Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Response: Comment on “Central Retinal Artery Occlusionin Rhino-Orbital-Cerebral Mucormycosis—An Inflammatory-Prothrombotic State”","authors":"Manjari Tandon, Abhishek Sheemar, Kavita Bhatnagar, Seema Meena, Jyoti Shakrawal","doi":"10.1097/APO.0000000000000616","DOIUrl":"10.1097/APO.0000000000000616","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100038"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000215/pdfft?md5=40d038fcf1306f4e9ccfa3ff185355a3&pid=1-s2.0-S2162098924000215-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phacogoniotomy versus phacotrabeculectomy for advanced primary angle-closure glaucoma with cataract: A randomized non-inferiority trial","authors":"Yunhe Song ,&nbsp;Fengbin Lin ,&nbsp;Aiguo Lv ,&nbsp;Yao Zhang ,&nbsp;Lan Lu ,&nbsp;Lin Xie ,&nbsp;Guangxian Tang ,&nbsp;Huiping Yuan ,&nbsp;Yangfan Yang ,&nbsp;Jiangang Xu ,&nbsp;Ping Lu ,&nbsp;Meichun Xiao ,&nbsp;Xiaomin Zhu ,&nbsp;Xiaowei Yan ,&nbsp;Wulian Song ,&nbsp;Xiaoyan Li ,&nbsp;Hengli Zhang ,&nbsp;Fei Li ,&nbsp;Zhenyu Wang ,&nbsp;Ling Jin ,&nbsp;Xiulan Zhang","doi":"10.1016/j.apjo.2023.100033","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100033","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the effectiveness and safety of phacogoniotomy versus phacotrabeculectomy (PVP) among patients with advanced primary angle-closure glaucoma (PACG) and cataracts.</p></div><div><h3>Design</h3><p>Multicenter, randomized controlled, non-inferiority trial.</p></div><div><h3>Methods</h3><p>A total of 124 patients (124 eyes) with advanced PACG and cataracts were enrolled, with 65 in the phacogoniotomy group and 59 in the phacotrabeculectomy group. Patients were followed up for 12 months with standardized evaluations. The primary outcome was the reduction in intraocular pressure (IOP) from baseline to 12 months postoperatively, of which a non-inferiority margin of 4 mmHg was evaluated. Secondary outcomes included the cumulative surgical success rate, postoperative complications, and changes in the number of glaucoma medications.</p></div><div><h3>Results</h3><p>After 12 months, phacogoniotomy demonstrated non-inferiority to phacotrabeculectomy in terms of IOP reduction, with mean IOP reductions of − 26.1 mmHg and − 25.7 mmHg (P = 0.383), respectively, from baseline values of around 40 mmHg. Both groups experienced a significant reduction in the mean number of medications used postoperatively (P &lt; 0.001). The cumulative success rate was comparable between the groups (P = 0.890). However, phacogoniotomy had a lower rate of postoperative complications and interventions (12.3% and 4.6%) compared to phacotrabeculectomy (23.7% and 20.3% respectively). The phacogoniotomy group reported shorter surgery time (22.1 ± 6.5 vs. 38.8 ± 11.1 min; P = 0.030) and higher quality of life (EQ-5D-5 L) improvement at 12 months (7.0 ± 11.5 vs. 3.0 ± 12.9, P = 0.010) than the phacotrabeculectomy group.</p></div><div><h3>Conclusions</h3><p>Phacogoniotomy was non-inferior to phacotrabeculectomy in terms of IOP reduction for advanced PACG and cataracts. Additionally, phacogoniotomy provided a shorter surgical time, lower postoperative complication rate, fewer postoperative interventions, and better postoperative quality of life.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100033"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923002359/pdfft?md5=8906aa135ca9c0b293fcaacf1fbd771b&pid=1-s2.0-S2162098923002359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The subretinal drusenoid deposit (SDD) of age-related macular degeneration (AMD) may have a specific and strong association with high-risk vascular diseases (HRVDs)","authors":"Steven J. Fliesler","doi":"10.1016/j.apjo.2024.100035","DOIUrl":"10.1016/j.apjo.2024.100035","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100035"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000185/pdfft?md5=9d7019cf988d0f7204196a9509c501cb&pid=1-s2.0-S2162098924000185-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease","authors":"R. Theodore Smith ,&nbsp;Timothy W. Olsen ,&nbsp;Victor Chong ,&nbsp;Judy Kim ,&nbsp;Martin Hammer ,&nbsp;Gareth Lema ,&nbsp;Avnish Deobhakta ,&nbsp;Anna Tan ,&nbsp;Yuehong Tong ,&nbsp;Katy Tai ,&nbsp;Yang Fei ,&nbsp;Emanuel Mordechaev ,&nbsp;Gerardo Ledesma-Gil ,&nbsp;Oscar Otero-Marquez ,&nbsp;Richard B Rosen ,&nbsp;Alauddin Bhuiyan ,&nbsp;Sobha Sivaprasad ,&nbsp;Philip J. Rosenfeld","doi":"10.1016/j.apjo.2024.100036","DOIUrl":"10.1016/j.apjo.2024.100036","url":null,"abstract":"<div><p>Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100036"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000197/pdfft?md5=c144f5027c9215045c6a30e28cc1caea&pid=1-s2.0-S2162098924000197-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of iris color on uveal melanoma-related outcomes in 7245 patients at a single ocular oncology center","authors":"Alexandra R. Zaloga,&nbsp;Charles DeYoung,&nbsp;Deepthi E. Kurian,&nbsp;Kevin R. Card,&nbsp;G. Brandon Caudill,&nbsp;Jennifer S. Zeiger,&nbsp;Carol L. Shields","doi":"10.1016/j.apjo.2023.100031","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100031","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the relationship between iris color and uveal melanoma (UM)-related metastasis and death in a large cohort of patients from a single ocular oncology center.</p></div><div><h3>Design</h3><p>Retrospective case series.</p></div><div><h3>Subjects</h3><p>Patients diagnosed with UM between February 1971 and August 2007.</p></div><div><h3>Methods</h3><p>Patient information was obtained from chart documentation.</p></div><div><h3>Main outcome measures</h3><p>UM-related metastasis and death.</p></div><div><h3>Results</h3><p>Out of 7245 patients, iris color was blue in 3702 (51%), green in 1458 (20%), and brown in 2085 (29%). Mean age was 58 ± 15 years and mean tumor thickness was 5.5 ± 3.3 millimeters. Some clinical features differed between iris color groups, with the blue irides group having a larger proportion of post-equatorial tumors with significantly closer proximity to the foveola and optic disc compared to the brown irides group. At a mean follow-up of 75 months, there was no statistically significant difference in metastasis between the various iris color groups. On univariate analysis, those with blue irides showed a higher incidence of UM-related death compared to the green and brown irides groups (8.3%, 5.9% and 7.5% respectively, <em>p</em> value = 0.02). Kaplan-Meier event free survival from UM-related death significantly differed only between the blue and green irides groups (<em>p</em> value = 0.007) with the green irides group showing the highest survival. However, on multivariate analysis, iris color was not predictive of UM-related death.</p></div><div><h3>Conclusion</h3><p>Iris color was not predictive of UM-related metastasis or death. However, Kaplan-Meier survival at 20 years was poorest for blue irides group compared to green.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100031"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000312/pdfft?md5=1eb8fe4d1fb10a8caae990563ff578e7&pid=1-s2.0-S2162098923000312-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Central retinal artery occlusion in rhino-orbital-cerebral mucormycosis: An inflammatory-prothrombotic state”","authors":"Damir Bosnar,&nbsp;Mira Knežić Zagorec,&nbsp;Mladen Bušić","doi":"10.1097/APO.0000000000000615","DOIUrl":"10.1097/APO.0000000000000615","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100045"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S216209892400029X/pdfft?md5=ba138172c15748eb3fe0907dcabfc27b&pid=1-s2.0-S216209892400029X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Course for Retinal Detachment in Morning Glory Disc Anomaly Based on a Grading System","authors":"Yihua Zou,&nbsp;Xiaohan Wang,&nbsp;Jing Li,&nbsp;Jie Peng,&nbsp;Peiquan Zhao","doi":"10.1097/APO.0000000000000572","DOIUrl":"10.1097/APO.0000000000000572","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100041"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000240/pdfft?md5=6993f4df65288d3737863ee060979ae2&pid=1-s2.0-S2162098924000240-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Regression and Recurrence of Corneal Intrastromal Cyst","authors":"Mona Bhargava,&nbsp;Raj S. Paul,&nbsp;Karan R. Nathani","doi":"10.1097/APO.0000000000000575","DOIUrl":"10.1097/APO.0000000000000575","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100037"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000203/pdfft?md5=dd014a4d85dfa496be2c6d5425b63400&pid=1-s2.0-S2162098924000203-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10632191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interocular difference in crystalline lens morphology in children and adolescents with unilateral high myopia","authors":"Yifan Zhang ,&nbsp;Jiaqing Zhang ,&nbsp;Aixia Jin ,&nbsp;Xuhua Tan ,&nbsp;Kyoko Ohno-Matsui ,&nbsp;Xiaotong Han ,&nbsp;Lixia Luo ,&nbsp;Yizhi Liu","doi":"10.1016/j.apjo.2023.100001","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100001","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the between-eye differences of the crystalline lens in subjects with unilateral high myopia and assess its contribution to the interocular refractive error disparity.</p></div><div><h3>Methods</h3><p>Children and adolescents with unilateral high myopia, defined as cycloplegic spherical equivalent (SE) ≤ −5D in one eye and ≥ −3D in the other eye, were recruited. Ocular biometric parameters, including axial length (AL) and lens thickness (LT), were measured by IOLMaster 700. Other lens-related parameters, including anterior lens radius of curvature (ALR) and posterior lens radius of curvature (PLR), were measured by CASIA2 swept-source optical coherence tomography. Lens power (LP) was calculated using Bennett’s formula. Paired t-test was used to assess the between-eye difference in biometric parameters, and multiple regression analysis was used to assess factors associated with the between-eye SE difference.</p></div><div><h3>Results</h3><p>Ninety-one participants (6–18 years of age; 52.75% girls) were included. The highly myopic eyes showed significantly lower LP (P &lt; 0.001) and smaller ALR (P &lt; 0.001) than the contralateral eyes, while no significant difference was found in central LT. In both eyes, ALR was significantly related to SE (P = 0.001 and P = 0.006, respectively); while LT was not associated with SE (P = 0.051 and P = 0.052, respectively). Paired-eye analysis showed that the between-eye difference in ALR was the only lenticular parameter significantly associated with the between-eye difference in SE (P = 0.005).</p></div><div><h3>Conclusion</h3><p>In highly myopic eyes, the crystalline lens reduced total power but morphologically changed to a more curved shape without significant lens thinning, suggesting that the LP loss is mainly achieved by reducing its internal power in high myopes.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100001"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000014/pdfft?md5=65c931b380df1f0898914ad88665a4bb&pid=1-s2.0-S2162098923000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic associations of central serous chorioretinopathy subtypes, neovascular age-related macular degeneration, and polypoidal choroidal vasculopathy","authors":"Zhen Ji Chen ,&nbsp;Danny S. Ng ,&nbsp;Mary Ho ,&nbsp;Shi Yao Lu ,&nbsp;Pancy O.S. Tam ,&nbsp;Alvin L. Young ,&nbsp;Marten E. Brelen ,&nbsp;Jason C. Yam ,&nbsp;Clement C. Tham ,&nbsp;Chi Pui Pang ,&nbsp;Li Jia Chen","doi":"10.1016/j.apjo.2023.100003","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100003","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the genetic associations of different subtypes of central serous chorioretinopathy (CSCR), neovascular age-related macular degeneration (nAMD), and polypoidal choroidal vasculopathy (PCV).</p></div><div><h3>Design</h3><p>A case-control genetic association study.</p></div><div><h3>Methods</h3><p>This study enrolled 217 CSCR, 341 nAMD, 288 PCV patients, and 1380 controls. The CSCR patients were classified into those with focal or diffuse leakage, with or without pigment epithelial detachment (PED), and with or without macular neovascularization (MNV). Associations between 11 variants from 8 genes, <em>ADAMTS9</em>, <em>ANGPT2</em>, <em>ARMS2</em>, <em>CFH</em>, <em>NR3C2</em>, <em>PGF</em>, <em>TNFRSF10A</em> and <em>VIPR2</em>, and diseases/subtypes were analyzed by logistic regression analysis adjusted for age and sex, and inter-phenotype comparison by heterogeneity test.</p></div><div><h3>Results</h3><p>The <em>CFH</em> rs800292-A conferred a protective effect for CSCR with MNV (OR=0.44, <em>P</em> = 0.002) and a risk effect for CSCR without MNV (OR=1.31, <em>P</em> = 0.023). CSCR patients carrying rs800292-G had a 3.23-fold of increased risk towards developing secondary MNV (<em>P</em> = 1.45 ×10^-4). <em>CFH</em> rs3753394, rs800292 and rs1329428 showed similar effects among CSCR with MNV, nAMD and PCV, but opposite effects on CSCR without MNV. <em>TNFRSF10A</em> rs13278062-T was associated with overall CSCR but not with CSCR subtypes, nAMD or PCV. Moreover, <em>CFH</em> and <em>ARMS2</em> SNPs showed heterogeneous effects in CSCR without MNV against CSCR with MNV, nAMD and PCV.</p></div><div><h3>Conclusions</h3><p>Genetic associations of CSCR with MNV resembled nAMD and PCV compared to CSCR without MNV, indicating differential genetic effects on neovascularization and choroidopathy. Further investigation of the functional roles of <em>CFH, ARMS2,</em> and <em>TNFRSF10A</em> in CSCR, nAMD and PCV should help elucidate the mechanisms of these maculopathies.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100003"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000038/pdfft?md5=e4f3cb82f59b58007c5c6fba34daf66b&pid=1-s2.0-S2162098923000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}