Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Evaluating photodynamic therapy as an adjuvant treatment for neovascular AMD: A comprehensive meta-analysis","authors":"Swara M. Sarvepalli ,&nbsp;Ishani Kapoor ,&nbsp;Kubra Sarici ,&nbsp;Sunir J. Garg ,&nbsp;Majda Hadziahmetovic","doi":"10.1016/j.apjo.2025.100173","DOIUrl":"10.1016/j.apjo.2025.100173","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to assess the role of photodynamic therapy (PDT) as an adjunct to anti-vascular endothelial growth factor (Anti-VEGF) intravitreal injections in the treatment of neovascular age-related macular degeneration (nvAMD).</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, and ClinicalTrials.gov were searched for keywords “macular degeneration” and “photodynamic therapy” and “placebo” or “ranibizumab” or “bevacizumab” or “aflibercept” from inception to 2023. Included studies were peer-reviewed primary data reporting 12-month treatment results of nvAMD with anti-VEGF and PDT, anti-VEGF alone, intravitreal triamcinolone, or placebo. 23 studies were included in the final analysis. The major outcomes were best-corrected visual acuity (BCVA), central retinal thickness (CRT), and injection burden at 12 months.</div></div><div><h3>Results</h3><div>Anti-VEGF + PDT had better BCVA at 12 months compared to anti-VEGF (MD −0.07; 95 % CI −0.12, −0.01; <em>P</em> = 0.02). There was no significant difference in CRT at 12 months in anti-VEGF + PDT group versus anti-VEGF (MD −3.66; 95 % CI −10.28, 2.98; <em>P</em> = 0.28). Anti-VEGF + PDT group had significantly fewer injections compared to anti-VEGF (MD −1.76; 95 % CI −1.95, −1.58; <em>P</em> &lt; 0.0001). There was no significant difference in pooled ocular adverse events between anti-VEGF + PDT versus anti-VEGF (MD 0.96; 95 % CI 0.68, 1.36; <em>P</em> = 0.41).</div></div><div><h3>Conclusions</h3><div>PDT is a successful adjunctive to anti-VEGF injections for the treatment of nvAMD. The combination of the therapies leads to improved BCVA at 12 months, decreased injection burden, and no difference in ocular safety.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100173"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a greener vision: A review on advancing sustainability in ophthalmology","authors":"Onnisa Nanegrungsunk,&nbsp;Paradee Kunavisarut","doi":"10.1016/j.apjo.2025.100182","DOIUrl":"10.1016/j.apjo.2025.100182","url":null,"abstract":"<div><div>The growing environmental impact from healthcare sector necessitates the adoption of sustainable strategies to reuse, recycle, reduce waste, lower carbon emissions, etc. In ophthalmology, surgical waste poses a significant environmental challenge, particularly due to the high volume of surgeries, along with single-use instruments, packaging materials and disposable surgical supplies. Examples of practical strategies to reduce surgical waste include adopting reusable surgical instruments when safe and feasible, minimizing unnecessary packaging and optimizing operating room protocols, e.g., multidose topical drops on multiple patients. An education regarding sustainability for medical personnel can further decrease waste production in the long term. Collaboration between healthcare providers, manufacturers and policymakers is essential to developing and integrating sustainability into ophthalmic practice. By implementing these strategies, ophthalmologists can contribute to a more environmentally responsible healthcare system without compromising patient safety.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100182"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision loss following mountain trip with intraocular gas","authors":"Ting-An Chang,&nbsp;Ming-Shan He","doi":"10.1016/j.apjo.2025.100175","DOIUrl":"10.1016/j.apjo.2025.100175","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100175"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation and computerized adaptive testing simulations of age-related macular degeneration quality of life item banks","authors":"Eva K. Fenwick ,&nbsp;Ryan E.K. Man ,&nbsp;Anna C.S. Tan ,&nbsp;Raymond P. Najjar ,&nbsp;Dan Milea ,&nbsp;Ester P.X. Lee ,&nbsp;Tien Yin Wong ,&nbsp;Gavin S.W. Tan ,&nbsp;Hwei Wuen Chan ,&nbsp;Augustinus Laude ,&nbsp;Kelvin Y.C. Teo ,&nbsp;Shu Yen Lee ,&nbsp;Ian Yew San Yeo ,&nbsp;Ranjana Mathur ,&nbsp;Gemmy C.M. Cheung ,&nbsp;Ecosse L. Lamoureux","doi":"10.1016/j.apjo.2025.100178","DOIUrl":"10.1016/j.apjo.2025.100178","url":null,"abstract":"<div><h3>Purpose</h3><div>To optimize the psychometric properties of age-related macular degeneration (AMD) quality of life (QoL) item banks (IBs), and evaluate their performance using computerized adaptive testing (CAT) simulations.</div></div><div><h3>Design</h3><div>Cross-sectional, clinical study.</div></div><div><h3>Methods</h3><div>261 AMD patients answered 219 items within seven IBs: Activity Limitation (AL); Lighting (LT); Mobility (MB); Emotional (EM); Concerns (CN); AMD Management (AM); and Work (WK), referred to collectively as “MacCAT”. The psychometric properties of each IB (e.g. measurement precision; item “fit”; differential item functioning (DIF)) were assessed using Rasch analysis. The mean number of items required for “high” and “moderate” measurement precision was determined using CAT simulations.</div></div><div><h3>Results</h3><div>Of the 261 participants (mean age 70.5 ± 7.6 years), 69 (26.4 %), 35 (13.4 %), 80 (30.7 %) and 77 (29.5 %) had no, early, intermediate and late AMD (better eye), respectively. AL, EM, CN and AM displayed good psychometric properties overall after collapsing response categories and deleting items for misfit and/or DIF. Despite similar reengineering efforts, LT and MB had suboptimal measurement precision but were retained due to otherwise good psychometric performances. Owing to unresolvable psychometric issues, WK was not considered further. Targeting for all IBs was suboptimal. In CAT simulations on the six remaining IBs, the mean number of items required per IB ranged from 8 (AL) to 13 (MB) for moderate, and 13 (AL) to19 (MB) for high measurement precision.</div></div><div><h3>Conclusions</h3><div>Six IBs demonstrated acceptable psychometric properties and potential CAT efficiency, suggesting MacCAT provides a comprehensive measurement of the QoL impact of AMD and associated treatments. Further testing in larger clinical cohorts is needed.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100178"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of school entrance age on myopia among primary schoolchildren using mixed-effect model: The Shantou Myopia Study (SMS)” [Asia-Pac J Ophthalmol 2024 13 (6) 100121]","authors":"Hongxi Wang ,&nbsp;Linrong Wu ,&nbsp;Yuancun Li ,&nbsp;Xin Tan ,&nbsp;Jianwei Lin ,&nbsp;Kunliang Qiu ,&nbsp;Yali Du ,&nbsp;Shengjie Yin ,&nbsp;Binyao Chen ,&nbsp;Jiao Jiang ,&nbsp;Hailiu Chen ,&nbsp;Mingzhi Zhang","doi":"10.1016/j.apjo.2025.100179","DOIUrl":"10.1016/j.apjo.2025.100179","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 2","pages":"Article 100179"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis, and goniotomy for advanced primary angle-closure glaucoma without cataract: A multicenter study.","authors":"Fengbin Lin, Liu Li, Ping Lu, Li Tang, Yao Zhang, Lin Xie, Xiaomin Zhu, Guangxian Tang, Hengli Zhang, Lan Lu, Meichun Xiao, Jiangang Xu, Yunhe Song, Yuying Peng, Xiaoyan Li, Weirong Chen, Fengqi Zhou, Ningli Wang, Keith Barton, Ki Ho Park, Tin Aung, Robert N Weinreb, Clement C Tham, Dennis S C Lam, Sujie Fan, Ying Han, Xiulan Zhang","doi":"10.1016/j.apjo.2025.100166","DOIUrl":"https://doi.org/10.1016/j.apjo.2025.100166","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the two-year outcomes of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract.</p><p><strong>Design: </strong>Multicenter prospective study.</p><p><strong>Methods: </strong>The study included patients who received a combined SPI + GSL + GT for advanced PACG without cataract, all completed a 24-month follow-up. Outcome measures included changes in intraocular pressure (IOP), best-corrected visual acuity (BCVA), use of anti-glaucoma medications, surgical success, and postoperative complications over the 24-month period.</p><p><strong>Results: </strong>A total of 63 eyes from 51 patients with advanced PACG were included in the study. Among these, 37 eyes (58.7 %) achieved complete success, and 55 eyes (87.3 %) achieved qualified success. The mean IOPs at baseline and after 24 months were 28.8 ± 7.51 mm Hg and 15.8 ± 4.40 mm Hg, respectively (P < 0.001). The average number of anti-glaucoma medications decreased from 1.9 ± 1.4-0.8 ± 1.2 over the 24-month period (P < 0.001). The overall BCVA was stable during the follow-up period (P = 0.225). The primary complications observed included IOP spike (n = 9), hyphema (n = 7), and shallow anterior chamber (n = 3), all of which occurred within the first month postoperatively. Regression analysis showed that older age was positively associated with both complete success [odds ratio (OR) = 1.05; P = 0.030] and qualified success (OR = 1.08; P = 0.024).</p><p><strong>Conclusions: </strong>SPI + GSL + GT demonstrated safety and effectiveness in treating advanced PACG without cataract over the 24-month study period. This combined surgical approach should be considered a viable alternative to trabeculectomy for these patients.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100166"},"PeriodicalIF":3.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumbling pseudo-Krukenberg spindle.","authors":"Jonathan T W Au Eong, Das Avranil, Kah-Guan Au Eong","doi":"10.1016/j.apjo.2025.100170","DOIUrl":"10.1016/j.apjo.2025.100170","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100170"},"PeriodicalIF":3.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-inverted and single-layer \"plastic bag\" ILM flap novel technique to treat large macular holes.","authors":"Tian Tian, Dian Jiao, Xiang Zhang, Mingyang Wang, Shipeng Guo, Jiao Lyu, Peiquan Zhao","doi":"10.1016/j.apjo.2025.100164","DOIUrl":"10.1016/j.apjo.2025.100164","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy and safety of a novel non-inverted, free single-layer internal limiting membrane (ILM) flap technique for treating large full-thickness macular holes (FTMHs).</p><p><strong>Methods: </strong>Patients with FTMHs underwent a standard 3-port pars plana vitrectomy using the 23-gauge vitrectomy system. Unique to this technique, a \"tongue-shaped\" ILM flap was initially created, followed by the formation of two \"handles\" and the bottom of \"plastic bag\" ILM flaps. Under perfluoro-n-octane (PFO), the two-point fixed \"plastic bag\" ILM flap was transferred to the free flap and dragged to cover MH using the ocular viscoelastic device (OVD) to cover the margin of the ILM flap, followed by gas tamponade. Preoperative and postoperative assessments included best-corrected visual acuity (BCVA) and spectral domain optical coherence tomography (SD-OCT).</p><p><strong>Results: </strong>The 13 patients (mean age 64.38 ± 8.08 years, macular diameter 664.85 ± 153.38μm) demonstrated a significant improvement in BCVA from 1.03 ± 0.22 logMAR preoperatively to 0.78 ± 0.26 logMAR postoperatively (P = 0.0004). In all cases, successful closure of the MH was accomplished, including 10 (76.92 %) U-shaped closure, 1 (7.69 %) flat closure, 1 (7.69 %) W-shaped closure, 1 (7.69 %) flap closure, with no ILM flap dislocations.</p><p><strong>Conclusions: </strong>The non-inverted single-layer \"plastic bag\" ILM flap technique has been demonstrated to be both a safe and effective method for managing large FTMHs, offering a promising alternative to traditional methods with improved anatomical restorations and stable visual outcomes.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100164"},"PeriodicalIF":3.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The whole life cycle myopia management.","authors":"Moxin Chen, Qin Shu, Fang Li, Lin Li, Xianqun Fan","doi":"10.1016/j.apjo.2025.100161","DOIUrl":"10.1016/j.apjo.2025.100161","url":null,"abstract":"<p><p>Myopia stands as a prevalent ocular condition with global implications, impacting individuals at various life stages. In school-age children and adolescents, uncorrected myopia impedes reading and academic performance. Among middle-aged and elderly populations, myopia poses severe risks such as macular degeneration, macular holes and retinal detachment, leading to irreversible visual impairment. The term \"myopia management\" is widely embraced by ophthalmic practitioners and optometry associations worldwide, encompassing strategies to correct refractive errors and ongoing assessment of disease progression, aiming to reduce the progression of myopia and axial elongation. To date, current management strategies for myopia include public health policies, optical solutions, medical interventions and surgical options, but these interventions are general and lack age specificity. Despite existing interventions, we propose the concept of \"Whole Life Cycle Myopia Management\" in this review. This approach outlined major risk factors of myopia through the whole life cycle, discussed current interventions for myopia and provided age-specific management strategies for myopia of eight different life stages-infancies, toddlers, preschoolers, school-age children, adolescents, young adults, middle-age and old-age, including the prevention of myopia onset, slowing of myopia progression and monitoring of myopia complications. Achieving the \"Whole Life Cycle Myopia Management\" requires collaborations efforts from government, schools, hospitals and families, to restore vision and enhance the quality of life for those individuals affected by myopia.</p>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100161"},"PeriodicalIF":3.7,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of caffeine in slowing progression of myopia: 1-year results from a prospective, longitudinal clinical trial","authors":"Huy D.M. Tran ,&nbsp;Yen H. Tran ,&nbsp;Thao T.X. Ha ,&nbsp;Tuan D. Tran ,&nbsp;Monica Jong ,&nbsp;Minas Coroneo ,&nbsp;Padmaja Sankaridurg","doi":"10.1016/j.apjo.2025.100138","DOIUrl":"10.1016/j.apjo.2025.100138","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the role of topical caffeine in slowing progression of myopia, both as a standalone treatment and in combination with atropine.</div></div><div><h3>Methods</h3><div>In a prospective, randomized, dispensing clinical trial, 96 children with myopia, aged 6–13 years, spherical equivalent (SE) from –0.50 diopters (D) to –6.00 D and astigmatism less than 2.00 D were randomly assigned to nightly use of either 2 % caffeine, 0.02 % atropine with 2 % caffeine (combination) or 0.02 % atropine eye drops. An additional 86 children with myopia were enrolled in a concurrent parallel group to wear single-vision (SV) spectacles. The primary outcomes were changes in SE and axial length (AL) over a period of 12 months for each group.</div></div><div><h3>Results</h3><div>All groups progressed in myopia. At 12 months, the mean change in SE/AL was –0.76 ± 0.51 D / 0.37 ± 0.20 mm and –0.70 ± 0.55 D / 0.35 ± 0.23 mm with SV and 2 % caffeine, respectively. In comparison, progression was slower at –0.46 ± 0.50 D / 0.24 ± 0.19 mm and –0.47 ± 0.38 D / 0.23 ± 0.18 mm with atropine monotherapy and combination groups, respectively. Compared to the change in AL with SV, the change in AL was significantly less with 0.02 % atropine and the combination group (post hoc analysis, <em>P</em> = 0.024 and 0.007, respectively). Similarly, the change in SE was significantly less with 0.02 % atropine compared to the SV group (<em>P</em> = 0.027).</div></div><div><h3>Conclusions</h3><div>Used as a standalone treatment, topical 2 % caffeine did not slow myopia progression. When combined with atropine, caffeine had no impact on the efficacy of atropine in slowing myopia.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100138"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}