Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Treatment modalities and trends for hospitalized patients with neovascular glaucoma: A retrospective study of 10 years","authors":"Huishan Lin ,&nbsp;Xinbo Gao ,&nbsp;Zhuoyi Wu ,&nbsp;Wengian Tam ,&nbsp;Wei Huang ,&nbsp;Yue Dong ,&nbsp;Xi Qin ,&nbsp;Yao Liu ,&nbsp;Chengguo Zuo ,&nbsp;Mingkai Lin","doi":"10.1016/j.apjo.2025.100136","DOIUrl":"10.1016/j.apjo.2025.100136","url":null,"abstract":"<div><div>To analyze the treatment modalities and trends for neovascular glaucoma (NVG) over the past 10 years, we conducted a retrospective analysis at Zhongshan Ophthalmic Center on 1331 NVG inpatients who received 1459 treatments for 1383 eyes between January 1, 2012, and December 31, 2021. Over time, we observed a progressive annual increase in both the number of patients and the volume of surgeries for NVG, with an annual percentage change (APC) of 10.23 % (95 % confidence interval [CI]: 5.5–15.2 %, <em>P</em> = 0.001) and 11.59 % (95 % CI: 6.6–16.9 %, <em>P</em> = 0.001), respectively. Drainage valve implantation (46.88 %), cyclodestructive procedures (22.55 %) and trabeculectomy (6.24 %) were the three most commonly selected treatment options. The frequency of drainage valve implantation (APC = 6.59 %, 95 % CI = 0.9–12.6 %, <em>P</em> = 0.028), cyclodestructive procedures (APC = 17.26 %, 95 % CI = 9.3–25.8 %, <em>P</em> = 0.001) and trabeculectomy (APC = 21.93 %, 95 % CI = 1.6–46.3 %, <em>P</em> = 0.036) increased. The proportion of drainage valve implantation gradually decreased (APC = –4.48 %, 95 % CI = –8.6 to –0.2 %, <em>P</em> = 0.042), while that of cyclodestructive procedures increased (APC = 5.08 %, 95 % CI = 0.6–9.8 %, <em>P</em> = 0.042), with no significant alteration observed in the proportion of trabeculectomy (APC = 9.26 %, 95 % CI = –8.8–30.9 %, <em>P</em> = 0.290). Over the course of the study, both the cases of NVG and the volume of related surgeries escalated year by year. Among the three most frequently employed procedures—drainage valve implantation, cyclodestructive procedures and trabeculectomy—annual frequency trends revealed an increase in drainage valve implantation alongside a decreasing proportion, while cyclodestructive procedures exhibited a rising trend in both frequency and proportion; simultaneously, trabeculectomy showed an increasing frequency without a significant change in its proportion.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100136"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triterpenoid saponin–mediated recovery of visual deficits in age-related macular degeneration (AMD): Double-blind, placebo-controlled, randomised clinical trial","authors":"Yunhee Lee ,&nbsp;Eun-Jung Ahn ,&nbsp;Soo-Wan Chae ,&nbsp;Ali Aijaz Hussain","doi":"10.1016/j.apjo.2025.100143","DOIUrl":"10.1016/j.apjo.2025.100143","url":null,"abstract":"<div><h3>Purpose</h3><div>Recovery rate of rod photoreceptor sensitivity (S2 gradient) following a bleach is reduced in age-related macular degeneration (AMD) due to diminished delivery of retinol across a grossly altered Bruch's membrane. Since triterpenoid saponins are known to improve transport across Bruch's, we have assessed their possible use for reversing the visual deficits in AMD.</div></div><div><h3>Design</h3><div>Double-blind, placebo controlled randomised clinical trial.</div></div><div><h3>Methods</h3><div>Altogether 11 AMD patients and seven age-matched control subjects were recruited to undertake a small proof-of-principle study. Dark adaptation curves were obtained and S2 gradients evaluated using a Humphrey Field Analyser. Following basal determination of S2 gradients, oral supplementation of saponins (200 mg/day) or placebo regime was instigated for a period of 4 months. S2 gradients were re-evaluated at two and four months.</div></div><div><h3>Results</h3><div>Basal S2 gradients of the AMD cohort were determined as 0.41 ± 0.24 dB/min and those of the control subjects as 1.44 ± 0.1 dB/min. After two months of the saponin treatment, AMD subjects showed improved S2 gradients of 0.92 ± 0.23 dB/min (<em>P</em> &lt; 0.005) with a further increase to 1.35 ± 0.19 dB/min at four months (<em>P</em> &lt; 0.01), the latter not being significantly different from control subjects. S2 gradients in placebo subjects were unaltered.</div></div><div><h3>Conclusions</h3><div>Oral supplementation with saponins results in reversing the reduced S2 gradients in AMD. This improvement in the transport properties of Bruch's is expected to slow, halt or reverse the progression of AMD.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100143"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practices on acute acquired comitant esotropia: A consensus statement proposed by the Council of Asia-Pacific Strabismus and Pediatric Ophthalmology Society","authors":"Wen Wen ,&nbsp;Sonal K. Farzavandi ,&nbsp;Miho Sato ,&nbsp;Boon Long Quah ,&nbsp;Simon T. Ko ,&nbsp;T.S. Surendran ,&nbsp;An-Guor Wang ,&nbsp;Jeong-Min Hwang ,&nbsp;Rita S. Sitorus ,&nbsp;Shuan Dai ,&nbsp;Wei Zhang ,&nbsp;Kanxing Zhao ,&nbsp;Jason C. Yam ,&nbsp;Frank Martin ,&nbsp;Chen Zhao","doi":"10.1016/j.apjo.2025.100134","DOIUrl":"10.1016/j.apjo.2025.100134","url":null,"abstract":"<div><div>Acute acquired comitant esotropia (AACE) is a concomitant strabismus characterized by sudden onset, mostly associated with diplopia. The prevalence of AACE has significantly increased, and various management approaches have been recommended in recent years. This study by the Council of Asia-Pacific Strabismus and Pediatric Ophthalmology Society aimed to provide an overview of the clinical features, etiology and the nonsurgical and surgical treatment recommendations for the condition to equip strabismus specialists with the most updated knowledge.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100134"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the Article: Exaggerated immune response to fungal keratitis post-COVID19 vaccination","authors":"Yann Bertolani,&nbsp;Albert Arnaiz-Camacho,&nbsp;Sara Martín Nalda","doi":"10.1016/j.apjo.2025.100147","DOIUrl":"10.1016/j.apjo.2025.100147","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100147"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes for childhood myopia","authors":"Yu Yao Wang ,&nbsp;Li Jia Chen ,&nbsp;Clement C. Tham ,&nbsp;Jason C. Yam ,&nbsp;Chi Pui Pang","doi":"10.1016/j.apjo.2025.100139","DOIUrl":"10.1016/j.apjo.2025.100139","url":null,"abstract":"<div><div>Myopia is associated with interactive effects of genetic and environmental factors. The development of myopia in childhood is likely to be more dependent on genetic background. Candidate gene analysis, whole exome sequencing, genome-wide association studies (GWAS) and subsequent metaanalyses have identified more than 400 loci that are associated with myopia. However, most genome studies have been conducted in adults and only a few of genetic single nucleotide polymorphisms identified in adult GWAS have been successfully replicated in children. In this review, we summarized these variants and compared the effect size between children and adults.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100139"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical registries: Factors impacting clinician engagement","authors":"James Pietris,&nbsp;Shrirajh Satheakeerthy,&nbsp;Stephen Bacchi,&nbsp;Robert Casson,&nbsp;Dinesh Selva,&nbsp;Weng Onn Chan","doi":"10.1016/j.apjo.2025.100146","DOIUrl":"10.1016/j.apjo.2025.100146","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100146"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Comment on “Exaggerated immune response to fungal keratitis post-COVID-19 vaccination”","authors":"Isana Nakajima,&nbsp;Ken Fukuda,&nbsp;Tamaki Sumi,&nbsp;Kenji Yamashiro","doi":"10.1016/j.apjo.2025.100148","DOIUrl":"10.1016/j.apjo.2025.100148","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100148"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outdoor activity during class recess prevents myopia onset and shift in premyopic children: Subgroup analysis in the recess outside classroom study","authors":"Pei-Chang Wu ,&nbsp;Chia-Ling Tsai ,&nbsp;Yi-Hsin Yang","doi":"10.1016/j.apjo.2025.100140","DOIUrl":"10.1016/j.apjo.2025.100140","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether premyopia is a risk factor for myopia onset and whether outdoor activities can protect against myopia development in premyopic children in the Recess Outside Classroom (ROC) study.</div></div><div><h3>Methods</h3><div>Nonmyopic schoolchildren aged 7–11 years were recruited from two schools in Taiwan. One school implemented the ROC program, which encouraged children to go outdoors during recess. The control school maintained its usual schedule. A cycloplegic autorefraction was performed. Premyopia was defined as spherical equivalent refraction ≤ +0.75 diopters (D) and &gt; –0.50 D.</div></div><div><h3>Results</h3><div>After one year of follow-up, multivariate logistic analysis revealed that the ROC program reduced the risk of myopia onset by 61 % (odds ratio [OR] = 0.39, 95 % confidence interval [CI]: 0.21–0.70, <em>P</em> = 0.002). However, premyopia status increased the risk of myopia onset by 14 times compared to hyperopic status (OR = 14.0, 95 % CI: 1.86–105.3, <em>P</em> = 0.010). In the subgroup analysis of premyopic children, the myopic shift was also significantly lower in the ROC group than in the control group (–0.20 ± 0.60 D/year vs. –0.40 ± 0.66 D/year, <em>P</em> = 0.017). Myopia incidence in premyopic children was significantly lower in the ROC group than in the control group (19.6 % vs. 37.8 %, <em>P</em> = 0.001). Multivariate regression analysis showed that participation in the ROC program was significantly associated with a lower myopic shift in premyopic children (–0.22 D/year, 95 % CI: –0.39 to –0.06, <em>P</em> = 0.008)</div></div><div><h3>Conclusions</h3><div>Premyopia is a risk factor for myopia onset. A school policy that includes more outdoor time can effectively prevent myopia onset and shift in premyopic children.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100140"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of substitutive growth hormone therapy on myopia control among Chinese children","authors":"Yi Lu ,&nbsp;Jiamin Xie ,&nbsp;Lele Cheng ,&nbsp;Qingdong Fu ,&nbsp;Miao Wu ,&nbsp;Ji Jin ,&nbsp;Xun Xu","doi":"10.1016/j.apjo.2025.100137","DOIUrl":"10.1016/j.apjo.2025.100137","url":null,"abstract":"<div><h3>Purpose</h3><div>To explore the correlation between recombinant human growth hormone (rhGH) therapy and myopia progression, and to optimize the myopia control strategies in myopic children undergoing rhGH therapy.</div></div><div><h3>Methods</h3><div>This retrospective study included 27 myopic children receiving rhGH therapy and 57 myopic children in the control group, all of whom underwent myopia interventions. Axial length (AL) and refraction were measured by IOLMaster and an autorefractor after cycloplegia. AL changes were compared between the rhGH and control groups, before and after rhGH therapy, and among different myopia control strategies. Univariate and multivariate regression models analyzed factors associated with axial elongation.</div></div><div><h3>Results</h3><div>The rhGH group exhibited greater median AL change than the control group (0.29 mm/year; interquartile range [IQR], 0.19–0.40; n = 27 vs. 0.18 mm/year; IQR, 0.12–0.27; n = 57; <em>P</em> &lt; 0.001). Median axial elongation increased after rhGH treatment (0.22 mm/year; IQR, 0.12–0.34 vs. 0.32 mm/year; IQR, 0.26–0.40; n = 14; <em>P</em> = 0.026), while it decreased after cessation (0.39 mm/year; IQR, 0.16–0.56 vs. 0.04 mm/year; IQR, –0.03–0.15; n = 6; <em>P</em> = 0.031). After adjusting for confounders, axial elongation was faster in the rhGH group (β = 0.13, <em>P</em> &lt; 0.001). Longer rhGH therapy duration and shorter myopia control duration were associated with accelerated axial elongation (β = 0.13, <em>P</em> = 0.027). Dual-therapy myopia control appeared to mitigate excessive axial elongation in rhGH-treated children more effectively than monotherapy (0.27 mm/year; IQR, 0.18–0.31; n = 20 vs. 0.40 mm/year; IQR, 0.32–0.70; n = 7; <em>P</em> = 0.026).</div></div><div><h3>Conclusions</h3><div>Myopic children undergoing rhGH therapy would exhibit accelerated axial elongation despite myopia control. Close monitoring and dual-therapy myopia control strategies are recommended for these children.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100137"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous drainage of a large valsalva premacular hemorrhage","authors":"Dezhi Zheng,&nbsp;Zijing Huang","doi":"10.1016/j.apjo.2025.100145","DOIUrl":"10.1016/j.apjo.2025.100145","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 1","pages":"Article 100145"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}