>Conclusions</h3><div>Continued RLRL intervention induced notable thickening of ChT in premyopic population, especially at the subfoveal sector. For participants received RLRL treatment, the 3-month change in ChT combined with other baseline factors have acceptable predictive discrimination of myopia prevention efficacy.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100115"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}