Asia-Pacific Journal of Ophthalmology最新文献

{"title":"Programme for ocular inflammation & infection translational research (PROTON) registry: Cross-sectional analysis of baseline patient characteristics","authors":"William Rojas-Carabali ,&nbsp;Kevin Chan ,&nbsp;Carlos Cifuentes-Gonzalez ,&nbsp;Manisha Agarwal ,&nbsp;Alok Sen ,&nbsp;Jyotirmay Biswas ,&nbsp;Ranju Kharel (Sitaula) ,&nbsp;Rina La Distia Nora ,&nbsp;Anna Utami ,&nbsp;Anadi Khatri ,&nbsp;Padmamalini Mahendradas ,&nbsp;Ariel Schlaen ,&nbsp;Chitaranjan Mishra ,&nbsp;Yan Guex-Crosier ,&nbsp;Edmund Tsui ,&nbsp;Apoorva Ayachit ,&nbsp;Sapna Gangaputra ,&nbsp;John H. Kempen ,&nbsp;Vishali Gupta ,&nbsp;Alejandra de-la-Torre ,&nbsp;Sagun Narayan Joshi","doi":"10.1016/j.apjo.2025.100199","DOIUrl":"10.1016/j.apjo.2025.100199","url":null,"abstract":"<div><h3>Purpose</h3><div>The Programme for Ocular Inflammation &amp; Infection Translational Research (PROTON) registry collects real-world data on infectious and non-infectious ocular inflammatory diseases (OID) to enhance understanding of disease progression and treatment outcomes. This report presents the baseline characteristics of patients enrolled in two international multicentric studies, OASIS 1 and OASIS 2, over the first two years.</div></div><div><h3>Design</h3><div>A cross-sectional observational study.</div></div><div><h3>Methods</h3><div>PROTON is an observational ambispective cohort registry comprising OASIS 1, a retrospective study (2000–2021), and OASIS 2, a prospective study (2021 onwards). Data is collected at multiple intervals over a 10-year period, focusing on various OID. Participants include patients diagnosed with anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis, scleritis, retinal vasculitis, and neuroretinitis. Baseline characteristics, ocular examinations, and treatment outcomes are recorded.</div></div><div><h3>Results</h3><div>A total of 2640 patients (3642 eyes) have been recruited across 17 centers worldwide. Infectious was the most common etiology (31.6 %), followed by idiopathic (28.1 %), undetermined (21.7 %), and non-infectious (16.0 %). Most patients (54.8 %) were male, with anterior uveitis being the most common anatomical location (37.5 %). Visual impairment was present in 53.2 % of cases, with 18.8 % experiencing moderate (0.5–1.0 LogMAR) and 22.6 % severe impairment (&gt;1.0 LogMAR). Tuberculosis (64.0 %) and toxoplasmosis (13.5 %) were the leading infectious causes, while HLA-B27-associated uveitis accounted for 19.4 % of non-infectious cases.</div></div><div><h3>Conclusions</h3><div>The PROTON registry provides valuable insights into the global spectrum of OID, with a substantial representation of infectious causes. This real-world evidence highlights the key prevalence of visual impairment and underscores the importance of research on this topic. As the registry evolves, it will help refine clinical management strategies and improve patient outcomes globally.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100199"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"70 MHz ultrahigh frequency ultrasound imaging in spontaneous sclerocorneal fistula","authors":"Mathilde Kaspi ,&nbsp;Jean Luc Perrot ,&nbsp;Vincent Borderie ,&nbsp;Thibaud Garcin","doi":"10.1016/j.apjo.2025.100171","DOIUrl":"10.1016/j.apjo.2025.100171","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100171"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of blindness and vision loss among children and adolescents: A systematic analysis for the global burden of disease study 2021","authors":"Yinwen Li ,&nbsp;Yiyang Shu ,&nbsp;Tianwei Qian ,&nbsp;Yuzhou Zhang ,&nbsp;Lijia Chen ,&nbsp;Jason C. Yam","doi":"10.1016/j.apjo.2025.100200","DOIUrl":"10.1016/j.apjo.2025.100200","url":null,"abstract":"<div><h3>Aim</h3><div>This study investigates the global burden of vision impairment caused by refraction disorders, near vision loss, and other vision loss among children and adolescents from 1990 to 2021. The analysis is categorized globally by sex, age, and socio-demographic index (SDI), with a focus on predicting trends to 2035.</div></div><div><h3>Methods</h3><div>Data weas obtained from the Global Burden of Disease Study 2021. We reported the prevalence and disability-adjusted life-years (DALYs) of vision impairment due to refraction disorders, near vision loss, and other vision loss globally. Then, we described the prevalence and DALYs numbers and rates by sex, SDI and age. Next, we analyzed the relationship between rate and SDI. Finally, bayesian age-period-cohort (BAPC) analysis model was used to predict the trends from 2022 to 2035 globally by sex and age.</div></div><div><h3>Results</h3><div>The prevalence and DALYs rates for refraction disorders had a statistically significant trend of reduction in four age groups globally and were positively associated with SDI. The prevalence and DALYs rates for near vision loss were increasing in four age groups, and were negatively associated with SDI. The BAPC model indicates that the age-specific prevalence and DALYs rates of refraction disorders and other vision loss in both men and women will remain on a downward trend until 2035, while near vision loss continues to rise.</div></div><div><h3>Conclusions</h3><div>The findings underscore that there are extensive variations based on the type of vision impairment, age group, sex and SDI. Policies should be tailored to specific types in order to effectively alleviate the burden.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100200"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey: Practice patterns of intravitreal injection in Japan","authors":"Kazuki Matsuura,&nbsp;Shin-ichi Sasaki,&nbsp;Hidenori Inoue,&nbsp;Takafumi Mori,&nbsp;Kazunobu Sugihara","doi":"10.1016/j.apjo.2025.100169","DOIUrl":"10.1016/j.apjo.2025.100169","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100169"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and projections of the burden of visual impairment in Asia: Findings from the Global Burden of Disease Study 2021","authors":"Shengsong Xu ,&nbsp;Jianqi Chen ,&nbsp;Xiao Wang ,&nbsp;Xiaohua Zhuo ,&nbsp;Yanbin Wang ,&nbsp;Jinyi Xu ,&nbsp;Chuqi Xiang ,&nbsp;Mingxin Lu ,&nbsp;Jingfeng Mu ,&nbsp;Xiao Yang","doi":"10.1016/j.apjo.2025.100196","DOIUrl":"10.1016/j.apjo.2025.100196","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to examine the trends in the burden of visual impairment across Asia from 1990 to 2021 and to project the burden through 2040.</div></div><div><h3>Methods</h3><div>This population-based study used data from the latest Global Burden of Disease 2021 study. Prevalence and years lived with disability (YLDs) were the main outcomes. The trends were analyzed by calculating the average annual percentage change (AAPC) using joinpoint regression analysis. The projection was performed by Bayesian age-period-cohort modeling.</div></div><div><h3>Results</h3><div>The prevalence of visual impairment in Asia increased from 1990 to 2021, with AAPCs of 0.77 (95 % confidence interval [CI], 0.44–1.11), while YLD rates decreased with AAPCs of − 0.21 (95 % CI, − 0.38 to − 0.03). Near vision loss was the main contributor to visual impairment in Asia. Notably, the prevalence in the working-age population (20–54 years) increased significantly from 1990 to 2021 (AAPC = 2.11 [95 % CI, 1.70–2.53]), which was accord with the YLDs (AAPC = 1.07 [95 % CI, 0.83–1.32]), whereas for children and adolescents (&lt; 20 years) and the elderly (≥ 55 years) it has decreased. According to the projection, the burden was predicted to significantly increase across all Asian sub-regions, especially in East Asia and South Asia.</div></div><div><h3>Conclusion</h3><div>The burden of visual impairment in Asia has been substantially increasing from 1990 to 2021. This trend is anticipated to persist significantly soon, especially in East Asia and South Asia, underlining the urgent need for concentrated attention and robust policy support for these regions.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100196"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the accuracy of twenty intraocular lens power calculation formulas in long eyes","authors":"Wiktor Stopyra ,&nbsp;Oleksiy Voytsekhivskyy ,&nbsp;Andrzej Grzybowski","doi":"10.1016/j.apjo.2025.100198","DOIUrl":"10.1016/j.apjo.2025.100198","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the accuracy of twenty intraocular lens (IOL) power calculation formulas in long eyes (26.00–29.99 mm)</div></div><div><h3>Design</h3><div>Retrospective accuracy and validity analysis</div></div><div><h3>Methods</h3><div>The data of patients who underwent uneventful phacoemulsification between August 2019 and July 2024 were reviewed. Pre-surgery IOL power was calculated using Haigis, Holladay 2, SRK/T and Barrett Universal II formulas. Three months after cataract surgery, refraction was measured. Post-surgery IOL power calculations were performed utilizing the following formulas: Castrop, EVO 2.0, Hill-RBF 3.0, Hoffer Q, Holladay 1, Hoffer QST, K6, Kane, Karmona, Ladas Super Formula AI (LSF AI), Naeser 2, Olsen (standalone), PEARL-DGS, T2, VRF and VRF-G. Root mean square absolute error (RMSAE), median absolute error (MedAE) and percentage of eyes with prediction error (PE) within ± 0.25 D, ± 0.50 D, ± 0.75 D and ± 1.00 were calculated.</div></div><div><h3>Results</h3><div>One hundred fifty-three eyes with axial length ranging between 26.00 mm and 29.47 mm, were studied. The SRK/T formula yielded the lowest RMSAE (0.349) with statistical superiority over Holladay 1 (0.519, <em>P</em> = 0.000), Olsen (standalone) (0.505, <em>P</em> = 0.000) and Hoffer Q (0.497, <em>P</em> = 0.000). In terms of MedAE, the lowest outcome was obtained by VRF-G (0.256) followed by Barrett Universal II, Hill-RBF 3.0 and LSF AI (all equally of 0.260). The highest percentage of eyes with prediction error within ± 0.50 D was achieved by SRK/T (84.97 %) statistically significant vs Holladay 1 (60.78 %), Hoffer Q (64.05 %) and Olsen(standalone) (68.63 %).</div></div><div><h3>Conclusions</h3><div>SRK/T has delivered highly accurate results in long eyes. Barrett Universal II, Hill-RBF 3.0, VRF-G and LSF AI are also very true.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100198"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on the clinical management of intraocular foreign body (IOFB)","authors":"Andrea Chor Kiu Au ,&nbsp;Daniel Ho Tak Wong ,&nbsp;Kenneth Kai Wang Li","doi":"10.1016/j.apjo.2025.100208","DOIUrl":"10.1016/j.apjo.2025.100208","url":null,"abstract":"<div><div>This review aims to summarise recent literature in the past decade, focusing on new insights, management strategies, and technique modifications for intraocular foreign body (IOFB) cases. We discuss the latest epidemiological data, diagnostic assessments, and challenging presentations of IOFB. Imaging, particularly non-contrast helical computed tomography with thin cuts, is a valuable diagnostic adjunct. The administration of perioperative prophylactic systemic and intravitreal antibiotics may be useful in reducing infective endophthalmitis risk. We recommend same stage IOFB removal with primary repair within 24 hours whenever feasible. Furthermore, the latest updates on surgical planning, techniques, and instrumentation for IOFB removal, including crystalline lens management, IOFB extraction routes, and intraoperative adjuncts such as perfluorocarbon liquid, cohesive viscoelastic, and mitomycin-C are described. Various IOFB removal techniques including magnet-based, scaffold, suture-based, aspiration and bimanual methods, specialised and innovative instruments are also discussed. This review compiles the most recent advancements and techniques, offering a comprehensive update on the clinical management and surgical removal of IOFB.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100208"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Saffron Repron® in counteracting the progression of retinitis pigmentosa: Neuroprotection and resilience","authors":"Francesca Corsi ,&nbsp;Alessia Galante ,&nbsp;Maria Anna Maggi ,&nbsp;Raffaele Mazziotti ,&nbsp;Silvia Bisti ,&nbsp;Ilaria Piano ,&nbsp;Claudia Gargini","doi":"10.1016/j.apjo.2025.100192","DOIUrl":"10.1016/j.apjo.2025.100192","url":null,"abstract":"<div><div>The mutations observed in the various forms of retinitis pigmentosa (RP) affect genes coding for rod-specific proteins and direct the progression of different forms of dystrophy toward total blindness. The present investigation aims to explore the protective effects of Saffron Repron®, in a mouse model of RP. Saffron was administered orally to pregnant females and weaned pups for 120 days. At different time points (P30, P60, P90, and P120), visual function, retinal function, cone lifespan, morphology, gene expression, and protein level were analyzed. The results indicate that chronic saffron treatment effectively slows the progression of long-term damage caused by genetic mutations in both the morphology and function of retinal neurons. Cellular mechanisms responsible for this action appear complex and, probably, due to coordinated and synergistic activities by its chemical components. Here we provide evidence that saffron is able to modulate the epigenetic pathway involved in neuroinflammation. Biochemical and molecular measures suggest that early saffron treatment may induce a form of adaptation known as acquired resilience.</div></div>","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100192"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision impairment-related burden of disease","authors":"Jost B. Jonas","doi":"10.1016/j.apjo.2025.100203","DOIUrl":"10.1016/j.apjo.2025.100203","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":"14 3","pages":"Article 100203"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vacuum evaporation in the vitreous cavity.","authors":"Alexander Jessup, Andrew Chang","doi":"10.1016/j.apjo.2025.100201","DOIUrl":"10.1016/j.apjo.2025.100201","url":null,"abstract":"","PeriodicalId":8594,"journal":{"name":"Asia-Pacific Journal of Ophthalmology","volume":" ","pages":"100201"},"PeriodicalIF":3.7,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}