Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Multi-omics integration uncovers key molecular mechanisms and therapeutic targets in myopia and pathological myopia","authors":"Jingwen Hui ,&nbsp;Xuehao Cui ,&nbsp;Quanhong Han","doi":"10.1016/j.apjo.2026.100277","DOIUrl":"10.1016/j.apjo.2026.100277","url":null,"abstract":"<div><h3>Purpose</h3><div>Myopia, particularly pathological myopia (PM), poses a significant global health burden due to its increasing prevalence and associated vision-threatening complications. Despite extensive genetic research, the molecular mechanisms underlying myopia progression remain unclear. This study aims to identify key causal proteins and metabolic pathways in myopia and PM and explore potential therapeutic targets.</div></div><div><h3>Methods</h3><div>We employed a multi-omics framework integrating Mendelian Randomization (MR), colocalization analysis, protein-protein interaction (PPI) networks, metabolic pathway enrichment, and molecular docking to investigate the molecular mechanisms of myopia and PM. We analyzed five proteome-wide pQTL datasets, two whole-blood eQTL datasets, and a metabolic GWAS to identify causal proteins, genes, and metabolites. Small-molecule docking and molecular dynamics (MD) simulations were performed to assess potential drug-target interactions.</div></div><div><h3>Results</h3><div>We identified PDGFRA, LRRTM2, and PCOLCE as key regulators of myopia and PM. PDGFRA was associated with extracellular matrix (ECM) remodeling and fibroblast activation, LRRTM2 with retinal neurotransmission and dopamine signaling, and PCOLCE with collagen stability and scleral biomechanics. Functional enrichment analysis highlighted immune signaling, lipid metabolism, and oxidative stress pathways as contributors to myopia pathogenesis. Molecular docking and MD simulations identified 1,3-Propanediol, Cis-9-Octadecenoic Acid, and 17-Beta-Estradiol as potential therapeutic compounds that may stabilize ECM, enhance neurotransmission, and reinforce scleral integrity.</div></div><div><h3>Conclusions</h3><div>Our multi-omics framework prioritizes PDGFRA, LRRTM2, and PCOLCE as candidates linked to ECM remodeling, neurotransmission, and scleral biomechanics in myopia and PM. Integrating MR with colocalization, PPI, and pathway analyses yields mechanistic hypotheses and testable targets. Docking/MD findings are exploratory and will require experimental validation before any therapeutic inference.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100277"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long anterior lens zonules in cataract surgery","authors":"Jiancheng Mu,&nbsp;Feng Xu,&nbsp;Wei Fan","doi":"10.1016/j.apjo.2025.100194","DOIUrl":"10.1016/j.apjo.2025.100194","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100194"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuum evaporation in the vitreous cavity","authors":"Alexander Jessup ,&nbsp;Andrew Chang","doi":"10.1016/j.apjo.2025.100201","DOIUrl":"10.1016/j.apjo.2025.100201","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100201"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between China-based DeepSeek and US-based major LLMs in answering social determinants of health questions in ophthalmology","authors":"Elizabeth T. Wang,&nbsp;Scott S. Song,&nbsp;Kenneth C. Peng,&nbsp;T.Y. Alvin Liu","doi":"10.1016/j.apjo.2026.100276","DOIUrl":"10.1016/j.apjo.2026.100276","url":null,"abstract":"<div><div>Large language models (LLMs) have shown promise in ophthalmology. However, their performance in addressing social determinants of health (SDoH), critical drivers of eye care outcomes, remains unclear. This study evaluates 8 LLMs (DeepSeek-V3, DeepSeek-R1, ChatGPT o1, ChatGPT-4o, ChatGPT-4, ChatGPT-3.5, Gemini 1, and Gemini 1.5 Pro) on their ability to distinguish true from false statements related to SDoH and disparities in ophthalmology. A total of 238 referenced true statements were drawn from published literature and edited to create direct contradictions, i.e., false statements. The true and false statements were presented to the models, and each model was tested on its ability to identify the correct statement in each pair. Model accuracy ranged from 78.2 % to 92.0 %. Among the top three performers, two (DeepSeek-R1 and ChatGPT o1) were reasoning models. DeepSeek-V3 achieved the highest accuracy (not statistically superior than DeepSeek-R1 or ChatGPT o1) and significantly outperformed ChatGPT 4o, ChatGPT 4, ChatGPT 3.5, Gemini 1.5 Pro, and Gemini 1. Across all LLMs, performance was lowest on statements concerning pediatric eye disease (52.4 %, <em>P</em> = 0.016) and Asian race (70.3 %, <em>P</em> = 0.044). Gemini 1.5 Pro exhibited significantly lower accuracy on statements involving White race (<em>P</em> = 0.041) compared to other racial categories. These findings reveal knowledge gaps and potential biases in LLM understanding of SDoH in ophthalmology. Further investigation is needed to understand why such variations exist and to guide improvements in LLM performance on this important topic.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100276"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International consensuses and guidelines on multifocal intraocular lenses (IOLs) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO)","authors":"Srinivas K. Rao ,&nbsp;Steven G. Safran ,&nbsp;Damien Gatinel ,&nbsp;Sanjeev P. Srinivas ,&nbsp;Kevin M. Miller ,&nbsp;Hiu Ying Enne Leung ,&nbsp;Soon-Phaik Chee ,&nbsp;Gerd U. Auffarth ,&nbsp;David F. Chang ,&nbsp;H. Burkhard Dick ,&nbsp;Youngsub Eom ,&nbsp;Ruth Lapid-Gortzak ,&nbsp;Andrzej Grzybowski ,&nbsp;Rohit C. Khanna ,&nbsp;Richard Lindstrom ,&nbsp;Mayank A. Nanavaty ,&nbsp;Tetsuro Oshika ,&nbsp;Namrata Sharma ,&nbsp;Jong Suk Song ,&nbsp;Ke Yao ,&nbsp;Jorge L. Alió","doi":"10.1016/j.apjo.2025.100274","DOIUrl":"10.1016/j.apjo.2025.100274","url":null,"abstract":"<div><div>Intraocular Lenses (IOLs) have revolutionized cataract surgery, evolving from simple monofocal designs to advanced multifocal technologies that aim to reduce dependence on glasses after surgery. However, multifocal IOLs remain one of the most debated topics in ophthalmology, with passionate advocates and critics. This controversy stems from the balance between their potential benefits and limitations. The Asia-Pacific Academy of Professors of Ophthalmology (AAPPO) formed an international panel of 25 experts from 14 countries/territories who prepared and voted on consensus statements in twelve key areas: (1) the concept of multifocality; (2) refractive vs diffractive designs; (3) blur and haloes; (4) dysphotopsia; (5) understanding diffractive IOL designs; (6) neuroadaptation; (7) factors that may affect the success of multifocal IOLs; (8) alternatives to multifocal IOLs; (9) extended depth of focus IOLs; (10) other considerations; (11) newer IOL designs; (12) future considerations. Among the 47 consensus statements, 46 (97.8 %) have achieved over 75 % agreement. These statements can provide a practical guide for ophthalmologists to provide the optimal care of patients when multifocal IOL implantation is considered when performing cataract surgery or refractive lensectomy.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100274"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of shared gene polymorphisms for refraction and axial length with corneal biomechanical properties in children","authors":"Ebenezer Zaabaar ,&nbsp;Erica Shing ,&nbsp;Ka Wai Kam ,&nbsp;Yuzhou Zhang ,&nbsp;Alvin L. Young ,&nbsp;Clement C. Tham ,&nbsp;Chi Pui Pang ,&nbsp;Jason C. Yam ,&nbsp;Li Jia Chen","doi":"10.1016/j.apjo.2025.100225","DOIUrl":"10.1016/j.apjo.2025.100225","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the associations of single-nucleotide polymorphisms (SNPs) for axial length (AL) and spherical equivalent (SE) with corneal biomechanical parameters in children.</div></div><div><h3>Methods</h3><div>A cohort of 2535 Chinese children, 4–12 years old, underwent measurements of corneal biomechanical properties, including corneal hysteresis (CH), corneal resistance factor (CRF), deformation amplitude (DA), peak distance (PD), highest concavity radius, as well as first and second applanation lengths and velocities (V1 and V2). Fifteen candidate SNPs for AL and SE were genotyped for association analyses.</div></div><div><h3>Results</h3><div>Overall, <em>ZC3H11B</em> rs994767 and <em>CHD7</em> rs437036 showed significant associations with DA (β = −0.016, <em>P</em> = 0.0012 and β = 0.018, <em>P</em> = 0.0012, respectively). <em>CHD7</em> rs437036 was associated with DA (β = 0.030, <em>P</em> = 0.0021) in 4–7-year-old children and <em>ZC3H11B</em> rs994767 with CRF (β = 0.216, <em>P</em> = 0.0027) in 8–12-year-old children. AL genetic risk score (GRS) showed associations with DA (β = 1.625, <em>P</em> = 0.014) and V2 (β = −1.630, <em>P</em> = 0.0019), and SE GRS with CRF (β = −64.94, <em>P</em> = 0.038). Compared to the first, the second and fourth AL GRS quantiles were associated with CH (β = 0.258, <em>P</em> = 0.008; β = 0.303, <em>P</em> = 0.002, respectively) and CRF (β = 0.282, <em>P</em> = 0.014; β = 0.373, <em>P</em> = 0.001, respectively), while the fifth was associated with DA (β = 0.029, <em>P</em> = 0.006), PD (β = 0.158, <em>P</em> = 0.011), V2 (β = −0.037, <em>P</em> = 1.24 ×10⁻⁵), and CH (β = 0.20, <em>P</em> = 0.041). The second SE GRS quantile was associated with V2 (β = −0.020, <em>P</em> = 0.02), and the fifth with CH (β = −0.235, <em>P</em> = 0.049), compared to the first.</div></div><div><h3>Conclusion</h3><div><em>ZC3H11B</em> and <em>CHD7</em> SNPs for AL and SE, along with GRS for both traits, showed associations with various corneal biomechanical parameters, suggesting their potential influence on the structure, composition and shape of eye size-related ocular tissues in children.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100225"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does semaglutide increase the risk of non-arteritic anterior ischemic optic neuropathy? A systematic review and meta-analysis of emerging evidence","authors":"Kai-Yang Chen ,&nbsp;Hoi-Chun Chan ,&nbsp;Chi-Ming Chan","doi":"10.1016/j.apjo.2025.100245","DOIUrl":"10.1016/j.apjo.2025.100245","url":null,"abstract":"<div><h3>Background</h3><div>Semaglutide, a GLP-1 receptor agonist widely prescribed for type 2 diabetes and obesity, has recently been linked to rare ocular adverse events, including non-arteritic anterior ischemic optic neuropathy (NAION). Given the growing concerns and limited clarity, this systematic review and meta-analysis aims to critically assess the potential association between semaglutide use and NAION risk.</div></div><div><h3>Objectives</h3><div>To evaluate the association between semaglutide use and the development of NAION.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted via different databases from inception to June 3rd, 2025. A reviewer screened the potential articles against prespecified eligibility criteria. The risk of bias in the eligible studies was then evaluated using the Newcastle Ottawa Scale (NOS). Data were then systematically extracted and analyzed.</div></div><div><h3>Results</h3><div>The database search yielded 3539 records, of which 10 research articles investigating the association between Semaglutide and NAION were included in this study. Semaglutide use was associated with a significantly increased risk of NAION compared to control medications, with a pooled hazard ratio of 2.620 (95 % CI: 1.808–3.795, <em>P</em> &lt; 0.001). Risk elevation showed time-dependency, becoming statistically significant after 2 years of exposure. Identified risk factors included older age, male sex, prolonged diabetes duration, elevated HbA1c, diabetic retinopathy, and obesity. Among GLP-1 receptor agonists, semaglutide accounted for 86.5 % of reported NAION cases. Clinical presentations featured optic disc edema, intraretinal fluid on OCT, and crowded optic discs. Cumulative incidence rates were substantially higher in semaglutide users versus non-GLP-1 receptor agonist comparators.</div></div><div><h3>Conclusions</h3><div>Semaglutide use shows association with increased NAION risk, particularly with prolonged exposure and in patients with predisposing factors. Risk-benefit assessment and targeted ophthalmologic monitoring are recommended while maintaining appropriate therapeutic use.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100245"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slanted versus conventional bilateral lateral rectus recession in children with convergence insufficiency intermittent exotropia: A multicentre, randomized trial","authors":"Jing Yao ,&nbsp;Xiying Wang ,&nbsp;Chenhao Yang ,&nbsp;Lingyan Dong ,&nbsp;Jiangtao Xu ,&nbsp;Xiaojun Ren ,&nbsp;Chao Jiang ,&nbsp;Wenqing Zhu ,&nbsp;Rongmei Zhou ,&nbsp;Tienan Feng ,&nbsp;Jie Hong ,&nbsp;Hu Liu ,&nbsp;Lianhong Zhou ,&nbsp;Lihua Wang ,&nbsp;Junhong Li ,&nbsp;Xiaoli Kang ,&nbsp;Yueping Li ,&nbsp;Wei Zhang ,&nbsp;Kanxing Zhao ,&nbsp;Chen Zhao","doi":"10.1016/j.apjo.2026.100275","DOIUrl":"10.1016/j.apjo.2026.100275","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the efficacy of slanted bilateral lateral rectus recession (S-BLR) versus conventional bilateral lateral rectus recession (C-BLR) in children with convergence insufficiency intermittent exotropia (CI-IXT).</div></div><div><h3>Design</h3><div>Multicentre, randomized controlled trial.</div></div><div><h3>Methods</h3><div>Chinese children aged 5–12 years with CI-IXT were consecutively enrolled, and randomly assigned (1:1) to receive either S-BLR or C-BLR. The primary outcome was the 12-month overall success rate, defined as a postoperative residual deviation between 10Δ of exodeviation and 5Δ of esodeviation with near-distance disparity (NDD) &lt; 10Δ.</div></div><div><h3>Results</h3><div>A total of 200 participants were enrolled, and 188 (97 S-BLR, 91 C-BLR) were finally included in the modified intention-to-treat analysis. The median age was 8 (6−9) years, and 90 (48 %) were male. The 12-month overall success rates did not differ significantly between the groups (group difference 8 %, <em>P</em> = 0.27, adjusted <em>P</em> = 0.36). However, S-BLR exhibited a lower rate of near undercorrection (group difference −12 %, <em>P</em> = 0.06), more collapse of NDD (-2.00^Δ, <em>P</em> = 0.001), less residual near exodeviation (-4.00^Δ, <em>P</em> &lt; 0.001), better control of near exodeviation (0.00, <em>P</em> = 0.01), and a higher proportion of improved stereoacuity (12 %, <em>P</em> = 0.06). Subgroup analysis for NDD≤ 15^Δ revealed a higher success rate of near deviation (86 % versus 69 %, <em>P</em> = 0.02), and a lower rate of near undercorrection (13 % versus 30 %, <em>P</em> = 0.01) in S-BLR group. Aside from undercorrection and overcorrection, no additional long-term suboptimal surgical outcomes were observed.</div></div><div><h3>Conclusions</h3><div>Although the overall success rates did not differ, S-BLR showed potential superiority at near in children with CI-IXT. More participants with NDD&gt; 15^Δ, and a longer follow-up are needed to validate these findings.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100275"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Envisioning the future: Ever-increasing quality of the journal","authors":"Jost B. Jonas,&nbsp;Dennis S.C. Lam","doi":"10.1016/j.apjo.2026.100281","DOIUrl":"10.1016/j.apjo.2026.100281","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100281"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oculomics and AI: The eye as a biomarker for health span","authors":"Joy Le Yi Wong ,&nbsp;Haoran Cheng ,&nbsp;Wen Jun Peh ,&nbsp;Dean Ho ,&nbsp;Tien Y. Wong ,&nbsp;Celene Yan Yan Hui ,&nbsp;Darren S.J. Ting ,&nbsp;Yong Mong Bee ,&nbsp;Su Yen Goh ,&nbsp;Rajendra S. Apte ,&nbsp;Vinit B. Mahajan ,&nbsp;Jeffrey L. Goldberg ,&nbsp;Evelyne Bischof ,&nbsp;David A. Sinclair ,&nbsp;Carol C. Cheung ,&nbsp;Hiok Hong Chan ,&nbsp;Kanae Fukutsu ,&nbsp;Ting Fang Tan ,&nbsp;Chrystie Wan Ning Quek ,&nbsp;Ashley Shuen Ying Hong ,&nbsp;Daniel S.W. Ting","doi":"10.1016/j.apjo.2026.100282","DOIUrl":"10.1016/j.apjo.2026.100282","url":null,"abstract":"<div><div>As the world’s population ages, the focus of healthcare is shifting from extending life span to promoting health span. There is an unmet need to identify sensitive and reliable markers of health span through more cost-effective and non-invasive methods, to enable early and effective intervention on modifiable aging factors. The eye offers a unique window into systemic health, providing direct visualization of the body’s vascular and neural health. This review presents an overview of how various ocular structures can serve as biomarkers of health span—drawing on insights from ocular imaging, metabolomics, and proteomics, with evidence from basic science, animal models, and human clinical trials. The role of artificial intelligence (AI) in predicting biological age and the risk of age-related systemic conditions is also highlighted, with a focus on current applications and how AI is being integrated to synthesize and interpret multimodal data.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100282"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}