Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Masquerade syndrome: A review of uveitic imposters","authors":"Parthopratim Dutta Majumder ,&nbsp;Vikas Khetan ,&nbsp;Jyotirmay Biswas","doi":"10.1016/j.apjo.2024.100054","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100054","url":null,"abstract":"<div><p>Masquerade syndromes in uveitis are complex clinical conditions where non-inflammatory diseases mimic uveitic manifestations, often leading to diagnostic and therapeutic challenges. This review delves into the diverse spectrum of masquerade syndromes, categorizing them into neoplastic and non-neoplastic entities. We explore the prevalence of primary intraocular lymphoma, leukaemia, retinoblastoma, and other malignancies, as well as conditions like retinitis pigmentosa and endophthalmitis that can present as uveitis. Through detailed analysis of symptoms, diagnostic methods, and treatment approaches, the review emphasizes the importance of considering masquerade syndromes in differential diagnoses to prevent mismanagement. The synthesis of current knowledge aims to enhance clinicians' ability to discern these complex presentations, advocating for a multidisciplinary approach to diagnosis and care, thereby improving patient outcomes in cases of uveitic masquerade syndromes.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100054"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000495/pdfft?md5=bbd4d91674bf79215796aba4fab25779&pid=1-s2.0-S2162098924000495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the spectrum: A comprehensive exploration of diverse ocular and orbital tumor entities","authors":"Xianqun Fan ,&nbsp;Martine J. Jager","doi":"10.1016/j.apjo.2024.100059","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100059","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100059"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000549/pdfft?md5=d8d92ec3fdd8f7efaf9194745c4b897c&pid=1-s2.0-S2162098924000549-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on chemotherapy modalities for retinoblastoma: Progress and challenges","authors":"Thanaporn Kritfuangfoo ,&nbsp;Duangnate Rojanaporn","doi":"10.1016/j.apjo.2024.100061","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100061","url":null,"abstract":"<div><p>Retinoblastoma stands as a paradigm of success in treating malignancies among pediatric patients. Over recent decades, the approach to managing retinoblastoma has evolved significantly, transitioning from the preservation of patients' lives to the preservation of eyes and vision while minimizing treatment-related complications. Chemotherapy, administered through diverse routes, has solidified its role as the cornerstone of retinoblastoma treatment. In addition to intravenous chemotherapy (IVC), alternative administration routes, including intraarterial (IAC), intravitreal, intracameral, and periocular delivery, have emerged as promising modalities for retinoblastoma management. Numerous studies have demonstrated outstanding outcomes, achieving nearly 100% salvage rates for eyes classified under groups A–C. However, for advanced intraocular retinoblastoma (groups D and E eyes), IAC appears to offer superior local control rates compared to IVC. Intravitreal injection of chemotherapeutic agents, when administered in a controlled and secure manner, holds promise in averting the need for enucleation and radiotherapy in advanced retinoblastoma cases presenting with vitreous seeds. The optimal chemotherapy strategy remains meticulously tailored based on numerous factors. This review provides a comprehensive update on chemotherapy across various routes, encompassing key considerations, dosages, administration methods, treatment outcomes, and potential complications. Furthermore, it explores emerging potential treatments and outlines future directions aimed at enhancing treatment outcomes.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100061"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000562/pdfft?md5=913c378222877e9710e848b97b7b7e99&pid=1-s2.0-S2162098924000562-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic renal cell carcinoma masquerading as an endogenous endophthalmitis: Role of vitreous cytology","authors":"Jasmine Yaowei Ge ,&nbsp;Y.H. Loo ,&nbsp;Anita S.Y. Chan","doi":"10.1016/j.apjo.2024.100055","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100055","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100055"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000501/pdfft?md5=65b8cc05ceb3d1b8399821a37ddf81d7&pid=1-s2.0-S2162098924000501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical 5-fluorouracil 1% for moderate to extensive ocular surface squamous neoplasia in 73 consecutive patients: Primary versus secondary treatment","authors":"Irwin Leventer ,&nbsp;Hartej Singh ,&nbsp;Bahram Pashaee ,&nbsp;Christian D. Raimondo ,&nbsp;Chenab K. Khakh ,&nbsp;Jonathan L. Martin ,&nbsp;Binod Acharya ,&nbsp;Qiang Zhang ,&nbsp;Sara E. Lally ,&nbsp;Carol L. Shields","doi":"10.1016/j.apjo.2024.100052","DOIUrl":"10.1016/j.apjo.2024.100052","url":null,"abstract":"<div><h3>Importance</h3><p>Ocular surface squamous neoplasia (OSSN) is a spectrum of malignancies that generally includes conjunctival intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC). OSSN can be treated with topical therapies including interferon α-2b (IFN), mitomycin C (MMC), or 5-fluorouracil 1% (5FU). Recently, due to unavailability of IFN and toxicity associated with MMC, therapy has shifted towards 5FU.</p></div><div><h3>Objective</h3><p>Herein, we compare the use of 5FU 1% as a primary versus (vs) secondary treatment regimen in eyes with moderate to extensive OSSN.</p></div><div><h3>Design Setting and Participants</h3><p>Retrospective cohort study of 73 consecutive patients with unilateral moderate to extensive OSSN treated at a single tertiary ocular oncology center from 2016 to 2023. Mean follow up time was 478.2 days overall, with 283.0 days for primary 5FU group and 860.3 days for secondary 5FU group.</p></div><div><h3>Intervention</h3><p>Topical 5FU 1% 4 times daily for 2 weeks with option for 2-weekly extension until tumor control, either as primary treatment or as secondary treatment to surgical resection, topical IFN or topical MMC, or cryotherapy.</p></div><div><h3>Main Outcomes</h3><p>Outcome measures included tumor response, need for additional surgery, complications, and visual outcomes.</p></div><div><h3>Results</h3><p>A comparison (primary vs secondary treatment) revealed no difference in mean tumor basal dimension (19.6 vs 17.2 mm, <em>P</em> = 0.46), thickness (3.7 vs 3.4 mm, <em>P</em> = 0.64), or tumor extent (4.4 vs 4.5 clock hours, <em>P</em> = 0.92). The primary treatment group showed greater complete tumor control (77% vs 38%, <em>P</em> = 0.04). Multivariable analysis comparison (primary vs secondary treatment) showed primary treatment more likely to achieve complete tumor control (<em>P</em> = 0.01). There was no difference in the complication rate from 5FU treatment between the groups. There was no difference in visual outcome, and no tumor-related metastasis (0%) or death (0%).</p></div><div><h3>Conclusion and Relevance</h3><p>Topical 5FU 1% is efficacious and safe as a primary or secondary treatment for moderate to extensive OSSN. Tumors treated with primary 5FU 1% demonstrated more complete resolution. In patients with moderate to extensive OSSN, primary treatment with topical 5FU 1% may be warranted.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100052"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000471/pdfft?md5=8252b5d4bb5e7c9034eb3aefa6fa446e&pid=1-s2.0-S2162098924000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Regression and Recurrence of Corneal Intrastromal Cyst.","authors":"Mona Bhargava, Raj S Paul, Karan R Nathani","doi":"10.1097/APO.0000000000000575","DOIUrl":"https://doi.org/10.1097/APO.0000000000000575","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100037"},"PeriodicalIF":4.4,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of Massive Open Online Course (MOOC) in Ophthalmic Skills Training for Medical Students: Outcomes and Perspectives.","authors":"Sasha Zaki","doi":"10.1097/APO.0000000000000601","DOIUrl":"https://doi.org/10.1097/APO.0000000000000601","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100039"},"PeriodicalIF":4.4,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and causes of vision impairment in elderly Chinese people living in suburban Shanghai","authors":"Jiahui Chen ,&nbsp;Shaohua Zhang ,&nbsp;Fan Yang ,&nbsp;Yongxiang Jiang ,&nbsp;Yi Lu ,&nbsp;Yating Tang","doi":"10.1016/j.apjo.2023.100002","DOIUrl":"https://doi.org/10.1016/j.apjo.2023.100002","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate the current prevalence and causes of moderate and severe visual impairment (MSVI) and blindness in elderly people in suburban Shanghai, China.</p></div><div><h3>Methods</h3><p>A cross-sectional study based on the population was conducted, which involved 5846 individuals (11,692 eyes) aged 65 years or older. Thorough eye examinations were performed to assess the prevalence and leading factors of MSVI (BCVA &lt;20/63 to ≥20/400) and blindness (BCVA &lt;20/400).</p></div><div><h3>Results</h3><p>The standardized prevalence of bilateral MSVI and blindness was 3.3% and 0.6%, correspondingly. The standardized prevalence of monocular MSVI and blindness was 7.4% and 2.0%, correspondingly. Cataract (47.9% and 20.7%, correspondingly) and myopic macular degeneration (MMD, 25.7% and 31.1%, correspondingly) were the principal causes of bilateral MSVI and blindness. As for monocular MSVI, the primary causes were cataract (39.4%), age-related macular degeneration (AMD, 16.6%), and MMD (16.6%). The primary causes of monocular blindness were other posterior segment eye diseases (30.1%) and MMD (14.2%). In adults aged 65–74 years, MMD was the foremost factor causing bilateral vision impairment. Conversely, cataract was identified as the primary cause of bilateral and monocular vision impairment among adults aged ≥ 75 years. AMD accounts for a significant proportion of individuals across all age groups.</p></div><div><h3>Conclusions</h3><p>The significant prevalence of MSVI and blindness among Chinese adults represents a critical public health issue. In addition to cataract, the vision impairment caused by MMD and AMD become an important issue in the elderly Chinese people.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100002"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098923000026/pdfft?md5=b994087682017880e15ca2632b5a33b4&pid=1-s2.0-S2162098923000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139901547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: “Integration of Massive Open Online Course (MOOC) in Ophthalmic Skills Training for Medical Students: Outcomes and Perspectives”","authors":"Zijing Huang,&nbsp;Haoyu Chen","doi":"10.1097/APO.0000000000000600","DOIUrl":"10.1097/APO.0000000000000600","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100040"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000239/pdfft?md5=08c6ea492edf23fe72227e886d478d02&pid=1-s2.0-S2162098924000239-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary shape changes on optical coherence tomography following optic nerve sheath fenestration","authors":"Yi Wang,&nbsp;Zhen Li,&nbsp;Yan Yan","doi":"10.1016/j.apjo.2024.100042","DOIUrl":"10.1016/j.apjo.2024.100042","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 1","pages":"Article 100042"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000252/pdfft?md5=2d257631984e0bf5d702cfa02011b91b&pid=1-s2.0-S2162098924000252-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}