Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics.","authors":"William Rojas-Carabali, Kevin Chan, Carlos Cifuentes-Gonzalez, Manisha Agarwal, Alok Sen, Jyotirmay Biswas, Ranju Kharel Sitaula, Rina La Distia Nora, Anna Utami, Anadi Khatri, Padmamalini Mahendradas, Ariel Schlaen, Chitaranjan Mishra, Yan Guex-Crosier, Edmund Tsui, Apoorva Ayachit, Sapna Gangaputra, John H Kempen, Vishali Gupta, Alejandra de-la-Torre, Bernett Lee, Rupesh Agrawal","doi":"10.1016/j.apjo.2025.100199","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100199","url":null,"abstract":"<p><strong>Purpose: </strong>The Programme for Ocular Inflammation & Infection Translational Research (PROTON) registry collects real-world data on infectious and non-infectious ocular inflammatory diseases (OID) to enhance understanding of disease progression and treatment outcomes. This report presents the baseline characteristics of patients enrolled in two international multicentric studies, OASIS 1 and OASIS 2, over the first two years.</p><p><strong>Design: </strong>A cross-sectional observational study.</p><p><strong>Methods: </strong>PROTON is an observational ambispective cohort registry comprising OASIS 1, a retrospective study (2000-2021), and OASIS 2, a prospective study (2021 onwards). Data is collected at multiple intervals over a 10-year period, focusing on various OID. Participants include patients diagnosed with anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis, scleritis, retinal vasculitis, and neuroretinitis. Baseline characteristics, ocular examinations, and treatment outcomes are recorded.</p><p><strong>Results: </strong>A total of 2640 patients (3642 eyes) have been recruited across 17 centers worldwide. Infectious was the most common etiology (31.6 %), followed by idiopathic (28.1 %), undetermined (21.7 %), and non-infectious (16.0 %). Most patients (54.8 %) were male, with anterior uveitis being the most common anatomical location (37.5 %). Visual impairment was present in 53.2 % of cases, with 18.8 % experiencing moderate (0.5-1.0 LogMAR) and 22.6 % severe impairment (>1.0 LogMAR). Tuberculosis (64.0 %) and toxoplasmosis (13.5 %) were the leading infectious causes, while HLA-B27-associated uveitis accounted for 19.4 % of non-infectious cases.</p><p><strong>Conclusions: </strong>The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importance of research on this topic. As the registry evolves, it will help refine clinical management strategies and improve patient outcomes globally.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100199"},"PeriodicalIF":3.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panretinal photocoagulation during vitrectomy for diabetic vitreous hemorrhage: A clinical trial comparing endolaser application amounts.","authors":"Ryan B Rush, Pedro Luis Gomez, Pedro Gomez Bastar, Sloan W Rush","doi":"10.1016/j.apjo.2025.100197","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100197","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of different endolaser photocoagulation treatment amounts during pars plana vitrectomy (PPV) in patients with a vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR).</p><p><strong>Design: </strong>Randomized clinical trial METHODS: One hundred and forty-four treatment-naïve PDR patients with an ocular media-obscuring VH were enrolled into this clinical trial. Participants were randomized into one of two possible treatment groups: Group A subjects underwent PPV and received 250 + /- 50 endolaser applications during surgery, while Group B subjects underwent PPV and received 550 + /- 50 endolaser applications during surgery. The primary outcome was the rate of postoperative VH, and the secondary outcome was visual acuity at 6 months.</p><p><strong>Results: </strong>Ninety-one patients underwent PPV and completed the 6-month trial period. Group A had 30.0 % (15/50) of participants develop a postoperative VH, while Group B had 12.2 % (5/41) of subjects develop a postoperative VH at 6 months (P = 0.002). The visual acuity of 0.4 (0.23-0.57) logMAR (Snellen 20/50) in Group B was better than that of 0.79 (0.58-1.01) logMAR (Snellen 20/120) in Group A at the end of the 6 month trial period (P = 0.006).</p><p><strong>Conclusions: </strong>Treatment-naïve PDR subjects undergoing PPV for an ocular media-obscuring VH have a lower incidence of postoperative VH and better visual acuity at 6 months when 550 + /- 50 endolaser applications were administered compared to 250 + /- 50 endolaser applications during PPV. Further research is warranted on this topic to verify the generalizability of these findings to a broader PDR population.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100197"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the accuracy of twenty intraocular lens power calculation formulas in long eyes.","authors":"Wiktor Stopyra, Oleksiy Voytsekhivskyy, Andrzej Grzybowski","doi":"10.1016/j.apjo.2025.100198","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100198","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the accuracy of twenty intraocular lens (IOL) power calculation formulas in long eyes (26.00-29.99 mm) DESIGN: Retrospective accuracy and validity analysis METHODS: The data of patients who underwent uneventful phacoemulsification between August 2019 and July 2024 were reviewed. Pre-surgery IOL power was calculated using Haigis, Holladay 2, SRK/T and Barrett Universal II formulas. Three months after cataract surgery, refraction was measured. Post-surgery IOL power calculations were performed utilizing the following formulas: Castrop, EVO 2.0, Hill-RBF 3.0, Hoffer Q, Holladay 1, Hoffer QST, K6, Kane, Karmona, Ladas Super Formula AI (LSF AI), Naeser 2, Olsen (standalone), PEARL-DGS, T2, VRF and VRF-G. Root mean square absolute error (RMSAE), median absolute error (MedAE) and percentage of eyes with prediction error (PE) within ± 0.25 D, ± 0.50 D, ± 0.75 D and ± 1.00 were calculated.</p><p><strong>Results: </strong>One hundred fifty-three eyes with axial length ranging between 26.00 mm and 29.47 mm, were studied. The SRK/T formula yielded the lowest RMSAE (0.349) with statistical superiority over Holladay 1 (0.519, P = 0.000), Olsen (standalone) (0.505, P = 0.000) and Hoffer Q (0.497, P = 0.000). In terms of MedAE, the lowest outcome was obtained by VRF-G (0.256) followed by Barrett Universal II, Hill-RBF 3.0 and LSF AI (all equally of 0.260). The highest percentage of eyes with prediction error within ± 0.50 D was achieved by SRK/T (84.97 %) statistically significant vs Holladay 1 (60.78 %), Hoffer Q (64.05 %) and Olsen(standalone) (68.63 %).</p><p><strong>Conclusions: </strong>SRK/T has delivered highly accurate results in long eyes. Barrett Universal II, Hill-RBF 3.0, VRF-G and LSF AI are also very true.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100198"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to MIGS adoption among glaucoma specialists in India: Insights from a targeted survey.","authors":"Sahebaan Sethi, Shweta Tripathi, Maneesh Singh, Nagalekshmi Ganesh, Mayav Movdawalla, Shahinur Tayab","doi":"10.1016/j.apjo.2025.100195","DOIUrl":"10.1016/j.apjo.2025.100195","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100195"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and projections of the burden of visual impairment in Asia: Findings from the Global Burden of Disease Study 2021.","authors":"Shengsong Xu, Jianqi Chen, Xiao Wang, Xiaohua Zhuo, Yanbin Wang, Jinyi Xu, Chuqi Xiang, Mingxin Lu, Jingfeng Mu, Xiao Yang","doi":"10.1016/j.apjo.2025.100196","DOIUrl":"10.1016/j.apjo.2025.100196","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to examine the trends in the burden of visual impairment across Asia from 1990 to 2021 and to project the burden through 2040.</p><p><strong>Methods: </strong>This population-based study used data from the latest Global Burden of Disease 2021 study. Prevalence and years lived with disability (YLDs) were the main outcomes. The trends were analyzed by calculating the average annual percentage change (AAPC) using joinpoint regression analysis. The projection was performed by Bayesian age-period-cohort modeling.</p><p><strong>Results: </strong>The prevalence of visual impairment in Asia increased from 1990 to 2021, with AAPCs of 0.77 (95 % confidence interval [CI], 0.44-1.11), while YLD rates decreased with AAPCs of - 0.21 (95 % CI, - 0.38 to - 0.03). Near vision loss was the main contributor to visual impairment in Asia. Notably, the prevalence in the working-age population (20-54 years) increased significantly from 1990 to 2021 (AAPC = 2.11 [95 % CI, 1.70-2.53]), which was accord with the YLDs (AAPC = 1.07 [95 % CI, 0.83-1.32]), whereas for children and adolescents (< 20 years) and the elderly (≥ 55 years) it has decreased. According to the projection, the burden was predicted to significantly increase across all Asian sub-regions, especially in East Asia and South Asia.</p><p><strong>Conclusion: </strong>The burden of visual impairment in Asia has been substantially increasing from 1990 to 2021. This trend is anticipated to persist significantly soon, especially in East Asia and South Asia, underlining the urgent need for concentrated attention and robust policy support for these regions.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100196"},"PeriodicalIF":3.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flourishing index measures among ophthalmologists in the Asia-Pacific region.","authors":"Joanna Ng, Nazli Gul, Arjun Shrestha, Hong Kee Ng, Raymond N Regalado, Rachel S Chong","doi":"10.1016/j.apjo.2025.100193","DOIUrl":"10.1016/j.apjo.2025.100193","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100193"},"PeriodicalIF":3.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long anterior lens zonules in cataract surgery.","authors":"Jiancheng Mu, Feng Xu, Wei Fan","doi":"10.1016/j.apjo.2025.100194","DOIUrl":"10.1016/j.apjo.2025.100194","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100194"},"PeriodicalIF":3.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Saffron Repron® in counteracting the progression of retinitis pigmentosa: Neuroprotection and resilience.","authors":"Francesca Corsi, Alessia Galante, Maria Anna Maggi, Raffaele Mazziotti, Silvia Bisti, Ilaria Piano, Claudia Gargini","doi":"10.1016/j.apjo.2025.100192","DOIUrl":"10.1016/j.apjo.2025.100192","url":null,"abstract":"<p><p>The mutations observed in the various forms of retinitis pigmentosa (RP) affect genes coding for rod-specific proteins and direct the progression of different forms of dystrophy toward total blindness. The present investigation aims to explore the protective effects of Saffron Repron®, in a mouse model of RP. Saffron was administered orally to pregnant females and weaned pups for 120 days. At different time points (P30, P60, P90, and P120), visual function, retinal function, cone lifespan, morphology, gene expression, and protein level were analyzed. The results indicate that chronic saffron treatment effectively slows the progression of long-term damage caused by genetic mutations in both the morphology and function of retinal neurons. Cellular mechanisms responsible for this action appear complex and, probably, due to coordinated and synergistic activities by its chemical components. Here we provide evidence that saffron is able to modulate the epigenetic pathway involved in neuroinflammation. Biochemical and molecular measures suggest that early saffron treatment may induce a form of adaptation known as acquired resilience.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100192"},"PeriodicalIF":3.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced visualization and removal of epithelial ingrowth after SMILE and LASIK using a fiberoptic illuminator.","authors":"Yi-Ting Hou, Le-Yu Chen, I-Hung Lin, Wei-Li Chen","doi":"10.1016/j.apjo.2025.100172","DOIUrl":"10.1016/j.apjo.2025.100172","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100172"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperreflective foci and subretinal fluid predicts microglia activation involved in the breakdown of outer blood-retinal barrier in treatment-naïve patients with diabetic macular edema.","authors":"Yiyang Shu, Chaoyang Zhang, Yanlong Bi, Jingfa Zhang","doi":"10.1016/j.apjo.2025.100168","DOIUrl":"10.1016/j.apjo.2025.100168","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the correlation between hyperreflective foci (HRF), the biomarker of activated microglia, and subretinal fluid (SRF), representing the dysfunction of retinal pigment epithelium (RPE), in treatment-naïve patients with diabetic macular edema (DME).</p><p><strong>Methods: </strong>Sixty-one treatment-naïve patients (61 eyes) with DME were included in the research. Participants were divided into two categories based on the presence or absence of SRF. Basic characteristics were recorded. The parameters, including the HRF number in inner and outer retina, central macular thickness (CMT), intraretinal cyst (IRC), as well as the width, height and area of SRF, were analyzed with optical coherence tomography angiography (OCTA). The correlations between HRF and the parameters including SRF, IRC and CMT were analyzed accordingly.</p><p><strong>Results: </strong>The mean CMT in DME with SRF group was much thicker than that in DME without SRF group (P < 0.0001). The mean HRF number in the outer retina and whole retina was markedly higher in DME patients with the presence of IRC or SRF when compared to those without IRC or SRF (P < 0.05). Further analysis showed that the width, height and area of SRF were positively correlated with the HRF number in the outer retina and the ratio of outer/whole retina HRFs (P < 0.05).</p><p><strong>Conclusion: </strong>The positive correlation between the increased number of HRF, especially in the outer retina, and the formation of SRF in patients with DME supports the hypothesis that microglia activation represented by HRF might cause the dysfunction of RPE and the breakdown of the outer blood-retinal barrier (oBRB), which leads to the increased fluid leakage in subretinal space.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100168"},"PeriodicalIF":3.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}