Asia-Pacific Journal of Ophthalmology最新文献_第2页

Outdoor activity during class recess prevents myopia onset and shift in premyopic children: Subgroup analysis in the recess outside classroom study. 课间休息时的户外活动可以预防近视儿童的近视发生和转移：课间休息研究的亚组分析

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-11 DOI: 10.1016/j.apjo.2025.100140

Pei-Chang Wu, Chia-Ling Tsai, Yi-Hsin Yang

{"title":"Outdoor activity during class recess prevents myopia onset and shift in premyopic children: Subgroup analysis in the recess outside classroom study.","authors":"Pei-Chang Wu, Chia-Ling Tsai, Yi-Hsin Yang","doi":"10.1016/j.apjo.2025.100140","DOIUrl":"10.1016/j.apjo.2025.100140","url":null,"abstract":"Purpose: To investigate whether premyopia is a risk factor for myopia onset and whether outdoor activities can protect against myopia development in premyopic children in the Recess Outside Classroom (ROC) study.Methods: Nonmyopic schoolchildren aged 7-11 years were recruited from two schools in Taiwan. One school implemented the ROC program, which encouraged children to go outdoors during recess. The control school maintained its usual schedule. A cycloplegic autorefraction was performed. Premyopia was defined as spherical equivalent refraction ≤ +0.75 diopters (D) and > -0.50 D.Results: After one year of follow-up, multivariate logistic analysis revealed that the ROC program reduced the risk of myopia onset by 61 % (odds ratio [OR] = 0.39, 95 % confidence interval [CI]: 0.21-0.70, P = 0.002). However, premyopia status increased the risk of myopia onset by 14 times compared to hyperopic status (OR = 14.0, 95 % CI: 1.86-105.3, P = 0.010). In the subgroup analysis of premyopic children, the myopic shift was also significantly lower in the ROC group than in the control group (-0.20 ± 0.60 D/year vs. -0.40 ± 0.66 D/year, P = 0.017). Myopia incidence in premyopic children was significantly lower in the ROC group than in the control group (19.6 % vs. 37.8 %, P = 0.001). Multivariate regression analysis showed that participation in the ROC program was significantly associated with a lower myopic shift in premyopic children (-0.22 D/year, 95 % CI: -0.39 to -0.06, P = 0.008) CONCLUSIONS: Premyopia is a risk factor for myopia onset. A school policy that includes more outdoor time can effectively prevent myopia onset and shift in premyopic children.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100140"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of substitutive growth hormone therapy on myopia control among Chinese children. 替代生长激素治疗对中国儿童近视控制的影响。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI: 10.1016/j.apjo.2025.100137

Yi Lu, Jiamin Xie, Lele Cheng, Qingdong Fu, Miao Wu, Ji Jin, Xun Xu

{"title":"Effect of substitutive growth hormone therapy on myopia control among Chinese children.","authors":"Yi Lu, Jiamin Xie, Lele Cheng, Qingdong Fu, Miao Wu, Ji Jin, Xun Xu","doi":"10.1016/j.apjo.2025.100137","DOIUrl":"10.1016/j.apjo.2025.100137","url":null,"abstract":"Purpose: To explore the correlation between recombinant human growth hormone (rhGH) therapy and myopia progression, and to optimize the myopia control strategies in myopic children undergoing rhGH therapy.Methods: This retrospective study included 27 myopic children receiving rhGH therapy and 57 myopic children in the control group, all of whom underwent myopia interventions. Axial length (AL) and refraction were measured by IOLMaster and an autorefractor after cycloplegia. AL changes were compared between the rhGH and control groups, before and after rhGH therapy, and among different myopia control strategies. Univariate and multivariate regression models analyzed factors associated with axial elongation.Results: The rhGH group exhibited greater median AL change than the control group (0.29 mm/year; interquartile range [IQR], 0.19-0.40; n = 27 vs. 0.18 mm/year; IQR, 0.12-0.27; n = 57; P < 0.001). Median axial elongation increased after rhGH treatment (0.22 mm/year; IQR, 0.12-0.34 vs. 0.32 mm/year; IQR, 0.26-0.40; n = 14; P = 0.026), while it decreased after cessation (0.39 mm/year; IQR, 0.16-0.56 vs. 0.04 mm/year; IQR, -0.03-0.15; n = 6; P = 0.031). After adjusting for confounders, axial elongation was faster in the rhGH group (β = 0.13, P < 0.001). Longer rhGH therapy duration and shorter myopia control duration were associated with accelerated axial elongation (β = 0.13, P = 0.027). Dual-therapy myopia control appeared to mitigate excessive axial elongation in rhGH-treated children more effectively than monotherapy (0.27 mm/year; IQR, 0.18-0.31; n = 20 vs. 0.40 mm/year; IQR, 0.32-0.70; n = 7; P = 0.026).Conclusions: Myopic children undergoing rhGH therapy would exhibit accelerated axial elongation despite myopia control. Close monitoring and dual-therapy myopia control strategies are recommended for these children.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100137"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous drainage of a large valsalva premacular hemorrhage. 大面积斑前出血的自然引流。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1016/j.apjo.2025.100145

Dezhi Zheng, Zijing Huang

引用次数: 0

Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation. 法昔单抗治疗新生血管性年龄相关性黄斑变性患者的疗效、耐久性和安全性：LUCERNE中国3期亚群48周的结果

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI: 10.1016/j.apjo.2025.100142

Wenjun Zou, Qin Jiang, Yanling Wang, Wenbin Wei, Xiaodong Sun, Karen Basu, Qiuyu Chen, Aachal Kotecha, Sijing Li, Ruyuan Liu, Vaibhavi Patel, Youxin Chen

{"title":"Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation.","authors":"Wenjun Zou, Qin Jiang, Yanling Wang, Wenbin Wei, Xiaodong Sun, Karen Basu, Qiuyu Chen, Aachal Kotecha, Sijing Li, Ruyuan Liu, Vaibhavi Patel, Youxin Chen","doi":"10.1016/j.apjo.2025.100142","DOIUrl":"10.1016/j.apjo.2025.100142","url":null,"abstract":"Purpose: To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.Design: LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.Methods: Treatment-naïve patients aged ≥50 years with nAMD were randomized 1:1 to receive faricimab 6.0 mg up to every 16 weeks (Q16W) based on prespecified disease criteria after four initial Q4W doses or aflibercept 2.0 mg Q8W after three initial Q4W doses. The primary endpoint was mean change from baseline in best-corrected visual acuity (BCVA) averaged over weeks 40 to 48. Anatomical, durability and safety outcomes were also evaluated.Results: The China subpopulation comprised 119 patients (faricimab: n = 59, aflibercept: n = 60). At weeks 40 to 48, adjusted mean (95% confidence interval [CI]) BCVA letter gains from baseline were +9.7 (7.4 to 12.0) and +9.8 (7.5 to 12.1) with faricimab and aflibercept, respectively. Central subfield thickness was reduced from baseline by weeks 40 to 48 in both arms, with an adjusted mean (95% CI) change of -145.4 µm (-156.2 to -134.6) and -156.5 µm (-167.3 to -145.7) for faricimab and aflibercept, respectively. By week 48, 87.3% of the patients were on extended ≥Q12W faricimab dosing. Faricimab was well tolerated with no new safety signals.Conclusions: Faricimab up to Q16W showed durable efficacy in the LUCERNE China subpopulation, consistent with global findings. Faricimab may reduce treatment burden for patients with nAMD in China, without compromising efficacy.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100142"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus and guidelines on diagnosis and management of polypoidal choroidal vasculopathy (PCV) from the Asia-Pacific Vitreo-retina Society (APVRS). 亚太玻璃体视网膜学会（APVRS）关于息肉样脉络膜血管病变（PCV）诊断和治疗的共识和指南。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-15 DOI: 10.1016/j.apjo.2025.100144

Paisan Ruamviboonsuk, Danny S C Ng, Voraporn Chaikitmongkol, Andrew Chang, Shih-Jen Chen, Youxin Chen, Chui Ming Gemmy Cheung, Fumi Gomi, Robyn Guymer, Judy E Kim, Adrian Koh, Gregg T Kokame, Chi-Chun Lai, Timothy Y Y Lai, Won Ki Lee, Yuichiro Ogura, Srinivas Sadda, Kelvin Y C Teo, Tien Yin Wong, Yasuo Yanagi, Dennis S C Lam

{"title":"Consensus and guidelines on diagnosis and management of polypoidal choroidal vasculopathy (PCV) from the Asia-Pacific Vitreo-retina Society (APVRS).","authors":"Paisan Ruamviboonsuk, Danny S C Ng, Voraporn Chaikitmongkol, Andrew Chang, Shih-Jen Chen, Youxin Chen, Chui Ming Gemmy Cheung, Fumi Gomi, Robyn Guymer, Judy E Kim, Adrian Koh, Gregg T Kokame, Chi-Chun Lai, Timothy Y Y Lai, Won Ki Lee, Yuichiro Ogura, Srinivas Sadda, Kelvin Y C Teo, Tien Yin Wong, Yasuo Yanagi, Dennis S C Lam","doi":"10.1016/j.apjo.2025.100144","DOIUrl":"10.1016/j.apjo.2025.100144","url":null,"abstract":"A panel of 21 international experts are formed by the Asia-Pacific Vitreo-retina Society to work out the consensus and guidelines on polypoidal choroidal vasculopathy (PCV). PCV is a common subtype of neovascular age-related macular degeneration and is more prevalent in Asian populations. Recent advancement in imaging technology allows greater understanding of the disease process of PCV. Furthermore, non-indocyanine green angiography features in optical coherence tomography angiography have been validated for PCV diagnosis and treatment response monitoring. Clinical trials provide new data on the safety and efficacy of various anti-vascular endothelial growth factor (anti-VEGF) agents as well as protocols that aim to improve the sustainability of treatments. In view of the myriads of emerging information, the panel gathered, reviewed, discussed, formulated and voted on the consensus and guidelines of PCV on four areas: 1) disease entity, 2) investigation and diagnosis, 3) treatment options, and 4) management protocol and future development in a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). We proposed using a consensus score in which the maximum was 100. The summation of the respective \"percentages\" of experts voting for \"agree\" or \"strongly agree\" would be counted as the actual score. Consensus was achieved when the actual score of 75 or more was reached, which meant at least 75 % of the experts had voted for \"strongly agree\" or \"agree\" on the consensus statement concerned.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100144"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definition for consensus statement much needed. 非常需要共识声明的定义。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2025-01-01 Epub Date: 2025-01-13 DOI: 10.1016/j.apjo.2025.100141

Xianqun Fan, Clement C Tham, Christopher K S Leung, Jost B Jonas

引用次数: 0

Changes in choroidal thickness in pre-myopic children after repeated low-level red-light therapy and their role in predicting myopia prevention and controlling myopic shift. 反复低强度红光治疗后近视前期儿童脉络膜厚度的变化及其在预测近视预防和控制近视移位中的作用

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-12-01 DOI: 10.1016/j.apjo.2024.100115

Kaidi Xiang, Jingjing Wang, Zhuoting Zhu, Xinzi Zhang, Bo Zhang, Jun Chen, Jinliuxing Yang, Linlin Du, Zhijian Ai, Xiangui He, Xun Xu

{"title":"Changes in choroidal thickness in pre-myopic children after repeated low-level red-light therapy and their role in predicting myopia prevention and controlling myopic shift.","authors":"Kaidi Xiang, Jingjing Wang, Zhuoting Zhu, Xinzi Zhang, Bo Zhang, Jun Chen, Jinliuxing Yang, Linlin Du, Zhijian Ai, Xiangui He, Xun Xu","doi":"10.1016/j.apjo.2024.100115","DOIUrl":"10.1016/j.apjo.2024.100115","url":null,"abstract":"Purpose: To investigate longitudinal changes in choroidal thickness (ChT) after 1-year treatment of repeated low-level red-light (RLRL) and their predictive value in efficacy on myopia prevention and myopic shift among pre-myopic children.Methods: 278 pre-myopic (-0.50 D < spherical equivalent refraction, SER ≤ 0.50 D) participants were assigned to the RLRL group and control group randomly and evenly. The OCT, visual acuity, AL, SER and other parameters were measured before enrollment and every 3 months after intervention. The data from both eyes of the included participants were analyzed.Results: A total of 463 eyes were analyzed. Due to the COVID-19 pandemic, 176 participants in the RLRL group had treatment interrupted. The continued RLRL group, interrupted RLRL group and control group were well balanced in baseline characteristics. In the continued and interrupted RLRL group, the average ChT increased significantly at 3-month visit (all P < 0.001) and the subfoveal ChT thickened evidently. The area under the curve (AUC) for the models including gender and 3-month change in ChT to predict satisfactory myopia prevention at 12 months was 0.983. The efficacy of the models that also used the combined indicators of baseline age, gender and the 3-month change in ChT to predict AL progression control over 12 months reached 0.944.Conclusions: Continued RLRL intervention induced notable thickening of ChT in premyopic population, especially at the subfoveal sector. For participants received RLRL treatment, the 3-month change in ChT combined with other baseline factors have acceptable predictive discrimination of myopia prevention efficacy.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100115"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Axial elongation in nonpathologic high myopia: Ocular structural changes and glaucoma diagnostic challenges. 非病理性高度近视的眼轴伸长：眼部结构改变和青光眼诊断挑战。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-12-16 DOI: 10.1016/j.apjo.2024.100123

Kangjie Kong, Xiaoyi Liu, Zige Fang, Jingwen Jiang, Jiaxuan Jiang, Deming Wang, Zefeng Yang, Fengqi Zhou, Evan M Chen, Jill Liang, Yunhe Song, Fengbin Lin, Kyoko Ohno-Matsui, Jost B Jonas, Ying Han, Fei Li, Xiulan Zhang

{"title":"Axial elongation in nonpathologic high myopia: Ocular structural changes and glaucoma diagnostic challenges.","authors":"Kangjie Kong, Xiaoyi Liu, Zige Fang, Jingwen Jiang, Jiaxuan Jiang, Deming Wang, Zefeng Yang, Fengqi Zhou, Evan M Chen, Jill Liang, Yunhe Song, Fengbin Lin, Kyoko Ohno-Matsui, Jost B Jonas, Ying Han, Fei Li, Xiulan Zhang","doi":"10.1016/j.apjo.2024.100123","DOIUrl":"10.1016/j.apjo.2024.100123","url":null,"abstract":"Axial elongation continues in highly myopic adult eyes, even in the absence of pathologic changes such as posterior staphyloma or chorioretinal atrophy. This ongoing axial elongation leads to structural changes in the macular and peripapillary regions, including chorioretinal thinning, reduced vascular perfusion and optic disc tilting and rotation, among others. These alterations can affect the acquisition and interpretation of optical coherence tomography, optical coherence tomography angiography and fundus photographs, potentially introducing artifacts and diminishing the accuracy of glaucoma diagnosis in highly myopic eyes. In this review, we compared the progression patterns of axial elongation across populations with varying demographic characteristics, genetic and environmental backgrounds and ocular features. We also discussed the implications of axial elongation-induced ocular structural changes for diagnosing glaucoma in nonpathologic high myopia. Finally, we highlighted the prospects for enhancing the diagnostic efficacy of glaucoma in nonpathologic highly myopic populations.","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100123"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid-onset central retinal vein occlusion following inactivated COVID-19 vaccination. 灭活COVID-19疫苗接种后快速发作的视网膜中央静脉闭塞。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-12-06 DOI: 10.1016/j.apjo.2024.100118

Yuchen Zhang, Hao Zhou, Suqin Yu, Chong Chen

引用次数: 0

Bilateral Coats' disease in a 5-year-old boy. 1例5岁男童双侧科茨病。

IF 3.7 3区医学

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-12-05 DOI: 10.1016/j.apjo.2024.100119

Meng-Chen Chiang, Shawn H Tsai, Nan-Kai Wang, Yung-Jen Lai

引用次数: 0