Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Microneedle-assisted embolectomy restoring retinal perfusion in branch retinal artery occlusion","authors":"Haibo Li , Yiling Zhou","doi":"10.1016/j.apjo.2025.100260","DOIUrl":"10.1016/j.apjo.2025.100260","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100260"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145399466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging microsporidia keratoconjunctivitis in China: A call for consensus statements","authors":"Zhengze Sun , Pei Zhang , Yingyu Li, Baikai Ma, Yiyun Liu, Hong Qi","doi":"10.1016/j.apjo.2025.100259","DOIUrl":"10.1016/j.apjo.2025.100259","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100259"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing perspectives on proliferative vitreoretinopathy: Updates in experimental research and emerging clinical treatments","authors":"Fang Zheng ,&nbsp;Elie Motulsky ,&nbsp;Luiz Roisman ,&nbsp;Xiaoyun Fang ,&nbsp;Kanae Fukutsu ,&nbsp;Chee Wai Wong ,&nbsp;Veluchamy Amutha Barathi ,&nbsp;Edmund Wong ,&nbsp;Andrew S.H. Tsai ,&nbsp;Leo A. Kim ,&nbsp;Gavin SW Tan","doi":"10.1016/j.apjo.2026.100302","DOIUrl":"10.1016/j.apjo.2026.100302","url":null,"abstract":"<div><div>Proliferative vitreoretinopathy (PVR) remains a major barrier in vitreoretinal surgery, being the leading cause of recurrent retinal detachment and surgical failure. PVR arises from abnormal wound healing, involving epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells, hyalocytes trans-differentiation into myofibroblasts, and dysregulated interactions among cytokines, growth factors, and chemokines. These lead to extracellular matrix remodeling and contractile membrane formation. Recent advancements have deepened insight into disease mechanisms and supported preclinical testing of therapies. Despite surgical progress, adjunctive treatments such as corticosteroids, antimetabolites, retinoids, and biologics show limited and inconsistent benefits in clinical trials. Emerging tools like proteomic biomarkers and advanced imaging offer promise for early risk detection and personalized care. However, major challenges remain in understanding disease complexity and improving tailored treatment outcomes. This review emphasizes the urgent need for targeted molecular therapies. Bridging basic science with clinical innovation will be key to advancing PVR management and preserving vision.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100302"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “International consensuses and guidelines on multifocal intraocular lenses (IOLs) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO)”, [Asia-Pacific J Ophthalmol, Available online 17 December 2025, 100274 (2025), DOI: https://doi.org/10.1016/j.apjo.2025.100274]","authors":"Dennis S.C. Lam ,&nbsp;Jorge L. Alió","doi":"10.1016/j.apjo.2026.100280","DOIUrl":"10.1016/j.apjo.2026.100280","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100280"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveal melanoma: Treatment approaches and prognostic outcomes based on the American joint committee on cancer staging","authors":"Thanaporn Kritfuangfoo ,&nbsp;Benja Udomlapsakul ,&nbsp;Daranee Piriyasang ,&nbsp;Rangsima Aroonroch ,&nbsp;Duangnate Rojanaporn","doi":"10.1016/j.apjo.2026.100295","DOIUrl":"10.1016/j.apjo.2026.100295","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the clinical characteristics, treatment outcomes, and prognosis of uveal melanoma (UM) based on the 8th edition of the American Joint Committee on Cancer (AJCC) staging system.</div></div><div><h3>Design</h3><div>Retrospective study.</div></div><div><h3>Methods</h3><div>Data on the clinical presentation, diagnostic methods, treatment approaches, and long-term outcomes of patients diagnosed with UM at a tertiary referral center in Thailand between 2010 and 2024 were included and analyzed.</div></div><div><h3>Results</h3><div>Of 106 patients included, the mean (range) age at diagnosis was 51.6 (16−86) years. The most common tumor location was the choroid (n = 100, 94.3%), followed by the ciliary body (n = 4, 3.8%) and iris (n = 2, 1.9%). AJCC tumor staging was T1 in 18.9%, T2 in 17.9%, T3 in 48.1%, and T4 in 15.1% of cases. Primary treatment included enucleation (n = 57, 53.8%), Ruthenium-106 (¹⁰⁶Ru) brachytherapy (n = 31, 29.2%), endoresection combined with ¹⁰⁶ Ru brachytherapy (n = 17, 16.0%), and exoresection (n = 1, 0.9%). At a median follow-up of 37.3 months, the overall globe salvage rate was 44.3%. Kaplan-Meier analysis showed a 5-year and 10-year distant metastasis rate of 22%, with disease-specific survival rates of 82% and 75%, respectively. The incidence of melanoma-related death was 3.4 per 100 person-years, increasing with tumor stage. In multivariate analysis, distant metastasis was the only significant factor associated with the overall survival outcome.</div></div><div><h3>Conclusions</h3><div>This study provides insights into the clinical features, treatment outcomes, and prognostic factors of UM in a Southeast Asian cohort. Tumor stage and the presence of metastasis significantly influence prognosis, highlighting the importance of early detection and individualized treatment strategies to improve patient outcomes.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100295"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predicting fluid-free retina and complete polypoidal regression in polypoidal choroidal vasculopathy eyes receiving 2-mg aflibercept treatments","authors":"Voraporn Chaikitmongkol ,&nbsp;Thidarat Somkuna ,&nbsp;Direk Patikulsila ,&nbsp;Paisan Ruamviboonsuk ,&nbsp;Pichai Jirarattanasopa ,&nbsp;Titipol Srisomboon ,&nbsp;Chanusnun Narongchai ,&nbsp;Mansing Ratanasukon ,&nbsp;Patama Bhurayanontachai ,&nbsp;Paradee Kunavisarut ,&nbsp;Nawat Watanachai ,&nbsp;Janejit Choovuthayakorn ,&nbsp;Peranut Chotcomwongse ,&nbsp;Apisara Sangkaew ,&nbsp;Thammasin Ingviya ,&nbsp;Neil M. Bressler","doi":"10.1016/j.apjo.2026.100298","DOIUrl":"10.1016/j.apjo.2026.100298","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine predictive factors for fluid-free retina and complete polypoidal choroidal vasculopathy (PCV) regression following 1-year aflibercept monotherapy in PCV.</div></div><div><h3>Methods</h3><div>Multicenter, retrospective cohort of treatment-naïve PCV eyes receiving 2-mg aflibercept treatments for 1 year from 2015 to 2018 collected demographic data, de-identified fundus photography, optical coherence tomography (OCT), and indocyanine green angiography (ICGA) images at baseline and 1-year of study eyes were graded to identify baseline features and outcomes.</div></div><div><h3>Results</h3><div>Of 100 study eyes, mean age [SD] was 63.8 [8] years; 100% were Thai patients. At 1 year, eighty-five eyes (85%) had fluid-free retina; 48 eyes (48%) had complete polypoidal regression. Multivariate analyses showed baseline OCT and ICGA features associated with 1-year outcomes: sharply-peaked PED with/without double-layer sign on OCT and smaller lesion size on ICGA (&lt;1 disc diameter) were associated with fluid-free retina (OR 6.57; 95%CI 1.27–34.10, and OR 7.86; 95%CI 1.33–46.54, respectively). Multilobulated PED on OCT was associated with poor (20/200 or worse) final VA (OR 4.53; 95%CI 1.33–15.36). Smaller number (1−5) of polypoidal lesions on ICGA was associated with complete polypoidal regression (OR 4.87; 95%CI 1.44–16.43)</div></div><div><h3>Conclusion</h3><div>Results suggest baseline OCT and ICGA features could predict fluid-free retina and complete polypoidal regression following aflibercept monotherapy.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100298"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal myeloid sarcoma as the initial manifestation of acute myeloid leukemia","authors":"Yidong Wu ,&nbsp;Xuemei Zhang ,&nbsp;Carol L. Shields ,&nbsp;Xiaolu Yang","doi":"10.1016/j.apjo.2025.100263","DOIUrl":"10.1016/j.apjo.2025.100263","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100263"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goniotomy and phacogoniotomy in glaucoma surgery","authors":"Bin Xie ,&nbsp;Zefeng Yang ,&nbsp;Zhixuan Wang ,&nbsp;Zige Fang ,&nbsp;Yunhe Song ,&nbsp;Fengbin Lin ,&nbsp;Guihua Xu ,&nbsp;Fengqi Zhou ,&nbsp;Joseph Anthony Tumbocon ,&nbsp;Ying Han ,&nbsp;Clement C. Tham ,&nbsp;Tin Aung ,&nbsp;Tanuj Dada ,&nbsp;Robert N. Weinreb ,&nbsp;Fei Li ,&nbsp;Xiulan Zhang","doi":"10.1016/j.apjo.2026.100296","DOIUrl":"10.1016/j.apjo.2026.100296","url":null,"abstract":"<div><div>Goniotomy (GT) or ab interno trabeculotomy facilitates aqueous humor drainage thereby resulting intraocular pressure (IOP) reduction by incising the trabecular meshwork and the inner wall of Schlemm’s canal. It can be performed alone or combined with cataract surgery, a procedure known as phacogoniotomy. As these procedures can be performed with non-device built instruments compared to other minimally invasive glaucoma surgery (MIGS) devices or procedures, they are increasingly adopted in low- and middle-income countries (LMICs) and primary-level hospitals. To summarize the clinical use and future directions of GT and phacogoniotomy, we conducted a comprehensive literature review by searching PubMed. The available evidence suggests that GT and phacogoniotomy are effective and safe procedures, providing a widely adopted surgical option applicable to glaucoma patients of all ages.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100296"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International consensuses and guidelines on clinical practices on abducens nerve palsy by the Asia-Pacific Strabismus and Pediatric Ophthalmology Society (APSPOS) and the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO)","authors":"Jing Yao ,&nbsp;Sonal K. Farzavandi ,&nbsp;Miho Sato ,&nbsp;Boon Long Quah ,&nbsp;Simon T. Ko ,&nbsp;Thandalam S. Surendran ,&nbsp;An-Guor Wang ,&nbsp;Jeong-Min Hwang ,&nbsp;Rita S. Sitorus ,&nbsp;Srijana Adhikari ,&nbsp;Deepanee Wewalwala ,&nbsp;Huy Van Nguyen ,&nbsp;Huy Dinh Minh Tran ,&nbsp;Charlene Yim ,&nbsp;Yueping Li ,&nbsp;Shuan Dai ,&nbsp;Wei Zhang ,&nbsp;Kanxing Zhao ,&nbsp;Jason C. Yam ,&nbsp;Frank Martin ,&nbsp;Chen Zhao","doi":"10.1016/j.apjo.2026.100297","DOIUrl":"10.1016/j.apjo.2026.100297","url":null,"abstract":"<div><div>Abducens nerve palsy is the most common ocular motor neuropathy, with a population-based annual incidence of approximately 4.7–11.3 per 100,000. It classically manifests as esotropia, horizontal diplopia, abduction deficit and compensatory head turn. Management follows a stepwise approach: immediate evaluation and treatment of underlying causes, followed by nonsurgical interventions, and surgical correction if misalignment persists beyond six months. However, various etiologies make it challenging to accurately diagnose and manage abducens nerve palsy in a cost-effective way. Controversies persist regarding the optimal timing of neuroimaging, the utility of botulinum toxin injection, and the selection of surgical procedures for partial versus complete palsy. To address these controversies and standardize the care, the Asia-Pacific Strabismus and Pediatric Ophthalmology Society (APSPOS) and the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) convened an expert panel of 21 experts from 12 countries/territories to discuss and vote on key consensus statements covering the evaluation and diagnosis, non-surgical management, and surgical management of abducens nerve palsy. 17 consensus statements were discussed, with 16 (94.12%) statements achieved ≥ 75% agreement. These statements can provide a practical, etiology-based algorithm to guide diagnosis and management of abducens nerve palsy.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 2","pages":"Article 100297"},"PeriodicalIF":4.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The extent of peripheral anterior synechiae and efficacy of combined phacoemulsification and goniosynechialysis in primary angle-closure glaucoma and cataracts: A multicenter prospective study","authors":"Kun Xiong ,&nbsp;Yachen Wang ,&nbsp;Bo Yu ,&nbsp;Shaodan Zhang ,&nbsp;Guoxing Li ,&nbsp;Qiangjie Huang ,&nbsp;Rongrong Le ,&nbsp;Yanqian Xie ,&nbsp;Huiyan Mao ,&nbsp;JingJing Zuo ,&nbsp;Qingyi Liu ,&nbsp;Muyao Xin ,&nbsp;Wuliang Li ,&nbsp;Lu Yang ,&nbsp;Lijun Zhao ,&nbsp;Xiaoli Xing ,&nbsp;Xiaoping Xu ,&nbsp;Yuanbo Liang ,&nbsp;Ningli Wang","doi":"10.1016/j.apjo.2026.100279","DOIUrl":"10.1016/j.apjo.2026.100279","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the association between the preoperative extent of peripheral anterior synechiae (PAS) and the efficacy of combined phacoemulsification (PEI) and goniosynechialysis (GSL) in primary angle-closure glaucoma (PACG) with cataracts.</div></div><div><h3>Design</h3><div>Multicenter prospective study</div></div><div><h3>Methods</h3><div>Patients with PACG and cataracts undergoing PEI–GSL were recruited from five hospitals between November 1, 2022, and March 12, 2024. According to the extent of PAS, the patients were divided into three groups: PAS &lt; 180°, 180°≤ PAS ≤ 270°, and 270°&lt; PAS ≤ 360°. Intraocular pressure (IOP), the number of antiglaucoma medications, cumulative success rates, complications, and reoperations were analyzed. The relationship between chamber angle and IOP was also examined using anterior segment optical coherence tomography (AS-OCT).</div></div><div><h3>Results</h3><div>Of 232 patients who were enrolled for the surgical outcome analysis. The IOP and the number of antiglaucoma medications were significantly reduced in the three groups after surgery. At 12 months postoperatively, the IOP values were 13.8 ± 3.2 mmHg, 14.3 ± 3.0 mmHg, and 13.6 ± 2.8 mmHg (<em>P</em> &gt; 0.05), and the number of antiglaucoma medications was 0.15 ± 0.66, 0.17 ± 0.50, and 0.04 ± 0.20 (<em>P</em> &gt; 0.05) for the PAS &lt; 180°, 180° ≤ PAS ≤ 270°, and 270°&lt; PAS ≤ 360° groups, respectively. The complete success rates were 83.0 %, 77.1 %, and 84.8 % (<em>P</em> = 0.345), and the qualified success rates were 85.9 %, 87.6 %, and 91.0 % (<em>P</em> = 0.690), respectively. There were no significant differences in complications and reoperation among the three groups (<em>P</em> &gt; 0.05). Furthermore, the change in IOP and the percentage change in IOP increased with the extent of PAS. The AS-OCT parameters were not associated with postoperative IOP (<em>P</em> &gt; 0.05), but some were associated with the change in IOP and the percentage change in IOP.</div></div><div><h3>Conclusions</h3><div>The success rate and complications of PEI–GSL in treating PACG and cataracts were independent of the baseline extent of PAS. The larger extent of baseline PAS achieved greater IOP reduction postoperatively, and the AS-OCT parameters were related to the change in IOP.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"15 1","pages":"Article 100279"},"PeriodicalIF":4.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145958257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}