Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Efficacy, durability and safety of faricimab for patients with neovascular age-related macular degeneration: 48-week results from the phase 3 LUCERNE China subpopulation","authors":"Wenjun Zou ,&nbsp;Qin Jiang ,&nbsp;Yanling Wang ,&nbsp;Wenbin Wei ,&nbsp;Xiaodong Sun ,&nbsp;Karen Basu ,&nbsp;Qiuyu Chen ,&nbsp;Aachal Kotecha ,&nbsp;Sijing Li ,&nbsp;Ruyuan Liu ,&nbsp;Vaibhavi Patel ,&nbsp;Youxin Chen","doi":"10.1016/j.apjo.2025.100142","DOIUrl":"10.1016/j.apjo.2025.100142","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.</div></div><div><h3>Design</h3><div>LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.</div></div><div><h3>Methods</h3><div>Treatment-naïve patients aged ≥50 years with nAMD were randomized 1:1 to receive faricimab 6.0 mg up to every 16 weeks (Q16W) based on prespecified disease criteria after four initial Q4W doses or aflibercept 2.0 mg Q8W after three initial Q4W doses. The primary endpoint was mean change from baseline in best-corrected visual acuity (BCVA) averaged over weeks 40 to 48. Anatomical, durability and safety outcomes were also evaluated.</div></div><div><h3>Results</h3><div>The China subpopulation comprised 119 patients (faricimab: n = 59, aflibercept: n = 60). At weeks 40 to 48, adjusted mean (95% confidence interval [CI]) BCVA letter gains from baseline were +9.7 (7.4 to 12.0) and +9.8 (7.5 to 12.1) with faricimab and aflibercept, respectively. Central subfield thickness was reduced from baseline by weeks 40 to 48 in both arms, with an adjusted mean (95% CI) change of −145.4 µm (−156.2 to −134.6) and −156.5 µm (−167.3 to −145.7) for faricimab and aflibercept, respectively. By week 48, 87.3% of the patients were on extended ≥Q12W faricimab dosing. Faricimab was well tolerated with no new safety signals.</div></div><div><h3>Conclusions</h3><div>Faricimab up to Q16W showed durable efficacy in the LUCERNE China subpopulation, consistent with global findings. Faricimab may reduce treatment burden for patients with nAMD in China, without compromising efficacy.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100142"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus and guidelines on diagnosis and management of polypoidal choroidal vasculopathy (PCV) from the Asia-Pacific Vitreo-retina Society (APVRS)","authors":"Paisan Ruamviboonsuk ,&nbsp;Danny S.C. Ng ,&nbsp;Voraporn Chaikitmongkol ,&nbsp;Andrew Chang ,&nbsp;Shih-Jen Chen ,&nbsp;Youxin Chen ,&nbsp;Chui Ming Gemmy Cheung ,&nbsp;Fumi Gomi ,&nbsp;Robyn Guymer ,&nbsp;Judy E. Kim ,&nbsp;Adrian Koh ,&nbsp;Gregg T. Kokame ,&nbsp;Chi-Chun Lai ,&nbsp;Timothy Y.Y. Lai ,&nbsp;Won Ki Lee ,&nbsp;Yuichiro Ogura ,&nbsp;Srinivas Sadda ,&nbsp;Kelvin Y.C. Teo ,&nbsp;Tien Yin Wong ,&nbsp;Yasuo Yanagi ,&nbsp;Dennis S.C. Lam","doi":"10.1016/j.apjo.2025.100144","DOIUrl":"10.1016/j.apjo.2025.100144","url":null,"abstract":"<div><div>A panel of 21 international experts are formed by the Asia-Pacific Vitreo-retina Society to work out the consensus and guidelines on polypoidal choroidal vasculopathy (PCV). PCV is a common subtype of neovascular age-related macular degeneration and is more prevalent in Asian populations. Recent advancement in imaging technology allows greater understanding of the disease process of PCV. Furthermore, non–indocyanine green angiography features in optical coherence tomography angiography have been validated for PCV diagnosis and treatment response monitoring. Clinical trials provide new data on the safety and efficacy of various anti–vascular endothelial growth factor (anti-VEGF) agents as well as protocols that aim to improve the sustainability of treatments. In view of the myriads of emerging information, the panel gathered, reviewed, discussed, formulated and voted on the consensus and guidelines of PCV on four areas: 1) disease entity, 2) investigation and diagnosis, 3) treatment options, and 4) management protocol and future development in a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). We proposed using a consensus score in which the maximum was 100. The summation of the respective “percentages” of experts voting for “agree” or “strongly agree” would be counted as the actual score. Consensus was achieved when the actual score of 75 or more was reached, which meant at least 75 % of the experts had voted for “strongly agree” or “agree” on the consensus statement concerned.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100144"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definition for consensus statement much needed","authors":"Xianqun Fan,&nbsp;Clement C. Tham,&nbsp;Christopher K.S. Leung,&nbsp;Jost B. Jonas","doi":"10.1016/j.apjo.2025.100141","DOIUrl":"10.1016/j.apjo.2025.100141","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100141"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial elongation in nonpathologic high myopia: Ocular structural changes and glaucoma diagnostic challenges","authors":"Kangjie Kong ,&nbsp;Xiaoyi Liu ,&nbsp;Zige Fang ,&nbsp;Jingwen Jiang ,&nbsp;Jiaxuan Jiang ,&nbsp;Deming Wang ,&nbsp;Zefeng Yang ,&nbsp;Fengqi Zhou ,&nbsp;Evan M. Chen ,&nbsp;Jill Liang ,&nbsp;Yunhe Song ,&nbsp;Fengbin Lin ,&nbsp;Kyoko Ohno-Matsui ,&nbsp;Jost B. Jonas ,&nbsp;Ying Han ,&nbsp;Fei Li ,&nbsp;Xiulan Zhang ,&nbsp;for the Glaucoma Suspects with High Myopia Study Group","doi":"10.1016/j.apjo.2024.100123","DOIUrl":"10.1016/j.apjo.2024.100123","url":null,"abstract":"<div><div>Axial elongation continues in highly myopic adult eyes, even in the absence of pathologic changes such as posterior staphyloma or chorioretinal atrophy. This ongoing axial elongation leads to structural changes in the macular and peripapillary regions, including chorioretinal thinning, reduced vascular perfusion and optic disc tilting and rotation, among others. These alterations can affect the acquisition and interpretation of optical coherence tomography, optical coherence tomography angiography and fundus photographs, potentially introducing artifacts and diminishing the accuracy of glaucoma diagnosis in highly myopic eyes. In this review, we compared the progression patterns of axial elongation across populations with varying demographic characteristics, genetic and environmental backgrounds and ocular features. We also discussed the implications of axial elongation–induced ocular structural changes for diagnosing glaucoma in nonpathologic high myopia. Finally, we highlighted the prospects for enhancing the diagnostic efficacy of glaucoma in nonpathologic highly myopic populations.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100123"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid-onset central retinal vein occlusion following inactivated COVID-19 vaccination","authors":"Yuchen Zhang ,&nbsp;Hao Zhou ,&nbsp;Suqin Yu ,&nbsp;Chong Chen","doi":"10.1016/j.apjo.2024.100118","DOIUrl":"10.1016/j.apjo.2024.100118","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100118"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Coats’ disease in a 5-year-old boy","authors":"Meng-Chen Chiang ,&nbsp;Shawn H. Tsai ,&nbsp;Nan-Kai Wang ,&nbsp;Yung-Jen Lai","doi":"10.1016/j.apjo.2024.100119","DOIUrl":"10.1016/j.apjo.2024.100119","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100119"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmology training trends: Insights from an anonymised survey of Australian ophthalmology trainees","authors":"William B. Yates,&nbsp;Adrian T. Fung,&nbsp;Clare Fraser,&nbsp;Robert Griffits,&nbsp;Anne Lee,&nbsp;Peter J. McCluskey","doi":"10.1016/j.apjo.2024.100120","DOIUrl":"10.1016/j.apjo.2024.100120","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100120"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of optic nerve head morphology and peripapillary retinal nerve fibre layer thickness with myopic severity and treatment in children","authors":"Bryan Sim ,&nbsp;Rachel S. Chong ,&nbsp;Hla Myint Htoon ,&nbsp;Maithily Balakrishnan ,&nbsp;Noel A. Brennan ,&nbsp;Audrey Chia","doi":"10.1016/j.apjo.2024.100112","DOIUrl":"10.1016/j.apjo.2024.100112","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate the longitudinal associations between myopic optic disc features and optical coherence tomography (OCT) measurements of peripapillary retinal nerve fibre layer (RNFL) thickness in young myopic children in Singapore.</div></div><div><h3>Methods</h3><div>A prospective, single-site cohort study was conducted, involving children aged 7–16 years who participated in the PROM-Kids clinical cohort study from 2019 to 2022. Participants underwent annual assessments, including cycloplegic refraction, axial length measurements, fundus photography, and OCT imaging, with ocular magnification correction. Children were classified into low (LM, 0 to −3D), moderate (MM, −3.01 to −6D), and high (HM, &gt; −6D) myopia, with or without treatment.</div></div><div><h3>Results</h3><div>Data from 1000 children (right eye) were analyzed, including 521 with 2-year follow-up. At baseline, the mean age was 10.2 ± 1.6 years, with 46.4 % male and 90.7 % ethnic Chinese. HM children were older and exhibited greater optic disc tilt (ODT, 92 % vs. 80 %) and more peripapillary atrophy (PPA, 94 % vs. 73 %) compared to LM children. RNFL thickness decreased in the superior, inferior, and nasal quadrants but increased in the temporal quadrant with higher myopia. In the follow-up cohort, myopia progression was associated with thicker temporal quadrant and average RNFL, particularly in younger children. Prior treatment with myopia-control lenses was also associated with increased RNFL thickness in the superior quadrant.</div></div><div><h3>Conclusion</h3><div>Optic disc changes occur early in life, even in low myopia. Increasing myopia is linked to varying RNFL thickness across quadrants and may be influenced by age and myopia treatment.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100112"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in myopia management and prevention: A call to action","authors":"Enne Hiu Ying Leung,&nbsp;Sun Li,&nbsp;Lizhen Chen,&nbsp;Dennis Shun Chiu Lam","doi":"10.1016/j.apjo.2024.100111","DOIUrl":"10.1016/j.apjo.2024.100111","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100111"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an impending epidemic of myopia in Southeast Asia? An appraisal of the evidence","authors":"Ian George Morgan","doi":"10.1016/j.apjo.2024.100113","DOIUrl":"10.1016/j.apjo.2024.100113","url":null,"abstract":"<div><div>Predictions on the future prevalence of myopia suggest one of the Global Burden of Disease regions will develop an epidemic like in East Asia and Singapore in Southeast Asia. This paper analyses the available evidence on prevalence of myopia in this region, concluding that the bulk of the evidence suggests that the prevalence of myopia at the end of schooling is still modest, although two papers suggest that in young adults in Thailand and Indonesia, the prevalence of myopia may be approaching levels typical of the epidemic of myopia. It also analyses an indicator of expected years of education at school entry, as well as current educational levels of adults, using data from the calculation of the UN Human Development Index. It then analyses the results obtained by the countries of the Southeast Asian region in the PISA international surveys of student achievement. Neither of these educational indicators suggests an impending epidemic of myopia. There is a need for more data to clarify this uncertainty. It is suggested that future collection of data concentrate on determining the prevalence of myopia in young adults finishing their schooling. Even methodology as simple as determining levels of lowered visual acuity in senior school students should be sufficient to resolve the uncertainty. This group provides a sound basis for the prediction of future levels of myopia in the adult population, and avoids the impact of the high levels of myopia and high myopia associated with cataract development that occur in much of Southeast Asia.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"13 6","pages":"Article 100113"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}