Asia-Pacific Journal of Ophthalmology最新文献

{"title":"41 Gauge transvitreal fine-needle aspiration biopsy for intraocular tumors without vitrectomy","authors":"Chul Hee Lee, Min Kim, Su-Jin Shin","doi":"10.1097/APO.0000000000000610","DOIUrl":"10.1097/APO.0000000000000610","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100056"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000513/pdfft?md5=31b3f87862336c476b60280c2c9a7f16&pid=1-s2.0-S2162098924000513-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9858935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular large B-cell lymphoma of the eye: Literature review and new findings","authors":"Eduardo Roditi ,&nbsp;Shyam Panicker ,&nbsp;Adrian T. Fung","doi":"10.1016/j.apjo.2024.100053","DOIUrl":"10.1016/j.apjo.2024.100053","url":null,"abstract":"<div><h3>Purpose</h3><p>Intravascular large B-cell lymphoma (IVLBCL) is an extremely rare, aggressive, multi-system disease that can affect the eye. We describe the ophthalmic presentation, multimodal imaging and treatment response of uveal IVLBCL.</p></div><div><h3>Methods</h3><p>Review and case report.</p></div><div><h3>Results</h3><p>Twenty-five published cases of IVLBCL involving the eye including our own were identified. Of these, 15 patients (60%) had clinically-detectable intraocular involvement, 6 (24%) had extraocular ophthalmic involvement only and 4 (16%) had subclinical, undiagnosed intraocular involvement that was retrospectively detected on post-mortem ocular histopathology. The male to female ratio was 1.08:1 with a mean presenting age of 65.1 ± 11.7 years (range 38–82 years). The majority of cases had bilateral involvement (21/25 patients, 84%). Extraocular manifestations included diplopia, ptosis and ophthalmoplegia. Intraocular manifestations included serous retinal detachment (13/28, 46%), retinal hemorrhages (9/28, 32%), vascular changes (9/28, 32%), retinal pigment epithelial changes (7/28, 25%), thickened choroid (6/28, 21%), vitritis (5/28, 17%), cotton-wool spots (3/28, 10%), and a subretinal lesion (1/28, 3%). Histopathological diagnosis was most commonly confirmed on post-mortem enucleation (8/25 patients, 32%), skin (6/25 patients, 24%) or brain biopsy (6/25 patients, 24%).</p></div><div><h3>Conclusion</h3><p>The presence of intra-retinal hemorrhages, cotton wool spots and/or Roth spots help differentiate IVLBCL from other similarly presenting diseases such as central serous chorioretinopathy and Vogt-Koyanagi-Harada disease. New signs not previously described in IVLBCL include macular bacillary layer detachment and hypo-cyanescent spots on ultra-wide field indocyanine green angiography. The diagnosis is elusive and requires tissue biopsy, but systemic chemotherapy and rituximab can lead to rapid improvement of the eye.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100053"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000483/pdfft?md5=83fb7b14d366b521f0b7f478f4278a02&pid=1-s2.0-S2162098924000483-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted therapy in ophthalmic oncology: The current status","authors":"Mrittika Sen ,&nbsp;Hakan Demirci ,&nbsp;Santosh G. Honavar","doi":"10.1016/j.apjo.2024.100062","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100062","url":null,"abstract":"<div><p>There have been rapid advancements in the field of ocular oncology for the diagnosis and management of intraocular, adnexal, and orbital tumors. Targeted therapy is in the forefront of medical research in all fields including ocular oncology. Targeted therapy include drugs that target specific genetic mutations, pathways or proteins involved in the development of cancer. In contrast to traditionally used chemotherapy, drugs used in targeted therapy are highly specific for tumor cells and preserve the function of normal cells. This review aims to familiarize ophthalmologists with the drugs that are currently approved or undergoing clinical trials for use in ocular oncology. Targeted therapy is particularly useful for locally advanced or metastatic tumors, including but not limited to eyelid and periocular basal cell carcinoma, periocular cutaneous and conjunctival squamous cell carcinoma, ocular adnexal lymphoma, conjunctival melanoma, and uveal melanoma. The results are promising with improved survival outcomes and better tolerability than chemotherapeutic drugs.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100062"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000574/pdfft?md5=85678c7a220df6a776bbd6d7db46735b&pid=1-s2.0-S2162098924000574-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral diffuse uveal melanocytic proliferation secondary to combined hepatocellular-cholangiocarcinoma","authors":"Xiaolu Yang ,&nbsp;Ruonan Wang ,&nbsp;Hao Zhou ,&nbsp;Suqin Yu","doi":"10.1016/j.apjo.2024.100051","DOIUrl":"10.1016/j.apjo.2024.100051","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100051"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S216209892400046X/pdfft?md5=61680a9e0dd48211954fae0c94a3cfb6&pid=1-s2.0-S216209892400046X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An optimized 3T MRI scan protocol to assess iris melanoma with subsequent histopathological verification – A prospective study","authors":"Joevy Z. Lim ,&nbsp;Akilesh Gokul ,&nbsp;Stuti L. Misra ,&nbsp;Xingzheng Pan ,&nbsp;Amanda Charlton ,&nbsp;Charles N.J. McGhee","doi":"10.1016/j.apjo.2024.100047","DOIUrl":"10.1016/j.apjo.2024.100047","url":null,"abstract":"<div><h3>Introduction</h3><p>Magnetic resonance imaging (MRI) has demonstrated high levels of tissue contrast, accuracy and reproducibility in evaluating posterior uveal melanoma. Owing to smaller size, the role of MRI in detecting and characterising iris melanoma has not yet been explored. Aims: To develop a protocol to image iris melanoma and describe the MRI characteristics of histopathological-confirmed iris melanoma.</p></div><div><h3>Materials and methods</h3><p>An optimised MRI protocol, using a 3T MRI scanner and a 32-channel head coil, was developed to image iris tumours. A prospective, single-centre, 12-month study was conducted on all patients with lesions suspicious for iris melanoma. All patients were offered an MRI scan in addition to the standardised clinical procedures. Image quality comparison was made with existing clinical investigations. Iris melanoma characteristics on MRI are described.</p></div><div><h3>Results</h3><p>A successful optimised MRI scan protocol was developed that was able to detect and characterise iris melanoma. One normal participant and five patients with subsequent histopathological-confirmed iris melanoma (n = 6) were recruited. Four patients completed the full MRI sequence. All iris melanoma were detected on at least one T1- or T2-weighted images. When compared to the vitreous, all iris melanomas demonstrated hyper-intensity on T1-weighted images and hypo-intensity on T2-weighted images. On T1-mapping, T1-values of iris melanoma demonstrated an inverse relationship with the degree of tumour pigmentation.</p></div><div><h3>Conclusions</h3><p>This study highlights an optimised, easily reproducible MRI scan protocol to image iris melanoma. Numerous MR imaging characteristics of iris melanoma are reported for the first time and a potential non-invasive tumour biomarker is described.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100047"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000422/pdfft?md5=83747ae401ee0d43d720708a9f770ffe&pid=1-s2.0-S2162098924000422-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of fitzpatrick skin type and iris color with tumor size in 823 patients with uveal melanoma","authors":"Kushal U. Agrawal,&nbsp;Matthew R. Barke,&nbsp;Lawrence Chiang,&nbsp;Roselind Ni,&nbsp;Rachel S. Kim,&nbsp;Qiang Zhang,&nbsp;Carol L. Shields","doi":"10.1016/j.apjo.2024.100046","DOIUrl":"10.1016/j.apjo.2024.100046","url":null,"abstract":"<div><h3>Purpose</h3><p>To determine the correlation of Fitzpatrick Skin Type (FST) and iris color with tumor size (tumor thickness and basal diameter) in patients with uveal melanoma.</p></div><div><h3>Design</h3><p>Retrospective Cohort</p></div><div><h3>Methods</h3><p>Retrospective cohort from a single ocular oncology center of 823 patients with uveal melanoma and documented FST, iris color, and tumor size. Patients were classified by FST (type I, II, and III–V) and iris color (blue, green, and brown) on the basis of external facial photography. There were no FST type VI patients. Tumor thickness was classified into small [&lt; 3 millimeter (mm)], medium (3.1–8.0 mm), or large (&gt; 8.0 mm), and basal diameter into small (&lt; 10 mm), medium (10.1–15 mm) or large (&gt; 15 mm). The correlation of FST and iris color with tumor thickness and basal diameter was evaluated using the Kruskal-Wallis H test.</p></div><div><h3>Results</h3><p>The FST classification was type I (n = 92, 11%), type II (n = 643, 78%), or III–V (n = 88, 11%), and iris color was blue (n = 472, 57%), green (n = 102, 12%), or brown (n = 249, 30%). A comparison of FST revealed differences in mean tumor thickness (<em>P</em> = 0.04) and basal diameter (<em>P</em> = 0.006). Iris color showed no difference for mean tumor thickness (<em>P</em> = 0.41) or basal diameter (<em>P</em> = 0.48). There was a statistically significant difference with brown iris color relative to FST III–V for mean tumor thickness (<em>P</em> = 0.003) and basal diameter (<em>P</em> = 0.001) but no difference with blue or green iris color (<em>P</em> &gt; 0.05).</p></div><div><h3>Conclusions</h3><p>Iris color alone showed no difference in tumor size, but those with brown iris color and FST type III–V demonstrated larger tumor thickness and basal diameter.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100046"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000306/pdfft?md5=706bc3e2d29bb003370b1e8f2b6e285c&pid=1-s2.0-S2162098924000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139696869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse preretinal vitreous seeding as a recurrence of uveal melanoma","authors":"L. Yamamoto-Rodríguez,&nbsp;D. Lorenzo,&nbsp;R. Mediavilla-Vallespín,&nbsp;JM Caminal","doi":"10.1016/j.apjo.2024.100048","DOIUrl":"10.1016/j.apjo.2024.100048","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100048"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000434/pdfft?md5=ed8f1797b7dba785b37683d358e0add5&pid=1-s2.0-S2162098924000434-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"41 Gauge transvitreal fine-needle aspiration biopsy for intraocular tumors without vitrectomy.","authors":"Chul Hee Lee, Min Kim, Su-Jin Shin","doi":"10.1097/APO.0000000000000610","DOIUrl":"https://doi.org/10.1097/APO.0000000000000610","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"100056"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveal melanoma: Current evidence on prognosis, treatment and potential developments","authors":"Maria Chiara Gelmi,&nbsp;Martine J. Jager","doi":"10.1016/j.apjo.2024.100060","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100060","url":null,"abstract":"<div><p>Uveal Melanoma (UM) is a rare disease, yet it is the most common primary intraocular malignancy in adult patients. Despite continuous advancements and research, the risk of metastasis remains high. It is possible to stratify patients according to their risk of metastases using a variety of known risk factors. Even though there is no gold standard for the prognostication of patients with uveal melanoma, it is becoming increasingly clear that combining histo-pathological, patient-related and molecular prognostic markers allows a more accurate prediction of the metastatic risk than by using one parameter. Primary UM in the eye are treated very effectively with eye-sparing radiation-based techniques or enucleation. However, it is not yet possible to prevent or treat metastases with the current therapeutic options. Nonetheless, the efforts to find new therapeutic targets continue and progress is being made, especially in the field of targeted therapy, as exemplified by the anti-gp100 bispecific molecule Tebentafusp. This review delves into the history of uveal melanoma, its incidence, presentation and diagnosis, the known prognostic factors and the treatment options, both for the primary tumour and for metastases. We show that different populations may have different risks for developing UM, and that each country should evaluate their own patients.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100060"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000550/pdfft?md5=370aeec9463fd109397c6f3e37edc461&pid=1-s2.0-S2162098924000550-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in retinoblastoma: Pathogenesis, presentation, diagnosis and management","authors":"Min Zhou ,&nbsp;Jieling Tang ,&nbsp;Jiayan Fan ,&nbsp;Xuyang Wen ,&nbsp;Jianfeng Shen ,&nbsp;Renbing Jia ,&nbsp;Peiwei Chai ,&nbsp;Xianqun Fan","doi":"10.1016/j.apjo.2024.100058","DOIUrl":"https://doi.org/10.1016/j.apjo.2024.100058","url":null,"abstract":"<div><p>Retinoblastoma, the primary ocular malignancy in pediatric patients, poses a substantial threat to mortality without prompt and effective management. The prognosis for survival and preservation of visual acuity hinges upon the disease severity at the time of initial diagnosis. Notably, retinoblastoma has played a crucial role in unraveling the genetic foundations of oncogenesis. The process of tumorigenesis commonly begins with the occurrence of biallelic mutation in the <em>RB1</em> tumor suppressor gene, which is then followed by a cascade of genetic and epigenetic alterations that correspond to the clinical stage and pathological features of the tumor. The <em>RB1</em> gene, recognized as a tumor suppressor, encodes the retinoblastoma protein, which plays a vital role in governing cellular replication through interactions with E2F transcription factors and chromatin remodeling proteins. The diagnosis and treatment of retinoblastoma necessitate consideration of numerous factors, including disease staging, germline mutation status, family psychosocial factors, and the resources available within the institution. This review has systematically compiled and categorized the latest developments in the diagnosis and treatment of retinoblastoma which enhanced the quality of care for this pediatric malignancy.</p></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 2","pages":"Article 100058"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2162098924000537/pdfft?md5=4574acbfced6f750ba7b6fccc6269c2e&pid=1-s2.0-S2162098924000537-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}